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The map label for this gene is rpiA

Identifier: 18977630

GI number: 18977630

Start: 1191971

End: 1192660

Strand: Reverse

Name: rpiA

Synonym: PF1258

Alternate gene names: 18977630

Gene position: 1192660-1191971 (Counterclockwise)

Preceding gene: 18977631

Following gene: 18977629

Centisome position: 62.5

GC content: 40.29

Gene sequence:

>690_bases
ATGAATGTGGAAGAAATGAAAAAGGCCGTGGCAAGGGCAGCACTTGAGTTTATAGAGGATGATATGGTGGTTGGACTAGG
AACAGGCTCCACCACAGCATACTTTATAAGATATTTAGGAGAGATGATAGAAAAAGGAAAAGTAGAAGATATCTATGGAG
TACCACCTCCTATCAAGCAAAAATTCTTGCGTATGGAAAGTGGGGTGCCAGTTCTTTCATTGGATCAAGTAGATGCAATA
GACATAGCGGTAGATGGTGCTGATGAAGTAGATCCAAATCTTAACTTAATCAAAGGCAGGGGTGCTGCCCTCACAATGGA
AAAAATAATCGAGTATAGGGCTGGAACATTCATCGTGCTGGTGGATGAGTCAAAGCTTGTCGATTATCTCTGCCAGAAAA
TGCCAGTTCCAATTGAAGTTATTCCAGCTGCATGGAAGGCGATTTTAGAAGAGTTAAGCATATTCAATGCAAAGGCTGAG
CTCAGGATGGGAGTTAAAAAGGATGGTCCAGTTGTTACTGAAAATGGGAACTTTATCATTGATGCAAAATTTCCAAGAAT
AGATGATCCCCTCGACATGGAAATCGAACTTAACACTATCCCAGGAGTAGTTGAAAATGGAATTTTTGCCGATATAGCGG
ACATAGTATTAGTAGGGACAAAAGAAGGAGTAAAAAGATTAGAAAGGTAA

Upstream 100 bases:

>100_bases
GCTATACTTTACAGGACTTACATACACTCTTATAACTAACTATGAACCAGTAGCATATTATGAGAAAGCTCTTTACTACA
ACATAACGAAGGGATGAACT

Downstream 100 bases:

>100_bases
AATGTTGGAGAAACTTTTTTCCCTCGGTTATTCTAAAACTTTTGCAGAAAGATACTATCAACTTTGGGGTGAAAGAGCTA
TAAGAATTGCTGAGGCCATG

Product: ribose-5-phosphate isomerase A

Products: NA

Alternate protein names: Phosphoriboisomerase A; PRI

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MNVEEMKKAVARAALEFIEDDMVVGLGTGSTTAYFIRYLGEMIEKGKVEDIYGVPPPIKQKFLRMESGVPVLSLDQVDAI
DIAVDGADEVDPNLNLIKGRGAALTMEKIIEYRAGTFIVLVDESKLVDYLCQKMPVPIEVIPAAWKAILEELSIFNAKAE
LRMGVKKDGPVVTENGNFIIDAKFPRIDDPLDMEIELNTIPGVVENGIFADIADIVLVGTKEGVKRLER

Sequences:

>Translated_229_residues
MNVEEMKKAVARAALEFIEDDMVVGLGTGSTTAYFIRYLGEMIEKGKVEDIYGVPPPIKQKFLRMESGVPVLSLDQVDAI
DIAVDGADEVDPNLNLIKGRGAALTMEKIIEYRAGTFIVLVDESKLVDYLCQKMPVPIEVIPAAWKAILEELSIFNAKAE
LRMGVKKDGPVVTENGNFIIDAKFPRIDDPLDMEIELNTIPGVVENGIFADIADIVLVGTKEGVKRLER
>Mature_229_residues
MNVEEMKKAVARAALEFIEDDMVVGLGTGSTTAYFIRYLGEMIEKGKVEDIYGVPPPIKQKFLRMESGVPVLSLDQVDAI
DIAVDGADEVDPNLNLIKGRGAALTMEKIIEYRAGTFIVLVDESKLVDYLCQKMPVPIEVIPAAWKAILEELSIFNAKAE
LRMGVKKDGPVVTENGNFIIDAKFPRIDDPLDMEIELNTIPGVVENGIFADIADIVLVGTKEGVKRLER

Specific function: Nonoxidative branch of the pentose phosphate pathway. [C]

COG id: COG0120

COG function: function code G; Ribose 5-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose 5-phosphate isomerase family

Homologues:

Organism=Homo sapiens, GI94536842, Length=224, Percent_Identity=39.7321428571429, Blast_Score=153, Evalue=1e-37,
Organism=Escherichia coli, GI1789280, Length=228, Percent_Identity=44.7368421052632, Blast_Score=170, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI17551758, Length=227, Percent_Identity=37.8854625550661, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6324669, Length=234, Percent_Identity=36.3247863247863, Blast_Score=136, Evalue=3e-33,
Organism=Drosophila melanogaster, GI281364072, Length=218, Percent_Identity=37.1559633027523, Blast_Score=130, Evalue=6e-31,

Paralogues:

None

Copy number: 740 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): RPIA_PYRFU (Q8U1F0)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_578987.1
- ProteinModelPortal:   Q8U1F0
- SMR:   Q8U1F0
- EnsemblBacteria:   EBPYRT00000004431
- GeneID:   1469131
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1258
- NMPDR:   fig|186497.1.peg.1302
- GeneTree:   EBGT00050000022434
- HOGENOM:   HBG515603
- OMA:   DKSIVGV
- ProtClustDB:   PRK00702
- BRENDA:   5.3.1.6
- HAMAP:   MF_00170
- InterPro:   IPR014036
- InterPro:   IPR004788
- InterPro:   IPR020672
- PANTHER:   PTHR11934
- TIGRFAMs:   TIGR00021

Pfam domain/function: PF00455 DeoR; PF06026 Rib_5-P_isom_A

EC number: =5.3.1.6

Molecular weight: Translated: 25195; Mature: 25195

Theoretical pI: Translated: 4.29; Mature: 4.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVEEMKKAVARAALEFIEDDMVVGLGTGSTTAYFIRYLGEMIEKGKVEDIYGVPPPIKQ
CCHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
KFLRMESGVPVLSLDQVDAIDIAVDGADEVDPNLNLIKGRGAALTMEKIIEYRAGTFIVL
HHHHHHCCCCEEEECCCCEEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHCCCEEEEE
VDESKLVDYLCQKMPVPIEVIPAAWKAILEELSIFNAKAELRMGVKKDGPVVTENGNFII
ECCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCEEECCCCEEE
DAKFPRIDDPLDMEIELNTIPGVVENGIFADIADIVLVGTKEGVKRLER
EECCCCCCCCCCCEEEECCCCCHHHCCCHHHHHHEEEECCHHHHHHHCC
>Mature Secondary Structure
MNVEEMKKAVARAALEFIEDDMVVGLGTGSTTAYFIRYLGEMIEKGKVEDIYGVPPPIKQ
CCHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
KFLRMESGVPVLSLDQVDAIDIAVDGADEVDPNLNLIKGRGAALTMEKIIEYRAGTFIVL
HHHHHHCCCCEEEECCCCEEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHCCCEEEEE
VDESKLVDYLCQKMPVPIEVIPAAWKAILEELSIFNAKAELRMGVKKDGPVVTENGNFII
ECCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCEEECCCCEEE
DAKFPRIDDPLDMEIELNTIPGVVENGIFADIADIVLVGTKEGVKRLER
EECCCCCCCCCCCEEEECCCCCHHHCCCHHHHHHEEEECCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA