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The map label for this gene is coaBC [H]

Identifier: 18977812

GI number: 18977812

Start: 1349191

End: 1350399

Strand: Direct

Name: coaBC [H]

Synonym: PF1440

Alternate gene names: 18977812

Gene position: 1349191-1350399 (Clockwise)

Preceding gene: 18977809

Following gene: 18977826

Centisome position: 70.7

GC content: 39.95

Gene sequence:

>1209_bases
ATGCTTCACCACGTCAAGCTAATCTACGCCACAAAAAGTCGAAAGCTAGTTGGAAAAAAGATAGTTCTCGCAATCCCAGG
GAGTATTGCAGCTGTGGAATGTGTAAAGCTTGCTAGGGAACTAATTAGGCATGGGGCCGAAGTTCATGCAGTGATGAGTG
AGGCAGCCACCAAGATAATTCATCCTTATGCAATGGAATTTGCCACGGGAAATCCAGTCATAACTGAGATCACTGGATTT
ATCGAGCATGTTGAGTTAGCAGGGGAACATGAGAATAAAGCAGATTTAATTTTGGTTTGTCCTGCCACTGCCAACACAAT
TAGTAAGATTGCATGTGGAATAGATGATACTCCAGTAACTACAGTCGTGACCACAGCATTTCCCCACATTCCAATTATGA
TAGCCCCAGCAATGCATGAGACAATGTACAGGCATCCCATAGTAAGGGAGAACATTGAAAGGTTAAAGAAGCTTGGCGTT
GAGTTTATAGGACCAAGAATTGAGGAGGGAAAGGCAAAAGTTGCAAGCATTGATGAAATAGTTTACAGAGTTATTAAAAA
GCTCCACAAAAAAACATTGGAAGGGAAGAGAGTCCTAGTAACGGCGGGAGCAACAAGAGAGTACATAGATCCAATAAGAT
TCATAACAAATGCCAGCAGTGGAAAAATGGGAGTAGCGTTGGCTGAAGAAGCAGATTTTAGAGGAGCTGAGGTTACCCTC
ATAAGAACAAAGGGAAGTGTAAAGAGCTTTGTAGAAAATCAAATTGAAGTTGAGACAGTGGAAGAAATGCTTTCAGCGAT
TGAAAATGAGTTGAGGAGTAAAAAGTATGACGTAGTTATTATGGCAGCTGCTGTAAGCGATTTTAGGCCAAAAATTAAAG
CAGAGGGAAAAATTAAAAGCGATAGATCAATAACGATAGAGCTCGTTCCAAATCCCAAAATCATTGATAGAATAAAGGAA
ATTCAACCAAATGTCTTTCTTGTTGGATTTAAAGCAGAAACTTCAAAAGAAAAGCTTATAGAAGAAGGTAAAAGGCAGAT
TGAGAGGGCCAAGGCTGACTTAGTCGTTGGTAACACATTGGAAGCCTTTGGAAGCGAGGAAAACCAAGTAGTATTAATTG
GCAGAGATTTCACAAAAGAACTTCCAAAAATGAAAAAGAGAGAGTTAGCAGAGAGAATTTGGGATGAGATAGAGAAATTA
CTGTCCTGA

Upstream 100 bases:

>100_bases
GCCAAGAGATGTATTTCCGCTTTCCATTATTTCCACCTCTTTCTAGAATAAAAGCAAAGGTTAATTAAACTTTCGACAAT
TAATCTTTGAGGGAAGAAAA

Downstream 100 bases:

>100_bases
TTCCTTCTTTTCTTCCTCTTGCTGTTTTGTTGTGGGCTGGGGTTTTACTGGAGGCTTAAGTCCATAACCAAGTATTTTGA
ATTTGAATGTGGTGCCATCT

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MLHHVKLIYATKSRKLVGKKIVLAIPGSIAAVECVKLARELIRHGAEVHAVMSEAATKIIHPYAMEFATGNPVITEITGF
IEHVELAGEHENKADLILVCPATANTISKIACGIDDTPVTTVVTTAFPHIPIMIAPAMHETMYRHPIVRENIERLKKLGV
EFIGPRIEEGKAKVASIDEIVYRVIKKLHKKTLEGKRVLVTAGATREYIDPIRFITNASSGKMGVALAEEADFRGAEVTL
IRTKGSVKSFVENQIEVETVEEMLSAIENELRSKKYDVVIMAAAVSDFRPKIKAEGKIKSDRSITIELVPNPKIIDRIKE
IQPNVFLVGFKAETSKEKLIEEGKRQIERAKADLVVGNTLEAFGSEENQVVLIGRDFTKELPKMKKRELAERIWDEIEKL
LS

Sequences:

>Translated_402_residues
MLHHVKLIYATKSRKLVGKKIVLAIPGSIAAVECVKLARELIRHGAEVHAVMSEAATKIIHPYAMEFATGNPVITEITGF
IEHVELAGEHENKADLILVCPATANTISKIACGIDDTPVTTVVTTAFPHIPIMIAPAMHETMYRHPIVRENIERLKKLGV
EFIGPRIEEGKAKVASIDEIVYRVIKKLHKKTLEGKRVLVTAGATREYIDPIRFITNASSGKMGVALAEEADFRGAEVTL
IRTKGSVKSFVENQIEVETVEEMLSAIENELRSKKYDVVIMAAAVSDFRPKIKAEGKIKSDRSITIELVPNPKIIDRIKE
IQPNVFLVGFKAETSKEKLIEEGKRQIERAKADLVVGNTLEAFGSEENQVVLIGRDFTKELPKMKKRELAERIWDEIEKL
LS
>Mature_402_residues
MLHHVKLIYATKSRKLVGKKIVLAIPGSIAAVECVKLARELIRHGAEVHAVMSEAATKIIHPYAMEFATGNPVITEITGF
IEHVELAGEHENKADLILVCPATANTISKIACGIDDTPVTTVVTTAFPHIPIMIAPAMHETMYRHPIVRENIERLKKLGV
EFIGPRIEEGKAKVASIDEIVYRVIKKLHKKTLEGKRVLVTAGATREYIDPIRFITNASSGKMGVALAEEADFRGAEVTL
IRTKGSVKSFVENQIEVETVEEMLSAIENELRSKKYDVVIMAAAVSDFRPKIKAEGKIKSDRSITIELVPNPKIIDRIKE
IQPNVFLVGFKAETSKEKLIEEGKRQIERAKADLVVGNTLEAFGSEENQVVLIGRDFTKELPKMKKRELAERIWDEIEKL
LS

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Escherichia coli, GI87082301, Length=409, Percent_Identity=33.7408312958435, Blast_Score=173, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24657262, Length=160, Percent_Identity=30.625, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44722; Mature: 44722

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHHVKLIYATKSRKLVGKKIVLAIPGSIAAVECVKLARELIRHGAEVHAVMSEAATKII
CCCEEEEEEEECCCHHCCCEEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
HPYAMEFATGNPVITEITGFIEHVELAGEHENKADLILVCPATANTISKIACGIDDTPVT
CHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCHH
TVVTTAFPHIPIMIAPAMHETMYRHPIVRENIERLKKLGVEFIGPRIEEGKAKVASIDEI
HHHHHCCCCCCEEEECHHHHHHHHCCHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHH
VYRVIKKLHKKTLEGKRVLVTAGATREYIDPIRFITNASSGKMGVALAEEADFRGAEVTL
HHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEE
IRTKGSVKSFVENQIEVETVEEMLSAIENELRSKKYDVVIMAAAVSDFRPKIKAEGKIKS
EECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCCCCCCCCCC
DRSITIELVPNPKIIDRIKEIQPNVFLVGFKAETSKEKLIEEGKRQIERAKADLVVGNTL
CCEEEEEECCCCHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCEEECCCH
EAFGSEENQVVLIGRDFTKELPKMKKRELAERIWDEIEKLLS
HHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MLHHVKLIYATKSRKLVGKKIVLAIPGSIAAVECVKLARELIRHGAEVHAVMSEAATKII
CCCEEEEEEEECCCHHCCCEEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
HPYAMEFATGNPVITEITGFIEHVELAGEHENKADLILVCPATANTISKIACGIDDTPVT
CHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCHH
TVVTTAFPHIPIMIAPAMHETMYRHPIVRENIERLKKLGVEFIGPRIEEGKAKVASIDEI
HHHHHCCCCCCEEEECHHHHHHHHCCHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHH
VYRVIKKLHKKTLEGKRVLVTAGATREYIDPIRFITNASSGKMGVALAEEADFRGAEVTL
HHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEE
IRTKGSVKSFVENQIEVETVEEMLSAIENELRSKKYDVVIMAAAVSDFRPKIKAEGKIKS
EECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCCCCCCCCCC
DRSITIELVPNPKIIDRIKEIQPNVFLVGFKAETSKEKLIEEGKRQIERAKADLVVGNTL
CCEEEEEECCCCHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCEEECCCH
EAFGSEENQVVLIGRDFTKELPKMKKRELAERIWDEIEKLLS
HHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]