Click here to switch to the map view.

The map label for this gene is wecB [H]

Identifier: 18978002

GI number: 18978002

Start: 1521080

End: 1522222

Strand: Reverse

Name: wecB [H]

Synonym: PF1630

Alternate gene names: 18978002

Gene position: 1522222-1521080 (Counterclockwise)

Preceding gene: 18978003

Following gene: 18977999

Centisome position: 79.77

GC content: 39.11

Gene sequence:

>1143_bases
ATGAGGCCAGCTATAATTTTTGGTACGAGACCTGAGATAATAAAACTCTCTCCCGTAATAAGGGGTTTTTTAGAGAAGAA
CGTTGAGCCACTGCTAATTCACACAGGTCAACATTATGATTACGAGATGAGCAAAATATTTCTTGAAGAGCTAGAATTGC
CAGAGATAGATTATCACCTAGAAGTGGGTTCTGGTACTCAGGCCGAGCAAACAGGAATTGCAATGATTAAAATAGAAAAA
GTTTTGATGGAAGAGAAGCCTGATGTCTCAATAGTCCAGGGTGATACAAACACTGTGCTGGCAGGAGCTTTGGCGAGCGT
GAAGCTGTTAATTCCTGTTGCTCACGTAGAAGCTGGATTGAGGAGTTTTGATAGGACTATGCCAGAGGAAATTAACAGGA
TATTGGCTGATCATGCAAGTGAAGTTCTATTTGCTCCAACAGAGGAAGCCAAGAAAAATCTTGAGAAAGAGGGAATAGTT
GAGAATGTGTACGTTGTGGGAAATACAATAGTCGATGCCGTTCTTCAGAATTCTGAAATTGCAGAAAGAAAAAGCAAAAT
TCTCAAAGAATTGGGGCTTAAAGAGAAAGAATACATATTGGTGACTGCACATAGAAAAGAGAACGTTGATTACAGGGAAA
AGCTTGAAAAATTAGTTGATATTTTAACTTCTCTTCCGCTTACAGTTGTTTATCCAATGCATCCCAGGACTAAAAAGAGG
CTTGAAGAATTTGGGTTGATCAACAAGCTCAACAAGGAGAACATAATAATAACTAAACCCCTGGGATATCTAGATTTTTT
GAAGCTCGAGAAAAATGCAAAGATAATAATGACGGACTCGGGAGGAATTCAGGAGGAGGCCATAATACTAGGTGTCCCCT
GCCTGACACTAAGATACAACACAGAGAGGCCTGAGACAGTTAAAGCTGGAGGAAATATTTTAGTTGGATTAGAAAAAGAG
AGGGTCCTTTACTATGTAACAAAGCTTCTTGAAGATGAGGAATTCTATGAAAAGATGGCCTCAGCAAAGAATCCTTTTGG
AGACGGAAATGCTGGAAAGAGAATAGTGGAGATTTTGTTGGAATTAAAGGCTAAAGGAAAGTTAAAAGTTAGATCCTCCA
ACTTTCTAAACTCCCTCGAATAA

Upstream 100 bases:

>100_bases
TAGGGAGGTTAATGAGACACAAAATATTGATCGATGGAAGGGGAATAGTTAGCAATCCTCCAAAAGGCTTCATATTTAAG
GGAGTGGGGAGAGGGGACGT

Downstream 100 bases:

>100_bases
TCTTTCGGCTAAAAATGGTGGTAACCCTGCTTTTATAATTTTTCTTGCTGCAGTTTCAACGTCGTATTCAACTCTAAAGA
ACTCCACTTCTCCATTTTCA

Product: UDP-n-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MRPAIIFGTRPEIIKLSPVIRGFLEKNVEPLLIHTGQHYDYEMSKIFLEELELPEIDYHLEVGSGTQAEQTGIAMIKIEK
VLMEEKPDVSIVQGDTNTVLAGALASVKLLIPVAHVEAGLRSFDRTMPEEINRILADHASEVLFAPTEEAKKNLEKEGIV
ENVYVVGNTIVDAVLQNSEIAERKSKILKELGLKEKEYILVTAHRKENVDYREKLEKLVDILTSLPLTVVYPMHPRTKKR
LEEFGLINKLNKENIIITKPLGYLDFLKLEKNAKIIMTDSGGIQEEAIILGVPCLTLRYNTERPETVKAGGNILVGLEKE
RVLYYVTKLLEDEEFYEKMASAKNPFGDGNAGKRIVEILLELKAKGKLKVRSSNFLNSLE

Sequences:

>Translated_380_residues
MRPAIIFGTRPEIIKLSPVIRGFLEKNVEPLLIHTGQHYDYEMSKIFLEELELPEIDYHLEVGSGTQAEQTGIAMIKIEK
VLMEEKPDVSIVQGDTNTVLAGALASVKLLIPVAHVEAGLRSFDRTMPEEINRILADHASEVLFAPTEEAKKNLEKEGIV
ENVYVVGNTIVDAVLQNSEIAERKSKILKELGLKEKEYILVTAHRKENVDYREKLEKLVDILTSLPLTVVYPMHPRTKKR
LEEFGLINKLNKENIIITKPLGYLDFLKLEKNAKIIMTDSGGIQEEAIILGVPCLTLRYNTERPETVKAGGNILVGLEKE
RVLYYVTKLLEDEEFYEKMASAKNPFGDGNAGKRIVEILLELKAKGKLKVRSSNFLNSLE
>Mature_380_residues
MRPAIIFGTRPEIIKLSPVIRGFLEKNVEPLLIHTGQHYDYEMSKIFLEELELPEIDYHLEVGSGTQAEQTGIAMIKIEK
VLMEEKPDVSIVQGDTNTVLAGALASVKLLIPVAHVEAGLRSFDRTMPEEINRILADHASEVLFAPTEEAKKNLEKEGIV
ENVYVVGNTIVDAVLQNSEIAERKSKILKELGLKEKEYILVTAHRKENVDYREKLEKLVDILTSLPLTVVYPMHPRTKKR
LEEFGLINKLNKENIIITKPLGYLDFLKLEKNAKIIMTDSGGIQEEAIILGVPCLTLRYNTERPETVKAGGNILVGLEKE
RVLYYVTKLLEDEEFYEKMASAKNPFGDGNAGKRIVEILLELKAKGKLKVRSSNFLNSLE

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) to produce UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=376, Percent_Identity=39.0957446808511, Blast_Score=213, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 42816; Mature: 42816

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPAIIFGTRPEIIKLSPVIRGFLEKNVEPLLIHTGQHYDYEMSKIFLEELELPEIDYHL
CCCEEEECCCCCEEEECHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCEEEE
EVGSGTQAEQTGIAMIKIEKVLMEEKPDVSIVQGDTNTVLAGALASVKLLIPVAHVEAGL
EECCCCCCHHCCEEEEEEHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
RSFDRTMPEEINRILADHASEVLFAPTEEAKKNLEKEGIVENVYVVGNTIVDAVLQNSEI
HHHHHCCHHHHHHHHHHHCCCEEECCCHHHHHCCHHCCCHHEEEEEHHHHHHHHHCCCHH
AERKSKILKELGLKEKEYILVTAHRKENVDYREKLEKLVDILTSLPLTVVYPMHPRTKKR
HHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHH
LEEFGLINKLNKENIIITKPLGYLDFLKLEKNAKIIMTDSGGIQEEAIILGVPCLTLRYN
HHHHHHHHCCCCCCEEEECCCCHHHHHEECCCCEEEEECCCCCCCCEEEEECCEEEEEEC
TERPETVKAGGNILVGLEKERVLYYVTKLLEDEEFYEKMASAKNPFGDGNAGKRIVEILL
CCCCCEEECCCCEEEEECHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHH
ELKAKGKLKVRSSNFLNSLE
HHCCCCEEEEECCCHHHCCC
>Mature Secondary Structure
MRPAIIFGTRPEIIKLSPVIRGFLEKNVEPLLIHTGQHYDYEMSKIFLEELELPEIDYHL
CCCEEEECCCCCEEEECHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCEEEE
EVGSGTQAEQTGIAMIKIEKVLMEEKPDVSIVQGDTNTVLAGALASVKLLIPVAHVEAGL
EECCCCCCHHCCEEEEEEHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
RSFDRTMPEEINRILADHASEVLFAPTEEAKKNLEKEGIVENVYVVGNTIVDAVLQNSEI
HHHHHCCHHHHHHHHHHHCCCEEECCCHHHHHCCHHCCCHHEEEEEHHHHHHHHHCCCHH
AERKSKILKELGLKEKEYILVTAHRKENVDYREKLEKLVDILTSLPLTVVYPMHPRTKKR
HHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHH
LEEFGLINKLNKENIIITKPLGYLDFLKLEKNAKIIMTDSGGIQEEAIILGVPCLTLRYN
HHHHHHHHCCCCCCEEEECCCCHHHHHEECCCCEEEEECCCCCCCCEEEEECCEEEEEEC
TERPETVKAGGNILVGLEKERVLYYVTKLLEDEEFYEKMASAKNPFGDGNAGKRIVEILL
CCCCCEEECCCCEEEEECHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHH
ELKAKGKLKVRSSNFLNSLE
HHCCCCEEEEECCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]