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The map label for this gene is glmS [H]

Identifier: 18976734

GI number: 18976734

Start: 375904

End: 376881

Strand: Direct

Name: glmS [H]

Synonym: PF0362

Alternate gene names: 18976734

Gene position: 375904-376881 (Clockwise)

Preceding gene: 18976733

Following gene: 18976735

Centisome position: 19.7

GC content: 41.62

Gene sequence:

>978_bases
ATGAAAACGCTAACAGAGATTAAACAAACTCCTAAAGGTATAATCAAGGCAGATGAGAGCTTTAATCAGGTGAAAGATAA
AATAAGACTACCACGCCGCATCCTATACCTGGGATGCGGCTCTTCCCACTTTTTAGCCAAGCTCTTAGCAATGGTCACAA
ACATGCACGGAGGAACTGGAGTAGCCCTACCTTGTTCGGAGTTCCTCTATTCTAAAGAAGCATATCCAATAGGGAAACCA
GAACTAGTAGTTGGGATATCAAGGTCAGGAGAAACAACAGAAGTTCTTCTGGCCCTAGAAAAGATCAATACTCCAAAGCT
TGGAATCTCTGCCTATGAAAGCTCTCTAACTAGAGCTTGCGATTATTCCCTGGTTGTTCCCACTATAGAAGAGAGCGTCG
TGATGACGCATTCATTTACAGCCTTTTACTTTGCATATCTCCAGTTACTGAGACACTCTTATGGACTTCCATTATTAGAG
GCCACTGAAGTTGCCAAAGCGACTGAAAAGGCTCTTGAATACGAGAATTATATAAAGGAGATAGTGGAAGATTTTGATTT
CCAAAATGTAATCTTCCTGGGTTCAGGGTTGTTATATCCAGTGGCCCTAGAGGCCAGTCTAAAAATGAAGGAAATGGCGA
TATTCTGGAGTGAAGCTTATCCAACATTCGAGGTAAGACATGGTTTCAAGGCAATAGCAGATGAAAACACTCTAGTTGTG
CTAATGGCCCAGGAACTTTTTGAATGGCATAAGAAGCTCGTTAATGAGTTCAAAGGTCAAAGAGCAAGAGTATTATTAAT
CTCAAATTCTCAACAGGAGTTTGGGCAAGACTATTCTATAGAGGTTCCCAGGTTGAGCAAGGATGCAACCCCAATTCCCT
ATCTTCCTGTGGTTCAGCTTCTTTCCTATTATAAAGCCGTAGCTCGGGGATTAAATCCAGACAATCCCAGGTTTTTAGAT
AAAGTTGTGAGGTGGTAA

Upstream 100 bases:

>100_bases
CTTACGCTAGAGAAGAATGCTACAAAAAACCACCACAAACAACCCAACCAGAAAAAAACCACCACGTAGCATGCTACCTC
TATGAAAGGGGTGAGGCTTT

Downstream 100 bases:

>100_bases
ACATGAGGGTTAGTCATGATGGTAAAACCTATCTTCCTTGATGGTAAAAGGATTGTTGTTTATGGAGGTACCCTTCAGTA
TTTTAGAGTTCCCAGGAACT

Product: glucosamine-fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MKTLTEIKQTPKGIIKADESFNQVKDKIRLPRRILYLGCGSSHFLAKLLAMVTNMHGGTGVALPCSEFLYSKEAYPIGKP
ELVVGISRSGETTEVLLALEKINTPKLGISAYESSLTRACDYSLVVPTIEESVVMTHSFTAFYFAYLQLLRHSYGLPLLE
ATEVAKATEKALEYENYIKEIVEDFDFQNVIFLGSGLLYPVALEASLKMKEMAIFWSEAYPTFEVRHGFKAIADENTLVV
LMAQELFEWHKKLVNEFKGQRARVLLISNSQQEFGQDYSIEVPRLSKDATPIPYLPVVQLLSYYKAVARGLNPDNPRFLD
KVVRW

Sequences:

>Translated_325_residues
MKTLTEIKQTPKGIIKADESFNQVKDKIRLPRRILYLGCGSSHFLAKLLAMVTNMHGGTGVALPCSEFLYSKEAYPIGKP
ELVVGISRSGETTEVLLALEKINTPKLGISAYESSLTRACDYSLVVPTIEESVVMTHSFTAFYFAYLQLLRHSYGLPLLE
ATEVAKATEKALEYENYIKEIVEDFDFQNVIFLGSGLLYPVALEASLKMKEMAIFWSEAYPTFEVRHGFKAIADENTLVV
LMAQELFEWHKKLVNEFKGQRARVLLISNSQQEFGQDYSIEVPRLSKDATPIPYLPVVQLLSYYKAVARGLNPDNPRFLD
KVVRW
>Mature_325_residues
MKTLTEIKQTPKGIIKADESFNQVKDKIRLPRRILYLGCGSSHFLAKLLAMVTNMHGGTGVALPCSEFLYSKEAYPIGKP
ELVVGISRSGETTEVLLALEKINTPKLGISAYESSLTRACDYSLVVPTIEESVVMTHSFTAFYFAYLQLLRHSYGLPLLE
ATEVAKATEKALEYENYIKEIVEDFDFQNVIFLGSGLLYPVALEASLKMKEMAIFWSEAYPTFEVRHGFKAIADENTLVV
LMAQELFEWHKKLVNEFKGQRARVLLISNSQQEFGQDYSIEVPRLSKDATPIPYLPVVQLLSYYKAVARGLNPDNPRFLD
KVVRW

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG2222

COG function: function code M; Predicted phosphosugar isomerases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=325, Percent_Identity=25.5384615384615, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1790167, Length=337, Percent_Identity=29.3768545994065, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17532897, Length=324, Percent_Identity=22.8395061728395, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17532899, Length=324, Percent_Identity=22.8395061728395, Blast_Score=68, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322745, Length=326, Percent_Identity=25.4601226993865, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21357745, Length=323, Percent_Identity=23.2198142414861, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 36737; Mature: 36737

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLTEIKQTPKGIIKADESFNQVKDKIRLPRRILYLGCGSSHFLAKLLAMVTNMHGGTG
CCCHHHHHHCCHHHEECCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCC
VALPCSEFLYSKEAYPIGKPELVVGISRSGETTEVLLALEKINTPKLGISAYESSLTRAC
EECCHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHC
DYSLVVPTIEESVVMTHSFTAFYFAYLQLLRHSYGLPLLEATEVAKATEKALEYENYIKE
CCEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
IVEDFDFQNVIFLGSGLLYPVALEASLKMKEMAIFWSEAYPTFEVRHGFKAIADENTLVV
HHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHCCCCCEEE
LMAQELFEWHKKLVNEFKGQRARVLLISNSQQEFGQDYSIEVPRLSKDATPIPYLPVVQL
EHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHCCCCEEECCCCCCCCCCCCHHHHHHH
LSYYKAVARGLNPDNPRFLDKVVRW
HHHHHHHHCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MKTLTEIKQTPKGIIKADESFNQVKDKIRLPRRILYLGCGSSHFLAKLLAMVTNMHGGTG
CCCHHHHHHCCHHHEECCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCC
VALPCSEFLYSKEAYPIGKPELVVGISRSGETTEVLLALEKINTPKLGISAYESSLTRAC
EECCHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHC
DYSLVVPTIEESVVMTHSFTAFYFAYLQLLRHSYGLPLLEATEVAKATEKALEYENYIKE
CCEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
IVEDFDFQNVIFLGSGLLYPVALEASLKMKEMAIFWSEAYPTFEVRHGFKAIADENTLVV
HHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHCCCCCEEE
LMAQELFEWHKKLVNEFKGQRARVLLISNSQQEFGQDYSIEVPRLSKDATPIPYLPVVQL
EHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHCCCCEEECCCCCCCCCCCCHHHHHHH
LSYYKAVARGLNPDNPRFLDKVVRW
HHHHHHHHCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12219091 [H]