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The map label for this gene is hisG

Identifier: 18978030

GI number: 18978030

Start: 1543881

End: 1544495

Strand: Direct

Name: hisG

Synonym: PF1658

Alternate gene names: 18978030

Gene position: 1543881-1544495 (Clockwise)

Preceding gene: 18978029

Following gene: 18978031

Centisome position: 80.91

GC content: 37.89

Gene sequence:

>615_bases
ATGAGGTTTGTTTTACCAAAGGGAAGGCTTTACCAAGATTCGATAAAAGTACTAGAACTCGCTGGAATAAAAGTTCCAAA
GAGAGACGAAAGAGCTCTAATCTGGGGGGATGGAAATAACGAATTCCTTTTAGCTAGAGCGTTTGACGTTCCCGTTTATG
TTGAACATGGAATTGATATAGGAATAGCGGGGAGTGATGTAGTAGAAGAGAGAGGAAGTGACGTGTTTATCCCCCTGGAA
CTACCTTTCGGAAAATGCAGGTTAAGTATAGCTGTCCCCAAGGAGAAAGTTGTAGACCCAGAAAATATGGATGGTTACAA
GATTGCAACAAAATATCCCAACATAACAAAGAGGTACTTTGAAAATCTCAATATTGAAGTTGAAGTGATAAAACTCCACG
GAAGTATAGAGCTAGCTCCAAGAATAGGAATAGCTGATGCAATAGTTGACATAGTGGAAACAGGAAATACATTAAGATCA
AATGGACTCGTTGAAGTTGCAAAGATAATGGATGTTTCAGCGCTCCTCTTAGTAAATCGCATTTCTCAAAAGATGTTCTT
TGAAGAAATTAATTCTTTCATAACAAAAATTAGGAGGTCTGTTTATGGACATTGA

Upstream 100 bases:

>100_bases
AAGATAGGGCAAGAAAAGTTATTTCTGAAATAGATCCTAAGAAAGCATATTCCACAGCTAGAGAAATGGTGAGACTAGGA
ATTCCAGTGGAGGTGAGGTT

Downstream 100 bases:

>100_bases
AGAATACGTCAGGGAGATTTTGAAAGATATCCGGGAAAGAGGATTAGAGGCAATAAGAGAGTACTCAAAAAAATTCGACG
GATATGAAGGCCCATTTGAA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MRFVLPKGRLYQDSIKVLELAGIKVPKRDERALIWGDGNNEFLLARAFDVPVYVEHGIDIGIAGSDVVEERGSDVFIPLE
LPFGKCRLSIAVPKEKVVDPENMDGYKIATKYPNITKRYFENLNIEVEVIKLHGSIELAPRIGIADAIVDIVETGNTLRS
NGLVEVAKIMDVSALLLVNRISQKMFFEEINSFITKIRRSVYGH

Sequences:

>Translated_204_residues
MRFVLPKGRLYQDSIKVLELAGIKVPKRDERALIWGDGNNEFLLARAFDVPVYVEHGIDIGIAGSDVVEERGSDVFIPLE
LPFGKCRLSIAVPKEKVVDPENMDGYKIATKYPNITKRYFENLNIEVEVIKLHGSIELAPRIGIADAIVDIVETGNTLRS
NGLVEVAKIMDVSALLLVNRISQKMFFEEINSFITKIRRSVYGH
>Mature_204_residues
MRFVLPKGRLYQDSIKVLELAGIKVPKRDERALIWGDGNNEFLLARAFDVPVYVEHGIDIGIAGSDVVEERGSDVFIPLE
LPFGKCRLSIAVPKEKVVDPENMDGYKIATKYPNITKRYFENLNIEVEVIKLHGSIELAPRIGIADAIVDIVETGNTLRS
NGLVEVAKIMDVSALLLVNRISQKMFFEEINSFITKIRRSVYGH

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=190, Percent_Identity=39.4736842105263, Blast_Score=115, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320896, Length=205, Percent_Identity=35.1219512195122, Blast_Score=102, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_PYRFU (Q8U0D4)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_579387.1
- ProteinModelPortal:   Q8U0D4
- SMR:   Q8U0D4
- EnsemblBacteria:   EBPYRT00000004508
- GeneID:   1469535
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1658
- NMPDR:   fig|186497.1.peg.1706
- GeneTree:   EBGT00050000023545
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- ProtClustDB:   PRK01686
- BRENDA:   2.4.2.17
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 22913; Mature: 22913

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFVLPKGRLYQDSIKVLELAGIKVPKRDERALIWGDGNNEFLLARAFDVPVYVEHGIDI
CEEECCCCCEEHHHHHEEEECCCCCCCCCCEEEEEECCCCCEEEEEECCCCEEEECCCEE
GIAGSDVVEERGSDVFIPLELPFGKCRLSIAVPKEKVVDPENMDGYKIATKYPNITKRYF
EECCCHHHHHCCCEEEEEEECCCCEEEEEEECCHHHCCCCCCCCCEEEEECCCCHHHHHH
ENLNIEVEVIKLHGSIELAPRIGIADAIVDIVETGNTLRSNGLVEVAKIMDVSALLLVNR
HCCCEEEEEEEEECCEEECCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
ISQKMFFEEINSFITKIRRSVYGH
HHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRFVLPKGRLYQDSIKVLELAGIKVPKRDERALIWGDGNNEFLLARAFDVPVYVEHGIDI
CEEECCCCCEEHHHHHEEEECCCCCCCCCCEEEEEECCCCCEEEEEECCCCEEEECCCEE
GIAGSDVVEERGSDVFIPLELPFGKCRLSIAVPKEKVVDPENMDGYKIATKYPNITKRYF
EECCCHHHHHCCCEEEEEEECCCCEEEEEEECCHHHCCCCCCCCCEEEEECCCCHHHHHH
ENLNIEVEVIKLHGSIELAPRIGIADAIVDIVETGNTLRSNGLVEVAKIMDVSALLLVNR
HCCCEEEEEEEEECCEEECCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
ISQKMFFEEINSFITKIRRSVYGH
HHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA