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The map label for this gene is ilvC [H]

Identifier: 18977308

GI number: 18977308

Start: 900021

End: 901019

Strand: Direct

Name: ilvC [H]

Synonym: PF0936

Alternate gene names: 18977308

Gene position: 900021-901019 (Clockwise)

Preceding gene: 18977307

Following gene: 18977309

Centisome position: 47.16

GC content: 46.45

Gene sequence:

>999_bases
GTGGTTAGAGTGGTAAAGGTTTGGTATGACAACGAGGTAAGTATGGATATACTCAAGGACAAGACCGTGGCTGTTATAGG
GTATGGAAGCCAGGGTGAAGCACAGGCAAAGAACATGAGGGATTCCGGAGTCCACGTTATACTTGGCCTAAGGCCAGAAG
GGAACTCCTGGAAGAGGGCTCAGAAGGATGGGTTTGAGGTCTATACTATAGAGGAGGCAACTAAGAGGGCTGATATAGTC
CACATACTCATTCCAGACCTTGTTCAGCCGAAGGTCTACAAGGAGAAGATAGCGCCTTACCTAAGAGAAGGACAGGCTCT
TGGGTTCTCCCATGGCTTCAACATCCACTATAAGCAGATTGTTCCTCCAGAGTACGTTGATGTGATAATGGTTGCTCCAA
AAAGCCCAGGGAGGAGAGTTAGAGAGGTTTTCCTTGAGGGCTTTGGCGTTCCAGCCCTTATAGCAGTTTATCAAGACTAC
ACTGGGCATGCAAAGGAACTTGCCTTGGCCATGGCTAAGGCAATAGGGGCAACAAGAGCTGGGGTAATTGAGACGACATT
CAAGGACGAAACTGAGAGTGATCTAATAGGAGAGCAGCTTGTCTTAGTTGGGGGCCTTATAGAATTAATCAAGAAGGGCT
TTGAAGTTTTAGTTGAGCTGGGGTATCCTCCAGAGCTAGCCTACTTTGAAGCATGTAATGAGGCAAAGCTGATAATGGAC
TTGATCTATGAAAGAGGATTTACAGGAATGCTAAAGGCAGTGTCAGATACGGCAAAGTACGGGGGGCTAACCGTAGGGCC
TAAGGTCATTGACGAGCACGTTAAGGAAAACATGAGGAAATATGCCGAAAGAGTGAGGAGTGGAGAATTTGCGAAAGAGT
GGATATCAAAGGCAGATAAGGCTGATGAAGTTCTCAAAGAGCTAATGAAAGAGATCGAGGAGCACGAGATCGAAAAAGTT
GGAAGGTTCATTAGGAGAATGTCAGGCCTTGAAAAGTGA

Upstream 100 bases:

>100_bases
GTTCCCACGGTTATAGACGTCCCAATCCATCCGGAGGATGATGTTCTCCCAATGGTTCCTCCTGGGCAACACATCTCAAA
CGTTGTGACAAGGTATTGAG

Downstream 100 bases:

>100_bases
TTTCTCCCCTTTCCACTTTTTTGGAGGGAAAGTGATGGCGAGGAAGATAAAGATTTTCGACACTACACTAAGGGATGGAG
AGCAGACCCCAGGAGTTAGC

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MVRVVKVWYDNEVSMDILKDKTVAVIGYGSQGEAQAKNMRDSGVHVILGLRPEGNSWKRAQKDGFEVYTIEEATKRADIV
HILIPDLVQPKVYKEKIAPYLREGQALGFSHGFNIHYKQIVPPEYVDVIMVAPKSPGRRVREVFLEGFGVPALIAVYQDY
TGHAKELALAMAKAIGATRAGVIETTFKDETESDLIGEQLVLVGGLIELIKKGFEVLVELGYPPELAYFEACNEAKLIMD
LIYERGFTGMLKAVSDTAKYGGLTVGPKVIDEHVKENMRKYAERVRSGEFAKEWISKADKADEVLKELMKEIEEHEIEKV
GRFIRRMSGLEK

Sequences:

>Translated_332_residues
MVRVVKVWYDNEVSMDILKDKTVAVIGYGSQGEAQAKNMRDSGVHVILGLRPEGNSWKRAQKDGFEVYTIEEATKRADIV
HILIPDLVQPKVYKEKIAPYLREGQALGFSHGFNIHYKQIVPPEYVDVIMVAPKSPGRRVREVFLEGFGVPALIAVYQDY
TGHAKELALAMAKAIGATRAGVIETTFKDETESDLIGEQLVLVGGLIELIKKGFEVLVELGYPPELAYFEACNEAKLIMD
LIYERGFTGMLKAVSDTAKYGGLTVGPKVIDEHVKENMRKYAERVRSGEFAKEWISKADKADEVLKELMKEIEEHEIEKV
GRFIRRMSGLEK
>Mature_332_residues
MVRVVKVWYDNEVSMDILKDKTVAVIGYGSQGEAQAKNMRDSGVHVILGLRPEGNSWKRAQKDGFEVYTIEEATKRADIV
HILIPDLVQPKVYKEKIAPYLREGQALGFSHGFNIHYKQIVPPEYVDVIMVAPKSPGRRVREVFLEGFGVPALIAVYQDY
TGHAKELALAMAKAIGATRAGVIETTFKDETESDLIGEQLVLVGGLIELIKKGFEVLVELGYPPELAYFEACNEAKLIMD
LIYERGFTGMLKAVSDTAKYGGLTVGPKVIDEHVKENMRKYAERVRSGEFAKEWISKADKADEVLKELMKEIEEHEIEKV
GRFIRRMSGLEK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=301, Percent_Identity=37.8737541528239, Blast_Score=156, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6323387, Length=333, Percent_Identity=39.039039039039, Blast_Score=179, Evalue=7e-46,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 37294; Mature: 37294

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRVVKVWYDNEVSMDILKDKTVAVIGYGSQGEAQAKNMRDSGVHVILGLRPEGNSWKRA
CEEEEEEEECCCCCHHHHCCCEEEEEEECCCCCHHHHCCCCCCCEEEEEECCCCCCCHHH
QKDGFEVYTIEEATKRADIVHILIPDLVQPKVYKEKIAPYLREGQALGFSHGFNIHYKQI
HHCCCEEEEECHHHHHHCEEEEECCHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEC
VPPEYVDVIMVAPKSPGRRVREVFLEGFGVPALIAVYQDYTGHAKELALAMAKAIGATRA
CCCCCEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCC
GVIETTFKDETESDLIGEQLVLVGGLIELIKKGFEVLVELGYPPELAYFEACNEAKLIMD
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHH
LIYERGFTGMLKAVSDTAKYGGLTVGPKVIDEHVKENMRKYAERVRSGEFAKEWISKADK
HHHHCCCHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCH
ADEVLKELMKEIEEHEIEKVGRFIRRMSGLEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVRVVKVWYDNEVSMDILKDKTVAVIGYGSQGEAQAKNMRDSGVHVILGLRPEGNSWKRA
CEEEEEEEECCCCCHHHHCCCEEEEEEECCCCCHHHHCCCCCCCEEEEEECCCCCCCHHH
QKDGFEVYTIEEATKRADIVHILIPDLVQPKVYKEKIAPYLREGQALGFSHGFNIHYKQI
HHCCCEEEEECHHHHHHCEEEEECCHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEC
VPPEYVDVIMVAPKSPGRRVREVFLEGFGVPALIAVYQDYTGHAKELALAMAKAIGATRA
CCCCCEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCC
GVIETTFKDETESDLIGEQLVLVGGLIELIKKGFEVLVELGYPPELAYFEACNEAKLIMD
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHH
LIYERGFTGMLKAVSDTAKYGGLTVGPKVIDEHVKENMRKYAERVRSGEFAKEWISKADK
HHHHCCCHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCH
ADEVLKELMKEIEEHEIEKVGRFIRRMSGLEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]