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The map label for this gene is yitJ [H]

Identifier: 18977639

GI number: 18977639

Start: 1199777

End: 1200793

Strand: Direct

Name: yitJ [H]

Synonym: PF1267

Alternate gene names: 18977639

Gene position: 1199777-1200793 (Clockwise)

Preceding gene: 18977638

Following gene: 18977640

Centisome position: 62.87

GC content: 40.71

Gene sequence:

>1017_bases
GTGTTTGGTTGTCCAAAGGATCTTCTAAACGGTCCCTGTGGAGGAGCACTCGATGGAAAGTGTGAGGTAAATTCAAATCT
CTGTCCATGGTACTCTCTAATGGAAAAATTTGAGCTTTTAGATGGAGCTCCTCTATTGGTAGAGCACCCTGTAGTCTTAG
AGATGGAAAGGATTTTCGAAGGGGAAGAAGTTGAGATCAAGAGAAGCTCCTTTATAAAAAATCTAGGGCGGGGAAAGGCT
ATTTCAGTCGAATTTCCCATTAGGTTGTTCGAAAAAGGAGTAAGGGAATTTAGGAAAGTTGGCGATCTTTACACAATTCC
AGACAATCCATTAGGTTACCCTCACATATCTCCTACAGCCCTGGGAACTTGGCTAAAATCGAAGGGACATTCTGTTATGC
CCCACCTAACAGCTAAGGACAGAAATGTGATAGCAATATCTTCAGAATTCAGAACAGCTCTAGAGTTTGACTTTGAGGGT
ATATTAATAACAACTGGTGACTGGTCAGGATTTATACTCCAAGGAAAACCAGTATTTGACTTGGATTCGGCGAACATGAT
AAGGCTGGCAAAGTTGATGTTTTCTGGCGTTCTACCCACAGGCGAAAGAGTTGAGGTTAAAGAGCGTCCATTTATAGCAG
GAACTGTAAATCCCAACTATCCGGCAAAATTAGAAGGAAAAAGATTGGCAAGAAAAATTATTGCGGGCGCTGATCTCGTT
ATAAGCCAAGTGGTTGCCAATAGAAAAGTTGTAAGAGAAATTCCAAAAATACTCCAGGAAGCACTTAAGTATTCTCCCCA
TGAAGTTCCAGTGGTTGTTTCAATTCTTTATCCATTAAAGAGGGAACTAGAGCCCATACTAAGAAAAATGGGGATAAAGA
CAGGTGATGATATTAGAGCAATAGTGGAGGAAATTTCTTCCCTTGAATTTGGGGGAATTAACGTCATTGTTTTTGAAGAG
ACTAGGTGGGAGGAAAAATTGAACGAGGTGTTAGATTTGCTGAAGGAATTGCTTTAG

Upstream 100 bases:

>100_bases
GAATAACGGATGGTCTAATTAGGCTTTCTGTGGGAATAGAAGAGGTTGATGAGCTAATAGAGGACTTAGATAGGGCCCTT
AAGGGGTGTTAGGTGTGAGG

Downstream 100 bases:

>100_bases
GGGGTGTAAGGAATGATTGTTCCAGCCCTTATAGGAAGTTTGCCGAGACCAATAGGATTAGCTAAGAAACTTGAGCAATA
CTACATAGGAAGATTAGATG

Product: hypothetical protein

Products: NA

Alternate protein names: Homocysteine S-methyltransferase; S-methylmethionine:homocysteine methyltransferase; 5,10-methylenetetrahydrofolate reductase [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MFGCPKDLLNGPCGGALDGKCEVNSNLCPWYSLMEKFELLDGAPLLVEHPVVLEMERIFEGEEVEIKRSSFIKNLGRGKA
ISVEFPIRLFEKGVREFRKVGDLYTIPDNPLGYPHISPTALGTWLKSKGHSVMPHLTAKDRNVIAISSEFRTALEFDFEG
ILITTGDWSGFILQGKPVFDLDSANMIRLAKLMFSGVLPTGERVEVKERPFIAGTVNPNYPAKLEGKRLARKIIAGADLV
ISQVVANRKVVREIPKILQEALKYSPHEVPVVVSILYPLKRELEPILRKMGIKTGDDIRAIVEEISSLEFGGINVIVFEE
TRWEEKLNEVLDLLKELL

Sequences:

>Translated_338_residues
MFGCPKDLLNGPCGGALDGKCEVNSNLCPWYSLMEKFELLDGAPLLVEHPVVLEMERIFEGEEVEIKRSSFIKNLGRGKA
ISVEFPIRLFEKGVREFRKVGDLYTIPDNPLGYPHISPTALGTWLKSKGHSVMPHLTAKDRNVIAISSEFRTALEFDFEG
ILITTGDWSGFILQGKPVFDLDSANMIRLAKLMFSGVLPTGERVEVKERPFIAGTVNPNYPAKLEGKRLARKIIAGADLV
ISQVVANRKVVREIPKILQEALKYSPHEVPVVVSILYPLKRELEPILRKMGIKTGDDIRAIVEEISSLEFGGINVIVFEE
TRWEEKLNEVLDLLKELL
>Mature_338_residues
MFGCPKDLLNGPCGGALDGKCEVNSNLCPWYSLMEKFELLDGAPLLVEHPVVLEMERIFEGEEVEIKRSSFIKNLGRGKA
ISVEFPIRLFEKGVREFRKVGDLYTIPDNPLGYPHISPTALGTWLKSKGHSVMPHLTAKDRNVIAISSEFRTALEFDFEG
ILITTGDWSGFILQGKPVFDLDSANMIRLAKLMFSGVLPTGERVEVKERPFIAGTVNPNYPAKLEGKRLARKIIAGADLV
ISQVVANRKVVREIPKILQEALKYSPHEVPVVVSILYPLKRELEPILRKMGIKTGDDIRAIVEEISSLEFGGINVIVFEE
TRWEEKLNEVLDLLKELL

Specific function: Unknown

COG id: COG0685

COG function: function code E; 5,10-methylenetetrahydrofolate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003171
- InterPro:   IPR003726 [H]

Pfam domain/function: PF02219 MTHFR; PF02574 S-methyl_trans [H]

EC number: =2.1.1.10; =1.5.1.20 [H]

Molecular weight: Translated: 37866; Mature: 37866

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGCPKDLLNGPCGGALDGKCEVNSNLCPWYSLMEKFELLDGAPLLVEHPVVLEMERIFE
CCCCCHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCEECCCHHEEHHHHCC
GEEVEIKRSSFIKNLGRGKAISVEFPIRLFEKGVREFRKVGDLYTIPDNPLGYPHISPTA
CCCEEEHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCHHH
LGTWLKSKGHSVMPHLTAKDRNVIAISSEFRTALEFDFEGILITTGDWSGFILQGKPVFD
HHHHHHCCCCCCCCCCCCCCCCEEEEEHHHHHHHEECCCEEEEEECCCCEEEEECCCEEE
LDSANMIRLAKLMFSGVLPTGERVEVKERPFIAGTVNPNYPAKLEGKRLARKIIAGADLV
CCCCHHHHHHHHHHHCCCCCCCCEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
ISQVVANRKVVREIPKILQEALKYSPHEVPVVVSILYPLKRELEPILRKMGIKTGDDIRA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
IVEEISSLEFGGINVIVFEETRWEEKLNEVLDLLKELL
HHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MFGCPKDLLNGPCGGALDGKCEVNSNLCPWYSLMEKFELLDGAPLLVEHPVVLEMERIFE
CCCCCHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCEECCCHHEEHHHHCC
GEEVEIKRSSFIKNLGRGKAISVEFPIRLFEKGVREFRKVGDLYTIPDNPLGYPHISPTA
CCCEEEHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCHHH
LGTWLKSKGHSVMPHLTAKDRNVIAISSEFRTALEFDFEGILITTGDWSGFILQGKPVFD
HHHHHHCCCCCCCCCCCCCCCCEEEEEHHHHHHHEECCCEEEEEECCCCEEEEECCCEEE
LDSANMIRLAKLMFSGVLPTGERVEVKERPFIAGTVNPNYPAKLEGKRLARKIIAGADLV
CCCCHHHHHHHHHHHCCCCCCCCEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
ISQVVANRKVVREIPKILQEALKYSPHEVPVVVSILYPLKRELEPILRKMGIKTGDDIRA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
IVEEISSLEFGGINVIVFEETRWEEKLNEVLDLLKELL
HHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353932; 9384377 [H]