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The map label for this gene is ppnK

Identifier: 18977475

GI number: 18977475

Start: 1050633

End: 1051466

Strand: Direct

Name: ppnK

Synonym: PF1103

Alternate gene names: 18977475

Gene position: 1050633-1051466 (Clockwise)

Preceding gene: 18977474

Following gene: 18977477

Centisome position: 55.06

GC content: 40.53

Gene sequence:

>834_bases
ATGAAGTTTGGAATAGTTGCAAGGAGGGATAAAGAGGAGGCTCTAAAGCTCGCCTACAGGGTCTATGATTTTCTTAAAGT
TAGTGGATATGATGTAGTTGTAGACAAAGATACTTACGAGCATTTCCCATATTTTAATGAGAGAGACGTAATACCTCTGG
AAGAATTCGATGTAGATTTCATAATAGCGATTGGTGGAGATGGAACGATACTCAGAATAGAACACATGACAAAAAAAGAT
ATTCCAATATTGAGCGTAAATATGGGAACTCTTGGCTTTCTTACAGAAGTTGAGCCCTCAGACACCTTTTTTGCATTAAG
CAGGCTGATAGAAGGAGAATACTACATAGATGAGAGAATTAAGGTCAGAACTTATATAAACGGGGAAAACAGAGTTCCTG
ATGCATTAAATGAAGTTGCAATATTAACTGGAATCCCAGGAAAGATAATTCACCTAAAGTATTACGTAGACGGAGGATTA
GCGGATGAAGTTAGGGCAGATGGATTAGTTGTTTCAACTCCTACCGGCTCTACTGGTTATGCAATGTCCGCTGGAGGTCC
ATTTGTAGATCCAAGGCTCGATGTAATCCTCGTGGTTCCTCTTCTCCCCCTCCCTAAAACCTCAGTCCCAATGGTAATCC
CAGGGAGCTCAAGGGTCGACATTACACTGGTTAGTGACAGGGAGATAATACTTGCTATAGATGGCCAGTACTACGAATAC
TTACCCCCAGATGTTGAGATAACGGTAGTAAAAAGCCCCAGGAAAACAAAGTTCGTTAGGTTTACAAAAGAGATATACCC
TAAGTACACGATGAAAATAAAGGAGAGGCATTAA

Upstream 100 bases:

>100_bases
ACTGCTAGCTAGATTCATTGTTGAAAGGGAGTATTAACTTTCCTTTTTGCACGTTCCATAAATCTTTTTAAGTCTAAGAT
TTCTTAAATAAACGATTCTC

Downstream 100 bases:

>100_bases
TTACCTAGCCTTTGGAAACCTTAGGGCAGCTTTGATTATATCTGTGAAAACTCCGCTCGCAGTAACTCTTCCTCCTCCCC
CTGGGCCTTTAAGAACAACT

Product: inorganic polyphosphate/ATP-NAD kinase

Products: NA

Alternate protein names: Poly(P)/ATP NAD kinase

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MKFGIVARRDKEEALKLAYRVYDFLKVSGYDVVVDKDTYEHFPYFNERDVIPLEEFDVDFIIAIGGDGTILRIEHMTKKD
IPILSVNMGTLGFLTEVEPSDTFFALSRLIEGEYYIDERIKVRTYINGENRVPDALNEVAILTGIPGKIIHLKYYVDGGL
ADEVRADGLVVSTPTGSTGYAMSAGGPFVDPRLDVILVVPLLPLPKTSVPMVIPGSSRVDITLVSDREIILAIDGQYYEY
LPPDVEITVVKSPRKTKFVRFTKEIYPKYTMKIKERH

Sequences:

>Translated_277_residues
MKFGIVARRDKEEALKLAYRVYDFLKVSGYDVVVDKDTYEHFPYFNERDVIPLEEFDVDFIIAIGGDGTILRIEHMTKKD
IPILSVNMGTLGFLTEVEPSDTFFALSRLIEGEYYIDERIKVRTYINGENRVPDALNEVAILTGIPGKIIHLKYYVDGGL
ADEVRADGLVVSTPTGSTGYAMSAGGPFVDPRLDVILVVPLLPLPKTSVPMVIPGSSRVDITLVSDREIILAIDGQYYEY
LPPDVEITVVKSPRKTKFVRFTKEIYPKYTMKIKERH
>Mature_277_residues
MKFGIVARRDKEEALKLAYRVYDFLKVSGYDVVVDKDTYEHFPYFNERDVIPLEEFDVDFIIAIGGDGTILRIEHMTKKD
IPILSVNMGTLGFLTEVEPSDTFFALSRLIEGEYYIDERIKVRTYINGENRVPDALNEVAILTGIPGKIIHLKYYVDGGL
ADEVRADGLVVSTPTGSTGYAMSAGGPFVDPRLDVILVVPLLPLPKTSVPMVIPGSSRVDITLVSDREIILAIDGQYYEY
LPPDVEITVVKSPRKTKFVRFTKEIYPKYTMKIKERH

Specific function: Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus

COG id: COG0061

COG function: function code G; Predicted sugar kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD kinase family

Homologues:

Organism=Homo sapiens, GI55743112, Length=197, Percent_Identity=31.9796954314721, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI1788968, Length=245, Percent_Identity=32.2448979591837, Blast_Score=132, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6322509, Length=249, Percent_Identity=27.710843373494, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320794, Length=206, Percent_Identity=29.126213592233, Blast_Score=96, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6325068, Length=191, Percent_Identity=28.7958115183246, Blast_Score=92, Evalue=6e-20,
Organism=Drosophila melanogaster, GI28573832, Length=209, Percent_Identity=30.1435406698565, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI161077047, Length=209, Percent_Identity=30.1435406698565, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI28573830, Length=209, Percent_Identity=30.1435406698565, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573828, Length=209, Percent_Identity=30.1435406698565, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573826, Length=189, Percent_Identity=31.2169312169312, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281363323, Length=216, Percent_Identity=27.3148148148148, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI281363321, Length=216, Percent_Identity=27.3148148148148, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24653422, Length=216, Percent_Identity=27.3148148148148, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24653424, Length=216, Percent_Identity=27.3148148148148, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI20129957, Length=216, Percent_Identity=27.3148148148148, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPNK_PYRFU (Q8U1V2)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_578832.1
- ProteinModelPortal:   Q8U1V2
- SMR:   Q8U1V2
- EnsemblBacteria:   EBPYRT00000004288
- GeneID:   1468971
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1103
- NMPDR:   fig|186497.1.peg.1142
- GeneTree:   EBGT00050000022545
- HOGENOM:   HBG713904
- OMA:   DPRLDVI
- ProtClustDB:   PRK03708
- BRENDA:   2.7.1.23
- GO:   GO:0005737
- HAMAP:   MF_00361
- InterPro:   IPR016064
- InterPro:   IPR017438
- InterPro:   IPR017437
- InterPro:   IPR002504
- Gene3D:   G3DSA:2.60.200.30
- Gene3D:   G3DSA:3.40.50.10330
- PANTHER:   PTHR20275

Pfam domain/function: PF01513 NAD_kinase; SSF111331 ATP-NAD_kinase_PpnK-typ

EC number: =2.7.1.23

Molecular weight: Translated: 31276; Mature: 31276

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFGIVARRDKEEALKLAYRVYDFLKVSGYDVVVDKDTYEHFPYFNERDVIPLEEFDVDF
CCCCEEEECCHHHHHHHHHHHHHHHEECCEEEEEECCCHHHCCCCCCCCCCCHHHCCEEE
IIAIGGDGTILRIEHMTKKDIPILSVNMGTLGFLTEVEPSDTFFALSRLIEGEYYIDERI
EEEECCCCEEEEEECCCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHCCCEEECCEE
KVRTYINGENRVPDALNEVAILTGIPGKIIHLKYYVDGGLADEVRADGLVVSTPTGSTGY
EEEEEECCCCCCCHHHHCEEEEECCCCEEEEEEEEECCCCCHHHCCCCEEEECCCCCCCE
AMSAGGPFVDPRLDVILVVPLLPLPKTSVPMVIPGSSRVDITLVSDREIILAIDGQYYEY
EEECCCCCCCCCCCEEEEEECCCCCCCCCCEEECCCCEEEEEEECCCEEEEEECCCEEEC
LPPDVEITVVKSPRKTKFVRFTKEIYPKYTMKIKERH
CCCCCEEEEEECCCCCHHEEEHHHHCCEEEEEEECCC
>Mature Secondary Structure
MKFGIVARRDKEEALKLAYRVYDFLKVSGYDVVVDKDTYEHFPYFNERDVIPLEEFDVDF
CCCCEEEECCHHHHHHHHHHHHHHHEECCEEEEEECCCHHHCCCCCCCCCCCHHHCCEEE
IIAIGGDGTILRIEHMTKKDIPILSVNMGTLGFLTEVEPSDTFFALSRLIEGEYYIDERI
EEEECCCCEEEEEECCCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHCCCEEECCEE
KVRTYINGENRVPDALNEVAILTGIPGKIIHLKYYVDGGLADEVRADGLVVSTPTGSTGY
EEEEEECCCCCCCHHHHCEEEEECCCCEEEEEEEEECCCCCHHHCCCCEEEECCCCCCCE
AMSAGGPFVDPRLDVILVVPLLPLPKTSVPMVIPGSSRVDITLVSDREIILAIDGQYYEY
EEECCCCCCCCCCCEEEEEECCCCCCCCCCEEECCCCEEEEEEECCCEEEEEECCCEEEC
LPPDVEITVVKSPRKTKFVRFTKEIYPKYTMKIKERH
CCCCCEEEEEECCCCCHHEEEHHHHCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA