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The map label for this gene is glyS [H]

Identifier: 18977999

GI number: 18977999

Start: 1517263

End: 1518969

Strand: Reverse

Name: glyS [H]

Synonym: PF1627

Alternate gene names: 18977999

Gene position: 1518969-1517263 (Counterclockwise)

Preceding gene: 18978002

Following gene: 18977998

Centisome position: 79.6

GC content: 41.48

Gene sequence:

>1707_bases
ATGAAGTTCGATAAATATGAGTACCTTCAGGATTTAATGAGAAGGAGAGGGTTTGCCTGGGGAAGCTTTGAGATATATGG
AGGGGCGAGAGGATTTTACGATTATGGGCCACTAGGAGCGACAATAAAAAGGAAAATAGAGAAAAAGATTAGAGAGGCCT
TTATTAGGGAAGGGTTCTTTGAGATTGAGACTCCAGATATAACCCCAGAGCAGGTGTTCATAGCCAGTGGCCACGTTGAG
AAGTTTGTGGATCCGTTGGTAGAGTGTAAGAAGTGTGGGGCAAGGTTTAGGGCTGATCACCTTATAGAGGAAACTCTAGG
AATTGACGTTGAAGGAAAGAGTGCTGAGGAGATGACGAAGATAATTAGAGAGCACAACATAAGATGTCCTGAGTGTGGAG
GAGAGCTGAGTGACGTTTGGTATTTCAATTTGATGTTCGAAACATACATAGGGCCTTATAAGGATAAGAAAGCATATTTA
AGGCCAGAAACGGCCCAGGGGATATTTGTGAACTTTAAGAGGTTAAATGCATTTGCTAGAAACAAGCTACCCTTTGGAGT
TTTCCAGATAGGGAAGGCATATAGGAATGAAATATCGCCAAGACAGGGAATGATTAGGCTTAGAGAATTCACCCAGGCTG
AGGTGGAGATATTTTTCAATCCTAACGAAACTGAGCATCCTCACTTTGATGAGGTTAAGGATGAAGTTCTGAGGTTATAT
CCAATAGAACACCAACTGAAAGACCTGGGAATGATTGAATTAACAGCTGAGGAGGCAGTGAAAAAAGGCTACGTCATGAA
CACCTTCTTTGCATATTACATGGTTATGATAAAGAGAATCCTGCTCGACATAGGAATTCCTGAGGACAAAATAAGGTTTA
GGCAACAACTCCCAGAAGAGAGGGCCCACTACTCTGCCGACACCTGGGATGCTGAGATATACAGTGAGAGATTTGGATGG
GTAGAGTGCGTTGGTTTAGCTTACAGAACTGATTATGACTTAAGTAGGCACATGAAAATGAGTGGAGCAGATTTGACCGT
AATGATTCACTATGACAAGCCGAAGATAGTGAAAAAGTTAAACGTAACATTGAACATGAAGAAGGTTGGGCCAAAGTTAA
AGGAGAAAGTGAAGGAGATAAATGAGAAGCTTAAATCAATGTCCCAGGAAGAGCTACGTAAGTTAGTTGAAGAGCTTAAT
GCAAATGGAAAGGTTATCATTGAGGGGCATGAGCTTGAGAAGGAAGACCTTATAATAAAAGAAGTAGAGGAGAAAATCCA
AGGAGAAAAAATTGTTCCCCATGTTCTTGAGCCAAGTTTTGGAATTGACAGGCCATTCTATCTCCTCCTTGAGAACTCAC
TAACTGTTGACGAGGATGGGAGAGTTTACTTAAAGATAAAGAAGGACATGGCCCCAATTGAAGTAGCAGTTCTGCCTTTA
GTTGCAAAGGAGCCTTTGACAACAATAGCTTATGAAATTTATAGGAACTTGCAGAAGGAAGGATTTATCGTAGTTTACGA
CGAAAAGGACAGTATAGGAAAGAGATATATGCGCTATGATGAAATCGGAACGCCCTACTGTGTGACTGTGGATAATCAAA
CGCCAGAAGATGGCACAGTCACAATAAGGGATAGGGACACCAGGGAGCAGATAAGGGTTAAGATCGAGGAAGTGCCAAGA
AAATTAAAGGAGTTGATTTTTGGCTAA

Upstream 100 bases:

>100_bases
CTTCAAAGTATGAGTTTGGGAGTTTGAGTCTTATCATCTTGTCAACATGTATAGACAAAGCTTTTTAGGTGTTAGCATTT
TTTCAGATAGGGGTAGAGTT

Downstream 100 bases:

>100_bases
ATCCAATATTTTTTGGTGGGAAAATGAGAAAAATTCGTCTGGTATATAGGAGGTTCCCAAACAGAGTTATTATGAGAGAA
GATGAAGTAATTGAAGACTT

Product: glycyl-tRNA synthetase

Products: NA

Alternate protein names: Glycine--tRNA ligase; GlyRS [H]

Number of amino acids: Translated: 568; Mature: 568

Protein sequence:

>568_residues
MKFDKYEYLQDLMRRRGFAWGSFEIYGGARGFYDYGPLGATIKRKIEKKIREAFIREGFFEIETPDITPEQVFIASGHVE
KFVDPLVECKKCGARFRADHLIEETLGIDVEGKSAEEMTKIIREHNIRCPECGGELSDVWYFNLMFETYIGPYKDKKAYL
RPETAQGIFVNFKRLNAFARNKLPFGVFQIGKAYRNEISPRQGMIRLREFTQAEVEIFFNPNETEHPHFDEVKDEVLRLY
PIEHQLKDLGMIELTAEEAVKKGYVMNTFFAYYMVMIKRILLDIGIPEDKIRFRQQLPEERAHYSADTWDAEIYSERFGW
VECVGLAYRTDYDLSRHMKMSGADLTVMIHYDKPKIVKKLNVTLNMKKVGPKLKEKVKEINEKLKSMSQEELRKLVEELN
ANGKVIIEGHELEKEDLIIKEVEEKIQGEKIVPHVLEPSFGIDRPFYLLLENSLTVDEDGRVYLKIKKDMAPIEVAVLPL
VAKEPLTTIAYEIYRNLQKEGFIVVYDEKDSIGKRYMRYDEIGTPYCVTVDNQTPEDGTVTIRDRDTREQIRVKIEEVPR
KLKELIFG

Sequences:

>Translated_568_residues
MKFDKYEYLQDLMRRRGFAWGSFEIYGGARGFYDYGPLGATIKRKIEKKIREAFIREGFFEIETPDITPEQVFIASGHVE
KFVDPLVECKKCGARFRADHLIEETLGIDVEGKSAEEMTKIIREHNIRCPECGGELSDVWYFNLMFETYIGPYKDKKAYL
RPETAQGIFVNFKRLNAFARNKLPFGVFQIGKAYRNEISPRQGMIRLREFTQAEVEIFFNPNETEHPHFDEVKDEVLRLY
PIEHQLKDLGMIELTAEEAVKKGYVMNTFFAYYMVMIKRILLDIGIPEDKIRFRQQLPEERAHYSADTWDAEIYSERFGW
VECVGLAYRTDYDLSRHMKMSGADLTVMIHYDKPKIVKKLNVTLNMKKVGPKLKEKVKEINEKLKSMSQEELRKLVEELN
ANGKVIIEGHELEKEDLIIKEVEEKIQGEKIVPHVLEPSFGIDRPFYLLLENSLTVDEDGRVYLKIKKDMAPIEVAVLPL
VAKEPLTTIAYEIYRNLQKEGFIVVYDEKDSIGKRYMRYDEIGTPYCVTVDNQTPEDGTVTIRDRDTREQIRVKIEEVPR
KLKELIFG
>Mature_568_residues
MKFDKYEYLQDLMRRRGFAWGSFEIYGGARGFYDYGPLGATIKRKIEKKIREAFIREGFFEIETPDITPEQVFIASGHVE
KFVDPLVECKKCGARFRADHLIEETLGIDVEGKSAEEMTKIIREHNIRCPECGGELSDVWYFNLMFETYIGPYKDKKAYL
RPETAQGIFVNFKRLNAFARNKLPFGVFQIGKAYRNEISPRQGMIRLREFTQAEVEIFFNPNETEHPHFDEVKDEVLRLY
PIEHQLKDLGMIELTAEEAVKKGYVMNTFFAYYMVMIKRILLDIGIPEDKIRFRQQLPEERAHYSADTWDAEIYSERFGW
VECVGLAYRTDYDLSRHMKMSGADLTVMIHYDKPKIVKKLNVTLNMKKVGPKLKEKVKEINEKLKSMSQEELRKLVEELN
ANGKVIIEGHELEKEDLIIKEVEEKIQGEKIVPHVLEPSFGIDRPFYLLLENSLTVDEDGRVYLKIKKDMAPIEVAVLPL
VAKEPLTTIAYEIYRNLQKEGFIVVYDEKDSIGKRYMRYDEIGTPYCVTVDNQTPEDGTVTIRDRDTREQIRVKIEEVPR
KLKELIFG

Specific function: Catalyzes the attachment of glycine to tRNA(Gly) [H]

COG id: COG0423

COG function: function code J; Glycyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI116805340, Length=592, Percent_Identity=38.1756756756757, Blast_Score=387, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI32564541, Length=598, Percent_Identity=40.9698996655518, Blast_Score=413, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17554996, Length=598, Percent_Identity=40.9698996655518, Blast_Score=413, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6325338, Length=598, Percent_Identity=37.9598662207358, Blast_Score=388, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6319597, Length=628, Percent_Identity=35.828025477707, Blast_Score=373, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24664462, Length=582, Percent_Identity=40.2061855670103, Blast_Score=415, Evalue=1e-116,
Organism=Drosophila melanogaster, GI21357965, Length=582, Percent_Identity=40.2061855670103, Blast_Score=414, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR022960
- InterPro:   IPR002315 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.14 [H]

Molecular weight: Translated: 66399; Mature: 66399

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFDKYEYLQDLMRRRGFAWGSFEIYGGARGFYDYGPLGATIKRKIEKKIREAFIREGFF
CCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCE
EIETPDITPEQVFIASGHVEKFVDPLVECKKCGARFRADHLIEETLGIDVEGKSAEEMTK
EEECCCCCCCEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHH
IIREHNIRCPECGGELSDVWYFNLMFETYIGPYKDKKAYLRPETAQGIFVNFKRLNAFAR
HHHHCCCCCCCCCCCHHHHHHHEEHHHHHCCCCCCCCCEECCCCCCCEEEEHHHHHHHHH
NKLPFGVFQIGKAYRNEISPRQGMIRLREFTQAEVEIFFNPNETEHPHFDEVKDEVLRLY
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHC
PIEHQLKDLGMIELTAEEAVKKGYVMNTFFAYYMVMIKRILLDIGIPEDKIRFRQQLPEE
CCHHHHHHCCEEEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHH
RAHYSADTWDAEIYSERFGWVECVGLAYRTDYDLSRHMKMSGADLTVMIHYDKPKIVKKL
HHCCCCCCCHHHHHHHHCCHHHHHHHHEECCCCHHHHHEECCCCEEEEEEECCCHHHHHC
NVTLNMKKVGPKLKEKVKEINEKLKSMSQEELRKLVEELNANGKVIIEGHELEKEDLIIK
CCEEEHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHH
EVEEKIQGEKIVPHVLEPSFGIDRPFYLLLENSLTVDEDGRVYLKIKKDMAPIEVAVLPL
HHHHHHCCCCCCCHHCCCCCCCCCCEEEEEECCEEECCCCEEEEEEECCCCCEEEEEECH
VAKEPLTTIAYEIYRNLQKEGFIVVYDEKDSIGKRYMRYDEIGTPYCVTVDNQTPEDGTV
HCCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCEE
TIRDRDTREQIRVKIEEVPRKLKELIFG
EEECCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKFDKYEYLQDLMRRRGFAWGSFEIYGGARGFYDYGPLGATIKRKIEKKIREAFIREGFF
CCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCE
EIETPDITPEQVFIASGHVEKFVDPLVECKKCGARFRADHLIEETLGIDVEGKSAEEMTK
EEECCCCCCCEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHH
IIREHNIRCPECGGELSDVWYFNLMFETYIGPYKDKKAYLRPETAQGIFVNFKRLNAFAR
HHHHCCCCCCCCCCCHHHHHHHEEHHHHHCCCCCCCCCEECCCCCCCEEEEHHHHHHHHH
NKLPFGVFQIGKAYRNEISPRQGMIRLREFTQAEVEIFFNPNETEHPHFDEVKDEVLRLY
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHC
PIEHQLKDLGMIELTAEEAVKKGYVMNTFFAYYMVMIKRILLDIGIPEDKIRFRQQLPEE
CCHHHHHHCCEEEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHH
RAHYSADTWDAEIYSERFGWVECVGLAYRTDYDLSRHMKMSGADLTVMIHYDKPKIVKKL
HHCCCCCCCHHHHHHHHCCHHHHHHHHEECCCCHHHHHEECCCCEEEEEEECCCHHHHHC
NVTLNMKKVGPKLKEKVKEINEKLKSMSQEELRKLVEELNANGKVIIEGHELEKEDLIIK
CCEEEHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHH
EVEEKIQGEKIVPHVLEPSFGIDRPFYLLLENSLTVDEDGRVYLKIKKDMAPIEVAVLPL
HHHHHHCCCCCCCHHCCCCCCCCCCEEEEEECCEEECCCCEEEEEEECCCCCEEEEEECH
VAKEPLTTIAYEIYRNLQKEGFIVVYDEKDSIGKRYMRYDEIGTPYCVTVDNQTPEDGTV
HCCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCEE
TIRDRDTREQIRVKIEEVPRKLKELIFG
EEECCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]