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The map label for this gene is bga [H]

Identifier: 18976735

GI number: 18976735

Start: 376900

End: 379218

Strand: Direct

Name: bga [H]

Synonym: PF0363

Alternate gene names: 18976735

Gene position: 376900-379218 (Clockwise)

Preceding gene: 18976734

Following gene: 18976737

Centisome position: 19.75

GC content: 43.77

Gene sequence:

>2319_bases
ATGGTAAAACCTATCTTCCTTGATGGTAAAAGGATTGTTGTTTATGGAGGTACCCTTCAGTATTTTAGAGTTCCCAGGAA
CTCCTGGGAAAGAATGCTAAAGAAAATGAAGTCTCACGGGCTAAACACCATTGATACGTACATTGCTTGGAATTGGCACG
AGCCCCAAGAAGGACTCTTCGACTTTACTGGCGAAACTCACCCCCAAAGAGATCTCGTCGGTTTTCTTGATCTAGCACAA
AAACTCGGCTTTTACGTTATCATAAGACCTGGCCCATACATTTGTGGAGAGTGGAAAAATGGAGGCATCCCTGAGTGGTT
GATTAACTCTCATCCAGAAATACTTGCAAAAGGCCCGAATGGTACTCTTCCAAGGGATATATACTATCCTCCAATCACAT
ACCTCCATCCCACTTACTTGGAATATGTAATGAAGTGGTATGAGAATGTTTTTCCTATAATAAAGGAATATCTGTACTCC
AATGGGGGGCCTATAATAAACGTGACGATTGATGACGAACCTTCCTACTGGGAAACCATCTTCCAGGCATTCTTGACCGA
TTACAACGAAATAGTAGTTAAGGAGAATGGGATCTGGCACTCTTGGCTAAAGGAAAACTACCAGTTGGATGAATTGGAGG
AGAGATACGGTCAGAAGTTTTCAGATTATGCTGAGATTGTCCCACCAACGTCATTCTCAGAGCCCCTTCCAAAGATACTC
GACTGGCATCACTTCAAGATATGGATGATCAACGAGTACGTAAGGATACTCTACGAAAAGATAAAGAAGTACGTTGATGT
TCCAATTAGCATTTTAGATCCCTATTTACTCTTAGCCGCATGGAAGGAGTTTTACCTCTACGTAACCAAGCACAAGCTCG
ACATCCACCTATGGACGGAGTTCTGGTACTCATTCTACAGAACATTTGACTTCAAAGAAGACAGACTCGGCCACCTCTAC
TATAAGACGGGGGTTTATAGATATTACATAAACAAGCTGAAGACTCCCCCACTAAGCATAGAGACCCAAACATCCCTCGC
CAATGTTATAGAGAAGGATGAGGCCGAGCTCCTCTATGCCCTCCTTCCAGCTTTGGGAATCCACAACATAAACTACTATC
TCTACGTGGGTGGCGAAAATCCGAAAGGTTATGAATCACACAACGGAGCTACCTGGGACGTGTATTCCCCCATAGGATTG
GATGGAAGAGAAAGACAGCACGTGGAACCAATAAAGTGGATTGGCGAGTTCTTAAAGTCTAACATGGACTTCATCGAGTC
CCAACTAAAGCCAAAAGTTGCCTTTGGGATGTACGAGCCTTATGAAGCCTTAAGCATGTGGGGACATCGGCCAGAAAGCT
TCGAAGAGAGCGTAAATCTCCAAGAATATCTCTTTGGGGAGAGAGGATTGCTCACACTCTTGGCCATGAGCAATGTTCCC
TTTGACGTCATAGACCTTGAACTTTCCACTGTAGAGGAGATGCTCCAATATGAGCAGATTTGGATTTACAGCCTGGATTT
CATGAGCAGAGAAGTTCAAGAAAAGCTTGCTAGATACGTGGAAGAGGGAGGAAACCTCGTGATCCTACCAACCCTTCCAT
CCCTTGATGAGAACATGAAGCCCTACACAAAGCTGAGGGACTTCCTAGGAATTGAAGTTGAGAAGGCCAAGGCAAGGGAT
AACATGAGGTTAATTCCCTACATCAGCGTTGATGCAGAGGAGATAGACAGGATGGTCGTCAGAAACGTCGTTAGGGAGGT
TAAAGGAGGGAAAGCTATAGCTTGGGTTGGAGATAAAGTAGTAGGGGTTATGGTAAGGAAAGGAAAAGGTTCTGCAGTTG
TCTTAGGGTTCAGGCTTCAGTACTACTCGAGCTACCACGATCTACACAGGAAGTTTGTTGATAAGATACTCCAGCTCCAA
GGGATTGAAAGGGATTTTGAAGTCTCAAACAGAGACATAATAGTAATTCCAAGAGGGAATTATCTGGTGGTGGTAAATCC
CAGGGACGACAAGGTTACTGGAAAAGTTAGATACAGGGGTGTCGAGTTTAATGTTGAGCTTAATAAGAGGGGAGTTCTCT
ACATCCCAATTAATGTGGAAATAAACGGCATTAAGGTGCTCTATGCCACAGCAACTCCAGTGGGAAGGGGAGAGGGAACA
ATTAGATTTAGAAACCATTTGGCAAATGTAACTGAAATTGCAATTAACGGCAAGATCAAGGAAGTCTCAGGGGGGTATAT
CCTCCAAGAGAAGAGCTCAGGAGAGAAAAACATCTATGTGATAAAACACGAGAGCGAAACATTCGAAATAAGAGTTTAG

Upstream 100 bases:

>100_bases
GCTTCTTTCCTATTATAAAGCCGTAGCTCGGGGATTAAATCCAGACAATCCCAGGTTTTTAGATAAAGTTGTGAGGTGGT
AAACATGAGGGTTAGTCATG

Downstream 100 bases:

>100_bases
CTTTCTTCCTTTTCCCTTCTCCCTATTTGCCAGGCCTCATAAAATCTCTTCCATTCTTCCTCAAAGTCTCTCTTAACCCC
CCATCTCCTTCTAAATGCGT

Product: beta-galactosidase precursor

Products: NA

Alternate protein names: Lactase [H]

Number of amino acids: Translated: 772; Mature: 772

Protein sequence:

>772_residues
MVKPIFLDGKRIVVYGGTLQYFRVPRNSWERMLKKMKSHGLNTIDTYIAWNWHEPQEGLFDFTGETHPQRDLVGFLDLAQ
KLGFYVIIRPGPYICGEWKNGGIPEWLINSHPEILAKGPNGTLPRDIYYPPITYLHPTYLEYVMKWYENVFPIIKEYLYS
NGGPIINVTIDDEPSYWETIFQAFLTDYNEIVVKENGIWHSWLKENYQLDELEERYGQKFSDYAEIVPPTSFSEPLPKIL
DWHHFKIWMINEYVRILYEKIKKYVDVPISILDPYLLLAAWKEFYLYVTKHKLDIHLWTEFWYSFYRTFDFKEDRLGHLY
YKTGVYRYYINKLKTPPLSIETQTSLANVIEKDEAELLYALLPALGIHNINYYLYVGGENPKGYESHNGATWDVYSPIGL
DGRERQHVEPIKWIGEFLKSNMDFIESQLKPKVAFGMYEPYEALSMWGHRPESFEESVNLQEYLFGERGLLTLLAMSNVP
FDVIDLELSTVEEMLQYEQIWIYSLDFMSREVQEKLARYVEEGGNLVILPTLPSLDENMKPYTKLRDFLGIEVEKAKARD
NMRLIPYISVDAEEIDRMVVRNVVREVKGGKAIAWVGDKVVGVMVRKGKGSAVVLGFRLQYYSSYHDLHRKFVDKILQLQ
GIERDFEVSNRDIIVIPRGNYLVVVNPRDDKVTGKVRYRGVEFNVELNKRGVLYIPINVEINGIKVLYATATPVGRGEGT
IRFRNHLANVTEIAINGKIKEVSGGYILQEKSSGEKNIYVIKHESETFEIRV

Sequences:

>Translated_772_residues
MVKPIFLDGKRIVVYGGTLQYFRVPRNSWERMLKKMKSHGLNTIDTYIAWNWHEPQEGLFDFTGETHPQRDLVGFLDLAQ
KLGFYVIIRPGPYICGEWKNGGIPEWLINSHPEILAKGPNGTLPRDIYYPPITYLHPTYLEYVMKWYENVFPIIKEYLYS
NGGPIINVTIDDEPSYWETIFQAFLTDYNEIVVKENGIWHSWLKENYQLDELEERYGQKFSDYAEIVPPTSFSEPLPKIL
DWHHFKIWMINEYVRILYEKIKKYVDVPISILDPYLLLAAWKEFYLYVTKHKLDIHLWTEFWYSFYRTFDFKEDRLGHLY
YKTGVYRYYINKLKTPPLSIETQTSLANVIEKDEAELLYALLPALGIHNINYYLYVGGENPKGYESHNGATWDVYSPIGL
DGRERQHVEPIKWIGEFLKSNMDFIESQLKPKVAFGMYEPYEALSMWGHRPESFEESVNLQEYLFGERGLLTLLAMSNVP
FDVIDLELSTVEEMLQYEQIWIYSLDFMSREVQEKLARYVEEGGNLVILPTLPSLDENMKPYTKLRDFLGIEVEKAKARD
NMRLIPYISVDAEEIDRMVVRNVVREVKGGKAIAWVGDKVVGVMVRKGKGSAVVLGFRLQYYSSYHDLHRKFVDKILQLQ
GIERDFEVSNRDIIVIPRGNYLVVVNPRDDKVTGKVRYRGVEFNVELNKRGVLYIPINVEINGIKVLYATATPVGRGEGT
IRFRNHLANVTEIAINGKIKEVSGGYILQEKSSGEKNIYVIKHESETFEIRV
>Mature_772_residues
MVKPIFLDGKRIVVYGGTLQYFRVPRNSWERMLKKMKSHGLNTIDTYIAWNWHEPQEGLFDFTGETHPQRDLVGFLDLAQ
KLGFYVIIRPGPYICGEWKNGGIPEWLINSHPEILAKGPNGTLPRDIYYPPITYLHPTYLEYVMKWYENVFPIIKEYLYS
NGGPIINVTIDDEPSYWETIFQAFLTDYNEIVVKENGIWHSWLKENYQLDELEERYGQKFSDYAEIVPPTSFSEPLPKIL
DWHHFKIWMINEYVRILYEKIKKYVDVPISILDPYLLLAAWKEFYLYVTKHKLDIHLWTEFWYSFYRTFDFKEDRLGHLY
YKTGVYRYYINKLKTPPLSIETQTSLANVIEKDEAELLYALLPALGIHNINYYLYVGGENPKGYESHNGATWDVYSPIGL
DGRERQHVEPIKWIGEFLKSNMDFIESQLKPKVAFGMYEPYEALSMWGHRPESFEESVNLQEYLFGERGLLTLLAMSNVP
FDVIDLELSTVEEMLQYEQIWIYSLDFMSREVQEKLARYVEEGGNLVILPTLPSLDENMKPYTKLRDFLGIEVEKAKARD
NMRLIPYISVDAEEIDRMVVRNVVREVKGGKAIAWVGDKVVGVMVRKGKGSAVVLGFRLQYYSSYHDLHRKFVDKILQLQ
GIERDFEVSNRDIIVIPRGNYLVVVNPRDDKVTGKVRYRGVEFNVELNKRGVLYIPINVEINGIKVLYATATPVGRGEGT
IRFRNHLANVTEIAINGKIKEVSGGYILQEKSSGEKNIYVIKHESETFEIRV

Specific function: Preferentially hydrolyzes beta(1->3) galactosyl linkages over beta(1->4) linkages [H]

COG id: COG1874

COG function: function code G; Beta-galactosidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 35 family [H]

Homologues:

Organism=Homo sapiens, GI40255043, Length=169, Percent_Identity=40.2366863905325, Blast_Score=129, Evalue=9e-30,
Organism=Homo sapiens, GI164519026, Length=172, Percent_Identity=37.2093023255814, Blast_Score=127, Evalue=5e-29,
Organism=Homo sapiens, GI119372312, Length=166, Percent_Identity=41.566265060241, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI119372308, Length=166, Percent_Identity=41.566265060241, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI31543093, Length=172, Percent_Identity=37.2093023255814, Blast_Score=117, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI72000600, Length=182, Percent_Identity=35.1648351648352, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17568491, Length=168, Percent_Identity=30.952380952381, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24582088, Length=168, Percent_Identity=36.3095238095238, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646169, Length=166, Percent_Identity=35.5421686746988, Blast_Score=114, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008979
- InterPro:   IPR019801
- InterPro:   IPR017853
- InterPro:   IPR013781
- InterPro:   IPR001944 [H]

Pfam domain/function: PF01301 Glyco_hydro_35 [H]

EC number: =3.2.1.23 [H]

Molecular weight: Translated: 90203; Mature: 90203

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKPIFLDGKRIVVYGGTLQYFRVPRNSWERMLKKMKSHGLNTIDTYIAWNWHEPQEGLF
CCCCEEECCCEEEEECCCEEEEECCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCE
DFTGETHPQRDLVGFLDLAQKLGFYVIIRPGPYICGEWKNGGIPEWLINSHPEILAKGPN
ECCCCCCCHHHHHHHHHHHHHCCEEEEECCCCEEEECCCCCCCCHHHHCCCCCEEEECCC
GTLPRDIYYPPITYLHPTYLEYVMKWYENVFPIIKEYLYSNGGPIINVTIDDEPSYWETI
CCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHH
FQAFLTDYNEIVVKENGIWHSWLKENYQLDELEERYGQKFSDYAEIVPPTSFSEPLPKIL
HHHHHCCCCEEEEECCCCCHHHHHCCCCHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHH
DWHHFKIWMINEYVRILYEKIKKYVDVPISILDPYLLLAAWKEFYLYVTKHKLDIHLWTE
CCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEEEEEEEEEEHHH
FWYSFYRTFDFKEDRLGHLYYKTGVYRYYINKLKTPPLSIETQTSLANVIEKDEAELLYA
HHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHHHH
LLPALGIHNINYYLYVGGENPKGYESHNGATWDVYSPIGLDGRERQHVEPIKWIGEFLKS
HHHHHCCCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHC
NMDFIESQLKPKVAFGMYEPYEALSMWGHRPESFEESVNLQEYLFGERGLLTLLAMSNVP
CHHHHHHHCCCCEEECCCCCHHHHHHCCCCCCCHHHHCCHHHHHCCCCCCEEEEECCCCC
FDVIDLELSTVEEMLQYEQIWIYSLDFMSREVQEKLARYVEEGGNLVILPTLPSLDENMK
EEEEEEEHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCC
PYTKLRDFLGIEVEKAKARDNMRLIPYISVDAEEIDRMVVRNVVREVKGGKAIAWVGDKV
HHHHHHHHHCCEEEHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHHHCCCCEEEEECCCE
VGVMVRKGKGSAVVLGFRLQYYSSYHDLHRKFVDKILQLQGIERDFEVSNRDIIVIPRGN
EEEEEECCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCC
YLVVVNPRDDKVTGKVRYRGVEFNVELNKRGVLYIPINVEINGIKVLYATATPVGRGEGT
EEEEECCCCCCEEEEEEEEEEEEEEEECCCEEEEEEEEEEECCEEEEEEECCCCCCCCCE
IRFRNHLANVTEIAINGKIKEVSGGYILQEKSSGEKNIYVIKHESETFEIRV
EEEHHHCCCEEEEEECCEEEECCCCEEEEECCCCCCEEEEEEECCCEEEEEC
>Mature Secondary Structure
MVKPIFLDGKRIVVYGGTLQYFRVPRNSWERMLKKMKSHGLNTIDTYIAWNWHEPQEGLF
CCCCEEECCCEEEEECCCEEEEECCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCE
DFTGETHPQRDLVGFLDLAQKLGFYVIIRPGPYICGEWKNGGIPEWLINSHPEILAKGPN
ECCCCCCCHHHHHHHHHHHHHCCEEEEECCCCEEEECCCCCCCCHHHHCCCCCEEEECCC
GTLPRDIYYPPITYLHPTYLEYVMKWYENVFPIIKEYLYSNGGPIINVTIDDEPSYWETI
CCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHH
FQAFLTDYNEIVVKENGIWHSWLKENYQLDELEERYGQKFSDYAEIVPPTSFSEPLPKIL
HHHHHCCCCEEEEECCCCCHHHHHCCCCHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHH
DWHHFKIWMINEYVRILYEKIKKYVDVPISILDPYLLLAAWKEFYLYVTKHKLDIHLWTE
CCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEEEEEEEEEEHHH
FWYSFYRTFDFKEDRLGHLYYKTGVYRYYINKLKTPPLSIETQTSLANVIEKDEAELLYA
HHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHHHH
LLPALGIHNINYYLYVGGENPKGYESHNGATWDVYSPIGLDGRERQHVEPIKWIGEFLKS
HHHHHCCCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHC
NMDFIESQLKPKVAFGMYEPYEALSMWGHRPESFEESVNLQEYLFGERGLLTLLAMSNVP
CHHHHHHHCCCCEEECCCCCHHHHHHCCCCCCCHHHHCCHHHHHCCCCCCEEEEECCCCC
FDVIDLELSTVEEMLQYEQIWIYSLDFMSREVQEKLARYVEEGGNLVILPTLPSLDENMK
EEEEEEEHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCC
PYTKLRDFLGIEVEKAKARDNMRLIPYISVDAEEIDRMVVRNVVREVKGGKAIAWVGDKV
HHHHHHHHHCCEEEHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHHHCCCCEEEEECCCE
VGVMVRKGKGSAVVLGFRLQYYSSYHDLHRKFVDKILQLQGIERDFEVSNRDIIVIPRGN
EEEEEECCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCC
YLVVVNPRDDKVTGKVRYRGVEFNVELNKRGVLYIPINVEINGIKVLYATATPVGRGEGT
EEEEECCCCCCEEEEEEEEEEEEEEEECCCEEEEEEEEEEECCEEEEEEECCCCCCCCCE
IRFRNHLANVTEIAINGKIKEVSGGYILQEKSSGEKNIYVIKHESETFEIRV
EEEHHHCCCEEEEEECCEEEECCCCEEEEECCCCCCEEEEEEECCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8563148 [H]