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The map label for this gene is thrB

Identifier: 18977426

GI number: 18977426

Start: 1008202

End: 1009080

Strand: Direct

Name: thrB

Synonym: PF1054

Alternate gene names: 18977426

Gene position: 1008202-1009080 (Clockwise)

Preceding gene: 161484711

Following gene: 18977427

Centisome position: 52.83

GC content: 46.3

Gene sequence:

>879_bases
ATGAAAGTCTACGCCCCAGCTACGATAGCGAACTTTGGGCCTGGGTTTGACGTCTTTGGCTTGGCAATAGAAACGCCAAG
GGATACTGTAATTGCAAAGGAAAGTGATGATTTCAGGATAGAGGTCGAAGGCTACAAAGTTCCAGAAAATGACGAAAACG
TAGCTTTAGTCGCTGCAAAAGCTTTATTTAAACTTGTGGGCGAGGAAGGAGGAATCTACCTAAAACTAAAGAAAGGAATT
AGGCCAAAAAGTGGCCTAGGAAGTTCTGGGGCATCTTCAATAGCAGGAGCAGTTGCTGCGGCTAGGATTTTAGGAGTAGA
AGATGATGAAATTATAATAAGAGCGGCTCTCGAAGGGGAAAGAAAAGCCTCTGGAAGCCCTCATGGAGATAATGTTGTCC
CCTCTTACTATGGAAACTTCACAATCGTGGAGTCCCTAAATCCCCTCAGAGTCCACAACATTGAGGTTGATTTCAAGGTA
GTCGTCATCCTTCCCAGTGTTGAAGTACCTACAAGTGAGGCTAGAAAAGTACTTCCGAAGAAAGTCCCTCTCAAAGATGC
CGTGAAAAACATAGCCCTCGCCTCTTCTCTAGTTCTGGCACTAAAGGAGGGAAACCTGGAGGAAGTAGGAAGGCTACTAG
AGGACCATTTAGCCCTCCCATACAGACTCAGCCTAGTTCCATGGTTTCCTAAGGTAAAGGAAGCCGCTAAGGAGGCAGGA
GCCTATGGGGTTATGATATCTGGCTCGGGACCAGCAGTATTTGCTCTTGGGGAGAACCTCAAAGAAATAGGGAAGGCTAT
GAAGGAGGCGTTTGAAAGTTTTGGAATTGAGGCTGAATACTGGGTGACAAAGGTTGGTAGGGGTGCAAAATGGTGCTGA

Upstream 100 bases:

>100_bases
TATGAAGTCTATGAGGAAGGAGATTTTTACTTTAAGATAAAAATTCCCAAGGAGCAGTTTTTGGAAGTTTTAAAAGATAT
ACACAGGAGAGTGGTGGAAA

Downstream 100 bases:

>100_bases
AATGTGTAGTCTGTGGGAGAGAGTATCCTGAAGACGAAGTTAGGTATAGGTGTGAGTGTGGAGGTCTATTAGAGGTTGTT
ATCGATCTAGATAAAGTTGA

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MKVYAPATIANFGPGFDVFGLAIETPRDTVIAKESDDFRIEVEGYKVPENDENVALVAAKALFKLVGEEGGIYLKLKKGI
RPKSGLGSSGASSIAGAVAAARILGVEDDEIIIRAALEGERKASGSPHGDNVVPSYYGNFTIVESLNPLRVHNIEVDFKV
VVILPSVEVPTSEARKVLPKKVPLKDAVKNIALASSLVLALKEGNLEEVGRLLEDHLALPYRLSLVPWFPKVKEAAKEAG
AYGVMISGSGPAVFALGENLKEIGKAMKEAFESFGIEAEYWVTKVGRGAKWC

Sequences:

>Translated_292_residues
MKVYAPATIANFGPGFDVFGLAIETPRDTVIAKESDDFRIEVEGYKVPENDENVALVAAKALFKLVGEEGGIYLKLKKGI
RPKSGLGSSGASSIAGAVAAARILGVEDDEIIIRAALEGERKASGSPHGDNVVPSYYGNFTIVESLNPLRVHNIEVDFKV
VVILPSVEVPTSEARKVLPKKVPLKDAVKNIALASSLVLALKEGNLEEVGRLLEDHLALPYRLSLVPWFPKVKEAAKEAG
AYGVMISGSGPAVFALGENLKEIGKAMKEAFESFGIEAEYWVTKVGRGAKWC
>Mature_292_residues
MKVYAPATIANFGPGFDVFGLAIETPRDTVIAKESDDFRIEVEGYKVPENDENVALVAAKALFKLVGEEGGIYLKLKKGI
RPKSGLGSSGASSIAGAVAAARILGVEDDEIIIRAALEGERKASGSPHGDNVVPSYYGNFTIVESLNPLRVHNIEVDFKV
VVILPSVEVPTSEARKVLPKKVPLKDAVKNIALASSLVLALKEGNLEEVGRLLEDHLALPYRLSLVPWFPKVKEAAKEAG
AYGVMISGSGPAVFALGENLKEIGKAMKEAFESFGIEAEYWVTKVGRGAKWC

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=271, Percent_Identity=31.3653136531365, Blast_Score=114, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6321814, Length=345, Percent_Identity=25.5072463768116, Blast_Score=96, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_PYRFU (Q8U1Z9)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_578783.1
- ProteinModelPortal:   Q8U1Z9
- SMR:   Q8U1Z9
- EnsemblBacteria:   EBPYRT00000004926
- GeneID:   1468920
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1054
- NMPDR:   fig|186497.1.peg.1091
- GeneTree:   EBGT00050000022725
- HOGENOM:   HBG646290
- OMA:   GSAHADN
- ProtClustDB:   PRK01212
- BRENDA:   2.7.1.39
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 31261; Mature: 31261

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVYAPATIANFGPGFDVFGLAIETPRDTVIAKESDDFRIEVEGYKVPENDENVALVAAK
CEEECCCHHCCCCCCCCEEEEEEECCCCEEEEECCCCEEEEEECEECCCCCCCEEEHHHH
ALFKLVGEEGGIYLKLKKGIRPKSGLGSSGASSIAGAVAAARILGVEDDEIIIRAALEGE
HHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCC
RKASGSPHGDNVVPSYYGNFTIVESLNPLRVHNIEVDFKVVVILPSVEVPTSEARKVLPK
HHCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEEEEEEEEEEECCCCCCHHHHHHHCCC
KVPLKDAVKNIALASSLVLALKEGNLEEVGRLLEDHLALPYRLSLVPWFPKVKEAAKEAG
CCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCC
AYGVMISGSGPAVFALGENLKEIGKAMKEAFESFGIEAEYWVTKVGRGAKWC
CEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHEECCCCCCCC
>Mature Secondary Structure
MKVYAPATIANFGPGFDVFGLAIETPRDTVIAKESDDFRIEVEGYKVPENDENVALVAAK
CEEECCCHHCCCCCCCCEEEEEEECCCCEEEEECCCCEEEEEECEECCCCCCCEEEHHHH
ALFKLVGEEGGIYLKLKKGIRPKSGLGSSGASSIAGAVAAARILGVEDDEIIIRAALEGE
HHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCC
RKASGSPHGDNVVPSYYGNFTIVESLNPLRVHNIEVDFKVVVILPSVEVPTSEARKVLPK
HHCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEEEEEEEEEEECCCCCCHHHHHHHCCC
KVPLKDAVKNIALASSLVLALKEGNLEEVGRLLEDHLALPYRLSLVPWFPKVKEAAKEAG
CCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCC
AYGVMISGSGPAVFALGENLKEIGKAMKEAFESFGIEAEYWVTKVGRGAKWC
CEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA