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The map label for this gene is gabT [H]

Identifier: 18977604

GI number: 18977604

Start: 1164636

End: 1165967

Strand: Direct

Name: gabT [H]

Synonym: PF1232

Alternate gene names: 18977604

Gene position: 1164636-1165967 (Clockwise)

Preceding gene: 18977600

Following gene: 18977607

Centisome position: 61.03

GC content: 40.24

Gene sequence:

>1332_bases
ATGGAACCTCTGGAAATAGTTAGGAGATATGAGAAAGTTATAGCTCCAGCAAATAGGACGACTTACTACCCTCTCATTCC
CGTTAAAGCGGAGAATGCAAAAGTGTGGGATATTACTGGAAAGGAATATATCGATTTCTTAAGCGATGCAGCCGTTCAAA
ACGTTGGTCACAATAACCCCAGGGTTGTTAAGGCAATAAAAGATCAGATAGAGAAACTAGTTCATGCATCGTATATATAC
CTCTTCCCAATAGAGCCTCTCTTGTTGGCCGAGAAGTTAGTAGAGATTGCTCCTATAGAAAATGCAAAGGTTTCTTTCGG
ATTAAGTGGTGCAGATGCAAACGATGGAGCAATAAAATTTGCTAGGGCGTACACTAAGAGGAACATGATTTTAAGTTACA
TGAAGAGTTTTTATGGATCAACGTATGGGGCAATGAGCCTAACTGGATTGGACTTTCAGGTTAGAGCCCTTGTAGGAGAG
CTCAGTGGGGTTCATTATATCCCTTACCCAAACTGTTATCGCTGTCCCTTTGGGAAAGATCGTAATAGCTGTAAAATGGA
GTGTGTGGAGTATATTAAAGAAAAATTCGAGGGAGAGGTGTATTCTGAGGGTGTGGCAGCTTTATTTGCGGAGGCCATCC
AAGGAGATTCGGGCATGATAGTGCCTCCACAAGACTACTTCAAAAAGGTGAAAAGAATTTTAGACGAACATGGAATCCTC
CTTGTTGTTGATGAAGTTCAGAGTGGACTTGGAAGGACTGGAAAGTGGTTTGCAATTGAACACTTTGATGTTAAACCTGA
TATAATAACGATTGCAAAACCTCTTGGAGGGGGTCTTCCGATTAGTGCAACCATAGGAAGAGCAGAAATCATGGATTCTC
TTCCTCCACTTAGTCACGCGTTTACCCTATCTGGAAATCCAACTGCTGCTAAAGCAGCTCTTGCAGTTATTGAAGAGATT
GAAGAAAAAGATTTGCTAAAGAGAGCGGAAAAGTTAGGTGAATATACGAAAAAGAAACTCGAAGAACTAAAAAAGAAGCA
CGAGTTAGTTGGTGATGTTCGTGGCTTAGGATTAATGTTAGGTGTTGAGTTGGTTAAAGATAGAGAGACAAAGGAAAGGG
CCTTTGAAGAAACTAAAAAAGTTGTGTGGAGAGCTTTCGAACTTGGCTTAATTGTAACTTTTCTACAGGGAAATGTTCTA
AGAATCCAACCTCCCTTAACAATTGAAAAGGATGTGCTAGACGAGGGTTTAGAAATTTTAGATCAAGCAATTGAAGATGT
GGAGGAAGGAAAAGTTCCAGACGAAGTAATAAAAAATGTAAGAGGATGGTAA

Upstream 100 bases:

>100_bases
AATCAGCAATTTCTATATAAATATTTATATCGAATTAGCAAAAATTTGGGGAAAAGATTATTGACTTTTTGCGAAAAATA
TAATTAATTGAGGGTGGGAT

Downstream 100 bases:

>100_bases
TATTCTTTCCCTTTTTCTACTTGATACTAGAACTTTCAATAGGGGAGATCTATCTGGAAGCCAGACTGAAAGTTTTTTTC
CAACTCATCAGAAGTTACTG

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MEPLEIVRRYEKVIAPANRTTYYPLIPVKAENAKVWDITGKEYIDFLSDAAVQNVGHNNPRVVKAIKDQIEKLVHASYIY
LFPIEPLLLAEKLVEIAPIENAKVSFGLSGADANDGAIKFARAYTKRNMILSYMKSFYGSTYGAMSLTGLDFQVRALVGE
LSGVHYIPYPNCYRCPFGKDRNSCKMECVEYIKEKFEGEVYSEGVAALFAEAIQGDSGMIVPPQDYFKKVKRILDEHGIL
LVVDEVQSGLGRTGKWFAIEHFDVKPDIITIAKPLGGGLPISATIGRAEIMDSLPPLSHAFTLSGNPTAAKAALAVIEEI
EEKDLLKRAEKLGEYTKKKLEELKKKHELVGDVRGLGLMLGVELVKDRETKERAFEETKKVVWRAFELGLIVTFLQGNVL
RIQPPLTIEKDVLDEGLEILDQAIEDVEEGKVPDEVIKNVRGW

Sequences:

>Translated_443_residues
MEPLEIVRRYEKVIAPANRTTYYPLIPVKAENAKVWDITGKEYIDFLSDAAVQNVGHNNPRVVKAIKDQIEKLVHASYIY
LFPIEPLLLAEKLVEIAPIENAKVSFGLSGADANDGAIKFARAYTKRNMILSYMKSFYGSTYGAMSLTGLDFQVRALVGE
LSGVHYIPYPNCYRCPFGKDRNSCKMECVEYIKEKFEGEVYSEGVAALFAEAIQGDSGMIVPPQDYFKKVKRILDEHGIL
LVVDEVQSGLGRTGKWFAIEHFDVKPDIITIAKPLGGGLPISATIGRAEIMDSLPPLSHAFTLSGNPTAAKAALAVIEEI
EEKDLLKRAEKLGEYTKKKLEELKKKHELVGDVRGLGLMLGVELVKDRETKERAFEETKKVVWRAFELGLIVTFLQGNVL
RIQPPLTIEKDVLDEGLEILDQAIEDVEEGKVPDEVIKNVRGW
>Mature_443_residues
MEPLEIVRRYEKVIAPANRTTYYPLIPVKAENAKVWDITGKEYIDFLSDAAVQNVGHNNPRVVKAIKDQIEKLVHASYIY
LFPIEPLLLAEKLVEIAPIENAKVSFGLSGADANDGAIKFARAYTKRNMILSYMKSFYGSTYGAMSLTGLDFQVRALVGE
LSGVHYIPYPNCYRCPFGKDRNSCKMECVEYIKEKFEGEVYSEGVAALFAEAIQGDSGMIVPPQDYFKKVKRILDEHGIL
LVVDEVQSGLGRTGKWFAIEHFDVKPDIITIAKPLGGGLPISATIGRAEIMDSLPPLSHAFTLSGNPTAAKAALAVIEEI
EEKDLLKRAEKLGEYTKKKLEELKKKHELVGDVRGLGLMLGVELVKDRETKERAFEETKKVVWRAFELGLIVTFLQGNVL
RIQPPLTIEKDVLDEGLEILDQAIEDVEEGKVPDEVIKNVRGW

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=433, Percent_Identity=30.2540415704388, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI13994255, Length=432, Percent_Identity=31.712962962963, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI24119277, Length=438, Percent_Identity=31.5068493150685, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI4557809, Length=417, Percent_Identity=31.89448441247, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI226442705, Length=433, Percent_Identity=29.7921478060046, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI226442709, Length=387, Percent_Identity=30.749354005168, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI284507298, Length=325, Percent_Identity=31.0769230769231, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI188536080, Length=441, Percent_Identity=21.9954648526077, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI38679950, Length=441, Percent_Identity=21.9954648526077, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI38679946, Length=441, Percent_Identity=21.9954648526077, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1789016, Length=429, Percent_Identity=36.3636363636364, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1787560, Length=403, Percent_Identity=37.7171215880893, Blast_Score=258, Evalue=4e-70,
Organism=Escherichia coli, GI1789759, Length=437, Percent_Identity=31.5789473684211, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI145693181, Length=381, Percent_Identity=34.1207349081365, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1788044, Length=420, Percent_Identity=30.4761904761905, Blast_Score=198, Evalue=6e-52,
Organism=Escherichia coli, GI1786349, Length=348, Percent_Identity=28.448275862069, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI1786991, Length=426, Percent_Identity=27.4647887323944, Blast_Score=129, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71992977, Length=443, Percent_Identity=32.7313769751693, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI32564660, Length=444, Percent_Identity=33.1081081081081, Blast_Score=201, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI25144271, Length=418, Percent_Identity=28.7081339712919, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI25144274, Length=231, Percent_Identity=33.7662337662338, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17541228, Length=429, Percent_Identity=23.0769230769231, Blast_Score=78, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6323470, Length=421, Percent_Identity=33.4916864608076, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6324432, Length=433, Percent_Identity=32.5635103926097, Blast_Score=202, Evalue=7e-53,
Organism=Saccharomyces cerevisiae, GI6321456, Length=431, Percent_Identity=25.9860788863109, Blast_Score=110, Evalue=6e-25,
Organism=Drosophila melanogaster, GI161085790, Length=423, Percent_Identity=34.51536643026, Blast_Score=225, Evalue=5e-59,
Organism=Drosophila melanogaster, GI28574759, Length=425, Percent_Identity=34.5882352941176, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI21356575, Length=406, Percent_Identity=31.2807881773399, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI21357415, Length=438, Percent_Identity=28.7671232876712, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI281366494, Length=381, Percent_Identity=24.1469816272966, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24667139, Length=381, Percent_Identity=24.1469816272966, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24667143, Length=381, Percent_Identity=24.1469816272966, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 49473; Mature: 49473

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPLEIVRRYEKVIAPANRTTYYPLIPVKAENAKVWDITGKEYIDFLSDAAVQNVGHNNP
CCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHCCCCCC
RVVKAIKDQIEKLVHASYIYLFPIEPLLLAEKLVEIAPIENAKVSFGLSGADANDGAIKF
HHHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHH
ARAYTKRNMILSYMKSFYGSTYGAMSLTGLDFQVRALVGELSGVHYIPYPNCYRCPFGKD
HHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHCCEEECCCCCCEECCCCCC
RNSCKMECVEYIKEKFEGEVYSEGVAALFAEAIQGDSGMIVPPQDYFKKVKRILDEHGIL
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHCCEE
LVVDEVQSGLGRTGKWFAIEHFDVKPDIITIAKPLGGGLPISATIGRAEIMDSLPPLSHA
EEEHHHHHCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCEECCCHHHHHHCCCCCCCE
FTLSGNPTAAKAALAVIEEIEEKDLLKRAEKLGEYTKKKLEELKKKHELVGDVRGLGLML
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVELVKDRETKERAFEETKKVVWRAFELGLIVTFLQGNVLRIQPPLTIEKDVLDEGLEIL
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHH
DQAIEDVEEGKVPDEVIKNVRGW
HHHHHHHHHCCCCHHHHHHCCCC
>Mature Secondary Structure
MEPLEIVRRYEKVIAPANRTTYYPLIPVKAENAKVWDITGKEYIDFLSDAAVQNVGHNNP
CCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHCCCCCC
RVVKAIKDQIEKLVHASYIYLFPIEPLLLAEKLVEIAPIENAKVSFGLSGADANDGAIKF
HHHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHH
ARAYTKRNMILSYMKSFYGSTYGAMSLTGLDFQVRALVGELSGVHYIPYPNCYRCPFGKD
HHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHCCEEECCCCCCEECCCCCC
RNSCKMECVEYIKEKFEGEVYSEGVAALFAEAIQGDSGMIVPPQDYFKKVKRILDEHGIL
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHCCEE
LVVDEVQSGLGRTGKWFAIEHFDVKPDIITIAKPLGGGLPISATIGRAEIMDSLPPLSHA
EEEHHHHHCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCEECCCHHHHHHCCCCCCCE
FTLSGNPTAAKAALAVIEEIEEKDLLKRAEKLGEYTKKKLEELKKKHELVGDVRGLGLML
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVELVKDRETKERAFEETKKVVWRAFELGLIVTFLQGNVLRIQPPLTIEKDVLDEGLEIL
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHH
DQAIEDVEEGKVPDEVIKNVRGW
HHHHHHHHHCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]