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The map label for this gene is nuoN [H]

Identifier: 18977819

GI number: 18977819

Start: 1356102

End: 1357583

Strand: Reverse

Name: nuoN [H]

Synonym: PF1447

Alternate gene names: 18977819

Gene position: 1357583-1356102 (Counterclockwise)

Preceding gene: 18977820

Following gene: 18977818

Centisome position: 71.14

GC content: 43.86

Gene sequence:

>1482_bases
ATGAGCCAGGTTGCAGCTTTGTTGATAGCTCTTCCTCTCATCAGTGCATTCTTCGTTCCCGTATTAAAGCAGATAGGAAA
GTCTCTAATTAAGCCATTCCTCGTCATAATAACTTTGCTCCAGACATTAATTGCTAGCTGGGCCTTTGTTCAAGTTTACT
CAACAGGAAAACCAATTATAATCTATGCTGGTGGATGGAAACCTCCAATTGGGATTAACCTATACATAGGTCACTTTGCG
GCGTTGTTCATATTAGTAATTGCGGTAGTGAGCTTTCTAATGGCCCTCTTCAACTTTAAAGCAGTAACTGTTGAGCCAAT
TGACAAGTATGCAATGCTCTTCCTACTTTTACTCCTGGGAGCTACAGGGATGATCGCTACAGGAGATATCTTTAACCTCT
TTGTCTTCATGGAGATTACAGCCATTTCCGCTTATGCACTAACTGCGTATAACAAGACTGGCGAAGCTGCAGAGGCATCT
ATGAAATACATAGTCCTGGGAGGAATTGGTTCAAGCTTCTTCTTGGTAGGTGTAGCCCTCATCTATGGAGCAACAGGAAC
GTTAAACATGGCCCACCTGGCAATGCTTGCTAATGACATTAACCCGACAGTTGTTCAGGTAGGATTGGCTTTGATAATCT
TTGGATTGGCAGTCGAGGCAGAACTCTTCCCACTGAATGCTTGGGCACCAGATGCCTATCAAGCAGCTCCTCACCCAATT
ACCGTAATGTTTTCAGCCTTTGTAGTTAAAGCGGGCCTATATGCAATGGCCAGAATCCTCTACTTGTTCAAAGATGTTTC
TGGCTGGTCTTCTCTAACTAAGCTATTAATTGCAATGGCAACGTTGACGGTTGTATTTGCCGAACTATCAGCCTTGAGGC
AGAAGAACGTAAAGAGAATGATTGCATACTCAAGTATAGGCCAAGTAGGCTTAATAGCACTTGCCCTTTCCCTGGGAACT
CAAGAGGGAGTTAGTGCTGGAGTATTTCACATGCTTAACCACGCCATAGTAAAGACAATGATGTTCATGGCCATTGGATA
TGTGGGAATTACCTTGGGTGGAACAATGATTGAAAACTTCGAGGGTTTGGGCAAAAGAATGCCATTAACGTCCTTGTCAC
TAACCATTGGAGGAATAGCCACCGTAGGAGTTCCATTGTTCAACGTGTTCTGGAGTAAACTTAGAATTATCCTTGCAGCA
GCCCATGAAGGAAACCTGTGGCCTGTGGCTTTGGTTCTCTTCGCTAGCGTAGTAGAGGCAGTTTATTACTTCAGGTTAAT
TCACACAATGTGGTTCAAAGGAAAGAGTGGGGAAAGAATTCCCGAGGGGGCTATTGCAATTGTCCTCTTACTATTGGCGA
TGCTCATCATAGTCATAGGAGTGTATCCAACGCCATTCTGGAACTTGGTGACGAAGGCTGGAAGCGATATTGTGGAGGTT
AGTAAATATGTTGCAAATGTACTTCCGGGGGTGAAACTATGA

Upstream 100 bases:

>100_bases
TCATTGGTGTTGCAACCACTGCAATGGCCCTTAGCGTTGCTATTCTATTGTATGAAAAGTATGGAACCCTCAACATAGAA
GAGATAAGGAGGTTGAGAGG

Downstream 100 bases:

>100_bases
ACGAGCTTCCTATAATCCTATTATCACCCCTCATAGGTGGAGCATTGGCATGGCTAATTAGAGTGAAAGGAATTAGAGAA
GCGATTGGTGTAGTTTCCTC

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 493; Mature: 492

Protein sequence:

>493_residues
MSQVAALLIALPLISAFFVPVLKQIGKSLIKPFLVIITLLQTLIASWAFVQVYSTGKPIIIYAGGWKPPIGINLYIGHFA
ALFILVIAVVSFLMALFNFKAVTVEPIDKYAMLFLLLLLGATGMIATGDIFNLFVFMEITAISAYALTAYNKTGEAAEAS
MKYIVLGGIGSSFFLVGVALIYGATGTLNMAHLAMLANDINPTVVQVGLALIIFGLAVEAELFPLNAWAPDAYQAAPHPI
TVMFSAFVVKAGLYAMARILYLFKDVSGWSSLTKLLIAMATLTVVFAELSALRQKNVKRMIAYSSIGQVGLIALALSLGT
QEGVSAGVFHMLNHAIVKTMMFMAIGYVGITLGGTMIENFEGLGKRMPLTSLSLTIGGIATVGVPLFNVFWSKLRIILAA
AHEGNLWPVALVLFASVVEAVYYFRLIHTMWFKGKSGERIPEGAIAIVLLLLAMLIIVIGVYPTPFWNLVTKAGSDIVEV
SKYVANVLPGVKL

Sequences:

>Translated_493_residues
MSQVAALLIALPLISAFFVPVLKQIGKSLIKPFLVIITLLQTLIASWAFVQVYSTGKPIIIYAGGWKPPIGINLYIGHFA
ALFILVIAVVSFLMALFNFKAVTVEPIDKYAMLFLLLLLGATGMIATGDIFNLFVFMEITAISAYALTAYNKTGEAAEAS
MKYIVLGGIGSSFFLVGVALIYGATGTLNMAHLAMLANDINPTVVQVGLALIIFGLAVEAELFPLNAWAPDAYQAAPHPI
TVMFSAFVVKAGLYAMARILYLFKDVSGWSSLTKLLIAMATLTVVFAELSALRQKNVKRMIAYSSIGQVGLIALALSLGT
QEGVSAGVFHMLNHAIVKTMMFMAIGYVGITLGGTMIENFEGLGKRMPLTSLSLTIGGIATVGVPLFNVFWSKLRIILAA
AHEGNLWPVALVLFASVVEAVYYFRLIHTMWFKGKSGERIPEGAIAIVLLLLAMLIIVIGVYPTPFWNLVTKAGSDIVEV
SKYVANVLPGVKL
>Mature_492_residues
SQVAALLIALPLISAFFVPVLKQIGKSLIKPFLVIITLLQTLIASWAFVQVYSTGKPIIIYAGGWKPPIGINLYIGHFAA
LFILVIAVVSFLMALFNFKAVTVEPIDKYAMLFLLLLLGATGMIATGDIFNLFVFMEITAISAYALTAYNKTGEAAEASM
KYIVLGGIGSSFFLVGVALIYGATGTLNMAHLAMLANDINPTVVQVGLALIIFGLAVEAELFPLNAWAPDAYQAAPHPIT
VMFSAFVVKAGLYAMARILYLFKDVSGWSSLTKLLIAMATLTVVFAELSALRQKNVKRMIAYSSIGQVGLIALALSLGTQ
EGVSAGVFHMLNHAIVKTMMFMAIGYVGITLGGTMIENFEGLGKRMPLTSLSLTIGGIATVGVPLFNVFWSKLRIILAAA
HEGNLWPVALVLFASVVEAVYYFRLIHTMWFKGKSGERIPEGAIAIVLLLLAMLIIVIGVYPTPFWNLVTKAGSDIVEVS
KYVANVLPGVKL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=363, Percent_Identity=25.8953168044077, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI1788831, Length=346, Percent_Identity=27.7456647398844, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI145693160, Length=387, Percent_Identity=27.390180878553, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1788829, Length=367, Percent_Identity=26.4305177111717, Blast_Score=118, Evalue=9e-28,
Organism=Escherichia coli, GI1788827, Length=362, Percent_Identity=25.414364640884, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1788614, Length=420, Percent_Identity=27.1428571428571, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI2367154, Length=329, Percent_Identity=25.2279635258359, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788613, Length=515, Percent_Identity=23.495145631068, Blast_Score=88, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 52985; Mature: 52853

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQVAALLIALPLISAFFVPVLKQIGKSLIKPFLVIITLLQTLIASWAFVQVYSTGKPII
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEE
IYAGGWKPPIGINLYIGHFAALFILVIAVVSFLMALFNFKAVTVEPIDKYAMLFLLLLLG
EEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHC
ATGMIATGDIFNLFVFMEITAISAYALTAYNKTGEAAEASMKYIVLGGIGSSFFLVGVAL
CCCCEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCEEEEECCCHHHHHHHHHH
IYGATGTLNMAHLAMLANDINPTVVQVGLALIIFGLAVEAELFPLNAWAPDAYQAAPHPI
HHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCH
TVMFSAFVVKAGLYAMARILYLFKDVSGWSSLTKLLIAMATLTVVFAELSALRQKNVKRM
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAYSSIGQVGLIALALSLGTQEGVSAGVFHMLNHAIVKTMMFMAIGYVGITLGGTMIENF
HHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
EGLGKRMPLTSLSLTIGGIATVGVPLFNVFWSKLRIILAAAHEGNLWPVALVLFASVVEA
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
VYYFRLIHTMWFKGKSGERIPEGAIAIVLLLLAMLIIVIGVYPTPFWNLVTKAGSDIVEV
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHH
SKYVANVLPGVKL
HHHHHHHCCCCCC
>Mature Secondary Structure 
SQVAALLIALPLISAFFVPVLKQIGKSLIKPFLVIITLLQTLIASWAFVQVYSTGKPII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEE
IYAGGWKPPIGINLYIGHFAALFILVIAVVSFLMALFNFKAVTVEPIDKYAMLFLLLLLG
EEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHC
ATGMIATGDIFNLFVFMEITAISAYALTAYNKTGEAAEASMKYIVLGGIGSSFFLVGVAL
CCCCEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCEEEEECCCHHHHHHHHHH
IYGATGTLNMAHLAMLANDINPTVVQVGLALIIFGLAVEAELFPLNAWAPDAYQAAPHPI
HHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCH
TVMFSAFVVKAGLYAMARILYLFKDVSGWSSLTKLLIAMATLTVVFAELSALRQKNVKRM
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAYSSIGQVGLIALALSLGTQEGVSAGVFHMLNHAIVKTMMFMAIGYVGITLGGTMIENF
HHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
EGLGKRMPLTSLSLTIGGIATVGVPLFNVFWSKLRIILAAAHEGNLWPVALVLFASVVEA
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
VYYFRLIHTMWFKGKSGERIPEGAIAIVLLLLAMLIIVIGVYPTPFWNLVTKAGSDIVEV
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHH
SKYVANVLPGVKL
HHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA