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The map label for this gene is 18977721

Identifier: 18977721

GI number: 18977721

Start: 1266619

End: 1267689

Strand: Direct

Name: 18977721

Synonym: PF1349

Alternate gene names: NA

Gene position: 1266619-1267689 (Clockwise)

Preceding gene: 18977718

Following gene: 18977722

Centisome position: 66.38

GC content: 47.99

Gene sequence:

>1071_bases
ATGGAGATAAAGTACAGGCCTGAAGAGCTGACAAAACTTCCAAGGAGCGTTGAGTATAGGGAAGGAAAGGTCTACATGAT
AAACCAGAGGCTCCTTCCCAGGGAATTCAAGGTTGAGGAATTCACAACGGTTGAGGCCGTTGCTGAGGCAATTAAGAACA
TGACGGTGAGAGGGGCCCCAGCAATTGGAGCTGCTGCAGCCTTTGGCTTGGCTTTATATGCCGAAACATCAAAAGCAAAG
ACCAAAGATGAGTTCTTCGATGGGTTTTATAGAGCATATGAAACTCTAAAGAACACAAGGCCGACGGCCGTAAATCTATT
CTGGGCCCTTAACAGGATAAAGAAGTTAGTCGAGGAGCATAGGGAGGACAGTTTGGATGAGATTAAGAGGTTGATAGTCG
AGGAGGCACAGAAGATTGCGGATGAGGACGTGGAGGCAAATTTGAGAATGGGCCACTACGGAGCTGAAGTCCTCCCAGAG
GGAAACATACTAACCCACTGCAACGCTGGTAGCTTAGCAACGGTTCACCTGGGAACCGTTGGGGCTGTGGTTAGGGTCAT
GCACAAGGAGGGAACACTAAAGCTTTTATGGCTCGACGAAACTAGGCCAGTCCTTCAAGGGGCCAGACTCTCCGCCTGGG
AGTATAGTTACGATGGGCTAAATGTTAAGTTGATAGCTGATAATGCTGCAGCCTTCGTGATGCAGCAAGGAAAGGTTGAT
GCAATAATAGTTGGTGCAGACAGGATAGTTGCCAATGGAGACTTCGCAAATAAAATAGGTACTTACATGCTAGCAGTGTT
GGCCAAGGAGCACGGGATACCCTTCTTTACCGTAGCTCCGCTTTCAAGCATTGACATGAGCTTGAGTAGCGGGAAGGAGA
TTCCAATTGAGGAGAGATCACCAGAGGAGGTGTTGACTTGTGGAGGGTGCAGAATTGCCCCAGATGTTCCAGTGTATAAC
CCAGCTTTCGACGTTACCCCCCACAAGTATCTGACAGGAATAATAACAGATAGAGGTGTAGTTTGGCCACCATTCAAGAG
GAACCTCAAGAAGCTCTTTGAAACCCTCTAA

Upstream 100 bases:

>100_bases
ATAAAAGGATTTCTATTAACATTTGTTAAAATTGGACTCGACGATTGTCGATGTCACAAAGTGATTTAAAGATTCCCCGC
GAAGCTTAATCGGTGGTATC

Downstream 100 bases:

>100_bases
TTTCTTTTTCCACTTCTTTGGGAGTTTATAAGTAAATGAGACTTATAAACCCCTTTCGAAGAGTTTATAAACTCCATGCC
TTCTTTCACCACCCTCGATG

Product: translation initiation factor IF-2B subunit beta

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; MTNA-like protein; aMTNA; S-methyl-5-thioribose-1-phosphate isomerase [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MEIKYRPEELTKLPRSVEYREGKVYMINQRLLPREFKVEEFTTVEAVAEAIKNMTVRGAPAIGAAAAFGLALYAETSKAK
TKDEFFDGFYRAYETLKNTRPTAVNLFWALNRIKKLVEEHREDSLDEIKRLIVEEAQKIADEDVEANLRMGHYGAEVLPE
GNILTHCNAGSLATVHLGTVGAVVRVMHKEGTLKLLWLDETRPVLQGARLSAWEYSYDGLNVKLIADNAAAFVMQQGKVD
AIIVGADRIVANGDFANKIGTYMLAVLAKEHGIPFFTVAPLSSIDMSLSSGKEIPIEERSPEEVLTCGGCRIAPDVPVYN
PAFDVTPHKYLTGIITDRGVVWPPFKRNLKKLFETL

Sequences:

>Translated_356_residues
MEIKYRPEELTKLPRSVEYREGKVYMINQRLLPREFKVEEFTTVEAVAEAIKNMTVRGAPAIGAAAAFGLALYAETSKAK
TKDEFFDGFYRAYETLKNTRPTAVNLFWALNRIKKLVEEHREDSLDEIKRLIVEEAQKIADEDVEANLRMGHYGAEVLPE
GNILTHCNAGSLATVHLGTVGAVVRVMHKEGTLKLLWLDETRPVLQGARLSAWEYSYDGLNVKLIADNAAAFVMQQGKVD
AIIVGADRIVANGDFANKIGTYMLAVLAKEHGIPFFTVAPLSSIDMSLSSGKEIPIEERSPEEVLTCGGCRIAPDVPVYN
PAFDVTPHKYLTGIITDRGVVWPPFKRNLKKLFETL
>Mature_356_residues
MEIKYRPEELTKLPRSVEYREGKVYMINQRLLPREFKVEEFTTVEAVAEAIKNMTVRGAPAIGAAAAFGLALYAETSKAK
TKDEFFDGFYRAYETLKNTRPTAVNLFWALNRIKKLVEEHREDSLDEIKRLIVEEAQKIADEDVEANLRMGHYGAEVLPE
GNILTHCNAGSLATVHLGTVGAVVRVMHKEGTLKLLWLDETRPVLQGARLSAWEYSYDGLNVKLIADNAAAFVMQQGKVD
AIIVGADRIVANGDFANKIGTYMLAVLAKEHGIPFFTVAPLSSIDMSLSSGKEIPIEERSPEEVLTCGGCRIAPDVPVYN
PAFDVTPHKYLTGIITDRGVVWPPFKRNLKKLFETL

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) [H]

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily [H]

Homologues:

Organism=Homo sapiens, GI72534748, Length=342, Percent_Identity=41.2280701754386, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI23943880, Length=333, Percent_Identity=38.1381381381381, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17557462, Length=339, Percent_Identity=39.2330383480826, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17557123, Length=183, Percent_Identity=28.4153005464481, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6325375, Length=400, Percent_Identity=33.5, Blast_Score=183, Evalue=4e-47,
Organism=Drosophila melanogaster, GI21357667, Length=361, Percent_Identity=37.1191135734072, Blast_Score=228, Evalue=5e-60,
Organism=Drosophila melanogaster, GI24651647, Length=361, Percent_Identity=37.1191135734072, Blast_Score=228, Evalue=5e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: =5.3.1.23 [H]

Molecular weight: Translated: 39657; Mature: 39657

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKYRPEELTKLPRSVEYREGKVYMINQRLLPREFKVEEFTTVEAVAEAIKNMTVRGAP
CCCCCCHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCEECCCC
AIGAAAAFGLALYAETSKAKTKDEFFDGFYRAYETLKNTRPTAVNLFWALNRIKKLVEEH
CHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
REDSLDEIKRLIVEEAQKIADEDVEANLRMGHYGAEVLPEGNILTHCNAGSLATVHLGTV
CCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCEEEECCCCCEEEEEHHHH
GAVVRVMHKEGTLKLLWLDETRPVLQGARLSAWEYSYDGLNVKLIADNAAAFVMQQGKVD
HHHHHHHCCCCCEEEEEECCCCHHHCCCCCEEEEEECCCEEEEEEECCCEEEEEECCCCC
AIIVGADRIVANGDFANKIGTYMLAVLAKEHGIPFFTVAPLSSIDMSLSSGKEIPIEERS
EEEEECCEEEECCCHHHHHHHHHHHHHHHHCCCCEEEECCCCHHCCHHCCCCCCCCCCCC
PEEVLTCGGCRIAPDVPVYNPAFDVTPHKYLTGIITDRGVVWPPFKRNLKKLFETL
CHHHEECCCCEECCCCCCCCCCCCCCCHHHHEEEEECCCCCCCHHHHHHHHHHHHC
>Mature Secondary Structure
MEIKYRPEELTKLPRSVEYREGKVYMINQRLLPREFKVEEFTTVEAVAEAIKNMTVRGAP
CCCCCCHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCEECCCC
AIGAAAAFGLALYAETSKAKTKDEFFDGFYRAYETLKNTRPTAVNLFWALNRIKKLVEEH
CHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
REDSLDEIKRLIVEEAQKIADEDVEANLRMGHYGAEVLPEGNILTHCNAGSLATVHLGTV
CCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCEEEECCCCCEEEEEHHHH
GAVVRVMHKEGTLKLLWLDETRPVLQGARLSAWEYSYDGLNVKLIADNAAAFVMQQGKVD
HHHHHHHCCCCCEEEEEECCCCHHHCCCCCEEEEEECCCEEEEEEECCCEEEEEECCCCC
AIIVGADRIVANGDFANKIGTYMLAVLAKEHGIPFFTVAPLSSIDMSLSSGKEIPIEERS
EEEEECCEEEECCCHHHHHHHHHHHHHHHHCCCCEEEECCCCHHCCHHCCCCCCCCCCCC
PEEVLTCGGCRIAPDVPVYNPAFDVTPHKYLTGIITDRGVVWPPFKRNLKKLFETL
CHHHEECCCCEECCCCCCCCCCCCCCCHHHHEEEEECCCCCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]