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The map label for this gene is ndhI [H]

Identifier: 18977813

GI number: 18977813

Start: 1350388

End: 1351014

Strand: Reverse

Name: ndhI [H]

Synonym: PF1441

Alternate gene names: 18977813

Gene position: 1351014-1350388 (Counterclockwise)

Preceding gene: 18977814

Following gene: 33359565

Centisome position: 70.8

GC content: 40.67

Gene sequence:

>627_bases
ATGGAGGAGGTAACATTTAGAATAGCTCCCGAGGAGAAGGTAAAGAAAAAACCTTCATTCCTCAAGCCTTGGTTTGGGCT
GAAATATCTCTTCAAGAAACCTGTCACTATAAAGATTCCCTATGAATTTATAGAGCCAGCTCCAAGGTATAGAGGATTTC
ATACCTTGGACTGGAAGAAGTGCATTGGATGTAATATGTGTGGCCAGATATGTCCTGCTAGGGCAATAGAGATGACTTGG
ATAGAGGGAGAGAAGAGGCCACATCCAAAGATAGACTATGGTAGATGTACATTCTGCCAGTTCTGTGTAGATGTTTGCCC
AACTGGAGCTCTAGGGTTCATAGAGACTTACATGCTCACCACAACTTGGAGAGAAGAAGAGTTGTTGCTTTATGATTGGG
TTCCAATAGAACCGGAAAAGTTCAAGGAAATTCAAGAAAAATTCAAAGATTATAAGTTCCCAGTTGAAAAGATAGAGTTC
AACAAAGAGACAAAGGAAGTAACCTACTACCTAAGAGATGGCACCACATTCAAATTCAAAATACTTGGTTATGGACTTAA
GCCTCCAGTAAAACCCCAGCCCACAACAAAACAGCAAGAGGAAGAAAAGAAGGAATCAGGACAGTAA

Upstream 100 bases:

>100_bases
GAGTTCTTGAGCAACTTTTAGTCGGAGCGAGATTAGCTGATGTCCCTGCAATATTAATGAGTCTTGATAATTGTCCTCCA
GACATTGATAGGTGAGGAAA

Downstream 100 bases:

>100_bases
TTTCTCTATCTCATCCCAAATTCTCTCTGCTAACTCTCTCTTTTTCATTTTTGGAAGTTCTTTTGTGAAATCTCTGCCAA
TTAATACTACTTGGTTTTCC

Product: NADH dehydrogenase subunit I

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I subunit I; NDH-1 subunit I; NDH-I [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MEEVTFRIAPEEKVKKKPSFLKPWFGLKYLFKKPVTIKIPYEFIEPAPRYRGFHTLDWKKCIGCNMCGQICPARAIEMTW
IEGEKRPHPKIDYGRCTFCQFCVDVCPTGALGFIETYMLTTTWREEELLLYDWVPIEPEKFKEIQEKFKDYKFPVEKIEF
NKETKEVTYYLRDGTTFKFKILGYGLKPPVKPQPTTKQQEEEKKESGQ

Sequences:

>Translated_208_residues
MEEVTFRIAPEEKVKKKPSFLKPWFGLKYLFKKPVTIKIPYEFIEPAPRYRGFHTLDWKKCIGCNMCGQICPARAIEMTW
IEGEKRPHPKIDYGRCTFCQFCVDVCPTGALGFIETYMLTTTWREEELLLYDWVPIEPEKFKEIQEKFKDYKFPVEKIEF
NKETKEVTYYLRDGTTFKFKILGYGLKPPVKPQPTTKQQEEEKKESGQ
>Mature_208_residues
MEEVTFRIAPEEKVKKKPSFLKPWFGLKYLFKKPVTIKIPYEFIEPAPRYRGFHTLDWKKCIGCNMCGQICPARAIEMTW
IEGEKRPHPKIDYGRCTFCQFCVDVCPTGALGFIETYMLTTTWREEELLLYDWVPIEPEKFKEIQEKFKDYKFPVEKIEF
NKETKEVTYYLRDGTTFKFKILGYGLKPPVKPQPTTKQQEEEKKESGQ

Specific function: NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cellular thylakoid membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI4505371, Length=118, Percent_Identity=37.2881355932203, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17555194, Length=139, Percent_Identity=32.3741007194245, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI17864306, Length=118, Percent_Identity=36.4406779661017, Blast_Score=71, Evalue=6e-13,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR004497
- InterPro:   IPR010226 [H]

Pfam domain/function: PF00037 Fer4 [H]

EC number: 1.6.5.3

Molecular weight: Translated: 24709; Mature: 24709

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEVTFRIAPEEKVKKKPSFLKPWFGLKYLFKKPVTIKIPYEFIEPAPRYRGFHTLDWKK
CCCEEEEECCHHHHHCCCCCCCCHHHHHHHHCCCEEEECCHHHHCCCCCCCCCCCCCHHH
CIGCNMCGQICPARAIEMTWIEGEKRPHPKIDYGRCTFCQFCVDVCPTGALGFIETYMLT
HCCCCCHHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHH
TTWREEELLLYDWVPIEPEKFKEIQEKFKDYKFPVEKIEFNKETKEVTYYLRDGTTFKFK
EECCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCEEEEEEEECCCEEEEE
ILGYGLKPPVKPQPTTKQQEEEKKESGQ
EEEECCCCCCCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MEEVTFRIAPEEKVKKKPSFLKPWFGLKYLFKKPVTIKIPYEFIEPAPRYRGFHTLDWKK
CCCEEEEECCHHHHHCCCCCCCCHHHHHHHHCCCEEEECCHHHHCCCCCCCCCCCCCHHH
CIGCNMCGQICPARAIEMTWIEGEKRPHPKIDYGRCTFCQFCVDVCPTGALGFIETYMLT
HCCCCCHHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHH
TTWREEELLLYDWVPIEPEKFKEIQEKFKDYKFPVEKIEFNKETKEVTYYLRDGTTFKFK
EECCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCEEEEEEEECCCEEEEE
ILGYGLKPPVKPQPTTKQQEEEKKESGQ
EEEECCCCCCCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA