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The map label for this gene is argH

Identifier: 18976580

GI number: 18976580

Start: 224091

End: 225470

Strand: Direct

Name: argH

Synonym: PF0208

Alternate gene names: 18976580

Gene position: 224091-225470 (Clockwise)

Preceding gene: 18976579

Following gene: 18976581

Centisome position: 11.74

GC content: 40.0

Gene sequence:

>1380_bases
ATGTACAGAAAGGCCTTGTTAGGGTCTACTAGGCTTGACATTCTCTCTTACATTTCTTCCATGGAGGAGGATAGGGAGAT
TGTTGAGGAGGTTATAGAGTGCCTTATTGCCCACGTTAAAGGTTTAATTCATTCAAAATTAATTCCCGAAGAAGAAGGAG
AGAAAATTCTAAAGGCATTGGAGGAGTTGAGAGCTTCAAAAGAAGCTTTATTTTCAATCGAAGCAGAAGATATTCATGAA
GCCATAGAGATTTACCTCAAGGAAAAGCTAGGAAAAACGGGAGGATACCTGCCCCTGGGAAGGAGCAGGAATGACCATGT
GGTATGCGCTTTAAGGCTAAAAGCAAAGAAGGCTCTTGTGGAGGAAATTGGCTTAATTTTAGAGCTTAGGAAGGCCTTAA
TTAAGAAGGCGGAGGAAAACGTTTATACACTTATGCCACTCTTCACTCACCTTCAACCAGCTCAACCCTCAACTTTTGCT
CACTATCTCTCAGCCATAATAGAAGAACTAGAAGATATCACAAAGATCTTGTTTAGTGGATTGGGGATTGTAGACAAATC
CTCCTTGGGAGCTGGAGCCATTGGGGGAACTTCGGTTCTGTTAGATAGGGGGTATATGGGTGGAATTCTATTTTCCGATA
TTATCACTAATTCTCTCTATGCAACCAGTAGCAGGACATTTTTACTATATTCATGCTTTCTAAGTGTTCTTATCTCCATT
GCTCTATCAAGGATAGCGGAAGATTTCGTAATATTCTCAACTCCAAACTTTGGCTACATAAAGCTTCCTAATGAGCATCT
TTCGACAAGTAGTATGATGCCTCAAAAGAAGAACCCAGTAACTATGGAGGTTGCTAGGGCATGGGCAGGCGAGGCTATTG
GTCATTTAGTGGCTATGATGAGCATATTAAAAGCCTTGCCTAGTGGATATAACTTGGATATGCAAGAAGTAAATAAGCAC
GCTTTTGCATTATTCAGCGGGACTATAAAAACCCTCAAAATCTTTGTTGATGCAATGAAAAGGGTTGAAGTTAATAAAGA
AAACATGAAAAAGGACTGTGACATCTTTCCAATTTTAGCCACAGATTATGCAGAAAAAATTGCAATGAACACTGGAAGGC
CCTATAGGGAGGTATACATGGAAGTTGCCTCGATAATTGGGGAACATGAGAGCACGGAAAAAATATATTCTGAGCTGTCT
TCGAAATATGGCATCTCAATCTCCCTTGAAGAGGGAATAAAGAAGCCTGTTGTTGGTTCGCCGAATCCTGAAGATGTTCT
TGAATTCTTAGAAAAAGCGAAAAAGAACGTTGAAAAAGATGAGAAAAAGCTTGAGGAGTTGAGGCAGAATGAAAATAGGG
ATAACGTTTACAATCCTTAG

Upstream 100 bases:

>100_bases
AGTGTTCTAGCTTATAATATGCTTCATGGAGTCCACTCCACCTCAAATATTTCGGAAATTAAAGAGGCAATAAAGACTTT
GGAGTGACATGGTGGGAAAT

Downstream 100 bases:

>100_bases
AAAAGAGGAGCTTATGTTTAAGAATAAGGCTAAAGAATTTGGGGAAGTTGTAATGATAAATGATAGAGAAGTTGTCTTCC
CAGGTAGATACGATGTTGAT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MYRKALLGSTRLDILSYISSMEEDREIVEEVIECLIAHVKGLIHSKLIPEEEGEKILKALEELRASKEALFSIEAEDIHE
AIEIYLKEKLGKTGGYLPLGRSRNDHVVCALRLKAKKALVEEIGLILELRKALIKKAEENVYTLMPLFTHLQPAQPSTFA
HYLSAIIEELEDITKILFSGLGIVDKSSLGAGAIGGTSVLLDRGYMGGILFSDIITNSLYATSSRTFLLYSCFLSVLISI
ALSRIAEDFVIFSTPNFGYIKLPNEHLSTSSMMPQKKNPVTMEVARAWAGEAIGHLVAMMSILKALPSGYNLDMQEVNKH
AFALFSGTIKTLKIFVDAMKRVEVNKENMKKDCDIFPILATDYAEKIAMNTGRPYREVYMEVASIIGEHESTEKIYSELS
SKYGISISLEEGIKKPVVGSPNPEDVLEFLEKAKKNVEKDEKKLEELRQNENRDNVYNP

Sequences:

>Translated_459_residues
MYRKALLGSTRLDILSYISSMEEDREIVEEVIECLIAHVKGLIHSKLIPEEEGEKILKALEELRASKEALFSIEAEDIHE
AIEIYLKEKLGKTGGYLPLGRSRNDHVVCALRLKAKKALVEEIGLILELRKALIKKAEENVYTLMPLFTHLQPAQPSTFA
HYLSAIIEELEDITKILFSGLGIVDKSSLGAGAIGGTSVLLDRGYMGGILFSDIITNSLYATSSRTFLLYSCFLSVLISI
ALSRIAEDFVIFSTPNFGYIKLPNEHLSTSSMMPQKKNPVTMEVARAWAGEAIGHLVAMMSILKALPSGYNLDMQEVNKH
AFALFSGTIKTLKIFVDAMKRVEVNKENMKKDCDIFPILATDYAEKIAMNTGRPYREVYMEVASIIGEHESTEKIYSELS
SKYGISISLEEGIKKPVVGSPNPEDVLEFLEKAKKNVEKDEKKLEELRQNENRDNVYNP
>Mature_459_residues
MYRKALLGSTRLDILSYISSMEEDREIVEEVIECLIAHVKGLIHSKLIPEEEGEKILKALEELRASKEALFSIEAEDIHE
AIEIYLKEKLGKTGGYLPLGRSRNDHVVCALRLKAKKALVEEIGLILELRKALIKKAEENVYTLMPLFTHLQPAQPSTFA
HYLSAIIEELEDITKILFSGLGIVDKSSLGAGAIGGTSVLLDRGYMGGILFSDIITNSLYATSSRTFLLYSCFLSVLISI
ALSRIAEDFVIFSTPNFGYIKLPNEHLSTSSMMPQKKNPVTMEVARAWAGEAIGHLVAMMSILKALPSGYNLDMQEVNKH
AFALFSGTIKTLKIFVDAMKRVEVNKENMKKDCDIFPILATDYAEKIAMNTGRPYREVYMEVASIIGEHESTEKIYSELS
SKYGISISLEEGIKKPVVGSPNPEDVLEFLEKAKKNVEKDEKKLEELRQNENRDNVYNP

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=368, Percent_Identity=33.1521739130435, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI68303542, Length=368, Percent_Identity=33.1521739130435, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI68303549, Length=368, Percent_Identity=32.0652173913043, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI68303547, Length=368, Percent_Identity=30.7065217391304, Blast_Score=162, Evalue=8e-40,
Organism=Escherichia coli, GI1790398, Length=378, Percent_Identity=33.8624338624339, Blast_Score=197, Evalue=9e-52,
Organism=Saccharomyces cerevisiae, GI6321806, Length=441, Percent_Identity=31.5192743764172, Blast_Score=191, Evalue=3e-49,
Organism=Drosophila melanogaster, GI221473854, Length=380, Percent_Identity=32.3684210526316, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI78706858, Length=380, Percent_Identity=32.3684210526316, Blast_Score=187, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_PYRFU (Q8U483)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_577937.1
- ProteinModelPortal:   Q8U483
- SMR:   Q8U483
- EnsemblBacteria:   EBPYRT00000004714
- GeneID:   1468040
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF0208
- NMPDR:   fig|186497.1.peg.211
- GeneTree:   EBGT00050000022760
- HOGENOM:   HBG539632
- OMA:   EDIHTVI
- ProtClustDB:   PRK00855
- BRENDA:   4.3.2.1
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51348; Mature: 51348

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRKALLGSTRLDILSYISSMEEDREIVEEVIECLIAHVKGLIHSKLIPEEEGEKILKAL
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
EELRASKEALFSIEAEDIHEAIEIYLKEKLGKTGGYLPLGRSRNDHVVCALRLKAKKALV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEHHHHHHHHH
EEIGLILELRKALIKKAEENVYTLMPLFTHLQPAQPSTFAHYLSAIIEELEDITKILFSG
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
LGIVDKSSLGAGAIGGTSVLLDRGYMGGILFSDIITNSLYATSSRTFLLYSCFLSVLISI
CCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ALSRIAEDFVIFSTPNFGYIKLPNEHLSTSSMMPQKKNPVTMEVARAWAGEAIGHLVAMM
HHHHHHHHCEEEECCCCCEEECCCHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SILKALPSGYNLDMQEVNKHAFALFSGTIKTLKIFVDAMKRVEVNKENMKKDCDIFPILA
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEHHH
TDYAEKIAMNTGRPYREVYMEVASIIGEHESTEKIYSELSSKYGISISLEEGIKKPVVGS
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEHHHCCCCCCCCC
PNPEDVLEFLEKAKKNVEKDEKKLEELRQNENRDNVYNP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MYRKALLGSTRLDILSYISSMEEDREIVEEVIECLIAHVKGLIHSKLIPEEEGEKILKAL
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
EELRASKEALFSIEAEDIHEAIEIYLKEKLGKTGGYLPLGRSRNDHVVCALRLKAKKALV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEHHHHHHHHH
EEIGLILELRKALIKKAEENVYTLMPLFTHLQPAQPSTFAHYLSAIIEELEDITKILFSG
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
LGIVDKSSLGAGAIGGTSVLLDRGYMGGILFSDIITNSLYATSSRTFLLYSCFLSVLISI
CCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ALSRIAEDFVIFSTPNFGYIKLPNEHLSTSSMMPQKKNPVTMEVARAWAGEAIGHLVAMM
HHHHHHHHCEEEECCCCCEEECCCHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SILKALPSGYNLDMQEVNKHAFALFSGTIKTLKIFVDAMKRVEVNKENMKKDCDIFPILA
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEHHH
TDYAEKIAMNTGRPYREVYMEVASIIGEHESTEKIYSELSSKYGISISLEEGIKKPVVGS
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEHHHCCCCCCCCC
PNPEDVLEFLEKAKKNVEKDEKKLEELRQNENRDNVYNP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA