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The map label for this gene is apt

Identifier: 18310921

GI number: 18310921

Start: 2221955

End: 2222473

Strand: Reverse

Name: apt

Synonym: CPE1939

Alternate gene names: 18310921

Gene position: 2222473-2221955 (Counterclockwise)

Preceding gene: 18310922

Following gene: 18310920

Centisome position: 73.31

GC content: 34.1

Gene sequence:

>519_bases
ATGAGTTTAAAGGATAAAATAAGAGTTATAGAAGATTTTCCTAAGAAGGGAATAAGTTTTAAAGATATAACTACTCTAAT
AGCAGATGGAGAAGGCTTAAGAGATTCAGTTGACCAAATGGCAGAATTCTTCAAAGATAAGAATATTGACGTTGTAGTTG
GACCAGAAGCTAGAGGATTTATATTTGGAGTTCCTGTAGCCTATGCTTTAGGTGTTGGATTCATTCCAGTAAGAAAGCCA
GGTAAACTTCCAGGGGACACAGTTAGAGTAGAATATGATTTAGAGTATGGAAAAGATGCTTTAGAAATACACAAAGATGC
TATAAAACCAGGTATGAGAGTTGCTATAGTTGACGATCTTTTAGCTACTGGTGGTACAATAGCTGCTGTTGCTAAATTAG
TAGAACAAGCTGGTGGAGAAGTTGCTGGATTAGCATTTACTATTGAGTTAACAGAATTAAAAGGAAGAGATAAATTAAAA
GGATACGAAGTAACATCATTAGTTGATTATGATGTTTAA

Upstream 100 bases:

>100_bases
ATAAGGATAGAGCGGAGCAAATAACTAAATATATTTATAATGAAAAAATAAGGTAGTAATTAAAAATTTATATATATTTA
TTGATTTTGGAGGGAAAGTA

Downstream 100 bases:

>100_bases
AATTCTTTAATTTTGTAAAAAATTATAATAGAGTTAAAAATGGCTGGTTTATCGACCAGCCATTAATTTTATTATTGGTT
TATTTTATTTTTTTGTTATA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 172; Mature: 171

Protein sequence:

>172_residues
MSLKDKIRVIEDFPKKGISFKDITTLIADGEGLRDSVDQMAEFFKDKNIDVVVGPEARGFIFGVPVAYALGVGFIPVRKP
GKLPGDTVRVEYDLEYGKDALEIHKDAIKPGMRVAIVDDLLATGGTIAAVAKLVEQAGGEVAGLAFTIELTELKGRDKLK
GYEVTSLVDYDV

Sequences:

>Translated_172_residues
MSLKDKIRVIEDFPKKGISFKDITTLIADGEGLRDSVDQMAEFFKDKNIDVVVGPEARGFIFGVPVAYALGVGFIPVRKP
GKLPGDTVRVEYDLEYGKDALEIHKDAIKPGMRVAIVDDLLATGGTIAAVAKLVEQAGGEVAGLAFTIELTELKGRDKLK
GYEVTSLVDYDV
>Mature_171_residues
SLKDKIRVIEDFPKKGISFKDITTLIADGEGLRDSVDQMAEFFKDKNIDVVVGPEARGFIFGVPVAYALGVGFIPVRKPG
KLPGDTVRVEYDLEYGKDALEIHKDAIKPGMRVAIVDDLLATGGTIAAVAKLVEQAGGEVAGLAFTIELTELKGRDKLKG
YEVTSLVDYDV

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=172, Percent_Identity=43.6046511627907, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=45.6, Blast_Score=114, Evalue=3e-26,
Organism=Escherichia coli, GI1786675, Length=164, Percent_Identity=56.7073170731707, Blast_Score=182, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI17509087, Length=171, Percent_Identity=46.1988304093567, Blast_Score=143, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6323619, Length=169, Percent_Identity=43.7869822485207, Blast_Score=119, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320649, Length=163, Percent_Identity=35.5828220858896, Blast_Score=91, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17136334, Length=172, Percent_Identity=45.3488372093023, Blast_Score=130, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_CLOP1 (Q0TP22)

Other databases:

- EMBL:   CP000246
- RefSeq:   YP_696618.1
- ProteinModelPortal:   Q0TP22
- SMR:   Q0TP22
- STRING:   Q0TP22
- GeneID:   4203608
- GenomeReviews:   CP000246_GR
- KEGG:   cpf:CPF_2194
- TIGR:   CPF_2194
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   CPER195103:CPF_2194-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18602; Mature: 18471

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER; PS00144 ASN_GLN_ASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKDKIRVIEDFPKKGISFKDITTLIADGEGLRDSVDQMAEFFKDKNIDVVVGPEARGF
CCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCE
IFGVPVAYALGVGFIPVRKPGKLPGDTVRVEYDLEYGKDALEIHKDAIKPGMRVAIVDDL
EEECHHHHHHCCCCEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEEHHH
LATGGTIAAVAKLVEQAGGEVAGLAFTIELTELKGRDKLKGYEVTSLVDYDV
HHCCCHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCCCCEEEEEEEECCC
>Mature Secondary Structure 
SLKDKIRVIEDFPKKGISFKDITTLIADGEGLRDSVDQMAEFFKDKNIDVVVGPEARGF
CCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCE
IFGVPVAYALGVGFIPVRKPGKLPGDTVRVEYDLEYGKDALEIHKDAIKPGMRVAIVDDL
EEECHHHHHHCCCCEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEEHHH
LATGGTIAAVAKLVEQAGGEVAGLAFTIELTELKGRDKLKGYEVTSLVDYDV
HHCCCHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA