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The map label for this gene is trxB [H]

Identifier: 18977794

GI number: 18977794

Start: 1336194

End: 1337264

Strand: Reverse

Name: trxB [H]

Synonym: PF1422

Alternate gene names: 18977794

Gene position: 1337264-1336194 (Counterclockwise)

Preceding gene: 18977810

Following gene: 18977793

Centisome position: 70.08

GC content: 39.96

Gene sequence:

>1071_bases
ATGTTTTATGGAATTACTCACAAATGTTCCAAAATGCTTTTAAGTAGGCACCACCAAGTTAGGGCAGGAGGTGAGGACAT
GTTCAGTTTAGGAGGATTAACAAAGAGTAGTGTTGATACTAGCAAAGTATGGGATGTTATTATCATCGGAGCTGGTCCAG
CTGGATACACAGCAGCAATTTATGCTGCAAGATTTGGACTTGATACACTCATCATCACAAAAGATCTTGGTGGAAATATG
GCATTGACAGACCTAATAGAAAATTATCCAGGATTTCCAGAAGGGATAAGTGGAGCAGAGCTTTCAAAAAGAATGTACGA
GCAAGTAAGGAAGTATGGGGTAGATGTAATTTTTGATGAAGTAGTAAGAATTGACCCAGCCGAATGTGCATATTATGAAG
GACCATGTAAGTTCACAATAAAGACTGCAAACGGTATGGAATATAAGTCGAGAACTGTGATAATAGCCGTTGGAGCAGAA
CCAAGGAAATTAAACGTCCCAGGAGAGAAAGAGTTCACTGGTAGGGGAGTTAGCTACTGTGCTACCTGTGATGGCCCTCT
ATTTGTTGGTAAAGAGGTAATTGTTGTTGGTGGAGGAAATACTGCCTTACAGGAGGCTCTATATCTTCACAGTATAGGAG
TTAAAGTTACCTTGGTTCACAGAAGAGATAAATTCAGGGCAGATAAGATACTTCAAGATAGATTTAGGGAGGCAGGAATT
CCTGCGATACTTAACACCGTTGTTACTGAAATTAGAGGAAAAGATAAAGTGGAAAGTGTAGTTCTGAAGAACGTTAAGAC
AGGAGAAACATTCGAGAAAAAAGTTGATGGTGTGTTTATCTTTATCGGATACGAGCCAAAGACAGACTTTGTAAAACATC
TGGGGATCACTGATGAATACGGCTATATAAAGGTAGATATGTACATGAGGACAAAGGTTCCTGGTATATTTGCAGCAGGA
GACATCACAAATGTTTTCAAGCAGATTGCAGTTGCAGTGGGACAAGGAGCCATAGCTGCCAACTCTGCAAAAGAATTCCT
AGAGAACTGGAACAAAAAGGATGTTGAGTAA

Upstream 100 bases:

>100_bases
TTTTCCTCTCTCCAAATTCGTATTGGCTTTGAAACATTAAAAAGGTTTTTTTGAAGCATTGAATTGAAAATAAAGGTATT
TAACTTTTGGTTTATAACAT

Downstream 100 bases:

>100_bases
TTCTTCTCCTGGTCTTCCTTATTTTTCGAAAATTTTTCGAACAAAAGTGCTCATTTTCGAGCTTAAGGTTAAAAGTGTGC
TCATCCACTATTTCCTGGTG

Product: thioredoxin reductase

Products: NA

Alternate protein names: TRXR; General stress protein 35; GSP35 [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MFYGITHKCSKMLLSRHHQVRAGGEDMFSLGGLTKSSVDTSKVWDVIIIGAGPAGYTAAIYAARFGLDTLIITKDLGGNM
ALTDLIENYPGFPEGISGAELSKRMYEQVRKYGVDVIFDEVVRIDPAECAYYEGPCKFTIKTANGMEYKSRTVIIAVGAE
PRKLNVPGEKEFTGRGVSYCATCDGPLFVGKEVIVVGGGNTALQEALYLHSIGVKVTLVHRRDKFRADKILQDRFREAGI
PAILNTVVTEIRGKDKVESVVLKNVKTGETFEKKVDGVFIFIGYEPKTDFVKHLGITDEYGYIKVDMYMRTKVPGIFAAG
DITNVFKQIAVAVGQGAIAANSAKEFLENWNKKDVE

Sequences:

>Translated_356_residues
MFYGITHKCSKMLLSRHHQVRAGGEDMFSLGGLTKSSVDTSKVWDVIIIGAGPAGYTAAIYAARFGLDTLIITKDLGGNM
ALTDLIENYPGFPEGISGAELSKRMYEQVRKYGVDVIFDEVVRIDPAECAYYEGPCKFTIKTANGMEYKSRTVIIAVGAE
PRKLNVPGEKEFTGRGVSYCATCDGPLFVGKEVIVVGGGNTALQEALYLHSIGVKVTLVHRRDKFRADKILQDRFREAGI
PAILNTVVTEIRGKDKVESVVLKNVKTGETFEKKVDGVFIFIGYEPKTDFVKHLGITDEYGYIKVDMYMRTKVPGIFAAG
DITNVFKQIAVAVGQGAIAANSAKEFLENWNKKDVE
>Mature_356_residues
MFYGITHKCSKMLLSRHHQVRAGGEDMFSLGGLTKSSVDTSKVWDVIIIGAGPAGYTAAIYAARFGLDTLIITKDLGGNM
ALTDLIENYPGFPEGISGAELSKRMYEQVRKYGVDVIFDEVVRIDPAECAYYEGPCKFTIKTANGMEYKSRTVIIAVGAE
PRKLNVPGEKEFTGRGVSYCATCDGPLFVGKEVIVVGGGNTALQEALYLHSIGVKVTLVHRRDKFRADKILQDRFREAGI
PAILNTVVTEIRGKDKVESVVLKNVKTGETFEKKVDGVFIFIGYEPKTDFVKHLGITDEYGYIKVDMYMRTKVPGIFAAG
DITNVFKQIAVAVGQGAIAANSAKEFLENWNKKDVE

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=300, Percent_Identity=30.3333333333333, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI226437568, Length=300, Percent_Identity=30.3333333333333, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI65787454, Length=300, Percent_Identity=30.3333333333333, Blast_Score=82, Evalue=6e-16,
Organism=Escherichia coli, GI1787114, Length=323, Percent_Identity=39.938080495356, Blast_Score=215, Evalue=3e-57,
Organism=Escherichia coli, GI87081763, Length=308, Percent_Identity=39.2857142857143, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1788468, Length=359, Percent_Identity=23.9554317548747, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17559934, Length=231, Percent_Identity=31.1688311688312, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71983429, Length=209, Percent_Identity=33.0143540669856, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71983419, Length=209, Percent_Identity=33.0143540669856, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321898, Length=328, Percent_Identity=36.280487804878, Blast_Score=196, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6320560, Length=315, Percent_Identity=37.4603174603175, Blast_Score=195, Evalue=1e-50,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 39095; Mature: 39095

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: PS00573 PYRIDINE_REDOX_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYGITHKCSKMLLSRHHQVRAGGEDMFSLGGLTKSSVDTSKVWDVIIIGAGPAGYTAAI
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCEEEEEEECCCCCHHHHH
YAARFGLDTLIITKDLGGNMALTDLIENYPGFPEGISGAELSKRMYEQVRKYGVDVIFDE
HHHHHCCEEEEEEECCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHEEHH
VVRIDPAECAYYEGPCKFTIKTANGMEYKSRTVIIAVGAEPRKLNVPGEKEFTGRGVSYC
HHHCCCHHHEEECCCEEEEEEECCCCCCCCCEEEEEECCCCCEECCCCCCCCCCCCCEEE
ATCDGPLFVGKEVIVVGGGNTALQEALYLHSIGVKVTLVHRRDKFRADKILQDRFREAGI
EECCCCEEECCEEEEEECCCHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHCCC
PAILNTVVTEIRGKDKVESVVLKNVKTGETFEKKVDGVFIFIGYEPKTDFVKHLGITDEY
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHCCCEEEEEEECCCCHHHHHHCCCCCCC
GYIKVDMYMRTKVPGIFAAGDITNVFKQIAVAVGQGAIAANSAKEFLENWNKKDVE
CEEEEEEEEEECCCCEEECCHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MFYGITHKCSKMLLSRHHQVRAGGEDMFSLGGLTKSSVDTSKVWDVIIIGAGPAGYTAAI
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCEEEEEEECCCCCHHHHH
YAARFGLDTLIITKDLGGNMALTDLIENYPGFPEGISGAELSKRMYEQVRKYGVDVIFDE
HHHHHCCEEEEEEECCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHEEHH
VVRIDPAECAYYEGPCKFTIKTANGMEYKSRTVIIAVGAEPRKLNVPGEKEFTGRGVSYC
HHHCCCHHHEEECCCEEEEEEECCCCCCCCCEEEEEECCCCCEECCCCCCCCCCCCCEEE
ATCDGPLFVGKEVIVVGGGNTALQEALYLHSIGVKVTLVHRRDKFRADKILQDRFREAGI
EECCCCEEECCEEEEEECCCHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHCCC
PAILNTVVTEIRGKDKVESVVLKNVKTGETFEKKVDGVFIFIGYEPKTDFVKHLGITDEY
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHCCCEEEEEEECCCCHHHHHHCCCCCCC
GYIKVDMYMRTKVPGIFAAGDITNVFKQIAVAVGQGAIAANSAKEFLENWNKKDVE
CEEEEEEEEEECCCCEEECCHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 9298659 [H]