BacMap

Definition	Pyrococcus furiosus DSM 3638, complete genome.
Accession	NC_003413
Length	1,908,256

Click here to switch to the map view.

The map label for this gene is psmA [H]

Identifier: 18977943

GI number: 18977943

Start: 1467425

End: 1468207

Strand: Reverse

Name: psmA [H]

Synonym: PF1571

Alternate gene names: 18977943

Gene position: 1468207-1467425 (Counterclockwise)

Preceding gene: 18977947

Following gene: 18977942

Centisome position: 76.94

GC content: 40.1

Gene sequence:

>783_bases
ATGGCATTTGTTCCACCTCAGGCTGGGTACGACAGAGCAATTACAGTTTTTAGTCCAGATGGAAGATTATTCCAAGTAAA
TTATGCAAGGGAAGCAGTAAAAAGAGGAGCTACAGCTGTGGGAGTTAAGTGTGGCGAGGGTGTTGTCTTAGCTGTTGAGA
AAAGGATAACGAGCAGGTTAATTGAACCTGACAGTTATGAGAAGATCTTTCAAATTGATGATCACATCGCTGCAGCTTCA
AGTGGTATTATAGCCGATGCGAGAGTTCTAGTTAACAGAGCAAGATTAGAAGCTCAAATTTATAGACTAACATATGGTGA
ACCAGCACCAGTTTCAGTTATAGTCAAAAAAATCTGTGACCTTAAGCAGATGCATACTCAGTATGGAGGCGTAAGGCCAT
TTGGAGCAGCGCTTTTAATGGCGGGTATAAATGACAGACCAGAGCTTTATGAGACAGATCCAAGTGGTGCATATTTTGCT
TGGAAAGCTGTAGCTATAGGAAGTGGAAGGAACACAGCAATGGCAATTTTCGAAGAAAAATATAGAGATGACATGAATTT
AGAAGATGCAATAAAGCTGGCTTTGATGGCACTGGCAAAGACAATGGAAAATCCTAGTGCAGATAATATAGAAGTGGCTG
TAATAACTGTAAAGGACAAAAAGTTTAGAAAACTTACTAGGGATGAAATAGAAAAGTACCTGTCGGAAGTGCTAAAAGAA
GTTGAAGAGGAAGAAGTCAAGGAAAAGGAAGAGGATTATTCGGAGCTGGATAGCAACTACTGA

Upstream 100 bases:

>100_bases
TCCATGTCATCAAATATACCTTTGGGTAGAGATATAAACCTTTGCTTCCACGGAAGGTATATAAACACTCCACGATAAAG
CTAACTTGGAGGTGAACGGA

Downstream 100 bases:

>100_bases
CTTTTCTCTAATTTTTATTTGGAGGTGGTGGGAATGCCAATTAGTGTTGATAAGGCTGTGATCGCAAGATTAAAAATTCA
TGGAGAAGTTTTTGAAATAT

Product: proteasome subunit alpha

Products: NA

Alternate protein names: 20S proteasome alpha subunit; Proteasome core protein PsmA [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MAFVPPQAGYDRAITVFSPDGRLFQVNYAREAVKRGATAVGVKCGEGVVLAVEKRITSRLIEPDSYEKIFQIDDHIAAAS
SGIIADARVLVNRARLEAQIYRLTYGEPAPVSVIVKKICDLKQMHTQYGGVRPFGAALLMAGINDRPELYETDPSGAYFA
WKAVAIGSGRNTAMAIFEEKYRDDMNLEDAIKLALMALAKTMENPSADNIEVAVITVKDKKFRKLTRDEIEKYLSEVLKE
VEEEEVKEKEEDYSELDSNY

Sequences:

>Translated_260_residues
MAFVPPQAGYDRAITVFSPDGRLFQVNYAREAVKRGATAVGVKCGEGVVLAVEKRITSRLIEPDSYEKIFQIDDHIAAAS
SGIIADARVLVNRARLEAQIYRLTYGEPAPVSVIVKKICDLKQMHTQYGGVRPFGAALLMAGINDRPELYETDPSGAYFA
WKAVAIGSGRNTAMAIFEEKYRDDMNLEDAIKLALMALAKTMENPSADNIEVAVITVKDKKFRKLTRDEIEKYLSEVLKE
VEEEEVKEKEEDYSELDSNY
>Mature_259_residues
AFVPPQAGYDRAITVFSPDGRLFQVNYAREAVKRGATAVGVKCGEGVVLAVEKRITSRLIEPDSYEKIFQIDDHIAAASS
GIIADARVLVNRARLEAQIYRLTYGEPAPVSVIVKKICDLKQMHTQYGGVRPFGAALLMAGINDRPELYETDPSGAYFAW
KAVAIGSGRNTAMAIFEEKYRDDMNLEDAIKLALMALAKTMENPSADNIEVAVITVKDKKFRKLTRDEIEKYLSEVLKEV
EEEEVKEKEEDYSELDSNY

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation [H]

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1A family [H]

Homologues:

Organism=Homo sapiens, GI4506181, Length=231, Percent_Identity=45.021645021645, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI4506189, Length=230, Percent_Identity=46.9565217391304, Blast_Score=198, Evalue=3e-51,
Organism=Homo sapiens, GI68303563, Length=230, Percent_Identity=46.0869565217391, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI23110942, Length=238, Percent_Identity=43.2773109243698, Blast_Score=196, Evalue=1e-50,
Organism=Homo sapiens, GI68303561, Length=236, Percent_Identity=44.9152542372881, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI156713442, Length=233, Percent_Identity=40.343347639485, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI4506185, Length=233, Percent_Identity=40.343347639485, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI23110944, Length=235, Percent_Identity=35.7446808510638, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI68303565, Length=230, Percent_Identity=40.4347826086956, Blast_Score=157, Evalue=8e-39,
Organism=Homo sapiens, GI4506183, Length=257, Percent_Identity=35.0194552529183, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI23110939, Length=255, Percent_Identity=35.2941176470588, Blast_Score=148, Evalue=4e-36,
Organism=Homo sapiens, GI23110935, Length=231, Percent_Identity=35.9307359307359, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI4506179, Length=231, Percent_Identity=35.9307359307359, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI156713444, Length=166, Percent_Identity=40.3614457831325, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI4506203, Length=242, Percent_Identity=31.8181818181818, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI221316716, Length=109, Percent_Identity=42.2018348623853, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI4506191, Length=212, Percent_Identity=28.3018867924528, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17508491, Length=234, Percent_Identity=44.8717948717949, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI25143215, Length=229, Percent_Identity=40.6113537117904, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17508493, Length=244, Percent_Identity=38.9344262295082, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17562790, Length=232, Percent_Identity=40.5172413793103, Blast_Score=169, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17562788, Length=236, Percent_Identity=36.0169491525424, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17562792, Length=235, Percent_Identity=31.9148936170213, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71998965, Length=246, Percent_Identity=30.0813008130081, Blast_Score=118, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6321574, Length=211, Percent_Identity=44.5497630331754, Blast_Score=205, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6324535, Length=240, Percent_Identity=40.8333333333333, Blast_Score=184, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6323547, Length=243, Percent_Identity=40.7407407407407, Blast_Score=177, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6321692, Length=252, Percent_Identity=39.6825396825397, Blast_Score=171, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6324938, Length=190, Percent_Identity=42.6315789473684, Blast_Score=160, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6321427, Length=236, Percent_Identity=33.0508474576271, Blast_Score=115, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6323974, Length=234, Percent_Identity=32.9059829059829, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6324731, Length=223, Percent_Identity=29.5964125560538, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17737927, Length=230, Percent_Identity=43.4782608695652, Blast_Score=192, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24654391, Length=240, Percent_Identity=41.6666666666667, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24654389, Length=240, Percent_Identity=41.6666666666667, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI17933602, Length=229, Percent_Identity=40.6113537117904, Blast_Score=174, Evalue=4e-44,
Organism=Drosophila melanogaster, GI17136420, Length=241, Percent_Identity=37.344398340249, Blast_Score=171, Evalue=5e-43,
Organism=Drosophila melanogaster, GI281360341, Length=234, Percent_Identity=36.3247863247863, Blast_Score=168, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24586406, Length=234, Percent_Identity=36.3247863247863, Blast_Score=168, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24586400, Length=234, Percent_Identity=36.3247863247863, Blast_Score=168, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24586402, Length=234, Percent_Identity=36.3247863247863, Blast_Score=168, Evalue=3e-42,
Organism=Drosophila melanogaster, GI21356137, Length=240, Percent_Identity=40.8333333333333, Blast_Score=167, Evalue=5e-42,
Organism=Drosophila melanogaster, GI19922898, Length=240, Percent_Identity=37.0833333333333, Blast_Score=165, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24651571, Length=235, Percent_Identity=34.0425531914894, Blast_Score=148, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24652204, Length=217, Percent_Identity=35.0230414746544, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI19921232, Length=233, Percent_Identity=34.7639484978541, Blast_Score=128, Evalue=3e-30,
Organism=Drosophila melanogaster, GI17737405, Length=234, Percent_Identity=35.8974358974359, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24639979, Length=195, Percent_Identity=30.2564102564103, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24584895, Length=165, Percent_Identity=29.0909090909091, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28573221, Length=186, Percent_Identity=27.4193548387097, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019982
- InterPro:   IPR000426
- InterPro:   IPR001353 [H]

Pfam domain/function: PF00227 Proteasome; PF10584 Proteasome_A_N [H]

EC number: =3.4.25.1 [H]

Molecular weight: Translated: 29009; Mature: 28878

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00388 PROTEASOME_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFVPPQAGYDRAITVFSPDGRLFQVNYAREAVKRGATAVGVKCGEGVVLAVEKRITSRL
CCCCCCCCCCCCEEEEECCCCCEEEEHHHHHHHHCCCCEEEEECCCCEEEEEHHHHHHHC
IEPDSYEKIFQIDDHIAAASSGIIADARVLVNRARLEAQIYRLTYGEPAPVSVIVKKICD
CCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHH
LKQMHTQYGGVRPFGAALLMAGINDRPELYETDPSGAYFAWKAVAIGSGRNTAMAIFEEK
HHHHHHHHCCCCHHHHHHHHHCCCCCCCCEECCCCCCEEEEEEEEECCCCCHHHHHHHHH
YRDDMNLEDAIKLALMALAKTMENPSADNIEVAVITVKDKKFRKLTRDEIEKYLSEVLKE
HCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHH
VEEEEVKEKEEDYSELDSNY
HHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AFVPPQAGYDRAITVFSPDGRLFQVNYAREAVKRGATAVGVKCGEGVVLAVEKRITSRL
CCCCCCCCCCCEEEEECCCCCEEEEHHHHHHHHCCCCEEEEECCCCEEEEEHHHHHHHC
IEPDSYEKIFQIDDHIAAASSGIIADARVLVNRARLEAQIYRLTYGEPAPVSVIVKKICD
CCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHH
LKQMHTQYGGVRPFGAALLMAGINDRPELYETDPSGAYFAWKAVAIGSGRNTAMAIFEEK
HHHHHHHHCCCCHHHHHHHHHCCCCCCCCEECCCCCCEEEEEEEEECCCCCHHHHHHHHH
YRDDMNLEDAIKLALMALAKTMENPSADNIEVAVITVKDKKFRKLTRDEIEKYLSEVLKE
HCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHH
VEEEEVKEKEEDYSELDSNY
HHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]