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The map label for this gene is fadA [C]

Identifier: 18977345

GI number: 18977345

Start: 932256

End: 933467

Strand: Direct

Name: fadA [C]

Synonym: PF0973

Alternate gene names: 18977345

Gene position: 932256-933467 (Clockwise)

Preceding gene: 18977344

Following gene: 18977346

Centisome position: 48.85

GC content: 44.06

Gene sequence:

>1212_bases
ATGCAAAGGCTAGAAGAAAGTACATCTTGTAGAGGGGTGGGAGATATGAGAAAAGCAATAATAGTTGGAGTTGGAATGAC
TCCTGTTGGAGAACATTGGAGGTCTTCTCTTAGGGATTTAGCCGTCGAAGCAATTTTAAACGCGATGGATGATGCGGGAA
TTGACAAAGTTGATTCTCTATATGTTGGTAACATGGCATCTGGTTCATTCGTAGAGCAAGAAAACCTGGGAGCATTAATA
GCTGATTGGGCTGGATTGGGGAATATTCCTGCCGTTAAAATTGAAGCTGCTTGTGCTTCTGGTGGAGCTGCAGTTCAAGA
AGGTGCTAAAGCTGTGCTTAGTGGTCTTGAAGATGTAGTTTTAGTCGTTGGAGTAGAGAAGATGACAGATGCTTGGCCTA
GTGATGCTACGAGATACTTGGGATATGCCGCTGATGCTGAGTGGGAGCTCTTCCATGGTGCCAGCTTTGTAGCTTTGAAT
GCTCTTATAATGAGACTTTACATGAACACTTACGGGTATAAGGAGGAGGATTTGGCACTATTTGCAGTTAATGCTCACGC
AAATGGTGCAAAGAATCCCTATGCAATGTTTAAGAAGCCAATAACAGTTGAAACAGTTATGAAGAGTCCCTACATTGCTG
ATCCACTTAAGCTCTTCGATGCATCTCCAGTTTGTGACGGTGCTGCAGCAGTTATAATTACCACACCAGAGAAGGCTAAA
GAGCTTGGTATTCCAAAGGACAAATGGATTGAGATTGCAGGAATGGGAAGGGCTATTGACACAATAAATCTGGCCAATAG
AGAAGATTTCCTAACTTTAAAAGCAGCTACAATTGCAGCAGAAAGAGCTTATAAGATGGCCGGAGTTAAGCCTGAGGATG
TTGACTTCTTTGAGGTCCACGATGCATTTACAGTTATGGCAGCATTAAGTCTAGAGGCGCTGGGAGTTGCAAAGAAGGGC
GAAGGAGCTAAACTCGCAATTGAGGGTCAAATAGCAATTGACGGGGATTATCCAATCCAAACAATGGGTGGATTGAAAGC
AAGAGGTCACCCAGTAGGAGCTACTGGGGTTTATCAGGTTGTAGAGGCTGTTCTCCAGCTAAGAGGAGAGGCTCCTGATG
GGATTCAAGTTCCCGATGCTGAAGTGGGATTAACTCAGAATATTGGAGGTACTGGATCAAATATCACCGTTACTGTTTTG
AGGAGGGTCTGA

Upstream 100 bases:

>100_bases
TTTAGTATAGTTGTTCAGGATGCCATAGAGGAGAAGAGAGATTTAGCGCCAAAAGTTGAGGATTATGTGAAGAGGAGAAA
AGTCATTGATTACGCTCTCT

Downstream 100 bases:

>100_bases
AATGGGGAAGCCGATGCAGGTTTCCAGGTATTGGAGACACTTTAGGGAGAAATACAGACTTATAGGTGGAAAGTGTGAAA
ATGGCCACCTTCTATTCCCC

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MQRLEESTSCRGVGDMRKAIIVGVGMTPVGEHWRSSLRDLAVEAILNAMDDAGIDKVDSLYVGNMASGSFVEQENLGALI
ADWAGLGNIPAVKIEAACASGGAAVQEGAKAVLSGLEDVVLVVGVEKMTDAWPSDATRYLGYAADAEWELFHGASFVALN
ALIMRLYMNTYGYKEEDLALFAVNAHANGAKNPYAMFKKPITVETVMKSPYIADPLKLFDASPVCDGAAAVIITTPEKAK
ELGIPKDKWIEIAGMGRAIDTINLANREDFLTLKAATIAAERAYKMAGVKPEDVDFFEVHDAFTVMAALSLEALGVAKKG
EGAKLAIEGQIAIDGDYPIQTMGGLKARGHPVGATGVYQVVEAVLQLRGEAPDGIQVPDAEVGLTQNIGGTGSNITVTVL
RRV

Sequences:

>Translated_403_residues
MQRLEESTSCRGVGDMRKAIIVGVGMTPVGEHWRSSLRDLAVEAILNAMDDAGIDKVDSLYVGNMASGSFVEQENLGALI
ADWAGLGNIPAVKIEAACASGGAAVQEGAKAVLSGLEDVVLVVGVEKMTDAWPSDATRYLGYAADAEWELFHGASFVALN
ALIMRLYMNTYGYKEEDLALFAVNAHANGAKNPYAMFKKPITVETVMKSPYIADPLKLFDASPVCDGAAAVIITTPEKAK
ELGIPKDKWIEIAGMGRAIDTINLANREDFLTLKAATIAAERAYKMAGVKPEDVDFFEVHDAFTVMAALSLEALGVAKKG
EGAKLAIEGQIAIDGDYPIQTMGGLKARGHPVGATGVYQVVEAVLQLRGEAPDGIQVPDAEVGLTQNIGGTGSNITVTVL
RRV
>Mature_403_residues
MQRLEESTSCRGVGDMRKAIIVGVGMTPVGEHWRSSLRDLAVEAILNAMDDAGIDKVDSLYVGNMASGSFVEQENLGALI
ADWAGLGNIPAVKIEAACASGGAAVQEGAKAVLSGLEDVVLVVGVEKMTDAWPSDATRYLGYAADAEWELFHGASFVALN
ALIMRLYMNTYGYKEEDLALFAVNAHANGAKNPYAMFKKPITVETVMKSPYIADPLKLFDASPVCDGAAAVIITTPEKAK
ELGIPKDKWIEIAGMGRAIDTINLANREDFLTLKAATIAAERAYKMAGVKPEDVDFFEVHDAFTVMAALSLEALGVAKKG
EGAKLAIEGQIAIDGDYPIQTMGGLKARGHPVGATGVYQVVEAVLQLRGEAPDGIQVPDAEVGLTQNIGGTGSNITVTVL
RRV

Specific function: Subunit Of The Multifunctional Enzyme Complex Of The Fatty Acid Degradation Cycle. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=402, Percent_Identity=30.3482587064677, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI302344760, Length=400, Percent_Identity=28.5, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI302344767, Length=323, Percent_Identity=29.4117647058824, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI302344762, Length=400, Percent_Identity=27.75, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI55956775, Length=355, Percent_Identity=25.9154929577465, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17537653, Length=393, Percent_Identity=29.0076335877863, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI19921506, Length=400, Percent_Identity=29.25, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24585051, Length=400, Percent_Identity=29.5, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 42631; Mature: 42631

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRLEESTSCRGVGDMRKAIIVGVGMTPVGEHWRSSLRDLAVEAILNAMDDAGIDKVDSL
CCCCCCCCCCCCCHHHCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHE
YVGNMASGSFVEQENLGALIADWAGLGNIPAVKIEAACASGGAAVQEGAKAVLSGLEDVV
EECCCCCCCEEECCCCCEEEEHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCHHHEE
LVVGVEKMTDAWPSDATRYLGYAADAEWELFHGASFVALNALIMRLYMNTYGYKEEDLAL
EEEEHHHHHCCCCCCHHHHHEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEE
FAVNAHANGAKNPYAMFKKPITVETVMKSPYIADPLKLFDASPVCDGAAAVIITTPEKAK
EEEECCCCCCCCCHHHHCCCCCHHHHHCCCCCCCCHHHHCCCCCCCCCEEEEEECCHHHH
ELGIPKDKWIEIAGMGRAIDTINLANREDFLTLKAATIAAERAYKMAGVKPEDVDFFEVH
HCCCCHHHEEEEEECCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCEEEHH
DAFTVMAALSLEALGVAKKGEGAKLAIEGQIAIDGDYPIQTMGGLKARGHPVGATGVYQV
HHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCCCCHHCCCCCCCCCCCCCHHHHHH
VEAVLQLRGEAPDGIQVPDAEVGLTQNIGGTGSNITVTVLRRV
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MQRLEESTSCRGVGDMRKAIIVGVGMTPVGEHWRSSLRDLAVEAILNAMDDAGIDKVDSL
CCCCCCCCCCCCCHHHCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHE
YVGNMASGSFVEQENLGALIADWAGLGNIPAVKIEAACASGGAAVQEGAKAVLSGLEDVV
EECCCCCCCEEECCCCCEEEEHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCHHHEE
LVVGVEKMTDAWPSDATRYLGYAADAEWELFHGASFVALNALIMRLYMNTYGYKEEDLAL
EEEEHHHHHCCCCCCHHHHHEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEE
FAVNAHANGAKNPYAMFKKPITVETVMKSPYIADPLKLFDASPVCDGAAAVIITTPEKAK
EEEECCCCCCCCCHHHHCCCCCHHHHHCCCCCCCCHHHHCCCCCCCCCEEEEEECCHHHH
ELGIPKDKWIEIAGMGRAIDTINLANREDFLTLKAATIAAERAYKMAGVKPEDVDFFEVH
HCCCCHHHEEEEEECCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCEEEHH
DAFTVMAALSLEALGVAKKGEGAKLAIEGQIAIDGDYPIQTMGGLKARGHPVGATGVYQV
HHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCCCCHHCCCCCCCCCCCCCHHHHHH
VEAVLQLRGEAPDGIQVPDAEVGLTQNIGGTGSNITVTVLRRV
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: Acyl group transfer; Claisen condensation [C]

Inhibitor: Tris (hydroxy methyl) aminomethane [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]