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The map label for this gene is tuaD [H]

Identifier: 18977727

GI number: 18977727

Start: 1273076

End: 1274359

Strand: Direct

Name: tuaD [H]

Synonym: PF1355

Alternate gene names: 18977727

Gene position: 1273076-1274359 (Clockwise)

Preceding gene: 18977726

Following gene: 18977728

Centisome position: 66.71

GC content: 41.12

Gene sequence:

>1284_bases
ATGAGAGTTTCGGTTGTTGGCTCTGGTTATGTTGGGCTTGTCACAGGGATAGGTTTTGTCAAGCTTGGGAATAGCGTTAT
CTTCGTTGATGTTGATGAGAGGAAGATCCAAATGATTAATAATGCTCAACCTCCAATTTATGAGGAGGGTTTGGAAGAAT
TAATGCAAGAATTTAGAGGTAAATATTACGCTACTAACGATTATAGAGATGCAATTCTCAATTCTGACATTACGTTCATA
GCCGTTGGAACTCCCTCAAGAGAAGACGGTTCGATTGACCTTACATACGTTAAAGAAGCCAGCAGAGCTATTGGAAAGGC
ACTAAGAGAAAAGGAAGATTATCATGTTGTCGTAGTTAAGAGCACTGTCCTCCCAGGAACTACCGAGGAAGTTGTAAGAC
CAATCCTTGAAAAGTATTCTGGTAAGAAGGCAATCCAAGACTTTGGCCTTGCAATGAATCCAGAGTTTTTGAGAGAAGGT
ACTGCATTGAAGGACTTCCTCAACCCGGATAGAATAGTCATTGGTGTTCAAGATGAGAGGACTAAGAAAGTCCTCGAAGA
GCTTTATGCTCCCATTAATGCACCAAAGTTAATTGTGGACATTAAGACTGCTGAAATGATAAAGTACGCCTCAAACGCTT
TCCTAGCAACAAAGATAAGCTTTGCAAACGAGATTGGGAATATTTGTAAAAAACTCGGAATAGATTCTTGGAAAGTTTTT
GAAGGAGTTGGCCTAGATCATAGGATAAGCCCCTACTTCTTCAGGACTGGAATTGGCTGGGGTGGCTCATGCTTTCCAAA
AGATGTCAGAGCCTTAATTAGGAAGGCGGAAGAACTGGGAGAGGACCCAATAATCCTAAAGGCAGTTGTTGAGGTCAATG
AGAGGCAACCTCTCAAGCTTATTGAATTGCTAAAGAAGCATGTTCCAGACCTTAAGGGAAAAACTGTCGGAGTGTTAGGA
TTAGCATTCAAGCCAAACACTGATGACGTGAGAGAGACTAGGGCTTATATTATAGTCAGAAAACTTCTGGAAAAAGGAGC
TCACATTATAGCTTACGATCCAAAAGCCATGGAGAATTTCAAGCGCTTTTATCCGGATGTTGGGGAAAAGATAGAATACG
CTAACTCGCCTGAAGAAGTTCTTGAAAAATCTGATGTTATTTTGATAGTTACAGAGTGGAATGAATTTGAGAAGGTAGAT
TACTCTGGGAAAATTGTTATTGACGGTAGGAGAATTAGAGCTGCCGAGAAAACAGCGAGAATTTACGAGGGGGTGTGCTG
GTGA

Upstream 100 bases:

>100_bases
AGCAACAGTGTGCACACAAGGGCTTGCAGTTCTCTTTTCGATTTTCTCTGTAAAAAATACTTTTAAGCAAGAAAGTTATC
AAGTGTTCTGAGGTGGTTTG

Downstream 100 bases:

>100_bases
AAGTGAGAAAAGCGGTAATTCCAGCAGCAGGCCTTGGAACAAGAATGTTACCACTGACTAAAGCACAACCAAAAGAAATG
CTCCCTGTTGTGAGAAAGCC

Product: NDP-sugar dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Teichuronic acid biosynthesis protein tuaD [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MRVSVVGSGYVGLVTGIGFVKLGNSVIFVDVDERKIQMINNAQPPIYEEGLEELMQEFRGKYYATNDYRDAILNSDITFI
AVGTPSREDGSIDLTYVKEASRAIGKALREKEDYHVVVVKSTVLPGTTEEVVRPILEKYSGKKAIQDFGLAMNPEFLREG
TALKDFLNPDRIVIGVQDERTKKVLEELYAPINAPKLIVDIKTAEMIKYASNAFLATKISFANEIGNICKKLGIDSWKVF
EGVGLDHRISPYFFRTGIGWGGSCFPKDVRALIRKAEELGEDPIILKAVVEVNERQPLKLIELLKKHVPDLKGKTVGVLG
LAFKPNTDDVRETRAYIIVRKLLEKGAHIIAYDPKAMENFKRFYPDVGEKIEYANSPEEVLEKSDVILIVTEWNEFEKVD
YSGKIVIDGRRIRAAEKTARIYEGVCW

Sequences:

>Translated_427_residues
MRVSVVGSGYVGLVTGIGFVKLGNSVIFVDVDERKIQMINNAQPPIYEEGLEELMQEFRGKYYATNDYRDAILNSDITFI
AVGTPSREDGSIDLTYVKEASRAIGKALREKEDYHVVVVKSTVLPGTTEEVVRPILEKYSGKKAIQDFGLAMNPEFLREG
TALKDFLNPDRIVIGVQDERTKKVLEELYAPINAPKLIVDIKTAEMIKYASNAFLATKISFANEIGNICKKLGIDSWKVF
EGVGLDHRISPYFFRTGIGWGGSCFPKDVRALIRKAEELGEDPIILKAVVEVNERQPLKLIELLKKHVPDLKGKTVGVLG
LAFKPNTDDVRETRAYIIVRKLLEKGAHIIAYDPKAMENFKRFYPDVGEKIEYANSPEEVLEKSDVILIVTEWNEFEKVD
YSGKIVIDGRRIRAAEKTARIYEGVCW
>Mature_427_residues
MRVSVVGSGYVGLVTGIGFVKLGNSVIFVDVDERKIQMINNAQPPIYEEGLEELMQEFRGKYYATNDYRDAILNSDITFI
AVGTPSREDGSIDLTYVKEASRAIGKALREKEDYHVVVVKSTVLPGTTEEVVRPILEKYSGKKAIQDFGLAMNPEFLREG
TALKDFLNPDRIVIGVQDERTKKVLEELYAPINAPKLIVDIKTAEMIKYASNAFLATKISFANEIGNICKKLGIDSWKVF
EGVGLDHRISPYFFRTGIGWGGSCFPKDVRALIRKAEELGEDPIILKAVVEVNERQPLKLIELLKKHVPDLKGKTVGVLG
LAFKPNTDDVRETRAYIIVRKLLEKGAHIIAYDPKAMENFKRFYPDVGEKIEYANSPEEVLEKSDVILIVTEWNEFEKVD
YSGKIVIDGRRIRAAEKTARIYEGVCW

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=450, Percent_Identity=33.1111111111111, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI296040438, Length=350, Percent_Identity=32.5714285714286, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI296040443, Length=290, Percent_Identity=33.7931034482759, Blast_Score=151, Evalue=1e-36,
Organism=Escherichia coli, GI1788340, Length=363, Percent_Identity=29.7520661157025, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI48994968, Length=416, Percent_Identity=25.7211538461538, Blast_Score=138, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17560350, Length=451, Percent_Identity=31.7073170731707, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI17136908, Length=463, Percent_Identity=33.4773218142549, Blast_Score=211, Evalue=7e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 48045; Mature: 48045

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVSVVGSGYVGLVTGIGFVKLGNSVIFVDVDERKIQMINNAQPPIYEEGLEELMQEFRG
CEEEEECCCHHHHHHCCHHEEECCEEEEEECCHHHHHHHCCCCCCHHHHHHHHHHHHHCC
KYYATNDYRDAILNSDITFIAVGTPSREDGSIDLTYVKEASRAIGKALREKEDYHVVVVK
CEEECCCHHHHHHCCCEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCEEEEEEE
STVLPGTTEEVVRPILEKYSGKKAIQDFGLAMNPEFLREGTALKDFLNPDRIVIGVQDER
ECCCCCCHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHCCCHHHHHCCCCEEEEECCCHH
TKKVLEELYAPINAPKLIVDIKTAEMIKYASNAFLATKISFANEIGNICKKLGIDSWKVF
HHHHHHHHHCCCCCCEEEEEECHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCEEHH
EGVGLDHRISPYFFRTGIGWGGSCFPKDVRALIRKAEELGEDPIILKAVVEVNERQPLKL
HCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCHHH
IELLKKHVPDLKGKTVGVLGLAFKPNTDDVRETRAYIIVRKLLEKGAHIIAYDPKAMENF
HHHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHH
KRFYPDVGEKIEYANSPEEVLEKSDVILIVTEWNEFEKVDYSGKIVIDGRRIRAAEKTAR
HHHCCCHHHHCCCCCCHHHHHCCCCEEEEEECCCCHHCCCCCCEEEECCCCHHHHHHHHH
IYEGVCW
HHCCCCC
>Mature Secondary Structure
MRVSVVGSGYVGLVTGIGFVKLGNSVIFVDVDERKIQMINNAQPPIYEEGLEELMQEFRG
CEEEEECCCHHHHHHCCHHEEECCEEEEEECCHHHHHHHCCCCCCHHHHHHHHHHHHHCC
KYYATNDYRDAILNSDITFIAVGTPSREDGSIDLTYVKEASRAIGKALREKEDYHVVVVK
CEEECCCHHHHHHCCCEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCEEEEEEE
STVLPGTTEEVVRPILEKYSGKKAIQDFGLAMNPEFLREGTALKDFLNPDRIVIGVQDER
ECCCCCCHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHCCCHHHHHCCCCEEEEECCCHH
TKKVLEELYAPINAPKLIVDIKTAEMIKYASNAFLATKISFANEIGNICKKLGIDSWKVF
HHHHHHHHHCCCCCCEEEEEECHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCEEHH
EGVGLDHRISPYFFRTGIGWGGSCFPKDVRALIRKAEELGEDPIILKAVVEVNERQPLKL
HCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCHHH
IELLKKHVPDLKGKTVGVLGLAFKPNTDDVRETRAYIIVRKLLEKGAHIIAYDPKAMENF
HHHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHH
KRFYPDVGEKIEYANSPEEVLEKSDVILIVTEWNEFEKVDYSGKIVIDGRRIRAAEKTAR
HHHCCCHHHHCCCCCCHHHHHCCCCEEEEEECCCCHHCCCCCCEEEECCCCHHHHHHHHH
IYEGVCW
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10048024; 9384377; 10376820 [H]