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The map label for this gene is mrpD [H]

Identifier: 18977818

GI number: 18977818

Start: 1354249

End: 1356105

Strand: Reverse

Name: mrpD [H]

Synonym: PF1446

Alternate gene names: 18977818

Gene position: 1356105-1354249 (Counterclockwise)

Preceding gene: 18977819

Following gene: 18977817

Centisome position: 71.07

GC content: 43.24

Gene sequence:

>1857_bases
ATGAACGAGCTTCCTATAATCCTATTATCACCCCTCATAGGTGGAGCATTGGCATGGCTAATTAGAGTGAAAGGAATTAG
AGAAGCGATTGGTGTAGTTTCCTCAGCTATCCCCTTATATTTCCTAATAAAACTCTATCCTGCTCTAGAGGGTGAGCCCA
TTAGGTATTCCTTGAACGTTGGAGGCTTCGAGCTAACCTTAGCTCTCAGTCACATATCTTGGATATTTGCCATGATAGCA
GCAGTTGTCGGCCTTTCTGCAGTCCTAGGATTAGTATCAACAGCAAAGGACAGCAATGAATGGCTCTTTGCTCTAATGAG
CCTAGCAGGGGCACTAGGCGTGTTCTTGGCAAATGACTTTGTCGTATTCTTCCTCTCCTGGGAAATAATGACATTTGCCA
GCTTTATGATGGTATTTAAGTACAATAGGCATGCTTCACTAAAGTATTTCGTGCTGAGCATTGCCGGTGCTTATGCAATG
TTATTGGCTATAGGAATAATCTACGCCAAGACGGGAAGTCTCAGCTTCCCAGAAATTTCAGCAATATTTAGGCAGGATGC
AATGATGGGAATGATGGGTGGAGGAGGAGTCTTTACCAAGACTGAAACTCTCCTAATCTACGCTCTGTTCCTAGTGGCCT
TTGGTGTTAAGGCTGGAATGTTTCCGCTTCATGTCTGGGCTCCCGATGCATACAGTGAGACAAACCAAAGTTATACTGCA
ATGTTCAGTGGAGTTCTCAGCAAGACTGGAGTTTACGGATTCTTCTTGCTGTATCTTCTAATGTATGGTAAACTAGCAAT
AACTTTGGGCAATGTGAGAAGTGCACCAACATTTGGCTACATTATTGCTTTCCTTGGTGGATTGACGATAATGGTTGGTG
GAATTTTAGCAGCTTTGCAGGAGGATATAAGGAAGCTCTTTGCATACTCCAGTATTAGCCAGATTGGTTACATATTAATA
GGATTAGGAATAGGAACTCCCCTAGGAATAGCAGCTGCAACATACCACGCAATAAGCCATGCTCTCTTCAAGGGATTGTT
CTTCCTCATAGTTGCTACTATAATTTACAGAACTGGAAAGACAGAATTCAAAGATTATGGCGGATTGGCAGAAAAGATGC
CCATAACCTTTGCAATGGCTTTCGTCGCAATATTAAGCCTAGCTGGAATTCCTCCAATGGCTGGATTTGCAAGCAAGTGG
CTTATATTTGAAGCAGTTATAAGCAGAAACTTACCGATTTTAGGCGCAATGGTCTTCTTCGGAAGTGCGATAGGTTTCGT
CTACCTTATAAGATTCACATATGCTGTTTGGTTTGGCCAGAGGCCTAGCGACCTAGAAGATGTTAAAGATGCACCACTTC
CTCTTGCAATAGGAATGGGGATACTCGCAATCCTGAATGTTATCTTTGGTGTTGCTCCGGGACTTGTGGCTAGAGAGCTC
AACAAACTATTCAGCAATCCTCCGATCGGAGGAACAATCTGGGAGCTTGACTTGGGCTTTGGAAGGTACAACGGATTACT
ACTCTCAATATGGCTCGTCATTGGACTAATAATTGCAGCAATACTTTACTTCATGGGAGCAGGGGTTAGAAAAGTTCCAG
TCACCGACACTTACCAGTCTGGTAACCCAGTGACAATGGAGTACAACCTAACCATAAGAAGGAACTTCTTCTTGCCACTC
AAGGAAGCAATGGCGTTCTGGCTTAAAATGAGCTTTGACAGGTTATATCATGACATATGGAAGGCGATTGAAGAGTTAGC
GGATTTGGCGAGGAGTTATGTGTATAATGGAAACATTCAGGCATATGCGTGGTACTTAGCAATAATCCTCCTAATATTGG
TAGCTATGGGGGTGTGA

Upstream 100 bases:

>100_bases
GAGTGTATCCAACGCCATTCTGGAACTTGGTGACGAAGGCTGGAAGCGATATTGTGGAGGTTAGTAAATATGTTGCAAAT
GTACTTCCGGGGGTGAAACT

Downstream 100 bases:

>100_bases
CAGATGATTGGGGTTTTCCTTAGGGCTCTCTTAATCATTATTTATGCAACGTTTGTTGGGTTCATATTCATGGGAATCAT
AAGGAAAGTAACCGCCAGAA

Product: NADH dehydrogenase subunit M

Products: NAD+; ubiquinol

Alternate protein names: Mrp complex subunit D; Multiple resistance and pH homeostasis protein D [H]

Number of amino acids: Translated: 618; Mature: 618

Protein sequence:

>618_residues
MNELPIILLSPLIGGALAWLIRVKGIREAIGVVSSAIPLYFLIKLYPALEGEPIRYSLNVGGFELTLALSHISWIFAMIA
AVVGLSAVLGLVSTAKDSNEWLFALMSLAGALGVFLANDFVVFFLSWEIMTFASFMMVFKYNRHASLKYFVLSIAGAYAM
LLAIGIIYAKTGSLSFPEISAIFRQDAMMGMMGGGGVFTKTETLLIYALFLVAFGVKAGMFPLHVWAPDAYSETNQSYTA
MFSGVLSKTGVYGFFLLYLLMYGKLAITLGNVRSAPTFGYIIAFLGGLTIMVGGILAALQEDIRKLFAYSSISQIGYILI
GLGIGTPLGIAAATYHAISHALFKGLFFLIVATIIYRTGKTEFKDYGGLAEKMPITFAMAFVAILSLAGIPPMAGFASKW
LIFEAVISRNLPILGAMVFFGSAIGFVYLIRFTYAVWFGQRPSDLEDVKDAPLPLAIGMGILAILNVIFGVAPGLVAREL
NKLFSNPPIGGTIWELDLGFGRYNGLLLSIWLVIGLIIAAILYFMGAGVRKVPVTDTYQSGNPVTMEYNLTIRRNFFLPL
KEAMAFWLKMSFDRLYHDIWKAIEELADLARSYVYNGNIQAYAWYLAIILLILVAMGV

Sequences:

>Translated_618_residues
MNELPIILLSPLIGGALAWLIRVKGIREAIGVVSSAIPLYFLIKLYPALEGEPIRYSLNVGGFELTLALSHISWIFAMIA
AVVGLSAVLGLVSTAKDSNEWLFALMSLAGALGVFLANDFVVFFLSWEIMTFASFMMVFKYNRHASLKYFVLSIAGAYAM
LLAIGIIYAKTGSLSFPEISAIFRQDAMMGMMGGGGVFTKTETLLIYALFLVAFGVKAGMFPLHVWAPDAYSETNQSYTA
MFSGVLSKTGVYGFFLLYLLMYGKLAITLGNVRSAPTFGYIIAFLGGLTIMVGGILAALQEDIRKLFAYSSISQIGYILI
GLGIGTPLGIAAATYHAISHALFKGLFFLIVATIIYRTGKTEFKDYGGLAEKMPITFAMAFVAILSLAGIPPMAGFASKW
LIFEAVISRNLPILGAMVFFGSAIGFVYLIRFTYAVWFGQRPSDLEDVKDAPLPLAIGMGILAILNVIFGVAPGLVAREL
NKLFSNPPIGGTIWELDLGFGRYNGLLLSIWLVIGLIIAAILYFMGAGVRKVPVTDTYQSGNPVTMEYNLTIRRNFFLPL
KEAMAFWLKMSFDRLYHDIWKAIEELADLARSYVYNGNIQAYAWYLAIILLILVAMGV
>Mature_618_residues
MNELPIILLSPLIGGALAWLIRVKGIREAIGVVSSAIPLYFLIKLYPALEGEPIRYSLNVGGFELTLALSHISWIFAMIA
AVVGLSAVLGLVSTAKDSNEWLFALMSLAGALGVFLANDFVVFFLSWEIMTFASFMMVFKYNRHASLKYFVLSIAGAYAM
LLAIGIIYAKTGSLSFPEISAIFRQDAMMGMMGGGGVFTKTETLLIYALFLVAFGVKAGMFPLHVWAPDAYSETNQSYTA
MFSGVLSKTGVYGFFLLYLLMYGKLAITLGNVRSAPTFGYIIAFLGGLTIMVGGILAALQEDIRKLFAYSSISQIGYILI
GLGIGTPLGIAAATYHAISHALFKGLFFLIVATIIYRTGKTEFKDYGGLAEKMPITFAMAFVAILSLAGIPPMAGFASKW
LIFEAVISRNLPILGAMVFFGSAIGFVYLIRFTYAVWFGQRPSDLEDVKDAPLPLAIGMGILAILNVIFGVAPGLVAREL
NKLFSNPPIGGTIWELDLGFGRYNGLLLSIWLVIGLIIAAILYFMGAGVRKVPVTDTYQSGNPVTMEYNLTIRRNFFLPL
KEAMAFWLKMSFDRLYHDIWKAIEELADLARSYVYNGNIQAYAWYLAIILLILVAMGV

Specific function: Mrp complex is a Na(+)/H(+) antiporter involved in Na(+) excretion and Na(+) resistance [H]

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=190, Percent_Identity=28.4210526315789, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI1788827, Length=403, Percent_Identity=27.7915632754342, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1788831, Length=301, Percent_Identity=28.9036544850498, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI2367154, Length=391, Percent_Identity=26.5984654731458, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788613, Length=479, Percent_Identity=25.0521920668058, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI145693160, Length=371, Percent_Identity=30.188679245283, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788614, Length=488, Percent_Identity=23.9754098360656, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788829, Length=377, Percent_Identity=25.4641909814324, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.6.5.3

Molecular weight: Translated: 67517; Mature: 67517

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNELPIILLSPLIGGALAWLIRVKGIREAIGVVSSAIPLYFLIKLYPALEGEPIRYSLNV
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
GGFELTLALSHISWIFAMIAAVVGLSAVLGLVSTAKDSNEWLFALMSLAGALGVFLANDF
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
VVFFLSWEIMTFASFMMVFKYNRHASLKYFVLSIAGAYAMLLAIGIIYAKTGSLSFPEIS
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
AIFRQDAMMGMMGGGGVFTKTETLLIYALFLVAFGVKAGMFPLHVWAPDAYSETNQSYTA
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHCCCHHHH
MFSGVLSKTGVYGFFLLYLLMYGKLAITLGNVRSAPTFGYIIAFLGGLTIMVGGILAALQ
HHHHHHHHCCHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EDIRKLFAYSSISQIGYILIGLGIGTPLGIAAATYHAISHALFKGLFFLIVATIIYRTGK
HHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TEFKDYGGLAEKMPITFAMAFVAILSLAGIPPMAGFASKWLIFEAVISRNLPILGAMVFF
CHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
GSAIGFVYLIRFTYAVWFGQRPSDLEDVKDAPLPLAIGMGILAILNVIFGVAPGLVAREL
HHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
NKLFSNPPIGGTIWELDLGFGRYNGLLLSIWLVIGLIIAAILYFMGAGVRKVPVTDTYQS
HHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCC
GNPVTMEYNLTIRRNFFLPLKEAMAFWLKMSFDRLYHDIWKAIEELADLARSYVYNGNIQ
CCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHH
AYAWYLAIILLILVAMGV
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNELPIILLSPLIGGALAWLIRVKGIREAIGVVSSAIPLYFLIKLYPALEGEPIRYSLNV
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
GGFELTLALSHISWIFAMIAAVVGLSAVLGLVSTAKDSNEWLFALMSLAGALGVFLANDF
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
VVFFLSWEIMTFASFMMVFKYNRHASLKYFVLSIAGAYAMLLAIGIIYAKTGSLSFPEIS
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
AIFRQDAMMGMMGGGGVFTKTETLLIYALFLVAFGVKAGMFPLHVWAPDAYSETNQSYTA
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHCCCHHHH
MFSGVLSKTGVYGFFLLYLLMYGKLAITLGNVRSAPTFGYIIAFLGGLTIMVGGILAALQ
HHHHHHHHCCHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EDIRKLFAYSSISQIGYILIGLGIGTPLGIAAATYHAISHALFKGLFFLIVATIIYRTGK
HHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TEFKDYGGLAEKMPITFAMAFVAILSLAGIPPMAGFASKWLIFEAVISRNLPILGAMVFF
CHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
GSAIGFVYLIRFTYAVWFGQRPSDLEDVKDAPLPLAIGMGILAILNVIFGVAPGLVAREL
HHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
NKLFSNPPIGGTIWELDLGFGRYNGLLLSIWLVIGLIIAAILYFMGAGVRKVPVTDTYQS
HHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCC
GNPVTMEYNLTIRRNFFLPLKEAMAFWLKMSFDRLYHDIWKAIEELADLARSYVYNGNIQ
CCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHH
AYAWYLAIILLILVAMGV
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11356194 [H]