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The map label for this gene is relA [H]

Identifier: 18310920

GI number: 18310920

Start: 2219623

End: 2221803

Strand: Reverse

Name: relA [H]

Synonym: CPE1938

Alternate gene names: 18310920

Gene position: 2221803-2219623 (Counterclockwise)

Preceding gene: 18310921

Following gene: 18310919

Centisome position: 73.29

GC content: 29.8

Gene sequence:

>2181_bases
ATGTTAGAAGAACTAATTTCTAAAATAAAAGCTAATGGGAATAATGTTGATATAGATTTAGTTAAAAAAGCATATGATTT
AGCTTTTGAAGCACATAAAGAACAAAAAAGAGAATCAGGAGAACCATACATAACTCATCCTATTAGTGTAGCTATGATAT
TAGCTGATATGGGAATGGATACAAATACTATAGTTGCAGGACTTCTCCATGATGTAATAGAGGATACGGATTATACTTAT
GAAGATATAAGCAATATTTTTAATGTTGAAGTAGCTAATTTAGTCGATGGAGTTACTAAGCTTGGAAAAATAAAATATAA
AAGCAAAGAAGAACAACAAGCTGACAATGTAAGAAAAATGCTTTTAGCAATGGCTAAAGACATAAGGGTTATAATAATAA
AACTAGCAGATAGACTTCATAATATGAGAACACTTAAATATATGAAGCCTGAAAAACAAAAGAAAAAAGCTCAAGAAACT
TTAGATATATTTGCACCTTTAGCTCATAGATTGGGTATATCTAAAATAAAGTGGGAGTTAGAAGATTTGTGTTTAAGATA
TATTCATCCAGAAGAATATTATGACTTAGTAAATATGATAGCTGAAAAAAGGGTGGAGAGAGAAAAATTTATTTCTCGTA
TAATTAAAGAGCTAAAAGAAAATTTAGATAAAGCTAATATAGATAGCGATATAGAAGGAAGACCAAAACATTTCTACAGT
ATATATAGAAAAATGGTGAATAAACATAAGAGCATAGAACAAATCTTTGATTTAACAGCTATAAGGATTTTAGTTAATAC
AGTTAAAGATTGCTATGCAGTACTAGGTATAGTACACACTATTTATAAGCCAATACCAGGTAGATTTAAAGATTATATAG
CAATGCCAAAACCTAATATGTATCAATCTTTACATACAACAGTAATAGGAAGCGAAGGAAAGACTTTTGAAATTCAAATA
AGAACTTTTGAAATGCATAGAACGGCTGAGTATGGAATAGCAGCTCATTGGAAATATAAGAGTGGTATTAATGGCACTGA
TTCAAAAGATATGACTTTTGAAAATAAGTTAACATGGCTTAGAGATATACTTGAGTGGCAAAAGGAAGCTGTTGATGCAA
CTGAGTTTATGGAAGGGTTTAAACTTGACTTATTCTCAGATGAAATATTTGTATTTACTCCTAAGGGAGTAGTTATAAAT
TTGCCAGCGGGAGCAACTCCCATAGACTTTGCATATAAGATTCATACAGATATAGGAAATAAATGCGTAGGAGCTAAAGT
AAACGGAAAGATAGTAACTCTAGATTACAAGCTTAAAACTGGAGAAATAGTAGAGATATTAACATCCTCATCATCTAGAG
GACCTAATATAGACTGGTTAAATATAGCTAATAGCAATCAAGCTAGAAGTAAAATAAAGCAGTGGCTTAGAAAAGCAAGA
AGAGAAGAGAATTTAGAAAGAGGAAAGGAAATGCTTGATAAGGAATGTAAAAAGCAATCCTTAGTATTTTCAGATCTTTC
CAAAGGGCCATTATATGATAAATTATTAAAGAGATATCATTTAAATAATGTTGAAGAAATATATGTAGCTATAGGAGAAG
GAGAGTTACTTTCATCTACTGTAATATCTAAGCTTAAAGAGAATATTGTAAAACAGGTTGCTGAAGAGGAATTAAATAAG
AATATTGAAGAACAAATAGCTAAAACTGAAAGACAAATAAAGAAAAAACAAAACTATGGAGTAACTGTTAAGGGATTAAA
TAATATAATGGTTAGATTTGCAAGGTGTTGTAATCCTGTACCTGGAGATGATATAGCTGGGTATATAACTAAGGGAAGAG
GAGTTTCTGTACATAGAAAAGACTGTTCTAATTTTAAAGCTATAGTAGAAAAACAGAGAGAGAAAGTTGTAGATGTTAGT
TGGGGAACTGAAAAAGGAGCTGCATATGTTGCTGAACTTGAGGTTAAAGCAGAAGATAGAATGTGTTTATTATCTGATGT
TATGTTAGTTATAACTGACTCTAATCTTAGCCTACTTTCTTTAAATGCTAAATCAGGTAGAAATGGAGTAGCAAATATAA
ATATTCAAGTAAAAATTGATAATATAGAACAATTAAAAGAATTAATGAAGAAAATAAGAAGACTACAAGGAATATTAGAC
GTTTATAGAGTAAATAAATAA

Upstream 100 bases:

>100_bases
TCGACCAGCCATTAATTTTATTATTGGTTTATTTTATTTTTTTGTTATATAATAATATAATATATTAAAAGAAATTTTAA
GTAGGGGAGAATAATCCAGT

Downstream 100 bases:

>100_bases
AAGGGGGCATAATCGTGAGAGTTGTAGTTCAAAGAGTGAATAAATCCTCTGTTAAAGTGGATAATGAGATAGTTGGAAGT
ATAAATAAAGGCTTTAATGT

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 726; Mature: 726

Protein sequence:

>726_residues
MLEELISKIKANGNNVDIDLVKKAYDLAFEAHKEQKRESGEPYITHPISVAMILADMGMDTNTIVAGLLHDVIEDTDYTY
EDISNIFNVEVANLVDGVTKLGKIKYKSKEEQQADNVRKMLLAMAKDIRVIIIKLADRLHNMRTLKYMKPEKQKKKAQET
LDIFAPLAHRLGISKIKWELEDLCLRYIHPEEYYDLVNMIAEKRVEREKFISRIIKELKENLDKANIDSDIEGRPKHFYS
IYRKMVNKHKSIEQIFDLTAIRILVNTVKDCYAVLGIVHTIYKPIPGRFKDYIAMPKPNMYQSLHTTVIGSEGKTFEIQI
RTFEMHRTAEYGIAAHWKYKSGINGTDSKDMTFENKLTWLRDILEWQKEAVDATEFMEGFKLDLFSDEIFVFTPKGVVIN
LPAGATPIDFAYKIHTDIGNKCVGAKVNGKIVTLDYKLKTGEIVEILTSSSSRGPNIDWLNIANSNQARSKIKQWLRKAR
REENLERGKEMLDKECKKQSLVFSDLSKGPLYDKLLKRYHLNNVEEIYVAIGEGELLSSTVISKLKENIVKQVAEEELNK
NIEEQIAKTERQIKKKQNYGVTVKGLNNIMVRFARCCNPVPGDDIAGYITKGRGVSVHRKDCSNFKAIVEKQREKVVDVS
WGTEKGAAYVAELEVKAEDRMCLLSDVMLVITDSNLSLLSLNAKSGRNGVANINIQVKIDNIEQLKELMKKIRRLQGILD
VYRVNK

Sequences:

>Translated_726_residues
MLEELISKIKANGNNVDIDLVKKAYDLAFEAHKEQKRESGEPYITHPISVAMILADMGMDTNTIVAGLLHDVIEDTDYTY
EDISNIFNVEVANLVDGVTKLGKIKYKSKEEQQADNVRKMLLAMAKDIRVIIIKLADRLHNMRTLKYMKPEKQKKKAQET
LDIFAPLAHRLGISKIKWELEDLCLRYIHPEEYYDLVNMIAEKRVEREKFISRIIKELKENLDKANIDSDIEGRPKHFYS
IYRKMVNKHKSIEQIFDLTAIRILVNTVKDCYAVLGIVHTIYKPIPGRFKDYIAMPKPNMYQSLHTTVIGSEGKTFEIQI
RTFEMHRTAEYGIAAHWKYKSGINGTDSKDMTFENKLTWLRDILEWQKEAVDATEFMEGFKLDLFSDEIFVFTPKGVVIN
LPAGATPIDFAYKIHTDIGNKCVGAKVNGKIVTLDYKLKTGEIVEILTSSSSRGPNIDWLNIANSNQARSKIKQWLRKAR
REENLERGKEMLDKECKKQSLVFSDLSKGPLYDKLLKRYHLNNVEEIYVAIGEGELLSSTVISKLKENIVKQVAEEELNK
NIEEQIAKTERQIKKKQNYGVTVKGLNNIMVRFARCCNPVPGDDIAGYITKGRGVSVHRKDCSNFKAIVEKQREKVVDVS
WGTEKGAAYVAELEVKAEDRMCLLSDVMLVITDSNLSLLSLNAKSGRNGVANINIQVKIDNIEQLKELMKKIRRLQGILD
VYRVNK
>Mature_726_residues
MLEELISKIKANGNNVDIDLVKKAYDLAFEAHKEQKRESGEPYITHPISVAMILADMGMDTNTIVAGLLHDVIEDTDYTY
EDISNIFNVEVANLVDGVTKLGKIKYKSKEEQQADNVRKMLLAMAKDIRVIIIKLADRLHNMRTLKYMKPEKQKKKAQET
LDIFAPLAHRLGISKIKWELEDLCLRYIHPEEYYDLVNMIAEKRVEREKFISRIIKELKENLDKANIDSDIEGRPKHFYS
IYRKMVNKHKSIEQIFDLTAIRILVNTVKDCYAVLGIVHTIYKPIPGRFKDYIAMPKPNMYQSLHTTVIGSEGKTFEIQI
RTFEMHRTAEYGIAAHWKYKSGINGTDSKDMTFENKLTWLRDILEWQKEAVDATEFMEGFKLDLFSDEIFVFTPKGVVIN
LPAGATPIDFAYKIHTDIGNKCVGAKVNGKIVTLDYKLKTGEIVEILTSSSSRGPNIDWLNIANSNQARSKIKQWLRKAR
REENLERGKEMLDKECKKQSLVFSDLSKGPLYDKLLKRYHLNNVEEIYVAIGEGELLSSTVISKLKENIVKQVAEEELNK
NIEEQIAKTERQIKKKQNYGVTVKGLNNIMVRFARCCNPVPGDDIAGYITKGRGVSVHRKDCSNFKAIVEKQREKVVDVS
WGTEKGAAYVAELEVKAEDRMCLLSDVMLVITDSNLSLLSLNAKSGRNGVANINIQVKIDNIEQLKELMKKIRRLQGILD
VYRVNK

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=136, Percent_Identity=38.2352941176471, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI1790082, Length=709, Percent_Identity=41.1847672778561, Blast_Score=563, Evalue=1e-161,
Organism=Escherichia coli, GI1789147, Length=691, Percent_Identity=38.6396526772793, Blast_Score=546, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI25143118, Length=138, Percent_Identity=35.5072463768116, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24650996, Length=123, Percent_Identity=34.9593495934959, Blast_Score=76, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 83104; Mature: 83104

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEELISKIKANGNNVDIDLVKKAYDLAFEAHKEQKRESGEPYITHPISVAMILADMGMD
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHCCCC
TNTIVAGLLHDVIEDTDYTYEDISNIFNVEVANLVDGVTKLGKIKYKSKEEQQADNVRKM
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LLAMAKDIRVIIIKLADRLHNMRTLKYMKPEKQKKKAQETLDIFAPLAHRLGISKIKWEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
EDLCLRYIHPEEYYDLVNMIAEKRVEREKFISRIIKELKENLDKANIDSDIEGRPKHFYS
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
IYRKMVNKHKSIEQIFDLTAIRILVNTVKDCYAVLGIVHTIYKPIPGRFKDYIAMPKPNM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHH
YQSLHTTVIGSEGKTFEIQIRTFEMHRTAEYGIAAHWKYKSGINGTDSKDMTFENKLTWL
HHHHHHHEECCCCCEEEEEEEEEEEHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHH
RDILEWQKEAVDATEFMEGFKLDLFSDEIFVFTPKGVVINLPAGATPIDFAYKIHTDIGN
HHHHHHHHHHCCHHHHHCCCCEEEECCCEEEEECCCEEEECCCCCCCCCEEEEEECCCCC
KCVGAKVNGKIVTLDYKLKTGEIVEILTSSSSRGPNIDWLNIANSNQARSKIKQWLRKAR
CEECCEECCEEEEEEEEECCCHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHH
REENLERGKEMLDKECKKQSLVFSDLSKGPLYDKLLKRYHLNNVEEIYVAIGEGELLSST
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEEECCCHHHHHH
VISKLKENIVKQVAEEELNKNIEEQIAKTERQIKKKQNYGVTVKGLNNIMVRFARCCNPV
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHCCCC
PGDDIAGYITKGRGVSVHRKDCSNFKAIVEKQREKVVDVSWGTEKGAAYVAELEVKAEDR
CCCCCCHHEECCCCCEEEHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEEEEECCCCC
MCLLSDVMLVITDSNLSLLSLNAKSGRNGVANINIQVKIDNIEQLKELMKKIRRLQGILD
HHHHHCEEEEEECCCCEEEEEECCCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHH
VYRVNK
HHHCCC
>Mature Secondary Structure
MLEELISKIKANGNNVDIDLVKKAYDLAFEAHKEQKRESGEPYITHPISVAMILADMGMD
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHCCCC
TNTIVAGLLHDVIEDTDYTYEDISNIFNVEVANLVDGVTKLGKIKYKSKEEQQADNVRKM
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LLAMAKDIRVIIIKLADRLHNMRTLKYMKPEKQKKKAQETLDIFAPLAHRLGISKIKWEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
EDLCLRYIHPEEYYDLVNMIAEKRVEREKFISRIIKELKENLDKANIDSDIEGRPKHFYS
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
IYRKMVNKHKSIEQIFDLTAIRILVNTVKDCYAVLGIVHTIYKPIPGRFKDYIAMPKPNM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHH
YQSLHTTVIGSEGKTFEIQIRTFEMHRTAEYGIAAHWKYKSGINGTDSKDMTFENKLTWL
HHHHHHHEECCCCCEEEEEEEEEEEHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHH
RDILEWQKEAVDATEFMEGFKLDLFSDEIFVFTPKGVVINLPAGATPIDFAYKIHTDIGN
HHHHHHHHHHCCHHHHHCCCCEEEECCCEEEEECCCEEEECCCCCCCCCEEEEEECCCCC
KCVGAKVNGKIVTLDYKLKTGEIVEILTSSSSRGPNIDWLNIANSNQARSKIKQWLRKAR
CEECCEECCEEEEEEEEECCCHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHH
REENLERGKEMLDKECKKQSLVFSDLSKGPLYDKLLKRYHLNNVEEIYVAIGEGELLSST
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEEECCCHHHHHH
VISKLKENIVKQVAEEELNKNIEEQIAKTERQIKKKQNYGVTVKGLNNIMVRFARCCNPV
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHCCCC
PGDDIAGYITKGRGVSVHRKDCSNFKAIVEKQREKVVDVSWGTEKGAAYVAELEVKAEDR
CCCCCCHHEECCCCCEEEHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEEEEECCCCC
MCLLSDVMLVITDSNLSLLSLNAKSGRNGVANINIQVKIDNIEQLKELMKKIRRLQGILD
HHHHHCEEEEEECCCCEEEEEECCCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHH
VYRVNK
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9383190; 9384377 [H]