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The map label for this gene is tuaD [H]

Identifier: 18977143

GI number: 18977143

Start: 763243

End: 764415

Strand: Reverse

Name: tuaD [H]

Synonym: PF0771

Alternate gene names: 18977143

Gene position: 764415-763243 (Counterclockwise)

Preceding gene: 18977145

Following gene: 18977142

Centisome position: 40.06

GC content: 43.82

Gene sequence:

>1173_bases
ATGATAAATAATGCACAACCTCCAATTTACGAGGAAGGCCTAGAAGAACTCATGCAAGAACTCAAGGGAAAGTACCATGC
AACCAACGATTACCGATGGGCAATTTTAAACTCTGACATAACATTCATAACCGTCGGAACCCCCTCCAAGCCAGACGGCT
CAATAGACTTAACCCACGTAAAGCAGGCAGCAAAATCCATTGGAAAAGCACTAAGAGACAAAGAAGACTATCACGTAGTT
GTAGTCAAGAGCACAGTCCTCCCAGGGACTACCGAAGAAGTCGTAAAGCCAATACTAGAAAAGCATTCAGGAAAAAAAGC
CTTCAAGGACTTTGGCCTAGCAATGAACCCCGAATTCCTAAGAGAAGGAGTAGCATTGAAAGACTTCCTAAACCCAGACA
GAATAGTACTCGGCGTTCAGGATGAGAAAACTAAGAAAATCCTAGAAGAACTCTACGAACCAATAAACGCCCCAAAACTC
ATCGTTGATATAAAAACCGCAGAGATGATAAAATACGCCTCAAACGCCTTCCTAGCGACAAAAATAAGCTTCGCCAACGA
GATAGGAAACATCTGCAAAAAGCTCGGCATCGACTCATGGAAAGTCTTCGAAGGCGTGGGCTTAGACCACAGGATAAGCC
CCCACTTCTTCAAAACCGGAATAGGCTTCGGGGGCTCATGCTTTCCAAAAGACGTAAAAGCACTAATCAAAAAAGCCGAA
GAAATCGGAGAGAATCCACTAATACTAAAGGCCGTCATAGAAGTTAATGAGAGACAACCATTAAAAATGATCGAACTCCT
GAAAAAACACATCCCAGAATTAAAAGGCAGAAAAATTGGGGTTTTAGGATTAGCATTCAAGCCAAACACAGATGATGTCC
GTGAAACTAGGGCTTACATAATTATCAAAAAACTCTTAGAGGAGGGGGCCTCCGTAATAGCTTACGATCCTAAGGCGATG
GAAAACTTCAAGCGTTTCTACCCAGACGTTAGTGGAGGTATAGAATACGCAACCTCCCCAGAGGACGTGTTGAAATCGAC
TGAAATCATCCTCATAGTCACGGAATGGCCCGACTTTGAGGAGTTAGATTACTCTGGGAAGATAGTGATCGACGGTAGGA
GGATTAAAGCCGCTGAGAGGACTGCAAGAATTTATGAGGGGGTGTGCTGGTGA

Upstream 100 bases:

>100_bases
AATTATCGCCTCAGCATATGAAATTAACTCCTTGGCTACTGGCTTTGTCAAGTTGGGAAACAAAGTCATTTTCGTAGACA
TTGACGAGAGAAAGATAAAG

Downstream 100 bases:

>100_bases
AGGTTAGGAAGGCCGTGATTCCAGCTGCTGGCTTGGGAACAAGAATGCTTCCGATAACCAAGTCGATGCCAAAGGAAATG
CTACCAATAGTTGACAGGCC

Product: NDP-sugar dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Teichuronic acid biosynthesis protein tuaD [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MINNAQPPIYEEGLEELMQELKGKYHATNDYRWAILNSDITFITVGTPSKPDGSIDLTHVKQAAKSIGKALRDKEDYHVV
VVKSTVLPGTTEEVVKPILEKHSGKKAFKDFGLAMNPEFLREGVALKDFLNPDRIVLGVQDEKTKKILEELYEPINAPKL
IVDIKTAEMIKYASNAFLATKISFANEIGNICKKLGIDSWKVFEGVGLDHRISPHFFKTGIGFGGSCFPKDVKALIKKAE
EIGENPLILKAVIEVNERQPLKMIELLKKHIPELKGRKIGVLGLAFKPNTDDVRETRAYIIIKKLLEEGASVIAYDPKAM
ENFKRFYPDVSGGIEYATSPEDVLKSTEIILIVTEWPDFEELDYSGKIVIDGRRIKAAERTARIYEGVCW

Sequences:

>Translated_390_residues
MINNAQPPIYEEGLEELMQELKGKYHATNDYRWAILNSDITFITVGTPSKPDGSIDLTHVKQAAKSIGKALRDKEDYHVV
VVKSTVLPGTTEEVVKPILEKHSGKKAFKDFGLAMNPEFLREGVALKDFLNPDRIVLGVQDEKTKKILEELYEPINAPKL
IVDIKTAEMIKYASNAFLATKISFANEIGNICKKLGIDSWKVFEGVGLDHRISPHFFKTGIGFGGSCFPKDVKALIKKAE
EIGENPLILKAVIEVNERQPLKMIELLKKHIPELKGRKIGVLGLAFKPNTDDVRETRAYIIIKKLLEEGASVIAYDPKAM
ENFKRFYPDVSGGIEYATSPEDVLKSTEIILIVTEWPDFEELDYSGKIVIDGRRIKAAERTARIYEGVCW
>Mature_390_residues
MINNAQPPIYEEGLEELMQELKGKYHATNDYRWAILNSDITFITVGTPSKPDGSIDLTHVKQAAKSIGKALRDKEDYHVV
VVKSTVLPGTTEEVVKPILEKHSGKKAFKDFGLAMNPEFLREGVALKDFLNPDRIVLGVQDEKTKKILEELYEPINAPKL
IVDIKTAEMIKYASNAFLATKISFANEIGNICKKLGIDSWKVFEGVGLDHRISPHFFKTGIGFGGSCFPKDVKALIKKAE
EIGENPLILKAVIEVNERQPLKMIELLKKHIPELKGRKIGVLGLAFKPNTDDVRETRAYIIIKKLLEEGASVIAYDPKAM
ENFKRFYPDVSGGIEYATSPEDVLKSTEIILIVTEWPDFEELDYSGKIVIDGRRIKAAERTARIYEGVCW

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=407, Percent_Identity=32.6781326781327, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI296040438, Length=347, Percent_Identity=31.9884726224784, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI296040443, Length=287, Percent_Identity=33.7979094076655, Blast_Score=149, Evalue=4e-36,
Organism=Escherichia coli, GI1788340, Length=325, Percent_Identity=29.5384615384615, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI48994968, Length=280, Percent_Identity=28.2142857142857, Blast_Score=108, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17560350, Length=403, Percent_Identity=32.5062034739454, Blast_Score=181, Evalue=4e-46,
Organism=Drosophila melanogaster, GI17136908, Length=419, Percent_Identity=32.6968973747017, Blast_Score=197, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 43775; Mature: 43775

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINNAQPPIYEEGLEELMQELKGKYHATNDYRWAILNSDITFITVGTPSKPDGSIDLTHV
CCCCCCCCHHHHHHHHHHHHHCCCEECCCCEEEEEEECCEEEEEECCCCCCCCCEEHHHH
KQAAKSIGKALRDKEDYHVVVVKSTVLPGTTEEVVKPILEKHSGKKAFKDFGLAMNPEFL
HHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHCCCCCCHHHH
REGVALKDFLNPDRIVLGVQDEKTKKILEELYEPINAPKLIVDIKTAEMIKYASNAFLAT
HCCCHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHCCCCEEE
KISFANEIGNICKKLGIDSWKVFEGVGLDHRISPHFFKTGIGFGGSCFPKDVKALIKKAE
HHHHHHHHHHHHHHHCCCCEEHHHCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHH
EIGENPLILKAVIEVNERQPLKMIELLKKHIPELKGRKIGVLGLAFKPNTDDVRETRAYI
HHCCCCEEEEEEECCCCCCCHHHHHHHHHHCHHHCCCEEEEEEEEECCCCCHHHHHHHHH
IIKKLLEEGASVIAYDPKAMENFKRFYPDVSGGIEYATSPEDVLKSTEIILIVTEWPDFE
HHHHHHHCCCCEEEECHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCHH
ELDYSGKIVIDGRRIKAAERTARIYEGVCW
HCCCCCEEEEECCEEHHHHHHHHHHHCCCC
>Mature Secondary Structure
MINNAQPPIYEEGLEELMQELKGKYHATNDYRWAILNSDITFITVGTPSKPDGSIDLTHV
CCCCCCCCHHHHHHHHHHHHHCCCEECCCCEEEEEEECCEEEEEECCCCCCCCCEEHHHH
KQAAKSIGKALRDKEDYHVVVVKSTVLPGTTEEVVKPILEKHSGKKAFKDFGLAMNPEFL
HHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHCCCCCCHHHH
REGVALKDFLNPDRIVLGVQDEKTKKILEELYEPINAPKLIVDIKTAEMIKYASNAFLAT
HCCCHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHCCCCEEE
KISFANEIGNICKKLGIDSWKVFEGVGLDHRISPHFFKTGIGFGGSCFPKDVKALIKKAE
HHHHHHHHHHHHHHHCCCCEEHHHCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHH
EIGENPLILKAVIEVNERQPLKMIELLKKHIPELKGRKIGVLGLAFKPNTDDVRETRAYI
HHCCCCEEEEEEECCCCCCCHHHHHHHHHHCHHHCCCEEEEEEEEECCCCCHHHHHHHHH
IIKKLLEEGASVIAYDPKAMENFKRFYPDVSGGIEYATSPEDVLKSTEIILIVTEWPDFE
HHHHHHHCCCCEEEECHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCHH
ELDYSGKIVIDGRRIKAAERTARIYEGVCW
HCCCCCEEEEECCEEHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10048024; 9384377; 10376820 [H]