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The map label for this gene is gabT [C]

Identifier: 18977793

GI number: 18977793

Start: 1334722

End: 1336086

Strand: Reverse

Name: gabT [C]

Synonym: PF1421

Alternate gene names: 18977793

Gene position: 1336086-1334722 (Counterclockwise)

Preceding gene: 18977794

Following gene: 18977790

Centisome position: 70.02

GC content: 43.88

Gene sequence:

>1365_bases
ATGGAGTTAAGGCCAAATGTTAAAGAAATCCCAGGTCCAAAGGCGAGAGAAATAATAGAGAAACACCACAAATACATGGC
AACTACCACCAATGATCCCAATGAGTACTTCTTAGTTATTGAGAGAGCGGAGGGAGTTTACTGGATTGATGTGGATGGAA
ATGTAATCCTCGACTTCTCTTCAGGAATTGGTGTTCTCAATGTTGGATTAAGGAATCCTAGGGTTGTTGAGGCCATAAAG
AAGCAGTTGGACTTAGTTCTTCATGCTGCTGGAACAGACTACTATAATCCATATCAAGTTGCCTTGGCAGAAAAGCTTGT
TCAAATAACACCTGGAGATTTCGAGAAGAAAGTATTCTTGAGCAACAGTGGAACTGAGGCCAACGAGGCAGCACTAAAGA
TAGCAAAGTGGTCCACAAACAGAAAGATGTTCATTGCATTTATAGGGGCATTCCACGGAAGAACTCATGGAACAATGAGC
CTCACCGCTAGTAAGCCCGTTCAGAGGAGCAGGATGTTCCCAACAATGCCTGGTGTTGAGCACGTTCCTTATCCAAACCC
ATACAGAAATCCCTGGCACATTGATGGTTATGAGAACCCAGACGAACTCATAAATAGAGTTCTGGAGTACATAGAGGAAT
ATCTCTTTAGTCACTATGTTCCAGCAGAAGAGGTTGCAGGAATAGTCTTTGAGCCAATTCAGGGAGAGGGTGGTTACGTC
GTTCCCCCAAGGAACTTCTTCAAGGAACTAAAGAAGCTGGCTGACAAGTACGGCATACTCTTAATTGATGACGAGGTTCA
AATGGGAATTGGTAGAACTGGAAAGATGTGGGCAATTGAGCACTTTGGAATAGCCCCAGATATCATCACTACAGCAAAGG
CTCTTGGTGGAGGCATTCCAATTGGAGCTACAATCTTCAGAAAGGATTTGGACTTTGGAGTTAGTGGAGTGCACAGCAAT
ACCTTTGGAGGAAATGCCGTAGCCGCAGCAGCTGCACTTGCAGTAATGGAGGAGTTGGAGAATGGATTGTTAGAGAATGT
CCAGAAATTAGAGCCCCTGTTCAGGGAGAGACTTGAAGAAATGAAGGAGAAGTATGAGATCATAGGAGATGTCAGAGGTA
TAGGCCTTGCATGGGGTGTAGAATTCGTAAAGGACAGAAAGACCAAGGAATATGCAACTAAGGAGAGAAATGAAGTAGTA
GTTGAGGCTCTTAAGAGAGGTCTAGCATTGCTAGGGTGTGGAAAGAGTGCCATAAGACTAATTCCACCACTAATAATCAG
CGAAGAGGAGGCCAAGATAGGACTTGACATATTTGAGGAAGCAATAAGGGTAGTCAGTGAGAGGTATGGATATAAGATCC
ACTAG

Upstream 100 bases:

>100_bases
CCTGGTCTTCCTTATTTTTCGAAAATTTTTCGAACAAAAGTGCTCATTTTCGAGCTTAAGGTTAAAAGTGTGCTCATCCA
CTATTTCCTGGTGATGAAAT

Downstream 100 bases:

>100_bases
TCTCTTCTAAACTTTTCTTTGATTCTACATATTTTTTCTTATCTAATGGAAAATTATTGGCGTTTTCGAGTAGAGCATTA
ATAAATTCGGCCTGTTCTTT

Product: 4-aminobutyrate aminotransferase

Products: succinate semialdehyde; L-glutamate

Alternate protein names: ORF B [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MELRPNVKEIPGPKAREIIEKHHKYMATTTNDPNEYFLVIERAEGVYWIDVDGNVILDFSSGIGVLNVGLRNPRVVEAIK
KQLDLVLHAAGTDYYNPYQVALAEKLVQITPGDFEKKVFLSNSGTEANEAALKIAKWSTNRKMFIAFIGAFHGRTHGTMS
LTASKPVQRSRMFPTMPGVEHVPYPNPYRNPWHIDGYENPDELINRVLEYIEEYLFSHYVPAEEVAGIVFEPIQGEGGYV
VPPRNFFKELKKLADKYGILLIDDEVQMGIGRTGKMWAIEHFGIAPDIITTAKALGGGIPIGATIFRKDLDFGVSGVHSN
TFGGNAVAAAAALAVMEELENGLLENVQKLEPLFRERLEEMKEKYEIIGDVRGIGLAWGVEFVKDRKTKEYATKERNEVV
VEALKRGLALLGCGKSAIRLIPPLIISEEEAKIGLDIFEEAIRVVSERYGYKIH

Sequences:

>Translated_454_residues
MELRPNVKEIPGPKAREIIEKHHKYMATTTNDPNEYFLVIERAEGVYWIDVDGNVILDFSSGIGVLNVGLRNPRVVEAIK
KQLDLVLHAAGTDYYNPYQVALAEKLVQITPGDFEKKVFLSNSGTEANEAALKIAKWSTNRKMFIAFIGAFHGRTHGTMS
LTASKPVQRSRMFPTMPGVEHVPYPNPYRNPWHIDGYENPDELINRVLEYIEEYLFSHYVPAEEVAGIVFEPIQGEGGYV
VPPRNFFKELKKLADKYGILLIDDEVQMGIGRTGKMWAIEHFGIAPDIITTAKALGGGIPIGATIFRKDLDFGVSGVHSN
TFGGNAVAAAAALAVMEELENGLLENVQKLEPLFRERLEEMKEKYEIIGDVRGIGLAWGVEFVKDRKTKEYATKERNEVV
VEALKRGLALLGCGKSAIRLIPPLIISEEEAKIGLDIFEEAIRVVSERYGYKIH
>Mature_454_residues
MELRPNVKEIPGPKAREIIEKHHKYMATTTNDPNEYFLVIERAEGVYWIDVDGNVILDFSSGIGVLNVGLRNPRVVEAIK
KQLDLVLHAAGTDYYNPYQVALAEKLVQITPGDFEKKVFLSNSGTEANEAALKIAKWSTNRKMFIAFIGAFHGRTHGTMS
LTASKPVQRSRMFPTMPGVEHVPYPNPYRNPWHIDGYENPDELINRVLEYIEEYLFSHYVPAEEVAGIVFEPIQGEGGYV
VPPRNFFKELKKLADKYGILLIDDEVQMGIGRTGKMWAIEHFGIAPDIITTAKALGGGIPIGATIFRKDLDFGVSGVHSN
TFGGNAVAAAAALAVMEELENGLLENVQKLEPLFRERLEEMKEKYEIIGDVRGIGLAWGVEFVKDRKTKEYATKERNEVV
VEALKRGLALLGCGKSAIRLIPPLIISEEEAKIGLDIFEEAIRVVSERYGYKIH

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=454, Percent_Identity=31.9383259911894, Blast_Score=205, Evalue=7e-53,
Organism=Homo sapiens, GI37574042, Length=429, Percent_Identity=30.3030303030303, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI226442705, Length=429, Percent_Identity=29.3706293706294, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI226442709, Length=401, Percent_Identity=30.1745635910224, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI4557809, Length=441, Percent_Identity=30.6122448979592, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI24119277, Length=411, Percent_Identity=30.9002433090024, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI188536080, Length=469, Percent_Identity=26.4392324093817, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI38679950, Length=469, Percent_Identity=26.4392324093817, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI38679946, Length=469, Percent_Identity=26.4392324093817, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI284507298, Length=332, Percent_Identity=31.0240963855422, Blast_Score=132, Evalue=9e-31,
Organism=Escherichia coli, GI1789016, Length=406, Percent_Identity=38.423645320197, Blast_Score=248, Evalue=7e-67,
Organism=Escherichia coli, GI1787560, Length=410, Percent_Identity=36.8292682926829, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI145693181, Length=396, Percent_Identity=36.3636363636364, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1788044, Length=409, Percent_Identity=34.718826405868, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1789759, Length=421, Percent_Identity=31.1163895486936, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1786991, Length=372, Percent_Identity=31.7204301075269, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1786349, Length=378, Percent_Identity=28.5714285714286, Blast_Score=125, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI71992977, Length=415, Percent_Identity=33.4939759036145, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI32564660, Length=430, Percent_Identity=30.9302325581395, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI25144271, Length=416, Percent_Identity=28.3653846153846, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17541228, Length=472, Percent_Identity=26.0593220338983, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI25144274, Length=295, Percent_Identity=30.5084745762712, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6324432, Length=441, Percent_Identity=33.5600907029478, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6323470, Length=449, Percent_Identity=29.8440979955457, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6321456, Length=482, Percent_Identity=28.0082987551867, Blast_Score=129, Evalue=8e-31,
Organism=Drosophila melanogaster, GI28574759, Length=427, Percent_Identity=33.0210772833724, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI161085790, Length=428, Percent_Identity=32.7102803738318, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI21356575, Length=419, Percent_Identity=31.980906921241, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI21357415, Length=445, Percent_Identity=29.2134831460674, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI281366494, Length=477, Percent_Identity=29.769392033543, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24667139, Length=477, Percent_Identity=29.769392033543, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24667143, Length=477, Percent_Identity=29.769392033543, Blast_Score=142, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.19

Molecular weight: Translated: 50757; Mature: 50757

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRPNVKEIPGPKAREIIEKHHKYMATTTNDPNEYFLVIERAEGVYWIDVDGNVILDFS
CCCCCCCHHCCCCHHHHHHHHHHHEEEECCCCCCEEEEEEEECCCEEEEEECCCEEEEEC
SGIGVLNVGLRNPRVVEAIKKQLDLVLHAAGTDYYNPYQVALAEKLVQITPGDFEKKVFL
CCCCEEEECCCCCHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEEE
SNSGTEANEAALKIAKWSTNRKMFIAFIGAFHGRTHGTMSLTASKPVQRSRMFPTMPGVE
ECCCCCHHHHHEEEEEECCCCEEEEEEEHHHCCCCCCEEEEECCCCHHHHCCCCCCCCCC
HVPYPNPYRNPWHIDGYENPDELINRVLEYIEEYLFSHYVPAEEVAGIVFEPIQGEGGYV
CCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCEEEECCCCCCCEE
VPPRNFFKELKKLADKYGILLIDDEVQMGIGRTGKMWAIEHFGIAPDIITTAKALGGGIP
CCCHHHHHHHHHHHHHCCEEEEECCHHHCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCC
IGATIFRKDLDFGVSGVHSNTFGGNAVAAAAALAVMEELENGLLENVQKLEPLFRERLEE
CCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKEKYEIIGDVRGIGLAWGVEFVKDRKTKEYATKERNEVVVEALKRGLALLGCGKSAIRL
HHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHH
IPPLIISEEEAKIGLDIFEEAIRVVSERYGYKIH
CCCCEECCCCHHCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MELRPNVKEIPGPKAREIIEKHHKYMATTTNDPNEYFLVIERAEGVYWIDVDGNVILDFS
CCCCCCCHHCCCCHHHHHHHHHHHEEEECCCCCCEEEEEEEECCCEEEEEECCCEEEEEC
SGIGVLNVGLRNPRVVEAIKKQLDLVLHAAGTDYYNPYQVALAEKLVQITPGDFEKKVFL
CCCCEEEECCCCCHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEEE
SNSGTEANEAALKIAKWSTNRKMFIAFIGAFHGRTHGTMSLTASKPVQRSRMFPTMPGVE
ECCCCCHHHHHEEEEEECCCCEEEEEEEHHHCCCCCCEEEEECCCCHHHHCCCCCCCCCC
HVPYPNPYRNPWHIDGYENPDELINRVLEYIEEYLFSHYVPAEEVAGIVFEPIQGEGGYV
CCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCEEEECCCCCCCEE
VPPRNFFKELKKLADKYGILLIDDEVQMGIGRTGKMWAIEHFGIAPDIITTAKALGGGIP
CCCHHHHHHHHHHHHHCCEEEEECCHHHCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCC
IGATIFRKDLDFGVSGVHSNTFGGNAVAAAAALAVMEELENGLLENVQKLEPLFRERLEE
CCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKEKYEIIGDVRGIGLAWGVEFVKDRKTKEYATKERNEVVVEALKRGLALLGCGKSAIRL
HHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHH
IPPLIISEEEAKIGLDIFEEAIRVVSERYGYKIH
CCCCEECCCCHHCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal 5'-phosphate lysine-residue [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 3.3 {4-aminobutanoate}} 1.1 {4-aminobutanoate}} 1.3 {2-oxoglutarate}} 0.7 {2-oxoglutarate}} [C]

Substrates: 4-aminobutanoate; 2-oxoglutarate

Specific reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate

General reaction: Amino group transfer [C]

Inhibitor: 2-Oxoglutarate; Lysyl reagents; SH-group reagents [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA