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The map label for this gene is dnaC [H]

Identifier: 18311616

GI number: 18311616

Start: 3007583

End: 3008917

Strand: Reverse

Name: dnaC [H]

Synonym: CPE2634

Alternate gene names: 18311616

Gene position: 3008917-3007583 (Counterclockwise)

Preceding gene: 18311617

Following gene: 18311615

Centisome position: 99.26

GC content: 34.46

Gene sequence:

>1335_bases
ATGGAAGCACCAGTAATGAAGAGTTTGCCACAAAGTATAGAAGCGGAACAATCTGTTTTAGGGGCAATGATAATAGATAG
AACAACCATAGCTCAAGCCGCTGAGGTTTTAAATAAGGATTCATTTTATAGAGATGCTCATAAGGTAATATTTCAAAGTA
TAATAGAAATGTACCAAAGAGATCAAGCCGTAGACCAATTAACTCTTTTAGAGTATTTAAAATCTACTGATAGACTTGAA
AAAGCCGGTGGTATAAGTTATGTAACAGAGATAAGTGCATCTGTACTTAGTACAGTTAACATAAAATCATACATAAAAAT
AGTTGATGAAAAAGCTATGCTTAGAAGACTTATAAAATCTTCTACAGAAATTATAGAGAATTGTTATAACAATCAAGAAG
ATGTTGAAAAAGTTATAGATTCAGCAGAGAAGAAAATATTTGATTTATCTGAAAAGAGATCATCAAATGATTTTGAACCT
TTAAGTGTTGTTCTTGAAAGAGGTTTTGAGCAAATAGAGGCTATATTTAATAATGAAGGAGAACTTACAGGTGTTGGTTC
TGGATTTAAAGACTTGGATGAGATGACCTCTGGATTCCAAAAGGGTGATATGGTGCTTATAGCAGCAAGACCATCTATGG
GTAAAACAACCTTTGCTCTTAACATAGCAGAACATGCTGCCTTAAGAGAGGGAAAGAGTGTTGTTATATTCTCTTTGGAA
ATGTCAAAGGAACAGCTTGCATATAAGTTATTATGTTCAGAGGCTAATGTAGATATGTTAAGTCTTAGAACAGGTAAATT
AACTCCTGAGGATTGGGACAATATAGCTAGAGCATCAGGCCCTTTAGCATCAGCTAAGATATACATAGATGATACTGCTG
GGGTTTCTGTAATGGAAATGAGATCTAAGTGTAGAAGATTAAAAATGGAATATGGAATAGATCTTATACTTATAGACTAC
TTACAACTTATGAGTGGAAGTGGTGAAAGTAGACAACAAGAGGTTGCGGAGATTTCAAGAAATATAAAAGCTATAGCTAA
GGAGATGGAATGTCCAGTTATAGCATTATCTCAGCTTTCTCGTGCTCCAGAGCAAAGAGCAGACCATAGACCTATGTTAT
CTGACCTTAGAGAATCTGGATCAATAGAGCAGGATGCTGACCTTGTTATGTTCTTATATAGAGATGAGTACTATAACAAG
GAAACAGAAGATAAAAATGTTGGAGAATGTATAATAGCTAAGCAAAGAAACGGTCCAGTTGGAACAGTTAAGCTTGCATG
GCTTGGTCAATACAGTAAATTTGCAGATTATGAAGCTATTCATAAGGATGTTTAA

Upstream 100 bases:

>100_bases
TATAAAAAGTTTAAGAAAAGTTTATAAGGTTTAAAATATCTTATAAACTTTTAATGATATTAGAAAATTATTTTAAGGGA
AAGGAGGAAAATTAGGAATA

Downstream 100 bases:

>100_bases
TAAATTTAGGGTGTATCAGAATGCTGATATGCCCTTTAATTTTATTATTGGTAGCTACATATTAAAAGGTATATAATAAT
TAAAGTATTTATAATTAGAT

Product: replicative DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MEAPVMKSLPQSIEAEQSVLGAMIIDRTTIAQAAEVLNKDSFYRDAHKVIFQSIIEMYQRDQAVDQLTLLEYLKSTDRLE
KAGGISYVTEISASVLSTVNIKSYIKIVDEKAMLRRLIKSSTEIIENCYNNQEDVEKVIDSAEKKIFDLSEKRSSNDFEP
LSVVLERGFEQIEAIFNNEGELTGVGSGFKDLDEMTSGFQKGDMVLIAARPSMGKTTFALNIAEHAALREGKSVVIFSLE
MSKEQLAYKLLCSEANVDMLSLRTGKLTPEDWDNIARASGPLASAKIYIDDTAGVSVMEMRSKCRRLKMEYGIDLILIDY
LQLMSGSGESRQQEVAEISRNIKAIAKEMECPVIALSQLSRAPEQRADHRPMLSDLRESGSIEQDADLVMFLYRDEYYNK
ETEDKNVGECIIAKQRNGPVGTVKLAWLGQYSKFADYEAIHKDV

Sequences:

>Translated_444_residues
MEAPVMKSLPQSIEAEQSVLGAMIIDRTTIAQAAEVLNKDSFYRDAHKVIFQSIIEMYQRDQAVDQLTLLEYLKSTDRLE
KAGGISYVTEISASVLSTVNIKSYIKIVDEKAMLRRLIKSSTEIIENCYNNQEDVEKVIDSAEKKIFDLSEKRSSNDFEP
LSVVLERGFEQIEAIFNNEGELTGVGSGFKDLDEMTSGFQKGDMVLIAARPSMGKTTFALNIAEHAALREGKSVVIFSLE
MSKEQLAYKLLCSEANVDMLSLRTGKLTPEDWDNIARASGPLASAKIYIDDTAGVSVMEMRSKCRRLKMEYGIDLILIDY
LQLMSGSGESRQQEVAEISRNIKAIAKEMECPVIALSQLSRAPEQRADHRPMLSDLRESGSIEQDADLVMFLYRDEYYNK
ETEDKNVGECIIAKQRNGPVGTVKLAWLGQYSKFADYEAIHKDV
>Mature_444_residues
MEAPVMKSLPQSIEAEQSVLGAMIIDRTTIAQAAEVLNKDSFYRDAHKVIFQSIIEMYQRDQAVDQLTLLEYLKSTDRLE
KAGGISYVTEISASVLSTVNIKSYIKIVDEKAMLRRLIKSSTEIIENCYNNQEDVEKVIDSAEKKIFDLSEKRSSNDFEP
LSVVLERGFEQIEAIFNNEGELTGVGSGFKDLDEMTSGFQKGDMVLIAARPSMGKTTFALNIAEHAALREGKSVVIFSLE
MSKEQLAYKLLCSEANVDMLSLRTGKLTPEDWDNIARASGPLASAKIYIDDTAGVSVMEMRSKCRRLKMEYGIDLILIDY
LQLMSGSGESRQQEVAEISRNIKAIAKEMECPVIALSQLSRAPEQRADHRPMLSDLRESGSIEQDADLVMFLYRDEYYNK
ETEDKNVGECIIAKQRNGPVGTVKLAWLGQYSKFADYEAIHKDV

Specific function: Participates In Initiation And Elongation During Chromosome Replication; It Exhibits DNA-Dependent ATPase Activity And Contains Distinct Active Sites For ATP Binding, DNA Binding, And Interaction With DNAc Protein, Primase, And Other Prepriming Proteins.

COG id: COG0305

COG function: function code L; Replicative DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SF4 helicase domain [H]

Homologues:

Organism=Escherichia coli, GI1790486, Length=446, Percent_Identity=45.2914798206278, Blast_Score=388, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR007692
- InterPro:   IPR007694
- InterPro:   IPR007693
- InterPro:   IPR016136 [H]

Pfam domain/function: PF00772 DnaB; PF03796 DnaB_C [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 49791; Mature: 49791

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS50162 RECA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAPVMKSLPQSIEAEQSVLGAMIIDRTTIAQAAEVLNKDSFYRDAHKVIFQSIIEMYQR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
DQAVDQLTLLEYLKSTDRLEKAGGISYVTEISASVLSTVNIKSYIKIVDEKAMLRRLIKS
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STEIIENCYNNQEDVEKVIDSAEKKIFDLSEKRSSNDFEPLSVVLERGFEQIEAIFNNEG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
ELTGVGSGFKDLDEMTSGFQKGDMVLIAARPSMGKTTFALNIAEHAALREGKSVVIFSLE
CEEECCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEHHHHHHHHCCCEEEEEEEC
MSKEQLAYKLLCSEANVDMLSLRTGKLTPEDWDNIARASGPLASAKIYIDDTAGVSVMEM
CCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCHHHHH
RSKCRRLKMEYGIDLILIDYLQLMSGSGESRQQEVAEISRNIKAIAKEMECPVIALSQLS
HHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
RAPEQRADHRPMLSDLRESGSIEQDADLVMFLYRDEYYNKETEDKNVGECIIAKQRNGPV
CCHHHHCCCCHHHHHHHHCCCCCCCCCEEEEEEHHHHCCCCCCCCCCCCEEEEECCCCCC
GTVKLAWLGQYSKFADYEAIHKDV
CEEEEEECCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MEAPVMKSLPQSIEAEQSVLGAMIIDRTTIAQAAEVLNKDSFYRDAHKVIFQSIIEMYQR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
DQAVDQLTLLEYLKSTDRLEKAGGISYVTEISASVLSTVNIKSYIKIVDEKAMLRRLIKS
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STEIIENCYNNQEDVEKVIDSAEKKIFDLSEKRSSNDFEPLSVVLERGFEQIEAIFNNEG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
ELTGVGSGFKDLDEMTSGFQKGDMVLIAARPSMGKTTFALNIAEHAALREGKSVVIFSLE
CEEECCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEHHHHHHHHCCCEEEEEEEC
MSKEQLAYKLLCSEANVDMLSLRTGKLTPEDWDNIARASGPLASAKIYIDDTAGVSVMEM
CCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCHHHHH
RSKCRRLKMEYGIDLILIDYLQLMSGSGESRQQEVAEISRNIKAIAKEMECPVIALSQLS
HHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
RAPEQRADHRPMLSDLRESGSIEQDADLVMFLYRDEYYNKETEDKNVGECIIAKQRNGPV
CCHHHHCCCCHHHHHHHHCCCCCCCCCEEEEEEHHHHCCCCCCCCCCCCEEEEECCCCCC
GTVKLAWLGQYSKFADYEAIHKDV
CEEEEEECCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 1312531 [H]