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The map label for this gene is nagB [H]

Identifier: 18311416

GI number: 18311416

Start: 2783097

End: 2783825

Strand: Reverse

Name: nagB [H]

Synonym: CPE2434

Alternate gene names: 18311416

Gene position: 2783825-2783097 (Counterclockwise)

Preceding gene: 18311417

Following gene: 18311415

Centisome position: 91.83

GC content: 31.96

Gene sequence:

>729_bases
ATGAGATTAATCGTTACTAAGAATTATGAGGAAATGAGTAAAGTTGCAGCTAAAGAAATGGCTGAAGATATAAAAAGAAA
TCCTGAAATTGTTTTAGGATTAGCTACTGGTGGAACTCCAGTTGGAATGTATAAAGAGCTTATTAGAATGTACAATGAAG
GAGAATTAGATTTCTCAAAAGTTACAAGTATAAATTTAGATGAATATGTTGGGTTATCAGGGGATCATGATCAAAGTTAT
AGATACTTTATGAATACAAACTTATTTAACCACATAAACATAGATAAAAATAATACATTCGTACCTAATGGACTAGCAGA
AAATGTTGAAGAAGAGTGCATGGCATATGATTCTAGAATTCAAGACATGGGAGGAATTGACCTTCAGTTACTAGGATTAG
GTGCAAATGGACATATAGGATTTAATGAGCCAGGAGAAGCTTTAAGTGTAGGAACTCACTTAACTGATCTTAAAGAATCA
ACTATAGAAGCAAATGCAAGATTCTTTGATTCAATTGATGATGTACCAAGAAAAGCTATAACTATGGGACTTGGTGGAAT
AATGAAGGCTAAAAAAATAATGGTTATAGCAAGTGGAGAAGGAAAAGCTGAAGTTGTAAAGGCAATGATGAGTGGAAAAA
TAACAACTGAAATTCCAGCTACTATGTTACAAATGCATAGAGATGTCATATTAATAGTTGATGAAGATGCAGCTAAATTA
TTAAAATAG

Upstream 100 bases:

>100_bases
TAAATTCAGAAGGCGAAATAATTTACGTTGAAGATGCAATTTATAGGTCAGACAAATATATATTAGAAATTAATATTTCT
AAAAGAGAGGGGAAATTGAA

Downstream 100 bases:

>100_bases
TTATTACTATCTTAGATTAATATATAAGAAGACTGTTTGTAGATAAAAGCATTATTTAAATGCTTAAATTTACAAACAGT
TTTTTATTTTTATTTTAATA

Product: glucosamine-6-phosphate deaminase

Products: NA

Alternate protein names: GlcN6P deaminase; GNPDA; Glucosamine-6-phosphate isomerase [H]

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MRLIVTKNYEEMSKVAAKEMAEDIKRNPEIVLGLATGGTPVGMYKELIRMYNEGELDFSKVTSINLDEYVGLSGDHDQSY
RYFMNTNLFNHINIDKNNTFVPNGLAENVEEECMAYDSRIQDMGGIDLQLLGLGANGHIGFNEPGEALSVGTHLTDLKES
TIEANARFFDSIDDVPRKAITMGLGGIMKAKKIMVIASGEGKAEVVKAMMSGKITTEIPATMLQMHRDVILIVDEDAAKL
LK

Sequences:

>Translated_242_residues
MRLIVTKNYEEMSKVAAKEMAEDIKRNPEIVLGLATGGTPVGMYKELIRMYNEGELDFSKVTSINLDEYVGLSGDHDQSY
RYFMNTNLFNHINIDKNNTFVPNGLAENVEEECMAYDSRIQDMGGIDLQLLGLGANGHIGFNEPGEALSVGTHLTDLKES
TIEANARFFDSIDDVPRKAITMGLGGIMKAKKIMVIASGEGKAEVVKAMMSGKITTEIPATMLQMHRDVILIVDEDAAKL
LK
>Mature_242_residues
MRLIVTKNYEEMSKVAAKEMAEDIKRNPEIVLGLATGGTPVGMYKELIRMYNEGELDFSKVTSINLDEYVGLSGDHDQSY
RYFMNTNLFNHINIDKNNTFVPNGLAENVEEECMAYDSRIQDMGGIDLQLLGLGANGHIGFNEPGEALSVGTHLTDLKES
TIEANARFFDSIDDVPRKAITMGLGGIMKAKKIMVIASGEGKAEVVKAMMSGKITTEIPATMLQMHRDVILIVDEDAAKL
LK

Specific function: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily [H]

Homologues:

Organism=Homo sapiens, GI13027378, Length=248, Percent_Identity=40.3225806451613, Blast_Score=189, Evalue=1e-48,
Organism=Homo sapiens, GI19923881, Length=248, Percent_Identity=39.1129032258064, Blast_Score=189, Evalue=2e-48,
Organism=Escherichia coli, GI1786893, Length=248, Percent_Identity=37.0967741935484, Blast_Score=182, Evalue=1e-47,
Organism=Escherichia coli, GI1789530, Length=228, Percent_Identity=29.8245614035088, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI48994958, Length=248, Percent_Identity=30.241935483871, Blast_Score=110, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17554876, Length=247, Percent_Identity=41.7004048582996, Blast_Score=200, Evalue=5e-52,
Organism=Drosophila melanogaster, GI24581960, Length=248, Percent_Identity=38.7096774193548, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI19920764, Length=248, Percent_Identity=38.7096774193548, Blast_Score=196, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006148
- InterPro:   IPR004547
- InterPro:   IPR018321 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.5.99.6 [H]

Molecular weight: Translated: 26669; Mature: 26669

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS01161 GLC_GALNAC_ISOMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
6.2 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
6.2 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLIVTKNYEEMSKVAAKEMAEDIKRNPEIVLGLATGGTPVGMYKELIRMYNEGELDFSK
CEEEEECCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCHHH
VTSINLDEYVGLSGDHDQSYRYFMNTNLFNHINIDKNNTFVPNGLAENVEEECMAYDSRI
HEECCHHHHCCCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
QDMGGIDLQLLGLGANGHIGFNEPGEALSVGTHLTDLKESTIEANARFFDSIDDVPRKAI
HHCCCCEEEEEEECCCCCCCCCCCCCCEECCCHHHHHHHHHHHHCHHHHHHHHHHHHHHH
TMGLGGIMKAKKIMVIASGEGKAEVVKAMMSGKITTEIPATMLQMHRDVILIVDEDAAKL
HHHHCCHHCEEEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECCCHHHH
LK
CC
>Mature Secondary Structure
MRLIVTKNYEEMSKVAAKEMAEDIKRNPEIVLGLATGGTPVGMYKELIRMYNEGELDFSK
CEEEEECCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCHHH
VTSINLDEYVGLSGDHDQSYRYFMNTNLFNHINIDKNNTFVPNGLAENVEEECMAYDSRI
HEECCHHHHCCCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
QDMGGIDLQLLGLGANGHIGFNEPGEALSVGTHLTDLKESTIEANARFFDSIDDVPRKAI
HHCCCCEEEEEEECCCCCCCCCCCCCCEECCCHHHHHHHHHHHHCHHHHHHHHHHHHHHH
TMGLGGIMKAKKIMVIASGEGKAEVVKAMMSGKITTEIPATMLQMHRDVILIVDEDAAKL
HHHHCCHHCEEEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECCCHHHH
LK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA