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The map label for this gene is glpK [H]

Identifier: 18311534

GI number: 18311534

Start: 2922805

End: 2924307

Strand: Reverse

Name: glpK [H]

Synonym: CPE2552

Alternate gene names: 18311534

Gene position: 2924307-2922805 (Counterclockwise)

Preceding gene: 18311535

Following gene: 18311533

Centisome position: 96.47

GC content: 33.4

Gene sequence:

>1503_bases
ATGAAAAAATATATAGTAGCATTAGATCAAGGAACAACAAGCTCTAGAGCAATAATTTTTGATAAAGAACAAAATATTAT
TGGGGTAAGCCAAAAGGAATTTAATCAAATTTATCCTAGAGAAGGATGGGTTGAGCATGATCCAATGGAAATATGGGCAA
CTCAATATAGTGTACTTCAAGAAGTTATGGCTAAATGTAATATAACTCAAGAAAATATAGCAGCCATTGGAATAACTAAC
CAAAGAGAAACTACAATAGTTTGGGACAAAAATACAGGGGTTCCAATATACAATGCAATTGTTTGGCAATGTAGAAGAAC
TGCTGATATATGCGATGAGTTAAAAGAAAGAGATGGACTTGTAGACTATATTAGAGAAAATACAGGACTTGTACTTGATG
CATATTTTTCAGGAACAAAAATAAAATGGATATTAGATAATGTTGAAGGTGCAAGAGAAAAAGCTGAAAAGGGTGAGCTT
TTATTTGGTACAGTAGATAGTTGGCTTGTTTGGAAGCTTACAAATGGAAAAGTTCATGTAACTGATTATACTAATGCATC
TAGAACTATGATATTTAACATAAAGAACCTTCAATGGGATGAAAGAATGTTAAAGGAACTAGACATTCCTAGAAGTATGT
TACCAGAAGTAAAAAATTCATCTGAAATTTACGGATATGCAAACCTTGGAGCAAAAGGTGGAATAAGAGTTCCTATAGCT
GGAATAGCTGGGGACCAACAAGCTGCTTTATTTGGACAAGCTGCATTTAATAAAGGTGACGTAAAAAATACTTATGGAAC
AGGATGTTTCTTATTAATGAACACAGGAGAAGAACTTGTTAAAAGTAAATCAGGACTTTTAACAACAATAGCTATTGGAT
TACACGGAAAAGTTCAATATGCTTTAGAAGGATCAGTATTTGTTGGAGGAGCTGTTATCCAATGGCTTAGAGATGAATTA
AGAATAATAAGTGATTCTAGTGATACTGAATACTTTGCTACAAAGGTAGAAGATAATGGTGGAGTATATGTTGTTCCTGC
CTTCGTTGGATTAGGAGCTCCTTATTGGGATATGTATGCTCGTGGAACTATAGTAGGATTAACACGTGGAACTAATAGAA
ATCATATAATAAGAGCAGCACTTGAATCAATTGCATATCAAACAAGAGATGTGCTTGAAGCTATGATAAACGATGTTGGA
TATGATATAAATTGTATAAAAGTAGATGGAGGAGCAAGTAGAAATAATTTCTTAATGCAATTCCAATCAGATTTAGTTGG
TAAAAAGGTAATTAAGCCTATAATTACAGAAACAACAGCTTTAGGAGCTGCTTACCTTGCAGGACTAGCAGTTGGTTACT
GGAGTGATAAAGAAGAAATAGCTAAGTTATGGTTTGCAAGTGAAGAATTTGAGCCAACTATTTCTGAAGAGAGAAGAAAT
AAATATCATAAGAAATGGAAAAAGGCTGTTGAAAGATCAAAGGGATGGGCACTTGAAGATTAA

Upstream 100 bases:

>100_bases
GATAAAGAGGATGTCATGGAAGCTTTAAGATCAGGAGCAACATGTATATCAACAACAAAAGAGGATATATGGAAGATATA
AAATTAAGAGGTGAGTTTTT

Downstream 100 bases:

>100_bases
AAAAAGTCTGGAAACATTTACAGAAATATGATATAATTAAATAAAAGTTAATAAATAATTTTAATTTTGTGTGTAAGAGA
GAAGAGAGCTAGACACAAAA

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MKKYIVALDQGTTSSRAIIFDKEQNIIGVSQKEFNQIYPREGWVEHDPMEIWATQYSVLQEVMAKCNITQENIAAIGITN
QRETTIVWDKNTGVPIYNAIVWQCRRTADICDELKERDGLVDYIRENTGLVLDAYFSGTKIKWILDNVEGAREKAEKGEL
LFGTVDSWLVWKLTNGKVHVTDYTNASRTMIFNIKNLQWDERMLKELDIPRSMLPEVKNSSEIYGYANLGAKGGIRVPIA
GIAGDQQAALFGQAAFNKGDVKNTYGTGCFLLMNTGEELVKSKSGLLTTIAIGLHGKVQYALEGSVFVGGAVIQWLRDEL
RIISDSSDTEYFATKVEDNGGVYVVPAFVGLGAPYWDMYARGTIVGLTRGTNRNHIIRAALESIAYQTRDVLEAMINDVG
YDINCIKVDGGASRNNFLMQFQSDLVGKKVIKPIITETTALGAAYLAGLAVGYWSDKEEIAKLWFASEEFEPTISEERRN
KYHKKWKKAVERSKGWALED

Sequences:

>Translated_500_residues
MKKYIVALDQGTTSSRAIIFDKEQNIIGVSQKEFNQIYPREGWVEHDPMEIWATQYSVLQEVMAKCNITQENIAAIGITN
QRETTIVWDKNTGVPIYNAIVWQCRRTADICDELKERDGLVDYIRENTGLVLDAYFSGTKIKWILDNVEGAREKAEKGEL
LFGTVDSWLVWKLTNGKVHVTDYTNASRTMIFNIKNLQWDERMLKELDIPRSMLPEVKNSSEIYGYANLGAKGGIRVPIA
GIAGDQQAALFGQAAFNKGDVKNTYGTGCFLLMNTGEELVKSKSGLLTTIAIGLHGKVQYALEGSVFVGGAVIQWLRDEL
RIISDSSDTEYFATKVEDNGGVYVVPAFVGLGAPYWDMYARGTIVGLTRGTNRNHIIRAALESIAYQTRDVLEAMINDVG
YDINCIKVDGGASRNNFLMQFQSDLVGKKVIKPIITETTALGAAYLAGLAVGYWSDKEEIAKLWFASEEFEPTISEERRN
KYHKKWKKAVERSKGWALED
>Mature_500_residues
MKKYIVALDQGTTSSRAIIFDKEQNIIGVSQKEFNQIYPREGWVEHDPMEIWATQYSVLQEVMAKCNITQENIAAIGITN
QRETTIVWDKNTGVPIYNAIVWQCRRTADICDELKERDGLVDYIRENTGLVLDAYFSGTKIKWILDNVEGAREKAEKGEL
LFGTVDSWLVWKLTNGKVHVTDYTNASRTMIFNIKNLQWDERMLKELDIPRSMLPEVKNSSEIYGYANLGAKGGIRVPIA
GIAGDQQAALFGQAAFNKGDVKNTYGTGCFLLMNTGEELVKSKSGLLTTIAIGLHGKVQYALEGSVFVGGAVIQWLRDEL
RIISDSSDTEYFATKVEDNGGVYVVPAFVGLGAPYWDMYARGTIVGLTRGTNRNHIIRAALESIAYQTRDVLEAMINDVG
YDINCIKVDGGASRNNFLMQFQSDLVGKKVIKPIITETTALGAAYLAGLAVGYWSDKEEIAKLWFASEEFEPTISEERRN
KYHKKWKKAVERSKGWALED

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=503, Percent_Identity=48.7077534791253, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI4504007, Length=503, Percent_Identity=48.7077534791253, Blast_Score=455, Evalue=1e-128,
Organism=Homo sapiens, GI42794763, Length=507, Percent_Identity=48.1262327416174, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI41393575, Length=502, Percent_Identity=47.4103585657371, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI88196792, Length=508, Percent_Identity=33.6614173228346, Blast_Score=322, Evalue=7e-88,
Organism=Escherichia coli, GI1790361, Length=499, Percent_Identity=68.937875751503, Blast_Score=730, Evalue=0.0,
Organism=Escherichia coli, GI1787789, Length=486, Percent_Identity=25.3086419753086, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790005, Length=504, Percent_Identity=22.6190476190476, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789987, Length=463, Percent_Identity=23.3261339092873, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1789168, Length=507, Percent_Identity=23.6686390532544, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17535599, Length=505, Percent_Identity=41.7821782178218, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI71986140, Length=525, Percent_Identity=26.2857142857143, Blast_Score=185, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI71986147, Length=267, Percent_Identity=33.3333333333333, Blast_Score=141, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6321755, Length=548, Percent_Identity=38.3211678832117, Blast_Score=326, Evalue=6e-90,
Organism=Drosophila melanogaster, GI17864214, Length=509, Percent_Identity=45.5795677799607, Blast_Score=423, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24655555, Length=502, Percent_Identity=42.4302788844622, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24655560, Length=502, Percent_Identity=42.4302788844622, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24655570, Length=502, Percent_Identity=42.4302788844622, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24655574, Length=502, Percent_Identity=42.4302788844622, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24655565, Length=502, Percent_Identity=42.4302788844622, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24654573, Length=437, Percent_Identity=47.5972540045767, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI19922058, Length=527, Percent_Identity=33.5863377609108, Blast_Score=295, Evalue=6e-80,
Organism=Drosophila melanogaster, GI24652871, Length=493, Percent_Identity=34.2799188640974, Blast_Score=281, Evalue=9e-76,
Organism=Drosophila melanogaster, GI24656367, Length=514, Percent_Identity=28.4046692607004, Blast_Score=224, Evalue=7e-59,
Organism=Drosophila melanogaster, GI21357867, Length=529, Percent_Identity=27.9773156899811, Blast_Score=219, Evalue=5e-57,
Organism=Drosophila melanogaster, GI24656372, Length=361, Percent_Identity=31.0249307479224, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI45552909, Length=302, Percent_Identity=29.1390728476821, Blast_Score=129, Evalue=5e-30,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 56002; Mature: 56002

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKYIVALDQGTTSSRAIIFDKEQNIIGVSQKEFNQIYPREGWVEHDPMEIWATQYSVLQ
CCCEEEEEECCCCCCEEEEEECCCCEEECCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
EVMAKCNITQENIAAIGITNQRETTIVWDKNTGVPIYNAIVWQCRRTADICDELKERDGL
HHHHHCCCCHHHEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCH
VDYIRENTGLVLDAYFSGTKIKWILDNVEGAREKAEKGELLFGTVDSWLVWKLTNGKVHV
HHHHHCCCCEEEEEEECCCEEEEEEECCHHHHHHHHCCCEEEEECCCEEEEEEECCEEEE
TDYTNASRTMIFNIKNLQWDERMLKELDIPRSMLPEVKNSSEIYGYANLGAKGGIRVPIA
EECCCCCEEEEEEECCCCHHHHHHHHCCCCHHHHHCCCCCCCEEEEECCCCCCCEEEEEE
GIAGDQQAALFGQAAFNKGDVKNTYGTGCFLLMNTGEELVKSKSGLLTTIAIGLHGKVQY
ECCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHCCCCCEEEEEEECCCEEEE
ALEGSVFVGGAVIQWLRDELRIISDSSDTEYFATKVEDNGGVYVVPAFVGLGAPYWDMYA
EEECCEEEHHHHHHHHHHHHHEECCCCCCCEEEEEEECCCCEEEEEHHHHCCCCHHHHHC
RGTIVGLTRGTNRNHIIRAALESIAYQTRDVLEAMINDVGYDINCIKVDGGASRNNFLMQ
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEE
FQSDLVGKKVIKPIITETTALGAAYLAGLAVGYWSDKEEIAKLWFASEEFEPTISEERRN
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHH
KYHKKWKKAVERSKGWALED
HHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKKYIVALDQGTTSSRAIIFDKEQNIIGVSQKEFNQIYPREGWVEHDPMEIWATQYSVLQ
CCCEEEEEECCCCCCEEEEEECCCCEEECCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
EVMAKCNITQENIAAIGITNQRETTIVWDKNTGVPIYNAIVWQCRRTADICDELKERDGL
HHHHHCCCCHHHEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCH
VDYIRENTGLVLDAYFSGTKIKWILDNVEGAREKAEKGELLFGTVDSWLVWKLTNGKVHV
HHHHHCCCCEEEEEEECCCEEEEEEECCHHHHHHHHCCCEEEEECCCEEEEEEECCEEEE
TDYTNASRTMIFNIKNLQWDERMLKELDIPRSMLPEVKNSSEIYGYANLGAKGGIRVPIA
EECCCCCEEEEEEECCCCHHHHHHHHCCCCHHHHHCCCCCCCEEEEECCCCCCCEEEEEE
GIAGDQQAALFGQAAFNKGDVKNTYGTGCFLLMNTGEELVKSKSGLLTTIAIGLHGKVQY
ECCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHCCCCCEEEEEEECCCEEEE
ALEGSVFVGGAVIQWLRDELRIISDSSDTEYFATKVEDNGGVYVVPAFVGLGAPYWDMYA
EEECCEEEHHHHHHHHHHHHHEECCCCCCCEEEEEEECCCCEEEEEHHHHCCCCHHHHHC
RGTIVGLTRGTNRNHIIRAALESIAYQTRDVLEAMINDVGYDINCIKVDGGASRNNFLMQ
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEE
FQSDLVGKKVIKPIITETTALGAAYLAGLAVGYWSDKEEIAKLWFASEEFEPTISEERRN
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHH
KYHKKWKKAVERSKGWALED
HHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA