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The map label for this gene is sdhA [H]

Identifier: 18311606

GI number: 18311606

Start: 2999253

End: 3000134

Strand: Direct

Name: sdhA [H]

Synonym: CPE2624

Alternate gene names: 18311606

Gene position: 2999253-3000134 (Clockwise)

Preceding gene: 18311605

Following gene: 18311607

Centisome position: 98.94

GC content: 37.07

Gene sequence:

>882_bases
ATGATTGCAAGAAGTGGTGCTGAATTATTAGAAATATGTAGAGAGAATAATTTCTCCTTAGCTGAATACGCTATTCAATA
TGAAATGGAAAGTAAAAACTGTACTAGAGAAGATGTAATAAAAGGTATGGAAAAAGTTCTTCAAGTTATGAAAGAGGCAG
CTAATGAAGGGCAAGAAAAAGAAGTTTATTCTGTAAGTGGATTAATTGGCGGAGATGCTTATAAATTAAAAAAATACTTA
GAAAAAGGGGATACTTTAACTGGGAATGTTATGGTTGGCGCTATGGCAAGAGCCTTATCTTGTTCAGAAGTAAATGCTTC
TATGGGAAGAATAGTGGCATGCCCAACAGCTGGTTCTTGCGGAATATTACCAGCTGTAATATTAACTGTAGGAGAAAGAT
TAAATCTAAGTGATGAAGAACTTATTCAAGGTTTATTAGCATCCTCTGCTGTAGGTATGATAATTGCGCAAAATGCAACA
TTAGCCGGTGCTGAAGGTGGATGCCAAGCTGAATGTGGGTCTGCTGCTGCTATGGGAGCTGCTGCCACTGTAGAAATGAT
GGGTGGAACTCCAGAAATGGCTTTAGATGCTGGGGCAATAGTATTTAAAAATATACTTGGTCTAGTTTGTGATCCAATAG
CTGGCTTAGTAGAAGTACCTTGTGCTAAAAGAAATTTTGCAGGAGCAGTTAGCGCCTTAACAACTGCCGACTTAGTTATG
GCAGGCATACATAGCAAGATACCTTTTGATGATACAGTTGAAGCTATGTATAGAGTAGGAAAATCTTTACCTGCTTCTCT
AAGAGAAACCGCCTTAGGTGGTTTAGCAATTACTAAAACAGGACTTAAATTAAAAGAAAAAGTTTTTGGTAAAGATAAAT
AA

Upstream 100 bases:

>100_bases
AATGGATAGCCCTATTACAAAGGACATTATTGATGAAATTAAGAAAGTTGAAGCTGTTGAAAAACTAGTTGTTATAAACC
CAGTAAAGGAGGATATTTAG

Downstream 100 bases:

>100_bases
TTCTTTTTTAATGAGCATATGTAATTATATATGCTCATTTTATTTTTAAATAATTAGCATTCAATATTAATATACGCTTT
TTAATTTTATATTGGTATTT

Product: L-serine dehydratase alpha subunit

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MIARSGAELLEICRENNFSLAEYAIQYEMESKNCTREDVIKGMEKVLQVMKEAANEGQEKEVYSVSGLIGGDAYKLKKYL
EKGDTLTGNVMVGAMARALSCSEVNASMGRIVACPTAGSCGILPAVILTVGERLNLSDEELIQGLLASSAVGMIIAQNAT
LAGAEGGCQAECGSAAAMGAAATVEMMGGTPEMALDAGAIVFKNILGLVCDPIAGLVEVPCAKRNFAGAVSALTTADLVM
AGIHSKIPFDDTVEAMYRVGKSLPASLRETALGGLAITKTGLKLKEKVFGKDK

Sequences:

>Translated_293_residues
MIARSGAELLEICRENNFSLAEYAIQYEMESKNCTREDVIKGMEKVLQVMKEAANEGQEKEVYSVSGLIGGDAYKLKKYL
EKGDTLTGNVMVGAMARALSCSEVNASMGRIVACPTAGSCGILPAVILTVGERLNLSDEELIQGLLASSAVGMIIAQNAT
LAGAEGGCQAECGSAAAMGAAATVEMMGGTPEMALDAGAIVFKNILGLVCDPIAGLVEVPCAKRNFAGAVSALTTADLVM
AGIHSKIPFDDTVEAMYRVGKSLPASLRETALGGLAITKTGLKLKEKVFGKDK
>Mature_293_residues
MIARSGAELLEICRENNFSLAEYAIQYEMESKNCTREDVIKGMEKVLQVMKEAANEGQEKEVYSVSGLIGGDAYKLKKYL
EKGDTLTGNVMVGAMARALSCSEVNASMGRIVACPTAGSCGILPAVILTVGERLNLSDEELIQGLLASSAVGMIIAQNAT
LAGAEGGCQAECGSAAAMGAAATVEMMGGTPEMALDAGAIVFKNILGLVCDPIAGLVEVPCAKRNFAGAVSALTTADLVM
AGIHSKIPFDDTVEAMYRVGKSLPASLRETALGGLAITKTGLKLKEKVFGKDK

Specific function: Anaerobic degradation of L-threonine to propionate. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI48994925, Length=285, Percent_Identity=34.0350877192982, Blast_Score=160, Evalue=8e-41,
Organism=Escherichia coli, GI1788116, Length=285, Percent_Identity=34.7368421052632, Blast_Score=157, Evalue=7e-40,
Organism=Escherichia coli, GI1789161, Length=284, Percent_Identity=33.8028169014084, Blast_Score=144, Evalue=9e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005130
- InterPro:   IPR004642 [H]

Pfam domain/function: PF03313 SDH_alpha [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 30467; Mature: 30467

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIARSGAELLEICRENNFSLAEYAIQYEMESKNCTREDVIKGMEKVLQVMKEAANEGQEK
CCCCCHHHHHHHHHCCCCCHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCH
EVYSVSGLIGGDAYKLKKYLEKGDTLTGNVMVGAMARALSCSEVNASMGRIVACPTAGSC
HHHHHHCCCCCHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCC
GILPAVILTVGERLNLSDEELIQGLLASSAVGMIIAQNATLAGAEGGCQAECGSAAAMGA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEEECCCEEECCCCCCCCCCCCHHHHHH
AATVEMMGGTPEMALDAGAIVFKNILGLVCDPIAGLVEVPCAKRNFAGAVSALTTADLVM
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
AGIHSKIPFDDTVEAMYRVGKSLPASLRETALGGLAITKTGLKLKEKVFGKDK
HHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCEEEECCCHHHHHHHCCCCC
>Mature Secondary Structure
MIARSGAELLEICRENNFSLAEYAIQYEMESKNCTREDVIKGMEKVLQVMKEAANEGQEK
CCCCCHHHHHHHHHCCCCCHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCH
EVYSVSGLIGGDAYKLKKYLEKGDTLTGNVMVGAMARALSCSEVNASMGRIVACPTAGSC
HHHHHHCCCCCHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCC
GILPAVILTVGERLNLSDEELIQGLLASSAVGMIIAQNATLAGAEGGCQAECGSAAAMGA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEEECCCEEECCCCCCCCCCCCHHHHHH
AATVEMMGGTPEMALDAGAIVFKNILGLVCDPIAGLVEVPCAKRNFAGAVSALTTADLVM
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
AGIHSKIPFDDTVEAMYRVGKSLPASLRETALGGLAITKTGLKLKEKVFGKDK
HHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCEEEECCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]