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The map label for this gene is lon [H]

Identifier: 18311617

GI number: 18311617

Start: 3009333

End: 3011192

Strand: Reverse

Name: lon [H]

Synonym: CPE2635

Alternate gene names: 18311617

Gene position: 3011192-3009333 (Counterclockwise)

Preceding gene: 18311618

Following gene: 18311616

Centisome position: 99.33

GC content: 32.04

Gene sequence:

>1860_bases
ATGAATAGTGAACTTGGAGTAGAATCTCAAGTTGAAGCACTAAAAGATATAATAAATAATATATTAGACGAAGGTGCATT
TAGAGCGAGAGTTATAAGATTTAAAGTACAAAATTATATAAATTCAACTGATCCTTATGAAAGACTTTATGGATTAAGTA
AAATTGTTTCTGAAGGAAAGGGTTTAAGTGAAGTTCCAACTGAAGAAACTATAAATGAAGCTTTAGAAGATGTTTGTGCT
ATGATATCAGATGCTATTGCTAGAAGATATGTTCAAAATAAAATAGAAAAAGAAGTTGAACAATTCTTAATGGAAAAGCA
AGAAAAGTATGTTGATGAACTTAGAGTAAACATAATGAAAAAGAAAAAAGGTCCAGAAAATGCTAAGACAGAGAAAAAGC
TTGAGGAGCTTGAAGAGTTAGATGAAAGAGTTCCAAATAAGAATATAATGTCTTTATTAAGACCTGATTCATTTGATGAG
GTAGTTGGTCAAGAGAGAGCTGTTAAGTCACTTCTTTCAAAACTAGCTTCACCATATCCTCAACATATAATACTTTATGG
ACCTCCAGGGGTTGGTAAAACAACAGCTGCTAGAATTGCTCTAGAAACAGCTAAGAAATTAAAATCAACTCCATTTGATG
ATAGATCAAAATTCATAGAGGTTAATGGTACAACTTTAAGATGGGATCCAAGAGAAATTACAAACCCACTTTTAGGTTCA
GTACATGATCCAATATATCAAGGTAGCAAAAGAGACTTAGCTGAAATAGGAGTTCCAGAACCAAAACCAGGTTTAGTTAC
TGAAGCTCACGGTGGTATATTATTTATAGATGAAATTGGAGAATTAGATGAAATACTTCAAAATAAACTTTTAAAAGTTT
TAGAAGATAAGAGAGTTGAATTCTCATCATCTTACTATGATCCAGACGATGAAAATACACCTAAATATATAAAATATCTT
TTTGATAAAGGAGCTCCAGCAGATTTTGTTTTAATAGGAGCAACTACTAGAGAACCAGGAGAAATCAATCCTGCTTTACG
TTCAAGATGTACAGAGGTTTATTTTGAACCACTATCATCAAGAGATATTGAAAAGATAGTATTAAATGCAGCTAAGAAGC
TTAATGTTAAGCTTGAAGAAGGTTTAGAAAAGAAAATAGCTTCTTATACTATAGAAGGTAGAAGAGCTGTAAATATATTA
GCAGATGCTTATGGTCATGCCATTTATGGCTTAGAGGGAGAAGTTCCAGAAGACTTAGAAATAACTTCAAAGGATTTAAA
TGAAGTTGTAAGCATAGGAAGATTTACTCCGTATGAAATACTAGAAAATTTAGAGGAAAAAGAAGTAGGTCATGTTTATG
GACTTGGAGTTTCAGGATTCTTAGGCTCAACAATAGAGATTGAAGCCACTGCTTTTAAAGCTAAGAAAAAGGGTGCTGGA
AAAATAAGATTCAATGATACTGCTGGTTCAATGGCTAAGGATTCTGTATTTAATGCTGCATCTGTAATAAAAAGGCTAAC
TGATAAGGATATAAATGACTATGATATACATGTTAACGTAATTGGTGGAGGAAAGATAGATGGACCATCTGCTGGAGCTG
CCATTACCATATGTATAATGAGTGCTTTATTAGAAAAGCCAATAAGACAAGACTTAGCTATAACTGGAGAGATTTCTTTA
AGAGGAAAGATTAAACCAGTTGGAGGTATATTTGAAAAAATATACGGGGCTAGAAGAAAGGGAATTAAGTTAGTAACTGT
TCCTAAAGATAATGAAAATGAAATCCCTAAAGGATTAGAAGATATAGAAGTTAAAGCTATAAGTTCTATAGAAGAGCTTA
TGGAAATTGCTTTTAATTAA

Upstream 100 bases:

>100_bases
AGAAGTTTCAACAAAAATGAAGGTTATGGTTGTTCCTGTTCAATAAGAGGAGGATTCTATTTTGAAATCAATTAAAGAAT
TAGAGGTTCTACAAGATGTT

Downstream 100 bases:

>100_bases
AAATAAAGAACCTAGATTTATTTCTAGGTTTTTTATTTTGTCTTTTAAATTTACCTAGTATAAATAAAACTATAGGTTTT
TTACAAGATTTCATGTATTA

Product: ATP-dependent proteinase La

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 619; Mature: 619

Protein sequence:

>619_residues
MNSELGVESQVEALKDIINNILDEGAFRARVIRFKVQNYINSTDPYERLYGLSKIVSEGKGLSEVPTEETINEALEDVCA
MISDAIARRYVQNKIEKEVEQFLMEKQEKYVDELRVNIMKKKKGPENAKTEKKLEELEELDERVPNKNIMSLLRPDSFDE
VVGQERAVKSLLSKLASPYPQHIILYGPPGVGKTTAARIALETAKKLKSTPFDDRSKFIEVNGTTLRWDPREITNPLLGS
VHDPIYQGSKRDLAEIGVPEPKPGLVTEAHGGILFIDEIGELDEILQNKLLKVLEDKRVEFSSSYYDPDDENTPKYIKYL
FDKGAPADFVLIGATTREPGEINPALRSRCTEVYFEPLSSRDIEKIVLNAAKKLNVKLEEGLEKKIASYTIEGRRAVNIL
ADAYGHAIYGLEGEVPEDLEITSKDLNEVVSIGRFTPYEILENLEEKEVGHVYGLGVSGFLGSTIEIEATAFKAKKKGAG
KIRFNDTAGSMAKDSVFNAASVIKRLTDKDINDYDIHVNVIGGGKIDGPSAGAAITICIMSALLEKPIRQDLAITGEISL
RGKIKPVGGIFEKIYGARRKGIKLVTVPKDNENEIPKGLEDIEVKAISSIEELMEIAFN

Sequences:

>Translated_619_residues
MNSELGVESQVEALKDIINNILDEGAFRARVIRFKVQNYINSTDPYERLYGLSKIVSEGKGLSEVPTEETINEALEDVCA
MISDAIARRYVQNKIEKEVEQFLMEKQEKYVDELRVNIMKKKKGPENAKTEKKLEELEELDERVPNKNIMSLLRPDSFDE
VVGQERAVKSLLSKLASPYPQHIILYGPPGVGKTTAARIALETAKKLKSTPFDDRSKFIEVNGTTLRWDPREITNPLLGS
VHDPIYQGSKRDLAEIGVPEPKPGLVTEAHGGILFIDEIGELDEILQNKLLKVLEDKRVEFSSSYYDPDDENTPKYIKYL
FDKGAPADFVLIGATTREPGEINPALRSRCTEVYFEPLSSRDIEKIVLNAAKKLNVKLEEGLEKKIASYTIEGRRAVNIL
ADAYGHAIYGLEGEVPEDLEITSKDLNEVVSIGRFTPYEILENLEEKEVGHVYGLGVSGFLGSTIEIEATAFKAKKKGAG
KIRFNDTAGSMAKDSVFNAASVIKRLTDKDINDYDIHVNVIGGGKIDGPSAGAAITICIMSALLEKPIRQDLAITGEISL
RGKIKPVGGIFEKIYGARRKGIKLVTVPKDNENEIPKGLEDIEVKAISSIEELMEIAFN
>Mature_619_residues
MNSELGVESQVEALKDIINNILDEGAFRARVIRFKVQNYINSTDPYERLYGLSKIVSEGKGLSEVPTEETINEALEDVCA
MISDAIARRYVQNKIEKEVEQFLMEKQEKYVDELRVNIMKKKKGPENAKTEKKLEELEELDERVPNKNIMSLLRPDSFDE
VVGQERAVKSLLSKLASPYPQHIILYGPPGVGKTTAARIALETAKKLKSTPFDDRSKFIEVNGTTLRWDPREITNPLLGS
VHDPIYQGSKRDLAEIGVPEPKPGLVTEAHGGILFIDEIGELDEILQNKLLKVLEDKRVEFSSSYYDPDDENTPKYIKYL
FDKGAPADFVLIGATTREPGEINPALRSRCTEVYFEPLSSRDIEKIVLNAAKKLNVKLEEGLEKKIASYTIEGRRAVNIL
ADAYGHAIYGLEGEVPEDLEITSKDLNEVVSIGRFTPYEILENLEEKEVGHVYGLGVSGFLGSTIEIEATAFKAKKKGAG
KIRFNDTAGSMAKDSVFNAASVIKRLTDKDINDYDIHVNVIGGGKIDGPSAGAAITICIMSALLEKPIRQDLAITGEISL
RGKIKPVGGIFEKIYGARRKGIKLVTVPKDNENEIPKGLEDIEVKAISSIEELMEIAFN

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG1067

COG function: function code O; Predicted ATP-dependent protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S16 family [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=657, Percent_Identity=24.2009132420091, Blast_Score=100, Evalue=8e-21,
Organism=Homo sapiens, GI31377667, Length=612, Percent_Identity=25.4901960784314, Blast_Score=98, Evalue=2e-20,
Organism=Escherichia coli, GI1786643, Length=495, Percent_Identity=28.0808080808081, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1790850, Length=109, Percent_Identity=34.8623853211009, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789828, Length=156, Percent_Identity=33.974358974359, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17556486, Length=505, Percent_Identity=26.9306930693069, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17505831, Length=217, Percent_Identity=31.7972350230415, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319449, Length=80, Percent_Identity=41.25, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221513036, Length=190, Percent_Identity=34.7368421052632, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24666867, Length=190, Percent_Identity=34.7368421052632, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR020568
- InterPro:   IPR014251 [H]

Pfam domain/function: PF00004 AAA; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 68745; Mature: 68745

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4 ; PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSELGVESQVEALKDIINNILDEGAFRARVIRFKVQNYINSTDPYERLYGLSKIVSEGK
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
GLSEVPTEETINEALEDVCAMISDAIARRYVQNKIEKEVEQFLMEKQEKYVDELRVNIMK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKKGPENAKTEKKLEELEELDERVPNKNIMSLLRPDSFDEVVGQERAVKSLLSKLASPYP
HCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCC
QHIILYGPPGVGKTTAARIALETAKKLKSTPFDDRSKFIEVNGTTLRWDPREITNPLLGS
CEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEEECHHHHHHHHHHH
VHDPIYQGSKRDLAEIGVPEPKPGLVTEAHGGILFIDEIGELDEILQNKLLKVLEDKRVE
HCCHHHCCCCCCHHHCCCCCCCCCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHCCH
FSSSYYDPDDENTPKYIKYLFDKGAPADFVLIGATTREPGEINPALRSRCTEVYFEPLSS
HCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCC
RDIEKIVLNAAKKLNVKLEEGLEKKIASYTIEGRRAVNILADAYGHAIYGLEGEVPEDLE
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEECCCCCCCCCCH
ITSKDLNEVVSIGRFTPYEILENLEEKEVGHVYGLGVSGFLGSTIEIEATAFKAKKKGAG
HHHHHHHHHHHHCCCCHHHHHHCHHHHHCCEEEECCHHHHCCCEEEEEHHHHHHHCCCCC
KIRFNDTAGSMAKDSVFNAASVIKRLTDKDINDYDIHVNVIGGGKIDGPSAGAAITICIM
EEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHH
SALLEKPIRQDLAITGEISLRGKIKPVGGIFEKIYGARRKGIKLVTVPKDNENEIPKGLE
HHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCHH
DIEVKAISSIEELMEIAFN
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNSELGVESQVEALKDIINNILDEGAFRARVIRFKVQNYINSTDPYERLYGLSKIVSEGK
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
GLSEVPTEETINEALEDVCAMISDAIARRYVQNKIEKEVEQFLMEKQEKYVDELRVNIMK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKKGPENAKTEKKLEELEELDERVPNKNIMSLLRPDSFDEVVGQERAVKSLLSKLASPYP
HCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCC
QHIILYGPPGVGKTTAARIALETAKKLKSTPFDDRSKFIEVNGTTLRWDPREITNPLLGS
CEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEEECHHHHHHHHHHH
VHDPIYQGSKRDLAEIGVPEPKPGLVTEAHGGILFIDEIGELDEILQNKLLKVLEDKRVE
HCCHHHCCCCCCHHHCCCCCCCCCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHCCH
FSSSYYDPDDENTPKYIKYLFDKGAPADFVLIGATTREPGEINPALRSRCTEVYFEPLSS
HCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCC
RDIEKIVLNAAKKLNVKLEEGLEKKIASYTIEGRRAVNILADAYGHAIYGLEGEVPEDLE
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEECCCCCCCCCCH
ITSKDLNEVVSIGRFTPYEILENLEEKEVGHVYGLGVSGFLGSTIEIEATAFKAKKKGAG
HHHHHHHHHHHHCCCCHHHHHHCHHHHHCCEEEECCHHHHCCCEEEEEHHHHHHHCCCCC
KIRFNDTAGSMAKDSVFNAASVIKRLTDKDINDYDIHVNVIGGGKIDGPSAGAAITICIM
EEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHH
SALLEKPIRQDLAITGEISLRGKIKPVGGIFEKIYGARRKGIKLVTVPKDNENEIPKGLE
HHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCHH
DIEVKAISSIEELMEIAFN
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377; 7961402; 11325926 [H]