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The map label for this gene is czcD [H]

Identifier: 18976930

GI number: 18976930

Start: 574633

End: 575520

Strand: Direct

Name: czcD [H]

Synonym: PF0558

Alternate gene names: 18976930

Gene position: 574633-575520 (Clockwise)

Preceding gene: 18976926

Following gene: 18976931

Centisome position: 30.11

GC content: 41.33

Gene sequence:

>888_bases
ATGGAAGAGAGTGGGGAAAGGCTCAAAAGAAGAATGATAATTTCCTTTGCCCTCAATATGGGGATAGCCTTAGTTGAAAT
CATTGGAGGCATAGTTTCCAGAAGTTTAGCCTTGTTTAGTGATTCCCTTCACAATTTCAGCGATTCTATGAGCATACTAA
CAAGCTACATTGCCATAAAAATAGGAGAAAGAGAGAAAAACGAGAAATATACTTTCGGGTATAAAAGGGCCGAAATTCTG
GTCGCATTTGTAAATTCAGCAATTCTTGTGGGAGTTGCCCTTTTCCTCATAGTAGAAGCATATAAGAGATTCAAGACTCC
TGAACCGATTAATGGGCCTTTAATGTTCTCAGTTGCTTTGATTGGCTTTCTAGCTAATTTGATTTCCGTTCTTCTCCTTC
ACGAGCATTCTCACGAGAACATCAACGTTCGTTCCGCCTATCTCCATCTCCTAAGCGATACCTTGTCATCAGTAGCTGTT
GTTCTGGGGGGTATTGCAATAATCAAGTGGAATGCCATTTGGGTTGATCCTCTCCTTAGCGCGCTAATCTCAATTTACAT
CCTTCGCGAAGCTTATGAAATTCTCAAGGAAAGCGTTGAAGTGCTTATGGAAGCTTCTCCTAATCTAGATTTCAATGAGA
TAAAGAGGGAAATTGAAAGCATTCCAGGGGTTAAGAATGCTCATCACTTTCATGCCTGGAGGGTGGGAGAAAAGGAGGTT
CACTTTGAGTGCCATGTTGAAGTTAATGACATGTTGATAAGTGAGGCCCAGCAAATAATAGATGTTATCGCGGAGAGGCT
TAGAAGATTTGGAATAACCCATGTAACTGTCCAGCTTGAGGCGGGAAGATGTAAAGAAAAGGGCATGATCTGTGATGAGG
GTGTTTAA

Upstream 100 bases:

>100_bases
TACGTGACTATGAACAAGTACTCCATTGGAAGTTTTCTATGAAGATCTTAACGTTCGAAAATCTTTTATATCACTGTTTG
GGAATTTGAGTGGAGAAGCA

Downstream 100 bases:

>100_bases
CCAAAGGTTGAAAATCCCCCTTCTGTTTCTAACTTTTGGTTTTAGAAACCTATAAAGGCTCCAAATTCGGAGATGTATCT
GGGGGAGAGAATGAAAGCTT

Product: cation efflux system protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MEESGERLKRRMIISFALNMGIALVEIIGGIVSRSLALFSDSLHNFSDSMSILTSYIAIKIGEREKNEKYTFGYKRAEIL
VAFVNSAILVGVALFLIVEAYKRFKTPEPINGPLMFSVALIGFLANLISVLLLHEHSHENINVRSAYLHLLSDTLSSVAV
VLGGIAIIKWNAIWVDPLLSALISIYILREAYEILKESVEVLMEASPNLDFNEIKREIESIPGVKNAHHFHAWRVGEKEV
HFECHVEVNDMLISEAQQIIDVIAERLRRFGITHVTVQLEAGRCKEKGMICDEGV

Sequences:

>Translated_295_residues
MEESGERLKRRMIISFALNMGIALVEIIGGIVSRSLALFSDSLHNFSDSMSILTSYIAIKIGEREKNEKYTFGYKRAEIL
VAFVNSAILVGVALFLIVEAYKRFKTPEPINGPLMFSVALIGFLANLISVLLLHEHSHENINVRSAYLHLLSDTLSSVAV
VLGGIAIIKWNAIWVDPLLSALISIYILREAYEILKESVEVLMEASPNLDFNEIKREIESIPGVKNAHHFHAWRVGEKEV
HFECHVEVNDMLISEAQQIIDVIAERLRRFGITHVTVQLEAGRCKEKGMICDEGV
>Mature_295_residues
MEESGERLKRRMIISFALNMGIALVEIIGGIVSRSLALFSDSLHNFSDSMSILTSYIAIKIGEREKNEKYTFGYKRAEIL
VAFVNSAILVGVALFLIVEAYKRFKTPEPINGPLMFSVALIGFLANLISVLLLHEHSHENINVRSAYLHLLSDTLSSVAV
VLGGIAIIKWNAIWVDPLLSALISIYILREAYEILKESVEVLMEASPNLDFNEIKREIESIPGVKNAHHFHAWRVGEKEV
HFECHVEVNDMLISEAQQIIDVIAERLRRFGITHVTVQLEAGRCKEKGMICDEGV

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=291, Percent_Identity=28.1786941580756, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI222080086, Length=298, Percent_Identity=25.8389261744966, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI40255009, Length=298, Percent_Identity=25.8389261744966, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI20070323, Length=322, Percent_Identity=24.8447204968944, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI21361112, Length=322, Percent_Identity=27.639751552795, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI21359890, Length=312, Percent_Identity=23.3974358974359, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI289803013, Length=285, Percent_Identity=27.719298245614, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI289803009, Length=285, Percent_Identity=27.719298245614, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI289803007, Length=285, Percent_Identity=27.719298245614, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI289803003, Length=285, Percent_Identity=27.719298245614, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI64762489, Length=285, Percent_Identity=27.719298245614, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI14210520, Length=215, Percent_Identity=27.906976744186, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI52352803, Length=133, Percent_Identity=33.0827067669173, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI52351208, Length=127, Percent_Identity=30.7086614173228, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786966, Length=294, Percent_Identity=38.7755102040816, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1790349, Length=245, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI193210990, Length=315, Percent_Identity=27.6190476190476, Blast_Score=130, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17555796, Length=316, Percent_Identity=29.1139240506329, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17555794, Length=315, Percent_Identity=28.8888888888889, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI32564488, Length=303, Percent_Identity=30.03300330033, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17550442, Length=132, Percent_Identity=30.3030303030303, Blast_Score=64, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI17550440, Length=132, Percent_Identity=30.3030303030303, Blast_Score=64, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6323899, Length=137, Percent_Identity=34.3065693430657, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324892, Length=117, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6320411, Length=164, Percent_Identity=31.0975609756098, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24656728, Length=335, Percent_Identity=28.3582089552239, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24656724, Length=335, Percent_Identity=28.3582089552239, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24656720, Length=335, Percent_Identity=28.3582089552239, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24656715, Length=335, Percent_Identity=28.3582089552239, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI21357035, Length=335, Percent_Identity=28.3582089552239, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24645863, Length=290, Percent_Identity=26.2068965517241, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24583858, Length=318, Percent_Identity=26.4150943396226, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24585900, Length=133, Percent_Identity=31.5789473684211, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24585898, Length=133, Percent_Identity=31.5789473684211, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24585896, Length=133, Percent_Identity=31.5789473684211, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19921672, Length=133, Percent_Identity=31.5789473684211, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24584409, Length=144, Percent_Identity=27.7777777777778, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI28574430, Length=144, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33114; Mature: 33114

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEESGERLKRRMIISFALNMGIALVEIIGGIVSRSLALFSDSLHNFSDSMSILTSYIAIK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
IGEREKNEKYTFGYKRAEILVAFVNSAILVGVALFLIVEAYKRFKTPEPINGPLMFSVAL
ECCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
IGFLANLISVLLLHEHSHENINVRSAYLHLLSDTLSSVAVVLGGIAIIKWNAIWVDPLLS
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCEEHHHHHH
ALISIYILREAYEILKESVEVLMEASPNLDFNEIKREIESIPGVKNAHHFHAWRVGEKEV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHEEECCCCEE
HFECHVEVNDMLISEAQQIIDVIAERLRRFGITHVTVQLEAGRCKEKGMICDEGV
EEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MEESGERLKRRMIISFALNMGIALVEIIGGIVSRSLALFSDSLHNFSDSMSILTSYIAIK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
IGEREKNEKYTFGYKRAEILVAFVNSAILVGVALFLIVEAYKRFKTPEPINGPLMFSVAL
ECCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
IGFLANLISVLLLHEHSHENINVRSAYLHLLSDTLSSVAVVLGGIAIIKWNAIWVDPLLS
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCEEHHHHHH
ALISIYILREAYEILKESVEVLMEASPNLDFNEIKREIESIPGVKNAHHFHAWRVGEKEV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHEEECCCCEE
HFECHVEVNDMLISEAQQIIDVIAERLRRFGITHVTVQLEAGRCKEKGMICDEGV
EEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]