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The map label for this gene is f1pep1 [H]

Identifier: 18977197

GI number: 18977197

Start: 803543

End: 805393

Strand: Reverse

Name: f1pep1 [H]

Synonym: PF0825

Alternate gene names: 18977197

Gene position: 805393-803543 (Counterclockwise)

Preceding gene: 18977198

Following gene: 18977193

Centisome position: 42.21

GC content: 45.76

Gene sequence:

>1851_bases
ATGGAAGATCCCTACATATGGATGGAAAACCTCGAGGATGAAAGGGTTCTGAAAATAATTGAAGAAGAAAACAAGAGGTT
TAGGGAGTTTATTGGTGAGCTAAGCGACAAGCTGTTCCCCGAGGTATGGGAACAATTTTCCCAACCCACAATTGGAATGG
CAAGGATAACCAAGAAAGGAATAATAGCTTCATACAGCGAGAAAGATAGAGTTGTGATAAAGTGGTTCAATGGTGATGTT
ATAGTTGATTCCAAGGAATTGGAAAGAGAAGTTGGAGATGAAGTTCTTCTCCAGGGATTCACAACGGATGAAGAGGGAGA
AAAGCTCGCCTATAGCTTTTCCATTGGAGGGGCGGATGAGGGAATAACGAGGATAATAGACCTCAAAACTGGGGAAGTCA
TAGAGGAGATAAAGCCCTCCATATGGAACATAACCTTCCTAAAGGACGGCTACTACTTCACAAGGTTTTACAGAAAGGAG
AAGACTCCCGATGGGGTTAATCCTCCAGCCGCAAGAATGTTCTGGAAGGACAGAGAAGGGGAGAGGATGGTCTTTGGAGA
AGGGCTAACATCGGGATACTTCATGAGCATTAGAAAAAGTTCCGACGGAAAGTTTGCGATTGTGACCCTAACTTATGGAT
GGAATCAAGGCGAGGTATACATCGGACCAATTGACAACCCCCAGGAATGGAAGAAGGTGTACTCTGCAAGTGTTCCAGTG
GAGGCGATAGATGTTGTCAATGGAAAGCTGTACATCCTCACCAAGGAAGGGAAAGGGCTAGGAAAAATAATTGCCATAAA
AAATGGGAAAATAGATGAGGTTATACCAGAGGGGGAGTTTCCGCTAGAGTGGGCTGTGATAGTGAGGGATAAGATATTGG
CTGGAAGGCTCGTCCACGCGAGCTATAAGCTTGAGGTATACACTTTAAACGGCGAAAAGATTAAAGAAATCACCTTCGAC
GTTCCAGGAAGCTTGTATCCCTTGGACAAGGATGAAGAGAGAGTTCTTCTTAGATACACAAGCTTTACCATCCCATATAG
GCTCTACGAGTTCAAGGACGATTTAAGGCTGATTGAGGAGAGAAAAGTTGAGGGGGAGTTCAGAGTTGAGGAAGACTTTG
CCACAAGCAAGGACGGGACAAAGGTTCACTACTTCATAGTGAAGGGAGAGAGGGATGAAAAGAGGGCCTGGGTATTTGGC
TACGGTGGATTCAACATCGCTCTAACTCCAATGTTCTTCCCTCAAGTGATACCATTCCTCAAGAGAGGAGGAACATTCAT
CATGGCCAACTTAAGGGGAGGAAGCGAGTATGGTGAGGAGTGGCATAGGGCTGGAATGAGAGAGAACAAGCAGAATGTCT
TCGATGACTTCATAGCAGTCCTTGAAAAGCTAAAGAAAGAAGGCTATAAGGTAGCTGCATGGGGAAGGAGCAACGGTGGC
CTCTTGGTTTCAGCAACATTAACTCAAAGACCCGACGTTATGGATTCCGCATTGATAGGGTACCCAGTGATTGACATGTT
GAGGTTCCACAAGCTCTATATTGGTAGCGTTTGGATTCCAGAATACGGAAATCCAGAAGATCCAAAAGATAGGGAGTTCC
TCCTGAAGTACTCTCCCTATCACAACGTTGATCCTAAAAAGAAGTACCCACCAACGCTAATCTACACTGGCCTCCACGAT
GACAGGGTTCACCCGGCACATGCCCTCAAGTTCTTCATGAAGCTGAAGGAAATAGGTGCCCCGGTTTATCTAAGAGTTGA
GACGAAGAGTGGTCATATGGGCGCTTCTCCAGAGACAAGAGCCAGGGAGCTCACAGATCTCCTGGCCTTTGTTCTCAAGA
CCCTTTCCTGA

Upstream 100 bases:

>100_bases
TACTCTTCGTTCCGATCTCATATCTTTTAGCCGCAACTCTAATTTTCCTGGACGAAAAACTTCATTAACCCTACCTTTCA
ACGCTAAGATGGTGATCTCT

Downstream 100 bases:

>100_bases
TATCCTCTTCTATTATTCTTTTCATCCACGTACCCTTCATGAACCACATGAGCGCTATTGTTGCCGCTAAAAAGTTGCTC
ATGCCCATGCCAAAGAACAC

Product: prolyl endopeptidase

Products: NA

Alternate protein names: Post-proline cleaving enzyme; Proline-specific endopeptidase; PE; PSE [H]

Number of amino acids: Translated: 616; Mature: 616

Protein sequence:

>616_residues
MEDPYIWMENLEDERVLKIIEEENKRFREFIGELSDKLFPEVWEQFSQPTIGMARITKKGIIASYSEKDRVVIKWFNGDV
IVDSKELEREVGDEVLLQGFTTDEEGEKLAYSFSIGGADEGITRIIDLKTGEVIEEIKPSIWNITFLKDGYYFTRFYRKE
KTPDGVNPPAARMFWKDREGERMVFGEGLTSGYFMSIRKSSDGKFAIVTLTYGWNQGEVYIGPIDNPQEWKKVYSASVPV
EAIDVVNGKLYILTKEGKGLGKIIAIKNGKIDEVIPEGEFPLEWAVIVRDKILAGRLVHASYKLEVYTLNGEKIKEITFD
VPGSLYPLDKDEERVLLRYTSFTIPYRLYEFKDDLRLIEERKVEGEFRVEEDFATSKDGTKVHYFIVKGERDEKRAWVFG
YGGFNIALTPMFFPQVIPFLKRGGTFIMANLRGGSEYGEEWHRAGMRENKQNVFDDFIAVLEKLKKEGYKVAAWGRSNGG
LLVSATLTQRPDVMDSALIGYPVIDMLRFHKLYIGSVWIPEYGNPEDPKDREFLLKYSPYHNVDPKKKYPPTLIYTGLHD
DRVHPAHALKFFMKLKEIGAPVYLRVETKSGHMGASPETRARELTDLLAFVLKTLS

Sequences:

>Translated_616_residues
MEDPYIWMENLEDERVLKIIEEENKRFREFIGELSDKLFPEVWEQFSQPTIGMARITKKGIIASYSEKDRVVIKWFNGDV
IVDSKELEREVGDEVLLQGFTTDEEGEKLAYSFSIGGADEGITRIIDLKTGEVIEEIKPSIWNITFLKDGYYFTRFYRKE
KTPDGVNPPAARMFWKDREGERMVFGEGLTSGYFMSIRKSSDGKFAIVTLTYGWNQGEVYIGPIDNPQEWKKVYSASVPV
EAIDVVNGKLYILTKEGKGLGKIIAIKNGKIDEVIPEGEFPLEWAVIVRDKILAGRLVHASYKLEVYTLNGEKIKEITFD
VPGSLYPLDKDEERVLLRYTSFTIPYRLYEFKDDLRLIEERKVEGEFRVEEDFATSKDGTKVHYFIVKGERDEKRAWVFG
YGGFNIALTPMFFPQVIPFLKRGGTFIMANLRGGSEYGEEWHRAGMRENKQNVFDDFIAVLEKLKKEGYKVAAWGRSNGG
LLVSATLTQRPDVMDSALIGYPVIDMLRFHKLYIGSVWIPEYGNPEDPKDREFLLKYSPYHNVDPKKKYPPTLIYTGLHD
DRVHPAHALKFFMKLKEIGAPVYLRVETKSGHMGASPETRARELTDLLAFVLKTLS
>Mature_616_residues
MEDPYIWMENLEDERVLKIIEEENKRFREFIGELSDKLFPEVWEQFSQPTIGMARITKKGIIASYSEKDRVVIKWFNGDV
IVDSKELEREVGDEVLLQGFTTDEEGEKLAYSFSIGGADEGITRIIDLKTGEVIEEIKPSIWNITFLKDGYYFTRFYRKE
KTPDGVNPPAARMFWKDREGERMVFGEGLTSGYFMSIRKSSDGKFAIVTLTYGWNQGEVYIGPIDNPQEWKKVYSASVPV
EAIDVVNGKLYILTKEGKGLGKIIAIKNGKIDEVIPEGEFPLEWAVIVRDKILAGRLVHASYKLEVYTLNGEKIKEITFD
VPGSLYPLDKDEERVLLRYTSFTIPYRLYEFKDDLRLIEERKVEGEFRVEEDFATSKDGTKVHYFIVKGERDEKRAWVFG
YGGFNIALTPMFFPQVIPFLKRGGTFIMANLRGGSEYGEEWHRAGMRENKQNVFDDFIAVLEKLKKEGYKVAAWGRSNGG
LLVSATLTQRPDVMDSALIGYPVIDMLRFHKLYIGSVWIPEYGNPEDPKDREFLLKYSPYHNVDPKKKYPPTLIYTGLHD
DRVHPAHALKFFMKLKEIGAPVYLRVETKSGHMGASPETRARELTDLLAFVLKTLS

Specific function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has an absolute requirement for an X-Pro bond in the trans configuration immediately preceding the Pro-Y scissible bond [H]

COG id: COG1505

COG function: function code E; Serine proteases of the peptidase family S9A

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=689, Percent_Identity=30.188679245283, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI108860686, Length=353, Percent_Identity=26.628895184136, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI284172438, Length=219, Percent_Identity=27.8538812785388, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI284172431, Length=219, Percent_Identity=27.8538812785388, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI284172420, Length=219, Percent_Identity=27.8538812785388, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI284172413, Length=219, Percent_Identity=27.8538812785388, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI70778815, Length=219, Percent_Identity=27.8538812785388, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI108860692, Length=196, Percent_Identity=27.5510204081633, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1788150, Length=679, Percent_Identity=23.7113402061856, Blast_Score=129, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24583414, Length=693, Percent_Identity=30.3030303030303, Blast_Score=232, Evalue=6e-61,
Organism=Drosophila melanogaster, GI221510989, Length=582, Percent_Identity=32.1305841924399, Blast_Score=224, Evalue=1e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.26 [H]

Molecular weight: Translated: 70825; Mature: 70825

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDPYIWMENLEDERVLKIIEEENKRFREFIGELSDKLFPEVWEQFSQPTIGMARITKKG
CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCC
IIASYSEKDRVVIKWFNGDVIVDSKELEREVGDEVLLQGFTTDEEGEKLAYSFSIGGADE
CEEECCCCCEEEEEEECCCEEEEHHHHHHHCCCHHEEECCCCCCCCCEEEEEEECCCCCC
GITRIIDLKTGEVIEEIKPSIWNITFLKDGYYFTRFYRKEKTPDGVNPPAARMFWKDREG
CCEEEEECCCHHHHHHCCCCCEEEEEEECCCEEEEEECCCCCCCCCCCCHHHHEECCCCC
ERMVFGEGLTSGYFMSIRKSSDGKFAIVTLTYGWNQGEVYIGPIDNPQEWKKVYSASVPV
CEEEEECCCCCCEEEEEEECCCCCEEEEEEEEECCCCEEEECCCCCHHHHHHHHCCCCCE
EAIDVVNGKLYILTKEGKGLGKIIAIKNGKIDEVIPEGEFPLEWAVIVRDKILAGRLVHA
EEEEECCCEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEEHHHHHHCEEEEE
SYKLEVYTLNGEKIKEITFDVPGSLYPLDKDEERVLLRYTSFTIPYRLYEFKDDLRLIEE
EEEEEEEEECCCEEEEEEEECCCCCCCCCCCCCEEEEEEEEEECCEEEEHHHHHHHHHHH
RKVEGEFRVEEDFATSKDGTKVHYFIVKGERDEKRAWVFGYGGFNIALTPMFFPQVIPFL
HCCCCCEEEECCCCCCCCCCEEEEEEEECCCCCCEEEEEEECCCEEEECHHHHHHHHHHH
KRGGTFIMANLRGGSEYGEEWHRAGMRENKQNVFDDFIAVLEKLKKEGYKVAAWGRSNGG
HCCCEEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
LLVSATLTQRPDVMDSALIGYPVIDMLRFHKLYIGSVWIPEYGNPEDPKDREFLLKYSPY
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCEEEEEECCC
HNVDPKKKYPPTLIYTGLHDDRVHPAHALKFFMKLKEIGAPVYLRVETKSGHMGASPETR
CCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHH
ARELTDLLAFVLKTLS
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEDPYIWMENLEDERVLKIIEEENKRFREFIGELSDKLFPEVWEQFSQPTIGMARITKKG
CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCC
IIASYSEKDRVVIKWFNGDVIVDSKELEREVGDEVLLQGFTTDEEGEKLAYSFSIGGADE
CEEECCCCCEEEEEEECCCEEEEHHHHHHHCCCHHEEECCCCCCCCCEEEEEEECCCCCC
GITRIIDLKTGEVIEEIKPSIWNITFLKDGYYFTRFYRKEKTPDGVNPPAARMFWKDREG
CCEEEEECCCHHHHHHCCCCCEEEEEEECCCEEEEEECCCCCCCCCCCCHHHHEECCCCC
ERMVFGEGLTSGYFMSIRKSSDGKFAIVTLTYGWNQGEVYIGPIDNPQEWKKVYSASVPV
CEEEEECCCCCCEEEEEEECCCCCEEEEEEEEECCCCEEEECCCCCHHHHHHHHCCCCCE
EAIDVVNGKLYILTKEGKGLGKIIAIKNGKIDEVIPEGEFPLEWAVIVRDKILAGRLVHA
EEEEECCCEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEEHHHHHHCEEEEE
SYKLEVYTLNGEKIKEITFDVPGSLYPLDKDEERVLLRYTSFTIPYRLYEFKDDLRLIEE
EEEEEEEEECCCEEEEEEEECCCCCCCCCCCCCEEEEEEEEEECCEEEEHHHHHHHHHHH
RKVEGEFRVEEDFATSKDGTKVHYFIVKGERDEKRAWVFGYGGFNIALTPMFFPQVIPFL
HCCCCCEEEECCCCCCCCCCEEEEEEEECCCCCCEEEEEEECCCEEEECHHHHHHHHHHH
KRGGTFIMANLRGGSEYGEEWHRAGMRENKQNVFDDFIAVLEKLKKEGYKVAAWGRSNGG
HCCCEEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
LLVSATLTQRPDVMDSALIGYPVIDMLRFHKLYIGSVWIPEYGNPEDPKDREFLLKYSPY
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCEEEEEECCC
HNVDPKKKYPPTLIYTGLHDDRVHPAHALKFFMKLKEIGAPVYLRVETKSGHMGASPETR
CCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHH
ARELTDLLAFVLKTLS
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1840588; 7764331 [H]