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The map label for this gene is lysC [C]

Identifier: 161484711

GI number: 161484711

Start: 1007172

End: 1008251

Strand: Direct

Name: lysC [C]

Synonym: PF1053

Alternate gene names: 161484711

Gene position: 1007172-1008251 (Clockwise)

Preceding gene: 18977424

Following gene: 18977426

Centisome position: 52.78

GC content: 41.39

Gene sequence:

>1080_bases
GTGGTGGAGAAACCTGTTGTTGTAAAGTTTGGAGGAACTTCAGTAAGGTACGCCTTTGAAGAAGCACTAGAGCTAGTTGC
AAATCTAAACGAAAATACAAGAACAATCGTTGTCGTTTCTGCACTTGCAGGGGTTACAGATTGTTTATTAAGGCTCGCGA
ATGGTGATATGTCTGCTCTTCTAGAAATCGAAGAAATACATGAAGAACTATCTCAAGAATTAGACGTTCAGCTTGACCAC
TTAATGTATCAGCTTCACAAGACACTTAATTCTAAATCAAGCTTTCCATCAAAAGAAGCATTTGTGGATGAAATAGCATC
CTTTGGAGAGAGATTTTCAGCCGAACTATTCTCAGAGGGGCTTAAAATACTCGGAATTAATGCTAAGGCTGTTGATTCAA
AGGATATACTCTTTGCCAAGGGGGATTATGGAAATGCAGAAGTAGACTTTAAAAAGAGCGTCTATGGAGCAGGCATCCTA
TATCGCATGCTTAGGAGGGGAATAGTCCCCGTTGTTACTGGATACTATGGAAATCTAAATGGATTCAGAGCAACTTTTGG
GAGGGGAGGAAGCGATTACTCAGCAACTTCAATAGCAAGACTAGTAAACGCAAAGGCCACTTTGATTATGAGCGATGTTG
AGGGAATTTACACGGCAGATCCAAAGCTTGTGCCTTCTGCAAAGTTAATCCACTACATCTCATACAGAGAAGCGAAAATA
GCTGCAAAACTAGGTATGAAAGCCCTTCATCATAGGGCTATTGATCCAGTAGAGGGAAGAATACCCGTAATCCTCGGAAA
GACTAGAGATTTGAAGTTTGGAACCTTGATTTCTCACAAGTCCCAGGGGATTCCTGTAGTGGTTCATAAATTGATCGAGG
ATCACGCCGAAGTTTCCGTGGTATCGACTAGAAGGAGCTTTTCTCTCCCCTATGAAGTCTATGAGGAAGGAGATTTTTAC
TTTAAGATAAAAATTCCCAAGGAGCAGTTTTTGGAAGTTTTAAAAGATATACACAGGAGAGTGGTGGAAAATGAAAGTCT
ACGCCCCAGCTACGATAGCGAACTTTGGGCCTGGGTTTGA

Upstream 100 bases:

>100_bases
ACTCAAGAATTTAACGAAAAAATATCAATTGAACAAGGAGAAAATCGAAAAATTTATTACAGTGAGGAAGAGGTTAACCT
TCCTGGGTGAACGACCATCG

Downstream 100 bases:

>100_bases
CGTCTTTGGCTTGGCAATAGAAACGCCAAGGGATACTGTAATTGCAAAGGAAAGTGATGATTTCAGGATAGAGGTCGAAG
GCTACAAAGTTCCAGAAAAT

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MVEKPVVVKFGGTSVRYAFEEALELVANLNENTRTIVVVSALAGVTDCLLRLANGDMSALLEIEEIHEELSQELDVQLDH
LMYQLHKTLNSKSSFPSKEAFVDEIASFGERFSAELFSEGLKILGINAKAVDSKDILFAKGDYGNAEVDFKKSVYGAGIL
YRMLRRGIVPVVTGYYGNLNGFRATFGRGGSDYSATSIARLVNAKATLIMSDVEGIYTADPKLVPSAKLIHYISYREAKI
AAKLGMKALHHRAIDPVEGRIPVILGKTRDLKFGTLISHKSQGIPVVVHKLIEDHAEVSVVSTRRSFSLPYEVYEEGDFY
FKIKIPKEQFLEVLKDIHRRVVENESLRPSYDSELWAWV

Sequences:

>Translated_359_residues
MVEKPVVVKFGGTSVRYAFEEALELVANLNENTRTIVVVSALAGVTDCLLRLANGDMSALLEIEEIHEELSQELDVQLDH
LMYQLHKTLNSKSSFPSKEAFVDEIASFGERFSAELFSEGLKILGINAKAVDSKDILFAKGDYGNAEVDFKKSVYGAGIL
YRMLRRGIVPVVTGYYGNLNGFRATFGRGGSDYSATSIARLVNAKATLIMSDVEGIYTADPKLVPSAKLIHYISYREAKI
AAKLGMKALHHRAIDPVEGRIPVILGKTRDLKFGTLISHKSQGIPVVVHKLIEDHAEVSVVSTRRSFSLPYEVYEEGDFY
FKIKIPKEQFLEVLKDIHRRVVENESLRPSYDSELWAWV
>Mature_359_residues
MVEKPVVVKFGGTSVRYAFEEALELVANLNENTRTIVVVSALAGVTDCLLRLANGDMSALLEIEEIHEELSQELDVQLDH
LMYQLHKTLNSKSSFPSKEAFVDEIASFGERFSAELFSEGLKILGINAKAVDSKDILFAKGDYGNAEVDFKKSVYGAGIL
YRMLRRGIVPVVTGYYGNLNGFRATFGRGGSDYSATSIARLVNAKATLIMSDVEGIYTADPKLVPSAKLIHYISYREAKI
AAKLGMKALHHRAIDPVEGRIPVILGKTRDLKFGTLISHKSQGIPVVVHKLIEDHAEVSVVSTRRSFSLPYEVYEEGDFY
FKIKIPKEQFLEVLKDIHRRVVENESLRPSYDSELWAWV

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=302, Percent_Identity=34.1059602649007, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1786183, Length=312, Percent_Identity=29.8076923076923, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790376, Length=169, Percent_Identity=34.9112426035503, Blast_Score=82, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320893, Length=314, Percent_Identity=26.7515923566879, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 40049; Mature: 40049

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEKPVVVKFGGTSVRYAFEEALELVANLNENTRTIVVVSALAGVTDCLLRLANGDMSAL
CCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHCCCHHHH
LEIEEIHEELSQELDVQLDHLMYQLHKTLNSKSSFPSKEAFVDEIASFGERFSAELFSEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
LKILGINAKAVDSKDILFAKGDYGNAEVDFKKSVYGAGILYRMLRRGIVPVVTGYYGNLN
CEEEECCCCCCCCCCEEEEECCCCCCCEEHHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
GFRATFGRGGSDYSATSIARLVNAKATLIMSDVEGIYTADPKLVPSAKLIHYISYREAKI
CCCHHCCCCCCCCHHHHHHHHHHCHHEEEEECCCCEEECCCCCCCCHHHHHHHHHHHHHH
AAKLGMKALHHRAIDPVEGRIPVILGKTRDLKFGTLISHKSQGIPVVVHKLIEDHAEVSV
HHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEHHHHCCCCCCCHHHHHHHHHHHHHEEE
VSTRRSFSLPYEVYEEGDFYFKIKIPKEQFLEVLKDIHRRVVENESLRPSYDSELWAWV
EECCCCCCCCHHHEECCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECC
>Mature Secondary Structure
MVEKPVVVKFGGTSVRYAFEEALELVANLNENTRTIVVVSALAGVTDCLLRLANGDMSAL
CCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHCCCHHHH
LEIEEIHEELSQELDVQLDHLMYQLHKTLNSKSSFPSKEAFVDEIASFGERFSAELFSEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
LKILGINAKAVDSKDILFAKGDYGNAEVDFKKSVYGAGILYRMLRRGIVPVVTGYYGNLN
CEEEECCCCCCCCCCEEEEECCCCCCCEEHHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
GFRATFGRGGSDYSATSIARLVNAKATLIMSDVEGIYTADPKLVPSAKLIHYISYREAKI
CCCHHCCCCCCCCHHHHHHHHHHCHHEEEEECCCCEEECCCCCCCCHHHHHHHHHHHHHH
AAKLGMKALHHRAIDPVEGRIPVILGKTRDLKFGTLISHKSQGIPVVVHKLIEDHAEVSV
HHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEHHHHCCCCCCCHHHHHHHHHHHHHEEE
VSTRRSFSLPYEVYEEGDFYFKIKIPKEQFLEVLKDIHRRVVENESLRPSYDSELWAWV
EECCCCCCCCHHHEECCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]