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The map label for this gene is gabT [H]

Identifier: 18976885

GI number: 18976885

Start: 532443

End: 533822

Strand: Reverse

Name: gabT [H]

Synonym: PF0513

Alternate gene names: 18976885

Gene position: 533822-532443 (Counterclockwise)

Preceding gene: 18976886

Following gene: 18976883

Centisome position: 27.97

GC content: 43.33

Gene sequence:

>1380_bases
ATGGAATATCCAAAGATTATTACTAAACTTCCTGGACCAAAAGCTACTGAGATAATTGAGCGAGAGAGCAGAATTCTTTC
CCCGGGAATTGGGGTTAAGTTGTTCCCACTAGTACCTAAGAGGGGATTTGGCGCTCTTATAGAAGATGTTGATGGGAATA
TATTCATAGACTTTTTAGCTGGTGCGGCTGCCGCGTCAACAGGTTATTCTCATCCCAAGCTAGTAAAAGCTGTGCAAGAG
CAAGTTGCCTTAATTCAACATTCCATGATAGGGTACACTCACAATGAAAGGGCAATAAGGGTGGCTGAAAAATTAGCAAA
AATCTCCCCAATTAAAAACCCTCGCATAATCTTTGGAATGAGTGGTAGCGATGCTGTGGATATGGCAATAAAAGTTTCAA
AATTCTCAACAAGAAGGCCCTGGATCCTCTCATTTATAGGGGCTTACCACGGACAAACCCTCGGTGCCACATCTATAGCA
GCCTTCCAAAGCTCACAAAAGAGGGGATTTTCTCCCCTAATGCCCAATGTTATTTGGCTACCTTACCCAAACCCCTACAG
AAATATCTGGGGCATTGACGGTTATGAGGAGCCAAATGAGCTTATAAACAGGTTCTTGGACTACCTTGAAAATTACGTGT
TCTCTCACCTATCTCCTTCAGATGAAGTTGCCGCTCTCTTTGCTGAACCCATTCAGGGGGACGCGGGAATCGTTGTTCCT
CCTGAAAACTTCTTTAAAGAGGTTCAAAAAGTTCTAAATGACCTGGGAATTCTCCTTGTTATGGATGAAGTTCAAACTGG
AATTGGAAGGACTGGAAAGTGGTTTGCGAGTGAGTGGTTTAGCGTTGAGCCCGACTTAATAATATTTGGTAAAGGCGTCG
CTAGCGGAATGGGATTGAGTGGAGTAATAGGGAGGAAAGAGTTAATGGATTTAACAAGCGGTGCAGCATTGTTAACTCCC
GCAGCAAATCCGGTTGTTTCGGCGGCAGCAGAAGCAACTTTAGAGATTATAGAGGAAGAAAACTTGCTTGAGAACGCTCT
CAAAGTAGGTAATTTTATCAAGAAAAGGCTAGAAGAGATGAAAGAAGTGTTTGAAGTGATAGGAGATGTGAGAGGAAAAG
GACTCATGATAGGAGTTGAAATAGTAAAGGACAGGGAAAGCAAAAAGCCAGACCCAGAACTTACTGGGAAGATATGCTGG
AGAGCCTTTGAGCTCGGACTAATACTCCCAAGCTATGGAATGTTCCAGAACGTCATAAGGATAACTCCTCCTTTAGTTAT
TACCCAGGAGATAGCAGAGAAGGGGTTAGAAATAATGGAGAGGGCAATTAAAGACGCCCTTGCAGGAAAAGTGGAGAGAA
AGGTAGTCACTTGGCACTAG

Upstream 100 bases:

>100_bases
ATCAAACAATACACTGAAGACTTTATCTCGAAGAATCCATAGAGACTTTTAGTTTTTCTCTTTGTTATCATTCCTATTTT
TTGTCATGGGGGGAACTATA

Downstream 100 bases:

>100_bases
TTACTTCTTCCTCTTCTTTACCTTTATTCTTGCAATATCTCCCAGTGTAGGCTCGTAGTCCTTTGGTATTCTCGGTTTTT
CTTCGAATTGAGGCTCAACT

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MEYPKIITKLPGPKATEIIERESRILSPGIGVKLFPLVPKRGFGALIEDVDGNIFIDFLAGAAAASTGYSHPKLVKAVQE
QVALIQHSMIGYTHNERAIRVAEKLAKISPIKNPRIIFGMSGSDAVDMAIKVSKFSTRRPWILSFIGAYHGQTLGATSIA
AFQSSQKRGFSPLMPNVIWLPYPNPYRNIWGIDGYEEPNELINRFLDYLENYVFSHLSPSDEVAALFAEPIQGDAGIVVP
PENFFKEVQKVLNDLGILLVMDEVQTGIGRTGKWFASEWFSVEPDLIIFGKGVASGMGLSGVIGRKELMDLTSGAALLTP
AANPVVSAAAEATLEIIEEENLLENALKVGNFIKKRLEEMKEVFEVIGDVRGKGLMIGVEIVKDRESKKPDPELTGKICW
RAFELGLILPSYGMFQNVIRITPPLVITQEIAEKGLEIMERAIKDALAGKVERKVVTWH

Sequences:

>Translated_459_residues
MEYPKIITKLPGPKATEIIERESRILSPGIGVKLFPLVPKRGFGALIEDVDGNIFIDFLAGAAAASTGYSHPKLVKAVQE
QVALIQHSMIGYTHNERAIRVAEKLAKISPIKNPRIIFGMSGSDAVDMAIKVSKFSTRRPWILSFIGAYHGQTLGATSIA
AFQSSQKRGFSPLMPNVIWLPYPNPYRNIWGIDGYEEPNELINRFLDYLENYVFSHLSPSDEVAALFAEPIQGDAGIVVP
PENFFKEVQKVLNDLGILLVMDEVQTGIGRTGKWFASEWFSVEPDLIIFGKGVASGMGLSGVIGRKELMDLTSGAALLTP
AANPVVSAAAEATLEIIEEENLLENALKVGNFIKKRLEEMKEVFEVIGDVRGKGLMIGVEIVKDRESKKPDPELTGKICW
RAFELGLILPSYGMFQNVIRITPPLVITQEIAEKGLEIMERAIKDALAGKVERKVVTWH
>Mature_459_residues
MEYPKIITKLPGPKATEIIERESRILSPGIGVKLFPLVPKRGFGALIEDVDGNIFIDFLAGAAAASTGYSHPKLVKAVQE
QVALIQHSMIGYTHNERAIRVAEKLAKISPIKNPRIIFGMSGSDAVDMAIKVSKFSTRRPWILSFIGAYHGQTLGATSIA
AFQSSQKRGFSPLMPNVIWLPYPNPYRNIWGIDGYEEPNELINRFLDYLENYVFSHLSPSDEVAALFAEPIQGDAGIVVP
PENFFKEVQKVLNDLGILLVMDEVQTGIGRTGKWFASEWFSVEPDLIIFGKGVASGMGLSGVIGRKELMDLTSGAALLTP
AANPVVSAAAEATLEIIEEENLLENALKVGNFIKKRLEEMKEVFEVIGDVRGKGLMIGVEIVKDRESKKPDPELTGKICW
RAFELGLILPSYGMFQNVIRITPPLVITQEIAEKGLEIMERAIKDALAGKVERKVVTWH

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=460, Percent_Identity=31.0869565217391, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI37574042, Length=413, Percent_Identity=28.0871670702179, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI4557809, Length=446, Percent_Identity=30.2690582959641, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI226442709, Length=394, Percent_Identity=28.4263959390863, Blast_Score=171, Evalue=9e-43,
Organism=Homo sapiens, GI226442705, Length=413, Percent_Identity=27.3607748184019, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI24119277, Length=459, Percent_Identity=27.4509803921569, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI284507298, Length=303, Percent_Identity=33.3333333333333, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI188536080, Length=476, Percent_Identity=24.3697478991597, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI38679950, Length=476, Percent_Identity=24.3697478991597, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI38679946, Length=476, Percent_Identity=24.3697478991597, Blast_Score=122, Evalue=9e-28,
Organism=Escherichia coli, GI1789016, Length=433, Percent_Identity=34.1801385681293, Blast_Score=244, Evalue=6e-66,
Organism=Escherichia coli, GI1787560, Length=432, Percent_Identity=33.7962962962963, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI145693181, Length=408, Percent_Identity=29.9019607843137, Blast_Score=171, Evalue=9e-44,
Organism=Escherichia coli, GI1788044, Length=416, Percent_Identity=28.6057692307692, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1789759, Length=414, Percent_Identity=26.5700483091787, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1786991, Length=427, Percent_Identity=26.9320843091335, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1786349, Length=362, Percent_Identity=25.414364640884, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI32564660, Length=444, Percent_Identity=32.8828828828829, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI71992977, Length=448, Percent_Identity=28.125, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI25144271, Length=451, Percent_Identity=27.7161862527716, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI25144274, Length=299, Percent_Identity=28.7625418060201, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17541228, Length=476, Percent_Identity=24.3697478991597, Blast_Score=108, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6323470, Length=429, Percent_Identity=30.0699300699301, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6324432, Length=427, Percent_Identity=27.8688524590164, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6324386, Length=452, Percent_Identity=26.5486725663717, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6321456, Length=369, Percent_Identity=24.390243902439, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28574759, Length=457, Percent_Identity=32.8227571115974, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI161085790, Length=454, Percent_Identity=33.0396475770925, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI21356575, Length=431, Percent_Identity=29.4663573085847, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI21357415, Length=422, Percent_Identity=30.0947867298578, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI281366494, Length=423, Percent_Identity=27.1867612293144, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24667139, Length=423, Percent_Identity=27.1867612293144, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24667143, Length=423, Percent_Identity=27.1867612293144, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 50555; Mature: 50555

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00600 AA_TRANSFER_CLASS_3 ; PS00238 OPSIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYPKIITKLPGPKATEIIERESRILSPGIGVKLFPLVPKRGFGALIEDVDGNIFIDFLA
CCCCHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHCCCCEEEEEHH
GAAAASTGYSHPKLVKAVQEQVALIQHSMIGYTHNERAIRVAEKLAKISPIKNPRIIFGM
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEC
SGSDAVDMAIKVSKFSTRRPWILSFIGAYHGQTLGATSIAAFQSSQKRGFSPLMPNVIWL
CCCCCCHHEEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEE
PYPNPYRNIWGIDGYEEPNELINRFLDYLENYVFSHLSPSDEVAALFAEPIQGDAGIVVP
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEC
PENFFKEVQKVLNDLGILLVMDEVQTGIGRTGKWFASEWFSVEPDLIIFGKGVASGMGLS
CHHHHHHHHHHHHHCCEEEEEHHHHHCCCCCCCHHHHHCCCCCCCEEEEECCCCCCCCCC
GVIGRKELMDLTSGAALLTPAANPVVSAAAEATLEIIEEENLLENALKVGNFIKKRLEEM
CCCCHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEVFEVIGDVRGKGLMIGVEIVKDRESKKPDPELTGKICWRAFELGLILPSYGMFQNVIR
HHHHHHHHCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
ITPPLVITQEIAEKGLEIMERAIKDALAGKVERKVVTWH
HCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECC
>Mature Secondary Structure
MEYPKIITKLPGPKATEIIERESRILSPGIGVKLFPLVPKRGFGALIEDVDGNIFIDFLA
CCCCHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHCCCCEEEEEHH
GAAAASTGYSHPKLVKAVQEQVALIQHSMIGYTHNERAIRVAEKLAKISPIKNPRIIFGM
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEC
SGSDAVDMAIKVSKFSTRRPWILSFIGAYHGQTLGATSIAAFQSSQKRGFSPLMPNVIWL
CCCCCCHHEEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEE
PYPNPYRNIWGIDGYEEPNELINRFLDYLENYVFSHLSPSDEVAALFAEPIQGDAGIVVP
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEC
PENFFKEVQKVLNDLGILLVMDEVQTGIGRTGKWFASEWFSVEPDLIIFGKGVASGMGLS
CHHHHHHHHHHHHHCCEEEEEHHHHHCCCCCCCHHHHHCCCCCCCEEEEECCCCCCCCCC
GVIGRKELMDLTSGAALLTPAANPVVSAAAEATLEIIEEENLLENALKVGNFIKKRLEEM
CCCCHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEVFEVIGDVRGKGLMIGVEIVKDRESKKPDPELTGKICWRAFELGLILPSYGMFQNVIR
HHHHHHHHCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
ITPPLVITQEIAEKGLEIMERAIKDALAGKVERKVVTWH
HCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]