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The map label for this gene is moaE [H]

Identifier: 18976472

GI number: 18976472

Start: 107145

End: 107582

Strand: Direct

Name: moaE [H]

Synonym: PF0100

Alternate gene names: 18976472

Gene position: 107145-107582 (Clockwise)

Preceding gene: 18976469

Following gene: 18976473

Centisome position: 5.61

GC content: 39.73

Gene sequence:

>438_bases
ATGAAGAAAGTTCGACTAGTAAAAAAGCCTGAGGATTTTAATTTAGATGAGGCAGTATCACTTGTTTCAAATCCCTCTGT
GGGAGCGATAGTTACATTTTTAGGGAAAGTGAGAAACGAAAATGCTGGAAGGGAGGTTCTTAAGCTTATTTACGAAGCAT
ACGAGGAAATGGCTGAAAAAGAAATGGGGAAAATTAGAAGGGAGGCTCTTGAAAAGTTTCCAATATTTGATGCAGTTATA
TGGCATAGGGCTGGAGAGTTGGATATCTCTGAGAATACAATTTTGGTTGTGGTTTCAGCGAAGCATAGGAAGGAGGCATT
TGAAGCTTGTTCCTGGATTGTAGATGAAGTTAAGAAGAGGGTGCCCGTATGGAAAAGAGAAATTACCACTAAGGGAGAAT
TTTGGATAGAGGGAGACAAACATATTCCAGCTCAGTAG

Upstream 100 bases:

>100_bases
CAATATTGCCTGCTTTGAGTGCATTAATAATATCTTCACTTGTCATGTAAACCCCTAAACTTATTAATTTTCCACTTTAA
TAGCTTAACTGGTGGATGAT

Downstream 100 bases:

>100_bases
AACATTTTTTGCATACTATCTTTAGTGGTATGCAAAATCCGTATAGAAAAAGTTAATATATCTCTTTCTAACCTTAAATT
TTTGGTGAGTCCTGTGGCAG

Product: molybdopterin converting factor subunit 2

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 145; Mature: 145

Protein sequence:

>145_residues
MKKVRLVKKPEDFNLDEAVSLVSNPSVGAIVTFLGKVRNENAGREVLKLIYEAYEEMAEKEMGKIRREALEKFPIFDAVI
WHRAGELDISENTILVVVSAKHRKEAFEACSWIVDEVKKRVPVWKREITTKGEFWIEGDKHIPAQ

Sequences:

>Translated_145_residues
MKKVRLVKKPEDFNLDEAVSLVSNPSVGAIVTFLGKVRNENAGREVLKLIYEAYEEMAEKEMGKIRREALEKFPIFDAVI
WHRAGELDISENTILVVVSAKHRKEAFEACSWIVDEVKKRVPVWKREITTKGEFWIEGDKHIPAQ
>Mature_145_residues
MKKVRLVKKPEDFNLDEAVSLVSNPSVGAIVTFLGKVRNENAGREVLKLIYEAYEEMAEKEMGKIRREALEKFPIFDAVI
WHRAGELDISENTILVVVSAKHRKEAFEACSWIVDEVKKRVPVWKREITTKGEFWIEGDKHIPAQ

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=130, Percent_Identity=40, Blast_Score=104, Evalue=3e-23,
Organism=Escherichia coli, GI1787003, Length=138, Percent_Identity=39.8550724637681, Blast_Score=102, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17509279, Length=114, Percent_Identity=37.719298245614, Blast_Score=86, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21356259, Length=129, Percent_Identity=38.7596899224806, Blast_Score=96, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 16694; Mature: 16694

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVRLVKKPEDFNLDEAVSLVSNPSVGAIVTFLGKVRNENAGREVLKLIYEAYEEMAEK
CCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
EMGKIRREALEKFPIFDAVIWHRAGELDISENTILVVVSAKHRKEAFEACSWIVDEVKKR
HHHHHHHHHHHHCCHHHHHHHHCCCCCEECCCEEEEEEECHHHHHHHHHHHHHHHHHHHH
VPVWKREITTKGEFWIEGDKHIPAQ
CCHHHHHHCCCCCEEEECCCCCCCC
>Mature Secondary Structure
MKKVRLVKKPEDFNLDEAVSLVSNPSVGAIVTFLGKVRNENAGREVLKLIYEAYEEMAEK
CCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
EMGKIRREALEKFPIFDAVIWHRAGELDISENTILVVVSAKHRKEAFEACSWIVDEVKKR
HHHHHHHHHHHHCCHHHHHHHHCCCCCEECCCEEEEEEECHHHHHHHHHHHHHHHHHHHH
VPVWKREITTKGEFWIEGDKHIPAQ
CCHHHHHHCCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]