| Definition | Pyrococcus furiosus DSM 3638, complete genome. |
|---|---|
| Accession | NC_003413 |
| Length | 1,908,256 |
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The map label for this gene is bhbA [H]
Identifier: 18977849
GI number: 18977849
Start: 1380572
End: 1382260
Strand: Reverse
Name: bhbA [H]
Synonym: PF1477
Alternate gene names: 18977849
Gene position: 1382260-1380572 (Counterclockwise)
Preceding gene: 18977856
Following gene: 18977848
Centisome position: 72.44
GC content: 43.81
Gene sequence:
>1689_bases ATGACGTTTGATAAAGAGGCACTAAAGAAGATTAGAGAGGAAGAGAAGCGCTGGGAAGAGACTACTGTGAAGAAGTTCCT CGAAAAAGCTCCTGAGAGGAAAGAAAAGTTCATGACGGATGATGGATTTGAAATTAAGAGGGTATACACTCCAGCTGATC TTGGCGAAGATTGGGATTACATGGAAAAGCTTGGTTTCCCAGGGGAGTACCCCTTCACAAGAGGAGTTTATGCAACGATG TACAGAGGTAGAATATGGACAATGAGGCAGTATGCTGGATATGCTACAGCGGAAGAGTCAAACAAAAGGTACAAGTACCT CTTAAGCCAAGGGCAGACTGGGTTAAGCGTAGCCTTTGACTTACCAACTCAACTCGGTTATGATTCAGATCATCCCTTGG CCGAGGGAGAAGTTGGGAAGGTAGGGGTTGCTATAGATTCACTCTGGGATATGGAGATACTATTTGATGGAATACCCTTA GATAAAGTATCTACATCGATGACAATTAACGCAACTGCGGCCAACTTGCTGGCAATGTATATTCTAGTGGCCGAAAAGCA GGGTGTTCCTCAACATGTTCTTAGGGGAACTGTTCAGAACGACATCTTGAAGGAGTATATTGCGAGAGGAACTTACATAT TCCCACCTCAGCCTAGCATGAGGCTTACAACTGATATAATCATGTATTGTGCTGAGAATGTTCCAAAGTGGAACCCGATA AGCATTAGCGGTTACCACATCAGAGAGGCTGGAGCAAACGCAGTCCAGGAAGTTGCATTCACTCTTGCAGATGGTATAGA ATACGTAAAAGCAGTAATCGAGAGGGGAATGGATGTTGACAAGTTTGCTCCAAGGTTGAGCTTCTTCTTTGCCGCACACA ACAACTTCCTCGAAGAGATAGCTAAGTTTAGGGCTGCTAGAAGATTGTGGGCTTACATTATGAAAGAATGGTTCAACGCT AAGAATCCCAGGTCAATGATGCTTAGGTTCCACACTCAGACAGCTGGTTCAACTCTAACAGCTCAGCAACCAGAGAATAA CATTGTTAGAGTTGCAATCCAAGCTCTAGCCGCAGTATTGGGAGGAACTCAGAGTCTGCACACCAACAGCTATGATGAGG CACTTTCATTACCAACCGAGAAGAGTGTAAGAATAGCCCTAAGAACTCAACAGATTATAGCTTACGAAAGTGGTGTTGTT GATACTGTGGATCCCCTGGGAGGTGCCTATTACATTGAGTGGCTTACAGACCACATCTATGAAGAGGCACTCAAATACAT TGAGAAGATCCAGAAGATGGGTGGAATGATGAGGGCAATTGAGAGAGGTTACATCCAAAAGGAGATCGCCGAGGCGGCAT ATAAATACCAGAAAGAAATTGAAGAGGGCAAGAGGATAATCGTTGGAGTCAATGCATTTGTAAGTGATGAGCCCATAGAG GTTGAAATTCTAAAAGTTGATCCAAGCATTAGAGAGAAGCAGATTGCAAGGTTGAAGAAGCTGAGAAGTGAAAGAGACAA CAAGAAGGTTCAGGAGACCTTAGATAAGCTTAGAAATGCAGCTGAAAAAGAAGATGTGAACTTAATGCCATACATTATTG AGGCCCACAAGCACTTAGCAACTCTCCAAGAGGTTACTGACGTACTAAGAGAAGTTTGGGGTGAATACAGGGCTCCCCTT ATCTTCTGA
Upstream 100 bases:
>100_bases ATATGAGAGTTGAAGAAGTGGATAAAAAAGCCAGCTATGAACTTTAGGTTTGTAAAGTTTTTTATAGGTAAAATATCTAA GATGTTCTTGGGTGATAATT
Downstream 100 bases:
>100_bases TGTTTCTTTCTTTTTTGTCAACTTTTCAAGCATTTTTATTCACTTCAAGTATTGGGTAACCGAAAAATATTTTAATAAGA TATGTTTTATGGTGAGAGAA
Product: methylmalonyl-CoA mutase
Products: NA
Alternate protein names: MCM [H]
Number of amino acids: Translated: 562; Mature: 561
Protein sequence:
>562_residues MTFDKEALKKIREEEKRWEETTVKKFLEKAPERKEKFMTDDGFEIKRVYTPADLGEDWDYMEKLGFPGEYPFTRGVYATM YRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAEGEVGKVGVAIDSLWDMEILFDGIPL DKVSTSMTINATAANLLAMYILVAEKQGVPQHVLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPI SISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIMKEWFNA KNPRSMMLRFHTQTAGSTLTAQQPENNIVRVAIQALAAVLGGTQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESGVV DTVDPLGGAYYIEWLTDHIYEEALKYIEKIQKMGGMMRAIERGYIQKEIAEAAYKYQKEIEEGKRIIVGVNAFVSDEPIE VEILKVDPSIREKQIARLKKLRSERDNKKVQETLDKLRNAAEKEDVNLMPYIIEAHKHLATLQEVTDVLREVWGEYRAPL IF
Sequences:
>Translated_562_residues MTFDKEALKKIREEEKRWEETTVKKFLEKAPERKEKFMTDDGFEIKRVYTPADLGEDWDYMEKLGFPGEYPFTRGVYATM YRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAEGEVGKVGVAIDSLWDMEILFDGIPL DKVSTSMTINATAANLLAMYILVAEKQGVPQHVLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPI SISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIMKEWFNA KNPRSMMLRFHTQTAGSTLTAQQPENNIVRVAIQALAAVLGGTQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESGVV DTVDPLGGAYYIEWLTDHIYEEALKYIEKIQKMGGMMRAIERGYIQKEIAEAAYKYQKEIEEGKRIIVGVNAFVSDEPIE VEILKVDPSIREKQIARLKKLRSERDNKKVQETLDKLRNAAEKEDVNLMPYIIEAHKHLATLQEVTDVLREVWGEYRAPL IF >Mature_561_residues TFDKEALKKIREEEKRWEETTVKKFLEKAPERKEKFMTDDGFEIKRVYTPADLGEDWDYMEKLGFPGEYPFTRGVYATMY RGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFDLPTQLGYDSDHPLAEGEVGKVGVAIDSLWDMEILFDGIPLD KVSTSMTINATAANLLAMYILVAEKQGVPQHVLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPIS ISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEIAKFRAARRLWAYIMKEWFNAK NPRSMMLRFHTQTAGSTLTAQQPENNIVRVAIQALAAVLGGTQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESGVVD TVDPLGGAYYIEWLTDHIYEEALKYIEKIQKMGGMMRAIERGYIQKEIAEAAYKYQKEIEEGKRIIVGVNAFVSDEPIEV EILKVDPSIREKQIARLKKLRSERDNKKVQETLDKLRNAAEKEDVNLMPYIIEAHKHLATLQEVTDVLREVWGEYRAPLI F
Specific function: Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA during the polyhydroxyalkanoate degradation pathway [H]
COG id: COG1884
COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 B12-binding domain [H]
Homologues:
Organism=Homo sapiens, GI156105689, Length=542, Percent_Identity=50.5535055350554, Blast_Score=544, Evalue=1e-155, Organism=Escherichia coli, GI1789284, Length=544, Percent_Identity=50.7352941176471, Blast_Score=526, Evalue=1e-150, Organism=Caenorhabditis elegans, GI25144500, Length=521, Percent_Identity=52.2072936660269, Blast_Score=547, Evalue=1e-156,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR006159 - InterPro: IPR016176 - InterPro: IPR014348 - InterPro: IPR006158 - InterPro: IPR006099 - InterPro: IPR006098 [H]
Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]
EC number: =5.4.99.2 [H]
Molecular weight: Translated: 64306; Mature: 64175
Theoretical pI: Translated: 5.79; Mature: 5.79
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.2 %Cys (Translated Protein) 3.2 %Met (Translated Protein) 3.4 %Cys+Met (Translated Protein) 0.2 %Cys (Mature Protein) 3.0 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTFDKEALKKIREEEKRWEETTVKKFLEKAPERKEKFMTDDGFEIKRVYTPADLGEDWDY CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCEEEEEECCCCCCCCHHH MEKLGFPGEYPFTRGVYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFD HHHCCCCCCCCCCCCHHHHHHCCCEEEHHHHCCCCCCHHCCHHHHHHHHCCCCCCEEEEE LPTQLGYDSDHPLAEGEVGKVGVAIDSLWDMEILFDGIPLDKVSTSMTINATAANLLAMY CCHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHCCCCCHHHCCCCEEEEHHHHHHHHHH ILVAEKQGVPQHVLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPI HHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCE SISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEI EECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH AKFRAARRLWAYIMKEWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIVRVAIQALAAVL HHHHHHHHHHHHHHHHHHCCCCCHHHHEEEECCCCCCEEECCCCCCHHHHHHHHHHHHHH GGTQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIY CCCCCCCCCCHHHHHCCCCCCCEEEEEEHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH EEALKYIEKIQKMGGMMRAIERGYIQKEIAEAAYKYQKEIEEGKRIIVGVNAFVSDEPIE HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHEECCCCCE VEILKVDPSIREKQIARLKKLRSERDNKKVQETLDKLRNAAEKEDVNLMPYIIEAHKHLA EEEEECCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH TLQEVTDVLREVWGEYRAPLIF HHHHHHHHHHHHHHHHCCCCCC >Mature Secondary Structure TFDKEALKKIREEEKRWEETTVKKFLEKAPERKEKFMTDDGFEIKRVYTPADLGEDWDY CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCEEEEEECCCCCCCCHHH MEKLGFPGEYPFTRGVYATMYRGRIWTMRQYAGYATAEESNKRYKYLLSQGQTGLSVAFD HHHCCCCCCCCCCCCHHHHHHCCCEEEHHHHCCCCCCHHCCHHHHHHHHCCCCCCEEEEE LPTQLGYDSDHPLAEGEVGKVGVAIDSLWDMEILFDGIPLDKVSTSMTINATAANLLAMY CCHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHCCCCCHHHCCCCEEEEHHHHHHHHHH ILVAEKQGVPQHVLRGTVQNDILKEYIARGTYIFPPQPSMRLTTDIIMYCAENVPKWNPI HHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCE SISGYHIREAGANAVQEVAFTLADGIEYVKAVIERGMDVDKFAPRLSFFFAAHNNFLEEI EECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH AKFRAARRLWAYIMKEWFNAKNPRSMMLRFHTQTAGSTLTAQQPENNIVRVAIQALAAVL HHHHHHHHHHHHHHHHHHCCCCCHHHHEEEECCCCCCEEECCCCCCHHHHHHHHHHHHHH GGTQSLHTNSYDEALSLPTEKSVRIALRTQQIIAYESGVVDTVDPLGGAYYIEWLTDHIY CCCCCCCCCCHHHHHCCCCCCCEEEEEEHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH EEALKYIEKIQKMGGMMRAIERGYIQKEIAEAAYKYQKEIEEGKRIIVGVNAFVSDEPIE HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHEECCCCCE VEILKVDPSIREKQIARLKKLRSERDNKKVQETLDKLRNAAEKEDVNLMPYIIEAHKHLA EEEEECCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH TLQEVTDVLREVWGEYRAPLIF HHHHHHHHHHHHHHHHCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9889346; 11481431 [H]