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The map label for this gene is proA [H]

Identifier: 18311560

GI number: 18311560

Start: 2953420

End: 2954667

Strand: Reverse

Name: proA [H]

Synonym: CPE2578

Alternate gene names: 18311560

Gene position: 2954667-2953420 (Counterclockwise)

Preceding gene: 18311561

Following gene: 18311559

Centisome position: 97.47

GC content: 30.93

Gene sequence:

>1248_bases
ATGAATAATGAACTTATTATAAAAGGTAAAAAAGCAAAAGAAGCTTCTTACACACTTTCATTTGCATCTACTAATGAAAA
AGATAATGGATTATTAAAAATAAGTGAATTCTTAATAAAAAGATGTGATGAGATATTAGAAGAAAATAAAAAAGATCTTG
AAAAGGCAATTGAAAAGGGAACATCTAATGCAATGCTTGATAGATTAAAATTAGATGAGGAAAGAGTAAAATCTATAGCA
AATGCTGTAGCAGATGTTGTTAAATTAGATGATCCAATAGGAGAAGTTACATCTATGTTTAAGAGACCTAATGGTCTTAG
AATAGGTGTACAAAGAGTTCCATTAGGAGTAGTTGGAATAATATATGAAGCAAGACCTAATGTAACTGCTGATGCTGCTG
CCCTATGTTTAAAAACAGGAAACGCTGTTATTTTAAGAGGAGGAAGTGAGGCTATAAATTCTAACTTAAAAATAGTTGAA
ATTATTAGTGATGCCTTAAAGGAAGCAGGACTTCCAGAGGGATCAGTTCAAATATTAGAGGATACTTCAAGAGAAACTGC
TACAGATTTTATGAGATTAAATGACTATTTAGATGTTTTAATTCCAAGAGGTGGAGCAGGACTTATAAAGGCCGTAGTAA
ATAATGCAACAGTACCTGTAATAGAGACTGGAGTTGGAAATTGTCATATATACATAGATGATGAAGCAGATATAAATATG
GGAGTAGATATAATAGTAAATGCTAAAACATCAAGACCTGCTGTATGTAATGCTGCTGAAAAACTATTAGTTAATGAAAA
AATTGCAGAGGAATTCTTACCAGTAGCAATAAAGGCTTTAAAAGAAAAAGGCGTTGAAATAAGAGGATGTGAAAAAACTA
AGGCAATTGTGAATGATATAAACTTAGCAACTGAAGAGGATTGGGGAAAAGAATATTTAGACTATATCCTTGGAGTTAAG
GTTGTTAAAGATTTAGATGAGGCTATCTCTCATATAAATAAATATGGAACAAAACATTCAGAATCAATAGTTACTAAAAA
TTATTTTAATTCAGAGAAATTCCTTCAAAGAGTTGATGCAGCTGCTGTATATGTAAATGCTTCAACAAGATTTACTGATG
GTGGAGAATTTGGATTTGGTGCTGAAATTGGAATAAGTACACAAAAGTTACATGCTAGAGGACCAATGGGACTTAAGGAA
TTAACAACAAATAAGTATATAATTTATGGAAATGGTCAAATTAGATAA

Upstream 100 bases:

>100_bases
ATATGATTTTAGCTAATGGAGAAAATCCAGAAATATTAATTGACATATTAAATGGTGAAGATATAGGAACTATGTTTGTA
GCTAAGAAGGGGGAATAAAA

Downstream 100 bases:

>100_bases
TTTATATAATCTTATAAAATTAAATTTCATATATTAAAGAAATATTTTAGGTGTTTAAGGGTAAGAGATTTTAATTTATG
AAAAAAGGAAGTATGGGAAA

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MNNELIIKGKKAKEASYTLSFASTNEKDNGLLKISEFLIKRCDEILEENKKDLEKAIEKGTSNAMLDRLKLDEERVKSIA
NAVADVVKLDDPIGEVTSMFKRPNGLRIGVQRVPLGVVGIIYEARPNVTADAAALCLKTGNAVILRGGSEAINSNLKIVE
IISDALKEAGLPEGSVQILEDTSRETATDFMRLNDYLDVLIPRGGAGLIKAVVNNATVPVIETGVGNCHIYIDDEADINM
GVDIIVNAKTSRPAVCNAAEKLLVNEKIAEEFLPVAIKALKEKGVEIRGCEKTKAIVNDINLATEEDWGKEYLDYILGVK
VVKDLDEAISHINKYGTKHSESIVTKNYFNSEKFLQRVDAAAVYVNASTRFTDGGEFGFGAEIGISTQKLHARGPMGLKE
LTTNKYIIYGNGQIR

Sequences:

>Translated_415_residues
MNNELIIKGKKAKEASYTLSFASTNEKDNGLLKISEFLIKRCDEILEENKKDLEKAIEKGTSNAMLDRLKLDEERVKSIA
NAVADVVKLDDPIGEVTSMFKRPNGLRIGVQRVPLGVVGIIYEARPNVTADAAALCLKTGNAVILRGGSEAINSNLKIVE
IISDALKEAGLPEGSVQILEDTSRETATDFMRLNDYLDVLIPRGGAGLIKAVVNNATVPVIETGVGNCHIYIDDEADINM
GVDIIVNAKTSRPAVCNAAEKLLVNEKIAEEFLPVAIKALKEKGVEIRGCEKTKAIVNDINLATEEDWGKEYLDYILGVK
VVKDLDEAISHINKYGTKHSESIVTKNYFNSEKFLQRVDAAAVYVNASTRFTDGGEFGFGAEIGISTQKLHARGPMGLKE
LTTNKYIIYGNGQIR
>Mature_415_residues
MNNELIIKGKKAKEASYTLSFASTNEKDNGLLKISEFLIKRCDEILEENKKDLEKAIEKGTSNAMLDRLKLDEERVKSIA
NAVADVVKLDDPIGEVTSMFKRPNGLRIGVQRVPLGVVGIIYEARPNVTADAAALCLKTGNAVILRGGSEAINSNLKIVE
IISDALKEAGLPEGSVQILEDTSRETATDFMRLNDYLDVLIPRGGAGLIKAVVNNATVPVIETGVGNCHIYIDDEADINM
GVDIIVNAKTSRPAVCNAAEKLLVNEKIAEEFLPVAIKALKEKGVEIRGCEKTKAIVNDINLATEEDWGKEYLDYILGVK
VVKDLDEAISHINKYGTKHSESIVTKNYFNSEKFLQRVDAAAVYVNASTRFTDGGEFGFGAEIGISTQKLHARGPMGLKE
LTTNKYIIYGNGQIR

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361368, Length=410, Percent_Identity=34.1463414634146, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI62912457, Length=410, Percent_Identity=34.1463414634146, Blast_Score=239, Evalue=3e-63,
Organism=Escherichia coli, GI1786438, Length=418, Percent_Identity=49.0430622009569, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1787493, Length=150, Percent_Identity=30.6666666666667, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17569967, Length=410, Percent_Identity=33.1707317073171, Blast_Score=241, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI17569969, Length=410, Percent_Identity=33.1707317073171, Blast_Score=241, Evalue=6e-64,
Organism=Saccharomyces cerevisiae, GI6324899, Length=427, Percent_Identity=36.768149882904, Blast_Score=280, Evalue=3e-76,
Organism=Drosophila melanogaster, GI21357643, Length=408, Percent_Identity=32.3529411764706, Blast_Score=238, Evalue=5e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 45301; Mature: 45301

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNELIIKGKKAKEASYTLSFASTNEKDNGLLKISEFLIKRCDEILEENKKDLEKAIEKG
CCCCEEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
TSNAMLDRLKLDEERVKSIANAVADVVKLDDPIGEVTSMFKRPNGLRIGVQRVPLGVVGI
CCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEHEECCCEEEEE
IYEARPNVTADAAALCLKTGNAVILRGGSEAINSNLKIVEIISDALKEAGLPEGSVQILE
EEECCCCCCHHHHHHHEECCCEEEEECCHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEE
DTSRETATDFMRLNDYLDVLIPRGGAGLIKAVVNNATVPVIETGVGNCHIYIDDEADINM
CCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHCCCCCEEEECCCCEEEEEECCCCCCCC
GVDIIVNAKTSRPAVCNAAEKLLVNEKIAEEFLPVAIKALKEKGVEIRGCEKTKAIVNDI
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHC
NLATEEDWGKEYLDYILGVKVVKDLDEAISHINKYGTKHSESIVTKNYFNSEKFLQRVDA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHCC
AAVYVNASTRFTDGGEFGFGAEIGISTQKLHARGPMGLKELTTNKYIIYGNGQIR
EEEEEECCCEECCCCCCCCCCEECCCHHHHHCCCCCCHHHHCCCCEEEECCCEEC
>Mature Secondary Structure
MNNELIIKGKKAKEASYTLSFASTNEKDNGLLKISEFLIKRCDEILEENKKDLEKAIEKG
CCCCEEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
TSNAMLDRLKLDEERVKSIANAVADVVKLDDPIGEVTSMFKRPNGLRIGVQRVPLGVVGI
CCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEHEECCCEEEEE
IYEARPNVTADAAALCLKTGNAVILRGGSEAINSNLKIVEIISDALKEAGLPEGSVQILE
EEECCCCCCHHHHHHHEECCCEEEEECCHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEE
DTSRETATDFMRLNDYLDVLIPRGGAGLIKAVVNNATVPVIETGVGNCHIYIDDEADINM
CCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHCCCCCEEEECCCCEEEEEECCCCCCCC
GVDIIVNAKTSRPAVCNAAEKLLVNEKIAEEFLPVAIKALKEKGVEIRGCEKTKAIVNDI
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHC
NLATEEDWGKEYLDYILGVKVVKDLDEAISHINKYGTKHSESIVTKNYFNSEKFLQRVDA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHCC
AAVYVNASTRFTDGGEFGFGAEIGISTQKLHARGPMGLKELTTNKYIIYGNGQIR
EEEEEECCCEECCCCCCCCCCEECCCHHHHHCCCCCCHHHHCCCCEEEECCCEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA