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The map label for this gene is mutS [H]

Identifier: 18311138

GI number: 18311138

Start: 2468553

End: 2470340

Strand: Reverse

Name: mutS [H]

Synonym: CPE2156

Alternate gene names: 18311138

Gene position: 2470340-2468553 (Counterclockwise)

Preceding gene: 18311139

Following gene: 18311137

Centisome position: 81.49

GC content: 27.4

Gene sequence:

>1788_bases
ATGGAGAATAGAAAAGATATTTATGAAAAAAGAATAGAAGAGTATTCAAGTGCTTTAAAGAGATTAAAGAGAGACTATAA
TATAATCAGCGCATTAAGATTAGTAGTTTCTTTAAGTATTTTATTTTTTATTTACTACGCTTATAGCATAGGGTCAATAA
GCTTTGGGATCATATTATTTTTGCTAAATTCTATATTATTTTTATATTTAGCAAAGGTTCATGAAGGTATAGTGAATAAA
ATAAGTAAAAGAGAAGCTCTTATAGAGGTTAATAAAAAAGAGATTCTTAGGTTAGAGGGAAAGTGGAGAGAATTTAATGA
CTTAGGAGGAGAATATTTAGATAATAAGCATCCTTTTATAAATGACTTAGATATATTCGGAAAAAACTCTTTATTTCAAT
GGATAAATGAAACTGGTACTGTCTATGGAAGAGAGAAATTAAGTCATTTATTAAAGTTAGGAGAACTTCCAAATAAAGAA
GAAATTTTATTAAGACAGGAAGCTTTAAAGGAGCTTTCTAAAAAAGTAGATTTTAGACATGAATTTATAGCTTCATTAAA
AGATAAAAAAGGAAAAAAAGAGAAGTATTTAGGGGAATGGTTAAAAGAAGACAGTAAAGCCATATCACCTTTATTAAATA
TTTTTAGAATAATAATGCCAGTAACAAATATTGGAATCACTATTTTAGTTGGTATGAATGTTATTTCATGGCAAATACTA
TTAATTTCTCTTGTTATAAGTTATGGTATTTTGAAGCTTGGCAATAAGGAAGTTATTAAAGGATTAAATATATTTGAAGA
TTTAAAATATAGAATAAAAACCTATGTAGAGGCTTTAGAGTTAATAGAAAAAGAGAATTTCCAGGCTAATATAATACAAG
GTATAAAAAGTAACTTAGACATGAATGGTAAAAGTGCTAGTAAAGAGCTTAAAAGCTTAGAAAAAATAACTAGCTGGCTT
TACGATAGGGGAAATGCCTTTTACCTTTTATTAAACTGTTATTTACTTTGGGATTATCAAATTCTATCAAAGCTTGAAAA
GTGGAAGAGTTCTAATAAAGATGAGTTTTATAAATGGATGATTTCTTTAGGAGATTTTGAGGCTTTAGTTTCTTTAGCTG
GATTTACTTATAATAATCATGGATGGGCTACACCAAAAATAAATGATGACTATACTTTAAAGGGAAAAAATCTTAGTCAT
CCTATGTTAGGAGAAAAAGGCGTTGGAAACAGTTTTGATATTAATAAGGATAAGAGAGTAATCTTAATAACAGGATCGAA
TATGTCTGGTAAGAGTACATTTTTAAGAACTGTTGGATTCAACTGTATATTAGCTTATCTAGGACTTCCTGTAAAAGGAG
AAAGTTTTGAAGCTCCAATATTAAAAGTTTATACCTGTATGAGAACTGGAGATAATCTTGAAGAGAGTATATCTTCATTT
TATGCAGAGATACTTAGAATAAAGATTATAGTTGAAGGCGTAAAAAGAGGAGAAAAGATTTTATTCTTGTTAGATGAAAT
ATTTAAAGGAACAAATTCCTTAGATAGACATGAGGGAGCAGAGATATTAATAAATCAGCTTTTAGAAGGAAATACCTTAG
GATTAGTTTCAACTCATGATTTTGAACTTTGCGATATGGAGAAAAAAGATTCTACTATACAAAATTATAATTTTAGAGAA
TATTATGAGGATAATAAATTAAAGTTTGATTATATTTTAAGAAAAGGTGTTTCACAAACAAGAAATGCTAGATATTTAAT
GAAGATGGCTGGAATAGATATTGAATAA

Upstream 100 bases:

>100_bases
TTCATATAAGTTTAGAAAGTGTCATAGTTTAAAGGATAGTCTTGCATTAAAATATGTTAACTATGGTATAATATTAAAAA
AGTGTTTTGAGAGGATAAAT

Downstream 100 bases:

>100_bases
AATTATACTTCTATATATAAACAGCAAAATAACTTAATTTTAGACAAATTAAATTAATTTTGATATAATAAACAAATGAT
GTATTTAGTGAAAAAGCCTT

Product: mutS domain protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 595; Mature: 595

Protein sequence:

>595_residues
MENRKDIYEKRIEEYSSALKRLKRDYNIISALRLVVSLSILFFIYYAYSIGSISFGIILFLLNSILFLYLAKVHEGIVNK
ISKREALIEVNKKEILRLEGKWREFNDLGGEYLDNKHPFINDLDIFGKNSLFQWINETGTVYGREKLSHLLKLGELPNKE
EILLRQEALKELSKKVDFRHEFIASLKDKKGKKEKYLGEWLKEDSKAISPLLNIFRIIMPVTNIGITILVGMNVISWQIL
LISLVISYGILKLGNKEVIKGLNIFEDLKYRIKTYVEALELIEKENFQANIIQGIKSNLDMNGKSASKELKSLEKITSWL
YDRGNAFYLLLNCYLLWDYQILSKLEKWKSSNKDEFYKWMISLGDFEALVSLAGFTYNNHGWATPKINDDYTLKGKNLSH
PMLGEKGVGNSFDINKDKRVILITGSNMSGKSTFLRTVGFNCILAYLGLPVKGESFEAPILKVYTCMRTGDNLEESISSF
YAEILRIKIIVEGVKRGEKILFLLDEIFKGTNSLDRHEGAEILINQLLEGNTLGLVSTHDFELCDMEKKDSTIQNYNFRE
YYEDNKLKFDYILRKGVSQTRNARYLMKMAGIDIE

Sequences:

>Translated_595_residues
MENRKDIYEKRIEEYSSALKRLKRDYNIISALRLVVSLSILFFIYYAYSIGSISFGIILFLLNSILFLYLAKVHEGIVNK
ISKREALIEVNKKEILRLEGKWREFNDLGGEYLDNKHPFINDLDIFGKNSLFQWINETGTVYGREKLSHLLKLGELPNKE
EILLRQEALKELSKKVDFRHEFIASLKDKKGKKEKYLGEWLKEDSKAISPLLNIFRIIMPVTNIGITILVGMNVISWQIL
LISLVISYGILKLGNKEVIKGLNIFEDLKYRIKTYVEALELIEKENFQANIIQGIKSNLDMNGKSASKELKSLEKITSWL
YDRGNAFYLLLNCYLLWDYQILSKLEKWKSSNKDEFYKWMISLGDFEALVSLAGFTYNNHGWATPKINDDYTLKGKNLSH
PMLGEKGVGNSFDINKDKRVILITGSNMSGKSTFLRTVGFNCILAYLGLPVKGESFEAPILKVYTCMRTGDNLEESISSF
YAEILRIKIIVEGVKRGEKILFLLDEIFKGTNSLDRHEGAEILINQLLEGNTLGLVSTHDFELCDMEKKDSTIQNYNFRE
YYEDNKLKFDYILRKGVSQTRNARYLMKMAGIDIE
>Mature_595_residues
MENRKDIYEKRIEEYSSALKRLKRDYNIISALRLVVSLSILFFIYYAYSIGSISFGIILFLLNSILFLYLAKVHEGIVNK
ISKREALIEVNKKEILRLEGKWREFNDLGGEYLDNKHPFINDLDIFGKNSLFQWINETGTVYGREKLSHLLKLGELPNKE
EILLRQEALKELSKKVDFRHEFIASLKDKKGKKEKYLGEWLKEDSKAISPLLNIFRIIMPVTNIGITILVGMNVISWQIL
LISLVISYGILKLGNKEVIKGLNIFEDLKYRIKTYVEALELIEKENFQANIIQGIKSNLDMNGKSASKELKSLEKITSWL
YDRGNAFYLLLNCYLLWDYQILSKLEKWKSSNKDEFYKWMISLGDFEALVSLAGFTYNNHGWATPKINDDYTLKGKNLSH
PMLGEKGVGNSFDINKDKRVILITGSNMSGKSTFLRTVGFNCILAYLGLPVKGESFEAPILKVYTCMRTGDNLEESISSF
YAEILRIKIIVEGVKRGEKILFLLDEIFKGTNSLDRHEGAEILINQLLEGNTLGLVSTHDFELCDMEKKDSTIQNYNFRE
YYEDNKLKFDYILRKGVSQTRNARYLMKMAGIDIE

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=527, Percent_Identity=25.2371916508539, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI36949366, Length=270, Percent_Identity=28.5185185185185, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1789089, Length=243, Percent_Identity=26.7489711934156, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17508445, Length=243, Percent_Identity=26.3374485596708, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17534743, Length=229, Percent_Identity=26.2008733624454, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17508447, Length=257, Percent_Identity=26.4591439688716, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321912, Length=197, Percent_Identity=30.4568527918782, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319935, Length=257, Percent_Identity=29.1828793774319, Blast_Score=67, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6324482, Length=221, Percent_Identity=25.7918552036199, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320302, Length=206, Percent_Identity=27.6699029126214, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 68722; Mature: 68722

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENRKDIYEKRIEEYSSALKRLKRDYNIISALRLVVSLSILFFIYYAYSIGSISFGIILF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLNSILFLYLAKVHEGIVNKISKREALIEVNKKEILRLEGKWREFNDLGGEYLDNKHPFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHCCCHHCCCCCCCC
NDLDIFGKNSLFQWINETGTVYGREKLSHLLKLGELPNKEEILLRQEALKELSKKVDFRH
CCHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
EFIASLKDKKGKKEKYLGEWLKEDSKAISPLLNIFRIIMPVTNIGITILVGMNVISWQIL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHH
LISLVISYGILKLGNKEVIKGLNIFEDLKYRIKTYVEALELIEKENFQANIIQGIKSNLD
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
MNGKSASKELKSLEKITSWLYDRGNAFYLLLNCYLLWDYQILSKLEKWKSSNKDEFYKWM
CCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ISLGDFEALVSLAGFTYNNHGWATPKINDDYTLKGKNLSHPMLGEKGVGNSFDINKDKRV
HHHHHHHHHHHHHCCEECCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCEE
ILITGSNMSGKSTFLRTVGFNCILAYLGLPVKGESFEAPILKVYTCMRTGDNLEESISSF
EEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHH
YAEILRIKIIVEGVKRGEKILFLLDEIFKGTNSLDRHEGAEILINQLLEGNTLGLVSTHD
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHCCCCEEEEECCC
FELCDMEKKDSTIQNYNFREYYEDNKLKFDYILRKGVSQTRNARYLMKMAGIDIE
CHHCCCCCCCCHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MENRKDIYEKRIEEYSSALKRLKRDYNIISALRLVVSLSILFFIYYAYSIGSISFGIILF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLNSILFLYLAKVHEGIVNKISKREALIEVNKKEILRLEGKWREFNDLGGEYLDNKHPFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHCCCHHCCCCCCCC
NDLDIFGKNSLFQWINETGTVYGREKLSHLLKLGELPNKEEILLRQEALKELSKKVDFRH
CCHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
EFIASLKDKKGKKEKYLGEWLKEDSKAISPLLNIFRIIMPVTNIGITILVGMNVISWQIL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHH
LISLVISYGILKLGNKEVIKGLNIFEDLKYRIKTYVEALELIEKENFQANIIQGIKSNLD
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
MNGKSASKELKSLEKITSWLYDRGNAFYLLLNCYLLWDYQILSKLEKWKSSNKDEFYKWM
CCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ISLGDFEALVSLAGFTYNNHGWATPKINDDYTLKGKNLSHPMLGEKGVGNSFDINKDKRV
HHHHHHHHHHHHHCCEECCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCEE
ILITGSNMSGKSTFLRTVGFNCILAYLGLPVKGESFEAPILKVYTCMRTGDNLEESISSF
EEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHH
YAEILRIKIIVEGVKRGEKILFLLDEIFKGTNSLDRHEGAEILINQLLEGNTLGLVSTHD
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHCCCCEEEEECCC
FELCDMEKKDSTIQNYNFREYYEDNKLKFDYILRKGVSQTRNARYLMKMAGIDIE
CHHCCCCCCCCHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]