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The map label for this gene is atpD [H]

Identifier: 18976556

GI number: 18976556

Start: 195110

End: 195754

Strand: Direct

Name: atpD [H]

Synonym: PF0184

Alternate gene names: 18976556

Gene position: 195110-195754 (Clockwise)

Preceding gene: 18976555

Following gene: 18976557

Centisome position: 10.22

GC content: 38.29

Gene sequence:

>645_bases
ATGCCAGAGATCCTGAAAGTTAAGCCAACAAGAATGGAGCTACTTAAGCTCAAAAGAAGAGTTAAGTTAGCTGAAAGGGG
CCATAAGCTTCTAAAAGAAAAGCAAGATGCTCTAATAATGGAATTCTTCACCATTTACGATGAAGCTTTAAGCATGAGAA
GAGAGCTAATAAAGAAAATTGGGGAGGCTTTTGAGGCTTTGAGATTGGCTCAGGTAGAAGTGGGAAGTGTAAGGCTTAAG
GAAATTGCCATCGGAGTCAACCCGAACAAGGAGATAGAAGTTAGAAGTAGAAATATTATGGGGGTTAGGGTCCCACTGAT
TGAAGTTCCTGAACTAAAGAGAAAGCCAAGTGAGAGAGGGTATGCTTTCATATCAACGTCTTCTGCAGTAGATGTTGCAG
CTGAAAAATTTGAAGAGGTTTTAGAGTTGGCAATAAGACTTGCTGAAGTTGAAGAATCTTTGAAAAGATTAGGTAAAGAA
ATTGAGAAAACCAAGAGAAGAGTCAATGCTTTAGAGTACATAATAATTCCCAGGATGAAAAATACAATAAAGTTCATTGA
GCAGCATTTGGATGAAATGGAGAGAGAAAACTTCTTCAGGCTCAAGAGAATTAAGGCATTGCTTGAGGCTAGAGAATCAA
TGTAA

Upstream 100 bases:

>100_bases
AGAACTCAAGAGGGTAAAGAAGGAAATGATCATGAAGTATCATCCAAAGTATAGGGGTCGCTCTTCCTAACTTTACAATT
TTAGCAGAGGGTGATCTATA

Downstream 100 bases:

>100_bases
TTTTTTTTATTTCGGGTTTGGGTGAAGTCTTATGGAGAGGTTATACTATATTGATCCCTATCTAAAGAAGGCAACCGCTA
AAATAGTTGATTTAAAATTT

Product: V-type ATP synthase subunit D

Products: ADP; phosphate; H+

Alternate protein names: V-ATPase subunit D [H]

Number of amino acids: Translated: 214; Mature: 213

Protein sequence:

>214_residues
MPEILKVKPTRMELLKLKRRVKLAERGHKLLKEKQDALIMEFFTIYDEALSMRRELIKKIGEAFEALRLAQVEVGSVRLK
EIAIGVNPNKEIEVRSRNIMGVRVPLIEVPELKRKPSERGYAFISTSSAVDVAAEKFEEVLELAIRLAEVEESLKRLGKE
IEKTKRRVNALEYIIIPRMKNTIKFIEQHLDEMERENFFRLKRIKALLEARESM

Sequences:

>Translated_214_residues
MPEILKVKPTRMELLKLKRRVKLAERGHKLLKEKQDALIMEFFTIYDEALSMRRELIKKIGEAFEALRLAQVEVGSVRLK
EIAIGVNPNKEIEVRSRNIMGVRVPLIEVPELKRKPSERGYAFISTSSAVDVAAEKFEEVLELAIRLAEVEESLKRLGKE
IEKTKRRVNALEYIIIPRMKNTIKFIEQHLDEMERENFFRLKRIKALLEARESM
>Mature_213_residues
PEILKVKPTRMELLKLKRRVKLAERGHKLLKEKQDALIMEFFTIYDEALSMRRELIKKIGEAFEALRLAQVEVGSVRLKE
IAIGVNPNKEIEVRSRNIMGVRVPLIEVPELKRKPSERGYAFISTSSAVDVAAEKFEEVLELAIRLAEVEESLKRLGKEI
EKTKRRVNALEYIIIPRMKNTIKFIEQHLDEMERENFFRLKRIKALLEARESM

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane [H]

COG id: COG1394

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit D

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the V-ATPase D subunit family [H]

Homologues:

Organism=Homo sapiens, GI7706757, Length=203, Percent_Identity=32.0197044334975, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17553636, Length=204, Percent_Identity=31.8627450980392, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320784, Length=215, Percent_Identity=32.093023255814, Blast_Score=88, Evalue=9e-19,
Organism=Drosophila melanogaster, GI20128937, Length=203, Percent_Identity=31.5270935960591, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21355551, Length=206, Percent_Identity=30.5825242718447, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI20129907, Length=223, Percent_Identity=28.2511210762332, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002699 [H]

Pfam domain/function: PF01813 ATP-synt_D [H]

EC number: 3.6.3.14

Molecular weight: Translated: 25026; Mature: 24895

Theoretical pI: Translated: 10.34; Mature: 10.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEILKVKPTRMELLKLKRRVKLAERGHKLLKEKQDALIMEFFTIYDEALSMRRELIKKI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEAFEALRLAQVEVGSVRLKEIAIGVNPNKEIEVRSRNIMGVRVPLIEVPELKRKPSERG
HHHHHHHHHHHHHHHHEEEEHEEECCCCCCCEEEECCCEEEEEECCEECCHHHCCCCCCC
YAFISTSSAVDVAAEKFEEVLELAIRLAEVEESLKRLGKEIEKTKRRVNALEYIIIPRMK
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
NTIKFIEQHLDEMERENFFRLKRIKALLEARESM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PEILKVKPTRMELLKLKRRVKLAERGHKLLKEKQDALIMEFFTIYDEALSMRRELIKKI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEAFEALRLAQVEVGSVRLKEIAIGVNPNKEIEVRSRNIMGVRVPLIEVPELKRKPSERG
HHHHHHHHHHHHHHHHEEEEHEEECCCCCCCEEEECCCEEEEEECCEECCHHHCCCCCCC
YAFISTSSAVDVAAEKFEEVLELAIRLAEVEESLKRLGKEIEKTKRRVNALEYIIIPRMK
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
NTIKFIEQHLDEMERENFFRLKRIKALLEARESM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]