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The map label for this gene is gluP [H]

Identifier: 18977600

GI number: 18977600

Start: 1162413

End: 1162994

Strand: Direct

Name: gluP [H]

Synonym: PF1228

Alternate gene names: 18977600

Gene position: 1162413-1162994 (Clockwise)

Preceding gene: 18977599

Following gene: 18977604

Centisome position: 60.91

GC content: 36.94

Gene sequence:

>582_bases
ATGAAAAACCTATTTAGATATTTCCCAGGAACTTCTATTCTAGCTTTCATGATAGTTGTTGGGTTTGTATACGAGATAGT
GGTGGGATTTGACAAAGCAATTATGCAATTTGCTCAAATAAACCTTTATGTTTATCTGGGTGAATTTTGGAGGGTGATAA
CGGCGATTTTTATTCACATGGGGTATATTCACTTTGCTCTAAACTTGTTCTGGTTAATTTACCTTGGCATGGATTTGGAG
GGTCTCTTGGGTAGCAGGAAATTTATCATCGTATTCTTTAGTGGCGCGGTAATTGGGAATATTTTATCCCTCTTTGTCTT
GCCCCCCTTTGTAGCATCAGGAGGAGCTAGTGGCGGATTATTTGCTATAGTGGGAGCATTATTAGCAGTTGAAGGAGTGT
TAAGAAAGAACATGCAGAAAGCCTTAATTAATGCACTCTTCCTATTCTTAATTAATAGCATCTTTCCGGGAGTAAATTAC
GTTGCCCACTTTGGTGGCTTAATTGTTGGAATTTTATTAGGTTATATCTATGGAAAAGATTTGAAGAGAAAACTTTTGGA
TATGAGCTATTGGTTTTCCTAA

Upstream 100 bases:

>100_bases
CTGAATGGCTTCAGGAGGTGATGCCCCAGTTATCCTAACAGTATCAGATGCAGGATAAAAATTATATAACCAATCTGACT
TTCAACATTGGGAGGTAAGA

Downstream 100 bases:

>100_bases
ACTCCTATCTTCGGACATAGCTCATTTAAAGGGCATAACTCACACTTAGGCTTTATTGGTCTACATATGCTTTTCCCATG
GTCAACCATAGCATGATTAA

Product: hypothetical protein

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MKNLFRYFPGTSILAFMIVVGFVYEIVVGFDKAIMQFAQINLYVYLGEFWRVITAIFIHMGYIHFALNLFWLIYLGMDLE
GLLGSRKFIIVFFSGAVIGNILSLFVLPPFVASGGASGGLFAIVGALLAVEGVLRKNMQKALINALFLFLINSIFPGVNY
VAHFGGLIVGILLGYIYGKDLKRKLLDMSYWFS

Sequences:

>Translated_193_residues
MKNLFRYFPGTSILAFMIVVGFVYEIVVGFDKAIMQFAQINLYVYLGEFWRVITAIFIHMGYIHFALNLFWLIYLGMDLE
GLLGSRKFIIVFFSGAVIGNILSLFVLPPFVASGGASGGLFAIVGALLAVEGVLRKNMQKALINALFLFLINSIFPGVNY
VAHFGGLIVGILLGYIYGKDLKRKLLDMSYWFS
>Mature_193_residues
MKNLFRYFPGTSILAFMIVVGFVYEIVVGFDKAIMQFAQINLYVYLGEFWRVITAIFIHMGYIHFALNLFWLIYLGMDLE
GLLGSRKFIIVFFSGAVIGNILSLFVLPPFVASGGASGGLFAIVGALLAVEGVLRKNMQKALINALFLFLINSIFPGVNY
VAHFGGLIVGILLGYIYGKDLKRKLLDMSYWFS

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter [H]

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

Organism=Homo sapiens, GI21264326, Length=165, Percent_Identity=31.5151515151515, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115532986, Length=130, Percent_Identity=33.0769230769231, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI133901888, Length=130, Percent_Identity=33.0769230769231, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764
- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF01694 Rhomboid; PF00515 TPR_1 [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 21564; Mature: 21564

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLFRYFPGTSILAFMIVVGFVYEIVVGFDKAIMQFAQINLYVYLGEFWRVITAIFIHM
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GYIHFALNLFWLIYLGMDLEGLLGSRKFIIVFFSGAVIGNILSLFVLPPFVASGGASGGL
HHHHHHHHHHHHHHHHCCHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCH
FAIVGALLAVEGVLRKNMQKALINALFLFLINSIFPGVNYVAHFGGLIVGILLGYIYGKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LKRKLLDMSYWFS
HHHHHHHHHHHCC
>Mature Secondary Structure
MKNLFRYFPGTSILAFMIVVGFVYEIVVGFDKAIMQFAQINLYVYLGEFWRVITAIFIHM
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GYIHFALNLFWLIYLGMDLEGLLGSRKFIIVFFSGAVIGNILSLFVLPPFVASGGASGGL
HHHHHHHHHHHHHHHHCCHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCH
FAIVGALLAVEGVLRKNMQKALINALFLFLINSIFPGVNYVAHFGGLIVGILLGYIYGKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LKRKLLDMSYWFS
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]