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The map label for this gene is ahpC [C]

Identifier: 18977405

GI number: 18977405

Start: 989258

End: 989908

Strand: Reverse

Name: ahpC [C]

Synonym: PF1033

Alternate gene names: 18977405

Gene position: 989908-989258 (Counterclockwise)

Preceding gene: 18977406

Following gene: 18977404

Centisome position: 51.88

GC content: 43.47

Gene sequence:

>651_bases
ATGATAGTGATAGGAGAAAAGTTTCCAGAAGTTGAGGTAAAAACTACACATGGAGTGATAAAGCTTCCAGACCACTTCAC
AAAGCAAGGGAAATGGTTTATGTTATTCAGCCACCCAGCAGACTTTACTCCAGTGTGTACAACCGAGTTTTATGGGCTTC
AAATTAGGCTTGAAAAGTTTAGAGAACTAGGGGTCGAGCCAATAGGCCTAAGTGTAGATCAGGTATTTAGCCACCTCAAG
TGGATGGAGTGGATTAAGGAGAAGCTTGGAGTTGAAATCGAGTTCCCAGTTATAGCTGATGATAGGGGAGATTTAGCAGA
AAAACTAGGAATGATTCCAAGTGGTTCAACAATAACAGCGAGAGCTGTGTTCATAGTTGATGACAAGGGAATAATAAGGG
CTATAGTTTACTACCCGGCTGAAGTAGGAAGAGATTGGGATGAGATTCTCAGATTAGTCAAGGCCCTCAAGATAAGCACT
GAGAAGGGAGTTGCTCTTCCGCACAAGTGGCCAAACAACGAGCTCATTGGAGACAAGGTCATTGTTCCACCTGCAAGCAG
TGTTGAGCAGATAAAAGAGCGTGAAGAAGCCAAGGCAAAGGGAGAAATTGAATGCTATGACTGGTGGTTCTGCTACAAGA
AGCTTGAGTGA

Upstream 100 bases:

>100_bases
ATATTGTTCTCTAATTTGTATCTTATTAGGCAAACCGAAAAGTTTATATATTCGAACTATATTAGTTCTTATTGAAAACA
AAACTTAGGAGGAATGCAAA

Downstream 100 bases:

>100_bases
TCTCTCTTTTATTATCTTTTCTGAAGTAATATTTTTAACTTGGCATCTTACATTCTTTCGAGATGACAATGAGGGTATGC
TATAGATGTGGAATATCGGA

Product: peroxiredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MIVIGEKFPEVEVKTTHGVIKLPDHFTKQGKWFMLFSHPADFTPVCTTEFYGLQIRLEKFRELGVEPIGLSVDQVFSHLK
WMEWIKEKLGVEIEFPVIADDRGDLAEKLGMIPSGSTITARAVFIVDDKGIIRAIVYYPAEVGRDWDEILRLVKALKIST
EKGVALPHKWPNNELIGDKVIVPPASSVEQIKEREEAKAKGEIECYDWWFCYKKLE

Sequences:

>Translated_216_residues
MIVIGEKFPEVEVKTTHGVIKLPDHFTKQGKWFMLFSHPADFTPVCTTEFYGLQIRLEKFRELGVEPIGLSVDQVFSHLK
WMEWIKEKLGVEIEFPVIADDRGDLAEKLGMIPSGSTITARAVFIVDDKGIIRAIVYYPAEVGRDWDEILRLVKALKIST
EKGVALPHKWPNNELIGDKVIVPPASSVEQIKEREEAKAKGEIECYDWWFCYKKLE
>Mature_216_residues
MIVIGEKFPEVEVKTTHGVIKLPDHFTKQGKWFMLFSHPADFTPVCTTEFYGLQIRLEKFRELGVEPIGLSVDQVFSHLK
WMEWIKEKLGVEIEFPVIADDRGDLAEKLGMIPSGSTITARAVFIVDDKGIIRAIVYYPAEVGRDWDEILRLVKALKIST
EKGVALPHKWPNNELIGDKVIVPPASSVEQIKEREEAKAKGEIECYDWWFCYKKLE

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4758638, Length=202, Percent_Identity=37.6237623762376, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI32189392, Length=159, Percent_Identity=38.9937106918239, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI4505591, Length=159, Percent_Identity=37.1069182389937, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI32455266, Length=159, Percent_Identity=37.1069182389937, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI32455264, Length=159, Percent_Identity=37.1069182389937, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI5453549, Length=159, Percent_Identity=37.7358490566038, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI5802974, Length=170, Percent_Identity=30.5882352941176, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI32483377, Length=170, Percent_Identity=30.5882352941176, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI1786822, Length=147, Percent_Identity=32.6530612244898, Blast_Score=88, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI25153706, Length=172, Percent_Identity=36.046511627907, Blast_Score=110, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17554494, Length=143, Percent_Identity=34.965034965035, Blast_Score=103, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI193204376, Length=159, Percent_Identity=33.9622641509434, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI32565831, Length=159, Percent_Identity=33.9622641509434, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319407, Length=216, Percent_Identity=39.3518518518519, Blast_Score=127, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6323613, Length=173, Percent_Identity=34.1040462427746, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320661, Length=143, Percent_Identity=32.1678321678322, Blast_Score=82, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24581278, Length=196, Percent_Identity=42.3469387755102, Blast_Score=146, Evalue=1e-35,
Organism=Drosophila melanogaster, GI17975518, Length=199, Percent_Identity=36.1809045226131, Blast_Score=113, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24652434, Length=199, Percent_Identity=36.1809045226131, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24652436, Length=194, Percent_Identity=36.5979381443299, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21357347, Length=143, Percent_Identity=36.3636363636364, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17738015, Length=157, Percent_Identity=34.3949044585987, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17157991, Length=152, Percent_Identity=35.5263157894737, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24641739, Length=152, Percent_Identity=35.5263157894737, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24656348, Length=142, Percent_Identity=33.0985915492958, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI17864676, Length=142, Percent_Identity=33.0985915492958, Blast_Score=94, Evalue=5e-20,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR022915
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 24747; Mature: 24747

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVIGEKFPEVEVKTTHGVIKLPDHFTKQGKWFMLFSHPADFTPVCTTEFYGLQIRLEKF
CEEECCCCCCEEEEECCCEEECCHHHCCCCCEEEEEECCCCCCCEECCEEEEEEEEEHHH
RELGVEPIGLSVDQVFSHLKWMEWIKEKLGVEIEFPVIADDRGDLAEKLGMIPSGSTITA
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHCCCCCCCEEEE
RAVFIVDDKGIIRAIVYYPAEVGRDWDEILRLVKALKISTEKGVALPHKWPNNELIGDKV
EEEEEECCCCCEEEEEECCHHHCCCHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCEE
IVPPASSVEQIKEREEAKAKGEIECYDWWFCYKKLE
EECCCHHHHHHHHHHHHHCCCCEEEEEEEEEEEECC
>Mature Secondary Structure
MIVIGEKFPEVEVKTTHGVIKLPDHFTKQGKWFMLFSHPADFTPVCTTEFYGLQIRLEKF
CEEECCCCCCEEEEECCCEEECCHHHCCCCCEEEEEECCCCCCCEECCEEEEEEEEEHHH
RELGVEPIGLSVDQVFSHLKWMEWIKEKLGVEIEFPVIADDRGDLAEKLGMIPSGSTITA
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHCCCCCCCEEEE
RAVFIVDDKGIIRAIVYYPAEVGRDWDEILRLVKALKISTEKGVALPHKWPNNELIGDKV
EEEEEECCCCCEEEEEECCHHHCCCHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCEE
IVPPASSVEQIKEREEAKAKGEIECYDWWFCYKKLE
EECCCHHHHHHHHHHHHHCCCCEEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]