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The map label for this gene is wecC [H]

Identifier: 18978003

GI number: 18978003

Start: 1522219

End: 1523523

Strand: Reverse

Name: wecC [H]

Synonym: PF1631

Alternate gene names: 18978003

Gene position: 1523523-1522219 (Counterclockwise)

Preceding gene: 18978005

Following gene: 18978002

Centisome position: 79.84

GC content: 41.15

Gene sequence:

>1305_bases
ATGAGAATCCTTAAATTTTGTGTTCTATTTGATAAGCTGGGGGTTAGAATGAAAATCGCGGTTATAGGATTAGGTTACAT
AGGGCTTCCCACTGCAATAATGTTTGCTGAAGCGGGATATGAAGTGATTGGGTTTGATGTAAAGAAGGATGTTGTTGATA
GAATAAATTCGGGTAAAGCTCACATAGTTGAGCCTGGTATTGAAGAAAAGCTGAATAAAGTCGTTAAGGAAGAAAGGCTC
AAGGCAACTACAAAGGTTGAAAAACTTAGAGGAGCAAATGCATTCATTATATGTGTCCAAACCCCATTAGAGGGAAATAA
GCCAAATTTAATTTACTTGGAGAACGCAATAAGATCTGTTGCGGAAGTAATTGATAGGGGGGCTCTAGTAATTATAGAAA
GCACTGTGCCCCCTGGGACTACAATAAAAATGGCTAAGCTTCTTGAAAGTTTGACTGGGTTTAGAGAAGGTGTGGACTTT
TACATGGCCCATGCCCCAGAGAGGGTAATGCCAGGTAGAATATTCTATGAGCTGGTTTACAATTCTAGGGTGATAGGAGG
AGTTAGTGAAAAAGCTACTGAACTAGCCGTGAAGTTGTATAAATCCTTTGTGAAAGGGGAGATATATGCTACAGATGCAA
CTACAGCCGAAATGATAAAGCTCATGGAGAACACTTACAGAGATGTAAATATCGCCCTTGCAAACGAGTTTGCACTTCTT
GCTCATCAATATGGTGTAAACATCTTTGAGGCAATAAGAATTGCAAATACTCATCCAAGAGTAAATATTCACTTCCCAGG
GATAGGGGTTGGAGGTCACTGCTTGCCGAAGGATCCCTACCTATTGTTGTCCAACGCTAAAAAAGAATTTGGGCTAATAA
GGTTGGCTAGGAAAATAAATGAAAGCATGCCAAAGTTTGTAGCAACTCTGCTTTTTGAAGCCCTAGAAGAAGGGGGAGTT
GAGGAGAGGGAGGCAGTTGTGACAGTCCTAGGTCTAGCTTATAAAGGAGGAACAGATGACATAAGGAACTCTCCCGCATT
GACCTTTGTGAAGCTTATAAGGGATAGAGTCCTTGAAGTTAGAACATATGATCCATACGTGGGAGGAACGCATAAGAGCT
TAGAAGATGCAATTGTGGAGGCCGATGCAGTAGTTATAGCTACAGACCACCCAGAATTCAAGGAGTTAAATTGGGAAGAA
ATAGGGAGGTTAATGAGACACAAAATATTGATCGATGGAAGGGGAATAGTTAGCAATCCTCCAAAAGGCTTCATATTTAA
GGGAGTGGGGAGAGGGGACGTATGA

Upstream 100 bases:

>100_bases
TTTTGTTTCTTTGTGCTTTTAATCTCTTATTTTTTCAAAAATTCCGACTTAAGTCCTGAACTTTGTAAAAGCAGAGATAT
TATCAGAATTTTGTTGTTTC

Downstream 100 bases:

>100_bases
GGCCAGCTATAATTTTTGGTACGAGACCTGAGATAATAAAACTCTCTCCCGTAATAAGGGGTTTTTTAGAGAAGAACGTT
GAGCCACTGCTAATTCACAC

Product: NDP-sugar dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MRILKFCVLFDKLGVRMKIAVIGLGYIGLPTAIMFAEAGYEVIGFDVKKDVVDRINSGKAHIVEPGIEEKLNKVVKEERL
KATTKVEKLRGANAFIICVQTPLEGNKPNLIYLENAIRSVAEVIDRGALVIIESTVPPGTTIKMAKLLESLTGFREGVDF
YMAHAPERVMPGRIFYELVYNSRVIGGVSEKATELAVKLYKSFVKGEIYATDATTAEMIKLMENTYRDVNIALANEFALL
AHQYGVNIFEAIRIANTHPRVNIHFPGIGVGGHCLPKDPYLLLSNAKKEFGLIRLARKINESMPKFVATLLFEALEEGGV
EEREAVVTVLGLAYKGGTDDIRNSPALTFVKLIRDRVLEVRTYDPYVGGTHKSLEDAIVEADAVVIATDHPEFKELNWEE
IGRLMRHKILIDGRGIVSNPPKGFIFKGVGRGDV

Sequences:

>Translated_434_residues
MRILKFCVLFDKLGVRMKIAVIGLGYIGLPTAIMFAEAGYEVIGFDVKKDVVDRINSGKAHIVEPGIEEKLNKVVKEERL
KATTKVEKLRGANAFIICVQTPLEGNKPNLIYLENAIRSVAEVIDRGALVIIESTVPPGTTIKMAKLLESLTGFREGVDF
YMAHAPERVMPGRIFYELVYNSRVIGGVSEKATELAVKLYKSFVKGEIYATDATTAEMIKLMENTYRDVNIALANEFALL
AHQYGVNIFEAIRIANTHPRVNIHFPGIGVGGHCLPKDPYLLLSNAKKEFGLIRLARKINESMPKFVATLLFEALEEGGV
EEREAVVTVLGLAYKGGTDDIRNSPALTFVKLIRDRVLEVRTYDPYVGGTHKSLEDAIVEADAVVIATDHPEFKELNWEE
IGRLMRHKILIDGRGIVSNPPKGFIFKGVGRGDV
>Mature_434_residues
MRILKFCVLFDKLGVRMKIAVIGLGYIGLPTAIMFAEAGYEVIGFDVKKDVVDRINSGKAHIVEPGIEEKLNKVVKEERL
KATTKVEKLRGANAFIICVQTPLEGNKPNLIYLENAIRSVAEVIDRGALVIIESTVPPGTTIKMAKLLESLTGFREGVDF
YMAHAPERVMPGRIFYELVYNSRVIGGVSEKATELAVKLYKSFVKGEIYATDATTAEMIKLMENTYRDVNIALANEFALL
AHQYGVNIFEAIRIANTHPRVNIHFPGIGVGGHCLPKDPYLLLSNAKKEFGLIRLARKINESMPKFVATLLFEALEEGGV
EEREAVVTVLGLAYKGGTDDIRNSPALTFVKLIRDRVLEVRTYDPYVGGTHKSLEDAIVEADAVVIATDHPEFKELNWEE
IGRLMRHKILIDGRGIVSNPPKGFIFKGVGRGDV

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=446, Percent_Identity=24.2152466367713, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI296040438, Length=352, Percent_Identity=23.0113636363636, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI48994968, Length=421, Percent_Identity=40.6175771971496, Blast_Score=302, Evalue=3e-83,
Organism=Escherichia coli, GI1788340, Length=358, Percent_Identity=31.8435754189944, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17560350, Length=449, Percent_Identity=25.6124721603563, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17136908, Length=464, Percent_Identity=24.1379310344828, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 48069; Mature: 48069

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILKFCVLFDKLGVRMKIAVIGLGYIGLPTAIMFAEAGYEVIGFDVKKDVVDRINSGKA
CHHHHHHHHHHHCCCEEEEEEEEECHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCCC
HIVEPGIEEKLNKVVKEERLKATTKVEKLRGANAFIICVQTPLEGNKPNLIYLENAIRSV
EEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEHHHHHHHH
AEVIDRGALVIIESTVPPGTTIKMAKLLESLTGFREGVDFYMAHAPERVMPGRIFYELVY
HHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHH
NSRVIGGVSEKATELAVKLYKSFVKGEIYATDATTAEMIKLMENTYRDVNIALANEFALL
CCEEECCCHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHCCCCEEEEEHHHHHHH
AHQYGVNIFEAIRIANTHPRVNIHFPGIGVGGHCLPKDPYLLLSNAKKEFGLIRLARKIN
HHHHCCCHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHH
ESMPKFVATLLFEALEEGGVEEREAVVTVLGLAYKGGTDDIRNSPALTFVKLIRDRVLEV
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHEE
RTYDPYVGGTHKSLEDAIVEADAVVIATDHPEFKELNWEEIGRLMRHKILIDGRGIVSNP
EECCCCCCCCCHHHHHHHHCCCEEEEECCCCCHHCCCHHHHHHHHHHEEEECCCCCCCCC
PKGFIFKGVGRGDV
CCCCEEECCCCCCC
>Mature Secondary Structure
MRILKFCVLFDKLGVRMKIAVIGLGYIGLPTAIMFAEAGYEVIGFDVKKDVVDRINSGKA
CHHHHHHHHHHHCCCEEEEEEEEECHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCCC
HIVEPGIEEKLNKVVKEERLKATTKVEKLRGANAFIICVQTPLEGNKPNLIYLENAIRSV
EEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEHHHHHHHH
AEVIDRGALVIIESTVPPGTTIKMAKLLESLTGFREGVDFYMAHAPERVMPGRIFYELVY
HHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHH
NSRVIGGVSEKATELAVKLYKSFVKGEIYATDATTAEMIKLMENTYRDVNIALANEFALL
CCEEECCCHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHCCCCEEEEEHHHHHHH
AHQYGVNIFEAIRIANTHPRVNIHFPGIGVGGHCLPKDPYLLLSNAKKEFGLIRLARKIN
HHHHCCCHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHH
ESMPKFVATLLFEALEEGGVEEREAVVTVLGLAYKGGTDDIRNSPALTFVKLIRDRVLEV
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHEE
RTYDPYVGGTHKSLEDAIVEADAVVIATDHPEFKELNWEEIGRLMRHKILIDGRGIVSNP
EECCCCCCCCCHHHHHHHHCCCEEEEECCCCCHHCCCHHHHHHHHHHEEEECCCCCCCCC
PKGFIFKGVGRGDV
CCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA