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The map label for this gene is nuoD [H]

Identifier: 18977814

GI number: 18977814

Start: 1351020

End: 1352195

Strand: Reverse

Name: nuoD [H]

Synonym: PF1442

Alternate gene names: 18977814

Gene position: 1352195-1351020 (Counterclockwise)

Preceding gene: 18977815

Following gene: 18977813

Centisome position: 70.86

GC content: 43.71

Gene sequence:

>1176_bases
ATGGTTAGTCAAGAAGAACTCATTAGGGAAGCGAGACAAAATGGAATGGAGCTGTATCCAATTGATAAAGATACCTATGA
GTTGTTCTTTGGACCTCAACACATGGCAACTGAAAACTTTAGTATCATCTTAAAGATGGATGGGAACAGAGTTGTAAAGG
CTATAGCTAATCCTGGGTTCCTTCACAGAGGTTTCGAAAAGTTGGCTGAGTATAGGCCTTGGTATACTAACATAGCTCTC
CTTCTTAGAATTTGTGTCCCAGAGCCCGACGTTCCGGAGGCAATATACTCAATGGCAGTGGATGAAATAATTGGATGGGA
AGTGCCAGAGAGAGCCCAGTGGATTAGAACTCTTGTGTTAGAGATGGCTAGAGTAACAGCATACCTCTTCTGGATAATGG
GTTTGAGCTTTAAGCTAGGTGTCTACACAGCTGGGCAATGGGCTGCTGCTTACAGAGAGAGGTTTATGGCATTATTTGAG
CAATTGACAGGAGCAAGAGTTTACCACATTTATACAATCCCAGGAGGAGTAAGAAGGGATATCCCAGGGGACAAGTGGTT
AAGACAGGTTAGAGATACAGTGGAATACCTCAAAGATAAGCTTAAAGACTTTGATAATGTCCTCTTCGAGAACTACATAA
CTTACAAGAGGCTTGAGGGAATTGGAGTAATGGACAAGAAGTTTGCACTAGAAGAGGGGGTAACGGGGCCAAACCTAAGG
GCAACTGGAGTTGCCTACGACGTTAGAAAATCTGATCCATACCTTTTGTATCCTGAGCTTGACTTTGAAATTCCAGTGTT
GAAGGAAGGGGATGCACTTGCAAGAGTTTTAGTTAGAAGATATGAGCTTGAGCAAGATCTCTACATAATTGAGCAGCTCC
TCGATATGGGACCACCAAGTGGGCCTTACAAGGTTCAAGATCCAAAACTGAAGAACCTTCCAAGGTTTAAAGTCCCGCCA
GGCGAGGCCTTTGCTCATGTTGAGGCAACAAAGGGTGATTTTGGAGCATACGTTGTTAGCGATGGGGGACATAAGCCATA
TAGGGTGCACATAAGAGGCCCTAGCATTGCTCATGGTGTAAGAGTTCTTGAGCAACTTTTAGTCGGAGCGAGATTAGCTG
ATGTCCCTGCAATATTAATGAGTCTTGATAATTGTCCTCCAGACATTGATAGGTGA

Upstream 100 bases:

>100_bases
AGAAAGGACTTTGACATGCTTGCCTATGTGAAGAAGAAGTATAAGATTCTTGATAGATTCGACGAGGATAAGGATAAGTA
TGTGATCTGAGGTGAGAATT

Downstream 100 bases:

>100_bases
GGAAAATGGAGGAGGTAACATTTAGAATAGCTCCCGAGGAGAAGGTAAAGAAAAAACCTTCATTCCTCAAGCCTTGGTTT
GGGCTGAAATATCTCTTCAA

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MVSQEELIREARQNGMELYPIDKDTYELFFGPQHMATENFSIILKMDGNRVVKAIANPGFLHRGFEKLAEYRPWYTNIAL
LLRICVPEPDVPEAIYSMAVDEIIGWEVPERAQWIRTLVLEMARVTAYLFWIMGLSFKLGVYTAGQWAAAYRERFMALFE
QLTGARVYHIYTIPGGVRRDIPGDKWLRQVRDTVEYLKDKLKDFDNVLFENYITYKRLEGIGVMDKKFALEEGVTGPNLR
ATGVAYDVRKSDPYLLYPELDFEIPVLKEGDALARVLVRRYELEQDLYIIEQLLDMGPPSGPYKVQDPKLKNLPRFKVPP
GEAFAHVEATKGDFGAYVVSDGGHKPYRVHIRGPSIAHGVRVLEQLLVGARLADVPAILMSLDNCPPDIDR

Sequences:

>Translated_391_residues
MVSQEELIREARQNGMELYPIDKDTYELFFGPQHMATENFSIILKMDGNRVVKAIANPGFLHRGFEKLAEYRPWYTNIAL
LLRICVPEPDVPEAIYSMAVDEIIGWEVPERAQWIRTLVLEMARVTAYLFWIMGLSFKLGVYTAGQWAAAYRERFMALFE
QLTGARVYHIYTIPGGVRRDIPGDKWLRQVRDTVEYLKDKLKDFDNVLFENYITYKRLEGIGVMDKKFALEEGVTGPNLR
ATGVAYDVRKSDPYLLYPELDFEIPVLKEGDALARVLVRRYELEQDLYIIEQLLDMGPPSGPYKVQDPKLKNLPRFKVPP
GEAFAHVEATKGDFGAYVVSDGGHKPYRVHIRGPSIAHGVRVLEQLLVGARLADVPAILMSLDNCPPDIDR
>Mature_391_residues
MVSQEELIREARQNGMELYPIDKDTYELFFGPQHMATENFSIILKMDGNRVVKAIANPGFLHRGFEKLAEYRPWYTNIAL
LLRICVPEPDVPEAIYSMAVDEIIGWEVPERAQWIRTLVLEMARVTAYLFWIMGLSFKLGVYTAGQWAAAYRERFMALFE
QLTGARVYHIYTIPGGVRRDIPGDKWLRQVRDTVEYLKDKLKDFDNVLFENYITYKRLEGIGVMDKKFALEEGVTGPNLR
ATGVAYDVRKSDPYLLYPELDFEIPVLKEGDALARVLVRRYELEQDLYIIEQLLDMGPPSGPYKVQDPKLKNLPRFKVPP
GEAFAHVEATKGDFGAYVVSDGGHKPYRVHIRGPSIAHGVRVLEQLLVGARLADVPAILMSLDNCPPDIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=388, Percent_Identity=34.2783505154639, Blast_Score=205, Evalue=5e-53,
Organism=Homo sapiens, GI260898743, Length=376, Percent_Identity=34.5744680851064, Blast_Score=202, Evalue=5e-52,
Organism=Escherichia coli, GI145693162, Length=412, Percent_Identity=32.0388349514563, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI1789076, Length=373, Percent_Identity=30.5630026809651, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788832, Length=382, Percent_Identity=29.0575916230367, Blast_Score=123, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17568379, Length=385, Percent_Identity=32.2077922077922, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17555284, Length=404, Percent_Identity=31.1881188118812, Blast_Score=205, Evalue=3e-53,
Organism=Drosophila melanogaster, GI221459469, Length=400, Percent_Identity=36, Blast_Score=224, Evalue=8e-59,
Organism=Drosophila melanogaster, GI24638644, Length=401, Percent_Identity=33.9152119700748, Blast_Score=220, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 44702; Mature: 44702

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSQEELIREARQNGMELYPIDKDTYELFFGPQHMATENFSIILKMDGNRVVKAIANPGF
CCCHHHHHHHHHHCCCEEEECCCCCEEEEECCHHHCCCCEEEEEEECCCHHHHHHCCCCH
LHRGFEKLAEYRPWYTNIALLLRICVPEPDVPEAIYSMAVDEIIGWEVPERAQWIRTLVL
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
EMARVTAYLFWIMGLSFKLGVYTAGQWAAAYRERFMALFEQLTGARVYHIYTIPGGVRRD
HHHHHHHHHHHHHHHHHEEEEEECHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCC
IPGDKWLRQVRDTVEYLKDKLKDFDNVLFENYITYKRLEGIGVMDKKFALEEGVTGPNLR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCE
ATGVAYDVRKSDPYLLYPELDFEIPVLKEGDALARVLVRRYELEQDLYIIEQLLDMGPPS
ECCEEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GPYKVQDPKLKNLPRFKVPPGEAFAHVEATKGDFGAYVVSDGGHKPYRVHIRGPSIAHGV
CCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCEEEEECCCCHHHHH
RVLEQLLVGARLADVPAILMSLDNCPPDIDR
HHHHHHHHCCHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MVSQEELIREARQNGMELYPIDKDTYELFFGPQHMATENFSIILKMDGNRVVKAIANPGF
CCCHHHHHHHHHHCCCEEEECCCCCEEEEECCHHHCCCCEEEEEEECCCHHHHHHCCCCH
LHRGFEKLAEYRPWYTNIALLLRICVPEPDVPEAIYSMAVDEIIGWEVPERAQWIRTLVL
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
EMARVTAYLFWIMGLSFKLGVYTAGQWAAAYRERFMALFEQLTGARVYHIYTIPGGVRRD
HHHHHHHHHHHHHHHHHEEEEEECHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCC
IPGDKWLRQVRDTVEYLKDKLKDFDNVLFENYITYKRLEGIGVMDKKFALEEGVTGPNLR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCE
ATGVAYDVRKSDPYLLYPELDFEIPVLKEGDALARVLVRRYELEQDLYIIEQLLDMGPPS
ECCEEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GPYKVQDPKLKNLPRFKVPPGEAFAHVEATKGDFGAYVVSDGGHKPYRVHIRGPSIAHGV
CCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCEEEEECCCCHHHHH
RVLEQLLVGARLADVPAILMSLDNCPPDIDR
HHHHHHHHCCHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA