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The map label for this gene is tdh [H]

Identifier: 18977363

GI number: 18977363

Start: 946117

End: 947163

Strand: Reverse

Name: tdh [H]

Synonym: PF0991

Alternate gene names: 18977363

Gene position: 947163-946117 (Counterclockwise)

Preceding gene: 18977364

Following gene: 18977358

Centisome position: 49.64

GC content: 43.65

Gene sequence:

>1047_bases
ATGTCCGAGAAGATGGTTGCTATCATGAAGACAAAACCAGAGTACGGTGCAGAGTTAGTTGAAGTAGATGTACCAAAACC
TGGGCCAGGGGAAGTCCTAATAAAAATTCTTGCAACAAGCATATGTGGAACTGACCTGCACATTTATGAATGGAATGAAT
GGGCTCAGACAAGAATTAGGCCACCTCAGATAATGGGGCATGAGGTTGCAGGAGAGGTTGTGGAAGTTGGTCCAGGTGTA
GAGGGAATTGAAGTTGGTGATTACGTTTCTGTTGAGACTCACATAGTCTGTGGAAAGTGTTACGCATGTAAAAGAGGGCA
ATATCACGTATGTCAAAACACAAAGATATTTGGAGTAGATACTGACGGTGTTTTTGCCGAATATGCAGTAGTTCCAGCAC
AAAACGTCTGGAAGAATCCAAAGAACATACCTCCCGAATATGCTACTCTACAAGAGCCATTGGGAAATGCTGTGGATACA
GTACTTGCTGGCCCAATTGCCGGAAAGAGCGTTCTCATTACTGGAGCAGGTCCCCTGGGACTTCTTGGAATAGCAGTGGC
AAAGGCATCCGGAGCCTATCCTGTGATAGTTTCTGAGCCAAGTGAATTTAGAAGAAACTTGGCAAAGAAGGTGGGTGCAG
ACTACGTAATAAATCCATTTGAAGAAGATGTTGTAAAGGAGGTAATGGACATAACCGACGGAAACGGAGTTGATGTGTTC
TTGGAGTTCAGCGGTGCTCCAAAGGCTCTTGAGCAAGGACTCCAGGCAGTAACTCCAGCTGGAAGGGTTTCTCTTCTCGG
ACTATTCCCAGGAAAAGTGAGCATAGACTTTAACAACCTTATAATATTCAAGGCATTGACAGTTTACGGAATCACTGGGA
GACACCTTTGGGAAACTTGGTATACAGTCTCTAGACTGCTCCAAAGTGGAAAATTAAATATAGACCCAATAATAACTCAC
AAGTACAAGGGATTTGACAAGTATGAAGAAGCCTTTGAGCTAATGAGGGCTGGCAAAACTGGCAAAGTTGTTTTCATGCT
TAAATGA

Upstream 100 bases:

>100_bases
GTCAACATTGGAGGGTTGTAGTTTCTATTATTTTATCTCCATAAACCGTTTAAATTCTCATTGCATTAGATATAGTGACG
AATAAAAGGGGTGGATTTCC

Downstream 100 bases:

>100_bases
ATACTTTACATTTGTAATATTTTTTGTCTATTTTTCAAAATATTTTGCCAAATGTTTATATTACATTATTGTATGCAACA
TCTTGGTGAGAGAATGGAAA

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MSEKMVAIMKTKPEYGAELVEVDVPKPGPGEVLIKILATSICGTDLHIYEWNEWAQTRIRPPQIMGHEVAGEVVEVGPGV
EGIEVGDYVSVETHIVCGKCYACKRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQNVWKNPKNIPPEYATLQEPLGNAVDT
VLAGPIAGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSEFRRNLAKKVGADYVINPFEEDVVKEVMDITDGNGVDVF
LEFSGAPKALEQGLQAVTPAGRVSLLGLFPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNIDPIITH
KYKGFDKYEEAFELMRAGKTGKVVFMLK

Sequences:

>Translated_348_residues
MSEKMVAIMKTKPEYGAELVEVDVPKPGPGEVLIKILATSICGTDLHIYEWNEWAQTRIRPPQIMGHEVAGEVVEVGPGV
EGIEVGDYVSVETHIVCGKCYACKRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQNVWKNPKNIPPEYATLQEPLGNAVDT
VLAGPIAGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSEFRRNLAKKVGADYVINPFEEDVVKEVMDITDGNGVDVF
LEFSGAPKALEQGLQAVTPAGRVSLLGLFPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNIDPIITH
KYKGFDKYEEAFELMRAGKTGKVVFMLK
>Mature_347_residues
SEKMVAIMKTKPEYGAELVEVDVPKPGPGEVLIKILATSICGTDLHIYEWNEWAQTRIRPPQIMGHEVAGEVVEVGPGVE
GIEVGDYVSVETHIVCGKCYACKRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQNVWKNPKNIPPEYATLQEPLGNAVDTV
LAGPIAGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSEFRRNLAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFL
EFSGAPKALEQGLQAVTPAGRVSLLGLFPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNIDPIITHK
YKGFDKYEEAFELMRAGKTGKVVFMLK

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=329, Percent_Identity=29.7872340425532, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI156523966, Length=368, Percent_Identity=27.7173913043478, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI4501939, Length=360, Percent_Identity=28.0555555555556, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI4501929, Length=359, Percent_Identity=28.9693593314763, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI34577061, Length=378, Percent_Identity=28.5714285714286, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI71565152, Length=367, Percent_Identity=26.158038147139, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI4501933, Length=359, Percent_Identity=28.133704735376, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI262073058, Length=357, Percent_Identity=28.2913165266106, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI71743840, Length=357, Percent_Identity=28.2913165266106, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI71565154, Length=356, Percent_Identity=29.4943820224719, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=43.9882697947214, Blast_Score=301, Evalue=3e-83,
Organism=Escherichia coli, GI1787863, Length=341, Percent_Identity=33.7243401759531, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1788075, Length=344, Percent_Identity=30.5232558139535, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI226510992, Length=312, Percent_Identity=31.0897435897436, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1788073, Length=321, Percent_Identity=29.2834890965732, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1788407, Length=332, Percent_Identity=30.421686746988, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI87082125, Length=339, Percent_Identity=30.3834808259587, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786825, Length=383, Percent_Identity=30.0261096605744, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1790718, Length=311, Percent_Identity=27.3311897106109, Blast_Score=111, Evalue=9e-26,
Organism=Escherichia coli, GI87081918, Length=265, Percent_Identity=29.811320754717, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786552, Length=377, Percent_Identity=27.3209549071618, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1786518, Length=345, Percent_Identity=26.9565217391304, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787572, Length=271, Percent_Identity=28.0442804428044, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=332, Percent_Identity=33.433734939759, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17562878, Length=333, Percent_Identity=29.7297297297297, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17562584, Length=295, Percent_Identity=29.8305084745763, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17562582, Length=295, Percent_Identity=28.8135593220339, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI25146526, Length=368, Percent_Identity=27.445652173913, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71988145, Length=295, Percent_Identity=28.4745762711864, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=386, Percent_Identity=26.6839378238342, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=345, Percent_Identity=27.8260869565217, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319257, Length=318, Percent_Identity=33.6477987421384, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322619, Length=317, Percent_Identity=30.9148264984227, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6319955, Length=317, Percent_Identity=30.9148264984227, Blast_Score=133, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6323099, Length=323, Percent_Identity=32.1981424148607, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6319258, Length=364, Percent_Identity=29.9450549450549, Blast_Score=125, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6319621, Length=271, Percent_Identity=32.1033210332103, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6324486, Length=279, Percent_Identity=30.8243727598566, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323961, Length=279, Percent_Identity=31.1827956989247, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=364, Percent_Identity=26.9230769230769, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323729, Length=253, Percent_Identity=30.4347826086957, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323980, Length=295, Percent_Identity=30.5084745762712, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319949, Length=233, Percent_Identity=33.0472103004292, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17737897, Length=330, Percent_Identity=28.7878787878788, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI17137530, Length=329, Percent_Identity=27.0516717325228, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI17737895, Length=362, Percent_Identity=27.9005524861878, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221457811, Length=189, Percent_Identity=30.1587301587302, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45550770, Length=189, Percent_Identity=30.1587301587302, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45551930, Length=189, Percent_Identity=30.1587301587302, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 37824; Mature: 37693

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKMVAIMKTKPEYGAELVEVDVPKPGPGEVLIKILATSICGTDLHIYEWNEWAQTRIR
CCCCEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHCCC
PPQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACKRGQYHVCQNTKIFGVD
CCHHCCHHHCCCCEECCCCCCCEECCCEEEEEEEEEECCEEECCCCCEEEECCCEEEEEC
TDGVFAEYAVVPAQNVWKNPKNIPPEYATLQEPLGNAVDTVLAGPIAGKSVLITGAGPLG
CCCCEEEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHH
LLGIAVAKASGAYPVIVSEPSEFRRNLAKKVGADYVINPFEEDVVKEVMDITDGNGVDVF
HHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHCCCCCCEEEE
LEFSGAPKALEQGLQAVTPAGRVSLLGLFPGKVSIDFNNLIIFKALTVYGITGRHLWETW
EEECCCHHHHHHHHHHCCCCCCEEEEEECCCEEEEECCCEEEEEEEHHHCCCCHHHHHHH
YTVSRLLQSGKLNIDPIITHKYKGFDKYEEAFELMRAGKTGKVVFMLK
HHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEC
>Mature Secondary Structure 
SEKMVAIMKTKPEYGAELVEVDVPKPGPGEVLIKILATSICGTDLHIYEWNEWAQTRIR
CCCEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHCCC
PPQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACKRGQYHVCQNTKIFGVD
CCHHCCHHHCCCCEECCCCCCCEECCCEEEEEEEEEECCEEECCCCCEEEECCCEEEEEC
TDGVFAEYAVVPAQNVWKNPKNIPPEYATLQEPLGNAVDTVLAGPIAGKSVLITGAGPLG
CCCCEEEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHH
LLGIAVAKASGAYPVIVSEPSEFRRNLAKKVGADYVINPFEEDVVKEVMDITDGNGVDVF
HHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHCCCCCCEEEE
LEFSGAPKALEQGLQAVTPAGRVSLLGLFPGKVSIDFNNLIIFKALTVYGITGRHLWETW
EEECCCHHHHHHHHHHCCCCCCEEEEEECCCEEEEECCCEEEEEEEHHHCCCCHHHHHHH
YTVSRLLQSGKLNIDPIITHKYKGFDKYEEAFELMRAGKTGKVVFMLK
HHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]