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The map label for this gene is phoR [H]

Identifier: 18310739

GI number: 18310739

Start: 2036077

End: 2037792

Strand: Reverse

Name: phoR [H]

Synonym: CPE1757

Alternate gene names: 18310739

Gene position: 2037792-2036077 (Counterclockwise)

Preceding gene: 18310740

Following gene: 18310738

Centisome position: 67.22

GC content: 27.21

Gene sequence:

>1716_bases
ATGAAAAAAAGGATTATTATTTTCACAACACTAATAATAACATTTTTTCTAGCAATAATGACTTCTATGTACTTAGTAAT
ATCAAATCATAAATATTTAGAGGAATCAAAGAATGTTCTAAATGAATATAATAAGGTTATAGCTTTATTGTTAGAAAATG
ATAATGGAAATATAAAGAGTGAATTAGAAAGAATAGAATCAAATAATGATATGAAAAATATAAGAATAACATATATCAGT
AAGGATGGAAATGTTATTTTTGATACCCATAAAAAATTAATCAATGATAATGAAAGTTATCTTAAGAGACAAGAAATAAT
AGAAGCCATAGAAAGTGGTTTAGGAAGCAGTGTAAGATATAGTAATGATCTTCATCAAAATATGATCTATAGTGCACTTA
AACTTAAGGATGGCTCTATTGTTAGAACATCAATAGCTGTTGAAAATGCAAAAATACTAGATAGCATAAATAGTAACTAT
TTATTAGTAGGGGTTATATTATCCTTAGTAATTGCCTTACTTTTAACTGTTAAAATAACCAATATAATATTAAATCCACT
AAAGGAGTTAGAACAATTAACCTCTACTATTGCAAGTGGTAATTTTCATAAGAGAGTAAAAATTAACTCTAAGGATGATG
AAATTCAAAGACTAGGAAAAAGCTTTAATTATATGGCAGAGCAATTAGAAATAACCATGGAGAGGTTTAAGGATAAACAA
AATGGCTTAGAAGCCATATTGAAAAGTATGGGTAGTGGAGTAATAGCTTTTGACAGGGATATGAATGTTTTAATGATAAA
TCCTTATGCTAAAAAAATATTTGGCATAAGCGGAGAGATTATTGGAAATAAACTTTTGGATTATATAACTGATAAAGAGG
TACTAAAGGCCTTTTTTGATGAAAAAGATAGGGTTGAAATTGAAGTTAACTATAATGATGATCCAAAAATATTAAAAATA
AGAAAAGCAAGTATAATAAATGAACCTGAAATAATAGGGACAGTTGTGGTTATACAAGATATTACAGATATTAAAAAGCT
TGAAAACATGAGAAGTCAATTCGTAGCTAATATATCTCATGAACTTAAGACCCCACTTACCTCAATTAAAGGTTTTGCAG
AAACCTTAAGATATGTAGAGGATGATGAAACTAGAAATAAATTTTTAAGCATAATAGATGAAGAATCAGATAGATTAGCA
AGACTTTTAGAGGATATATTATGTCTTTATGAAATAGAACAAAAAAGAAGTACTATTTTAGAAGAATTTAATGTTGATGA
AGAAATTGAAAAAGTTTATATGCTATTAAATGATCAAGCAAAGAAAAAAGGTGTGGAAATATTTTTAGATACAAATAGCA
ATTGTGTTCTTATGGGAGATAAGGATAAGTTTAAACAAATGTTACTTAATCTTGTAAGCAATTCTGTTAAATATACTGAA
AAAGGTGGAAAGGTAAGAGTTGAAAGTTATAATCGTGACATGAATCTTATTTTAGTTATTGAGGATAACGGAATTGGAAT
AAGTGCAGAGGATCTTCCAAGGATATTTGAAAGATTTTATAGAGTAGATAAAGCTAGAAGTAGAGAAAGTGGTGGAACTG
GACTAGGTCTTGCCATAGTTAAACATATAGTTAGACTTTTTGATGGTGAGATAAATGTAACTAGTGAACTAGGAGTAGGA
ACTAAAATAGTAATAACTATACCTATAAATATATAA

Upstream 100 bases:

>100_bases
TATTGTGAAAAAGAAGTGAAGATGCATAGTTATAGACAGGATCAAGAAAAGTCAGGAAGATTATTTTCATCAATATTTAT
TGATTAAGGTGGATTAATAA

Downstream 100 bases:

>100_bases
TTCTAGTTAATTAATACTTTATAACACCTTTAAATTTATAACACTTATTATATAATTAGTTATATATTTAAAAATTTTTT
TACTATAATAGAATTAAGAG

Product: sensory box histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 571; Mature: 571

Protein sequence:

>571_residues
MKKRIIIFTTLIITFFLAIMTSMYLVISNHKYLEESKNVLNEYNKVIALLLENDNGNIKSELERIESNNDMKNIRITYIS
KDGNVIFDTHKKLINDNESYLKRQEIIEAIESGLGSSVRYSNDLHQNMIYSALKLKDGSIVRTSIAVENAKILDSINSNY
LLVGVILSLVIALLLTVKITNIILNPLKELEQLTSTIASGNFHKRVKINSKDDEIQRLGKSFNYMAEQLEITMERFKDKQ
NGLEAILKSMGSGVIAFDRDMNVLMINPYAKKIFGISGEIIGNKLLDYITDKEVLKAFFDEKDRVEIEVNYNDDPKILKI
RKASIINEPEIIGTVVVIQDITDIKKLENMRSQFVANISHELKTPLTSIKGFAETLRYVEDDETRNKFLSIIDEESDRLA
RLLEDILCLYEIEQKRSTILEEFNVDEEIEKVYMLLNDQAKKKGVEIFLDTNSNCVLMGDKDKFKQMLLNLVSNSVKYTE
KGGKVRVESYNRDMNLILVIEDNGIGISAEDLPRIFERFYRVDKARSRESGGTGLGLAIVKHIVRLFDGEINVTSELGVG
TKIVITIPINI

Sequences:

>Translated_571_residues
MKKRIIIFTTLIITFFLAIMTSMYLVISNHKYLEESKNVLNEYNKVIALLLENDNGNIKSELERIESNNDMKNIRITYIS
KDGNVIFDTHKKLINDNESYLKRQEIIEAIESGLGSSVRYSNDLHQNMIYSALKLKDGSIVRTSIAVENAKILDSINSNY
LLVGVILSLVIALLLTVKITNIILNPLKELEQLTSTIASGNFHKRVKINSKDDEIQRLGKSFNYMAEQLEITMERFKDKQ
NGLEAILKSMGSGVIAFDRDMNVLMINPYAKKIFGISGEIIGNKLLDYITDKEVLKAFFDEKDRVEIEVNYNDDPKILKI
RKASIINEPEIIGTVVVIQDITDIKKLENMRSQFVANISHELKTPLTSIKGFAETLRYVEDDETRNKFLSIIDEESDRLA
RLLEDILCLYEIEQKRSTILEEFNVDEEIEKVYMLLNDQAKKKGVEIFLDTNSNCVLMGDKDKFKQMLLNLVSNSVKYTE
KGGKVRVESYNRDMNLILVIEDNGIGISAEDLPRIFERFYRVDKARSRESGGTGLGLAIVKHIVRLFDGEINVTSELGVG
TKIVITIPINI
>Mature_571_residues
MKKRIIIFTTLIITFFLAIMTSMYLVISNHKYLEESKNVLNEYNKVIALLLENDNGNIKSELERIESNNDMKNIRITYIS
KDGNVIFDTHKKLINDNESYLKRQEIIEAIESGLGSSVRYSNDLHQNMIYSALKLKDGSIVRTSIAVENAKILDSINSNY
LLVGVILSLVIALLLTVKITNIILNPLKELEQLTSTIASGNFHKRVKINSKDDEIQRLGKSFNYMAEQLEITMERFKDKQ
NGLEAILKSMGSGVIAFDRDMNVLMINPYAKKIFGISGEIIGNKLLDYITDKEVLKAFFDEKDRVEIEVNYNDDPKILKI
RKASIINEPEIIGTVVVIQDITDIKKLENMRSQFVANISHELKTPLTSIKGFAETLRYVEDDETRNKFLSIIDEESDRLA
RLLEDILCLYEIEQKRSTILEEFNVDEEIEKVYMLLNDQAKKKGVEIFLDTNSNCVLMGDKDKFKQMLLNLVSNSVKYTE
KGGKVRVESYNRDMNLILVIEDNGIGISAEDLPRIFERFYRVDKARSRESGGTGLGLAIVKHIVRLFDGEINVTSELGVG
TKIVITIPINI

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=236, Percent_Identity=36.4406779661017, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1788549, Length=377, Percent_Identity=25.7294429708223, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1786783, Length=234, Percent_Identity=32.9059829059829, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI1788393, Length=237, Percent_Identity=30.379746835443, Blast_Score=118, Evalue=8e-28,
Organism=Escherichia coli, GI145693157, Length=223, Percent_Identity=32.2869955156951, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1789149, Length=226, Percent_Identity=32.7433628318584, Blast_Score=115, Evalue=9e-27,
Organism=Escherichia coli, GI48994928, Length=245, Percent_Identity=32.6530612244898, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790346, Length=234, Percent_Identity=30.7692307692308, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI87081816, Length=240, Percent_Identity=30, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1790861, Length=218, Percent_Identity=29.8165137614679, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790436, Length=223, Percent_Identity=27.3542600896861, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1788713, Length=255, Percent_Identity=28.6274509803922, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1788279, Length=243, Percent_Identity=27.9835390946502, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082128, Length=229, Percent_Identity=29.2576419213974, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1789403, Length=197, Percent_Identity=30.4568527918782, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1787894, Length=234, Percent_Identity=28.6324786324786, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786912, Length=225, Percent_Identity=27.5555555555556, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1787374, Length=203, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789808, Length=232, Percent_Identity=27.5862068965517, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790300, Length=231, Percent_Identity=27.7056277056277, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790551, Length=254, Percent_Identity=25.1968503937008, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1790567, Length=345, Percent_Identity=25.2173913043478, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=92, Percent_Identity=34.7826086956522, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 65093; Mature: 65093

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRIIIFTTLIITFFLAIMTSMYLVISNHKYLEESKNVLNEYNKVIALLLENDNGNIKS
CCCEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEEEECCCCCHHH
ELERIESNNDMKNIRITYISKDGNVIFDTHKKLINDNESYLKRQEIIEAIESGLGSSVRY
HHHHHHCCCCCCEEEEEEEECCCCEEEECHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCC
SNDLHQNMIYSALKLKDGSIVRTSIAVENAKILDSINSNYLLVGVILSLVIALLLTVKIT
CCHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHH
NIILNPLKELEQLTSTIASGNFHKRVKINSKDDEIQRLGKSFNYMAEQLEITMERFKDKQ
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NGLEAILKSMGSGVIAFDRDMNVLMINPYAKKIFGISGEIIGNKLLDYITDKEVLKAFFD
HHHHHHHHHHCCCEEEEECCCCEEEECHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHC
EKDRVEIEVNYNDDPKILKIRKASIINEPEIIGTVVVIQDITDIKKLENMRSQFVANISH
CCCCEEEEEEECCCCCEEEEEHHHCCCCCHHHEEEEEEHHHHHHHHHHHHHHHHHHHHHH
ELKTPLTSIKGFAETLRYVEDDETRNKFLSIIDEESDRLARLLEDILCLYEIEQKRSTIL
HHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EEFNVDEEIEKVYMLLNDQAKKKGVEIFLDTNSNCVLMGDKDKFKQMLLNLVSNSVKYTE
HHCCCCHHHHHHHHHHCCHHHCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHCCCEEEC
KGGKVRVESYNRDMNLILVIEDNGIGISAEDLPRIFERFYRVDKARSRESGGTGLGLAIV
CCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
KHIVRLFDGEINVTSELGVGTKIVITIPINI
HHHHHHHCCCCEEEEECCCCEEEEEEEEECC
>Mature Secondary Structure
MKKRIIIFTTLIITFFLAIMTSMYLVISNHKYLEESKNVLNEYNKVIALLLENDNGNIKS
CCCEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEEEECCCCCHHH
ELERIESNNDMKNIRITYISKDGNVIFDTHKKLINDNESYLKRQEIIEAIESGLGSSVRY
HHHHHHCCCCCCEEEEEEEECCCCEEEECHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCC
SNDLHQNMIYSALKLKDGSIVRTSIAVENAKILDSINSNYLLVGVILSLVIALLLTVKIT
CCHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHH
NIILNPLKELEQLTSTIASGNFHKRVKINSKDDEIQRLGKSFNYMAEQLEITMERFKDKQ
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NGLEAILKSMGSGVIAFDRDMNVLMINPYAKKIFGISGEIIGNKLLDYITDKEVLKAFFD
HHHHHHHHHHCCCEEEEECCCCEEEECHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHC
EKDRVEIEVNYNDDPKILKIRKASIINEPEIIGTVVVIQDITDIKKLENMRSQFVANISH
CCCCEEEEEEECCCCCEEEEEHHHCCCCCHHHEEEEEEHHHHHHHHHHHHHHHHHHHHHH
ELKTPLTSIKGFAETLRYVEDDETRNKFLSIIDEESDRLARLLEDILCLYEIEQKRSTIL
HHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EEFNVDEEIEKVYMLLNDQAKKKGVEIFLDTNSNCVLMGDKDKFKQMLLNLVSNSVKYTE
HHCCCCHHHHHHHHHHCCHHHCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHCCCEEEC
KGGKVRVESYNRDMNLILVIEDNGIGISAEDLPRIFERFYRVDKARSRESGGTGLGLAIV
CCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
KHIVRLFDGEINVTSELGVGTKIVITIPINI
HHHHHHHCCCCEEEEECCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]