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The map label for this gene is uppS

Identifier: 18977971

GI number: 18977971

Start: 1491721

End: 1492515

Strand: Reverse

Name: uppS

Synonym: PF1599

Alternate gene names: 18977971

Gene position: 1492515-1491721 (Counterclockwise)

Preceding gene: 18977972

Following gene: 18977965

Centisome position: 78.21

GC content: 36.98

Gene sequence:

>795_bases
ATGATTTACAGAATAATTTCTCATATCCCTTCAATATTTTTCAAACCTGCATATGACTTGTACGAGAGATACCTCCTAGA
GAAAGTTAAGGCTGGGGTTATCCCAAAACACGTAGCCATAATTATGGACGGAAATAGAAGATGGGCTCGAAAAAGAGAGA
AACCCCCTTGGTATGGGCACTTTTTTGGTTCAAAGAAGCTTGAGGAAATAGTTGAGTGGTGTCATGAGCTGGGGATAAGG
ATATTAACGGTCTATGCATTTTCAACGGAAAACTTCAAGAGATCAAAGGAGGAAGTCGATAGGCTAATGAAACTCTTCGA
AGAGAAATTTAGAGAATTAGTTACGGATAGAAGAGTCCATGAATATGGGATTAGGGTAAATGTTATGGGGAGAAAGGAGC
TTCTCCCAAAGAATGTGAGAGAGGCTGCAGAAGAAGCGGAGAGGGTTACAAGGAAATACAACAATTACTTCTTAAACATT
GCTTTGGCCTATGGGGGAAGAAGTGAAATTGTGGATGCAATAAAAGATATTGTTAACGATGTATTAGAAGGGAGATTAAA
GCTTGAAGATATAAATGAAGAAATTGTGAGGAAGTATTTATATGTACCTAATATGCCAGACCCAGACATTGTTATAAGAA
CGGGAGGGGAAGTTAGAATAAGCAATTTCTTGCTATATCAAATCGCATATAGTGAACTGTTTTTTGTCGATGTGTACTTC
CCAGAATTTAGAAAAATTGACTTTTTAAGAATAATTAGAGAATTTCAAAAGAGAGAAAGGAGATTTGGACGTTAG

Upstream 100 bases:

>100_bases
TAGTAAGGCAACTCAGCGAAGAAGAAATAGAGTGGACAAAGAAGAATGCAGAGGTATATGTGGAGCTCGCTGAAAAGCAT
ATGAAGGGGAGAAAGAAGAT

Downstream 100 bases:

>100_bases
TCTTTTTCTTCATTCTTACAACCACAGAATTCTGGGAATAATTCCTCTAAAAACTGCAAGACTCTCTCTTTTGGCAGCTT
AAACTGTCTTATTTTAATTA

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MIYRIISHIPSIFFKPAYDLYERYLLEKVKAGVIPKHVAIIMDGNRRWARKREKPPWYGHFFGSKKLEEIVEWCHELGIR
ILTVYAFSTENFKRSKEEVDRLMKLFEEKFRELVTDRRVHEYGIRVNVMGRKELLPKNVREAAEEAERVTRKYNNYFLNI
ALAYGGRSEIVDAIKDIVNDVLEGRLKLEDINEEIVRKYLYVPNMPDPDIVIRTGGEVRISNFLLYQIAYSELFFVDVYF
PEFRKIDFLRIIREFQKRERRFGR

Sequences:

>Translated_264_residues
MIYRIISHIPSIFFKPAYDLYERYLLEKVKAGVIPKHVAIIMDGNRRWARKREKPPWYGHFFGSKKLEEIVEWCHELGIR
ILTVYAFSTENFKRSKEEVDRLMKLFEEKFRELVTDRRVHEYGIRVNVMGRKELLPKNVREAAEEAERVTRKYNNYFLNI
ALAYGGRSEIVDAIKDIVNDVLEGRLKLEDINEEIVRKYLYVPNMPDPDIVIRTGGEVRISNFLLYQIAYSELFFVDVYF
PEFRKIDFLRIIREFQKRERRFGR
>Mature_264_residues
MIYRIISHIPSIFFKPAYDLYERYLLEKVKAGVIPKHVAIIMDGNRRWARKREKPPWYGHFFGSKKLEEIVEWCHELGIR
ILTVYAFSTENFKRSKEEVDRLMKLFEEKFRELVTDRRVHEYGIRVNVMGRKELLPKNVREAAEEAERVTRKYNNYFLNI
ALAYGGRSEIVDAIKDIVNDVLEGRLKLEDINEEIVRKYLYVPNMPDPDIVIRTGGEVRISNFLLYQIAYSELFFVDVYF
PEFRKIDFLRIIREFQKRERRFGR

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is probably the precursor of glycosyl carrier lipids

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580742, Length=239, Percent_Identity=44.3514644351464, Blast_Score=211, Evalue=7e-55,
Organism=Homo sapiens, GI45580738, Length=239, Percent_Identity=44.3514644351464, Blast_Score=211, Evalue=8e-55,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=41.2280701754386, Blast_Score=184, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI71993029, Length=240, Percent_Identity=37.0833333333333, Blast_Score=162, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6319474, Length=256, Percent_Identity=35.9375, Blast_Score=142, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6323748, Length=226, Percent_Identity=32.7433628318584, Blast_Score=126, Evalue=4e-30,
Organism=Drosophila melanogaster, GI18857969, Length=242, Percent_Identity=40.495867768595, Blast_Score=184, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_PYRFU (Q8U0I8)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_579328.1
- ProteinModelPortal:   Q8U0I8
- SMR:   Q8U0I8
- EnsemblBacteria:   EBPYRT00000005287
- GeneID:   1469475
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1599
- NMPDR:   fig|186497.1.peg.1646
- GeneTree:   EBGT00050000022831
- HOGENOM:   HBG627837
- OMA:   YGGQQEI
- ProtClustDB:   CLSK254348
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 31756; Mature: 31756

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 43-43

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYRIISHIPSIFFKPAYDLYERYLLEKVKAGVIPKHVAIIMDGNRRWARKREKPPWYGH
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHCCCCCCCCCC
FFGSKKLEEIVEWCHELGIRILTVYAFSTENFKRSKEEVDRLMKLFEEKFRELVTDRRVH
CCCCHHHHHHHHHHHHCCHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EYGIRVNVMGRKELLPKNVREAAEEAERVTRKYNNYFLNIALAYGGRSEIVDAIKDIVND
HHCCEEEECCHHHHCHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCHHHHHHHHHHHHHH
VLEGRLKLEDINEEIVRKYLYVPNMPDPDIVIRTGGEVRISNFLLYQIAYSELFFVDVYF
HHHCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEHHHHHHHHHHHHHEEEEEEEC
PEFRKIDFLRIIREFQKRERRFGR
CCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIYRIISHIPSIFFKPAYDLYERYLLEKVKAGVIPKHVAIIMDGNRRWARKREKPPWYGH
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHCCCCCCCCCC
FFGSKKLEEIVEWCHELGIRILTVYAFSTENFKRSKEEVDRLMKLFEEKFRELVTDRRVH
CCCCHHHHHHHHHHHHCCHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EYGIRVNVMGRKELLPKNVREAAEEAERVTRKYNNYFLNIALAYGGRSEIVDAIKDIVND
HHCCEEEECCHHHHCHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCHHHHHHHHHHHHHH
VLEGRLKLEDINEEIVRKYLYVPNMPDPDIVIRTGGEVRISNFLLYQIAYSELFFVDVYF
HHHCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEHHHHHHHHHHHHHEEEEEEEC
PEFRKIDFLRIIREFQKRERRFGR
CCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA