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The map label for this gene is uppS

Identifier: 18310678

GI number: 18310678

Start: 1975244

End: 1976005

Strand: Reverse

Name: uppS

Synonym: CPE1696

Alternate gene names: 18310678

Gene position: 1976005-1975244 (Counterclockwise)

Preceding gene: 18310679

Following gene: 18310677

Centisome position: 65.18

GC content: 30.05

Gene sequence:

>762_bases
ATGTTAGATTTTTTTAGTAAAAAAGGAAATGAAGATTCAGAAGAAATAGTTCTAATTGAAGATAAAATGCCAAAGCATAT
TGCCATAATAATGGATGGTAATGGAAGATGGGCAAAAAAAAGAGGTCTTCCAAGAACTATGGGACATAGAGCTGGGGTTA
AGACTATAAAAACTATTGTAAAAGAATGCGATAAATTAGGAGTGAAATATTTAACTTTATATGCTTTCTCTACTGAAAAC
TGGAAAAGACCAGAAGATGAAGTTAATGCTCTTATGAAGTTAGTTGTTGAATTTATAAAAAATGAAATTGATGAACTTCA
TCAAAACGGAGTAAGGGTACAAACTATAGGTGATTTATCAAGATTCCCAGAAGAACCTAAAAAAGCTATACTTTGGGCTA
TGGAAAAAACTAAAGATAACACTGGAGTAGTTTTAAGCTTAGCATTAAATTATGGTGGAAGAAATGAAATAGTTAGAGGT
ATAAAATCTGTAATAGAAGATGTTAAAGCGGGCAAAATAAGTATAGATGATATAAACGAAGATATGTTTAATGACTATCT
TTATACTAAAGGAATGCCAGATCCAGATCTTATAATAAGACCAAGTGGAGAACAAAGACTTAGCAACTTCTTATTATGGC
AATGTGCATACTCAGAATTTTGGTATTCTCAAATAAACTGGCCAGATTTTAATGGTGAAGATTTAAGAAAAGCTATTTTT
GATTATCAAAATAGAGATAGAAGATTTGGTGGAATTAAATAA

Upstream 100 bases:

>100_bases
GTGGCAGCTAAAGAAAAAGAGATTATGTCAATTTAATTTAAAAAACCTGCTCTTTAGCAGGTTTTTTATTTTATAATTGA
ATTATAAGGAGGAACCTTCT

Downstream 100 bases:

>100_bases
ATAATGAGGTGATTTGGGTGAAATCTAATAGCAGATATCTAGGCGCACTTATAATGGCTCCATTTATTGCGTTTATATTC
CTAGGTGGAATTTGGCTTAA

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MLDFFSKKGNEDSEEIVLIEDKMPKHIAIIMDGNGRWAKKRGLPRTMGHRAGVKTIKTIVKECDKLGVKYLTLYAFSTEN
WKRPEDEVNALMKLVVEFIKNEIDELHQNGVRVQTIGDLSRFPEEPKKAILWAMEKTKDNTGVVLSLALNYGGRNEIVRG
IKSVIEDVKAGKISIDDINEDMFNDYLYTKGMPDPDLIIRPSGEQRLSNFLLWQCAYSEFWYSQINWPDFNGEDLRKAIF
DYQNRDRRFGGIK

Sequences:

>Translated_253_residues
MLDFFSKKGNEDSEEIVLIEDKMPKHIAIIMDGNGRWAKKRGLPRTMGHRAGVKTIKTIVKECDKLGVKYLTLYAFSTEN
WKRPEDEVNALMKLVVEFIKNEIDELHQNGVRVQTIGDLSRFPEEPKKAILWAMEKTKDNTGVVLSLALNYGGRNEIVRG
IKSVIEDVKAGKISIDDINEDMFNDYLYTKGMPDPDLIIRPSGEQRLSNFLLWQCAYSEFWYSQINWPDFNGEDLRKAIF
DYQNRDRRFGGIK
>Mature_253_residues
MLDFFSKKGNEDSEEIVLIEDKMPKHIAIIMDGNGRWAKKRGLPRTMGHRAGVKTIKTIVKECDKLGVKYLTLYAFSTEN
WKRPEDEVNALMKLVVEFIKNEIDELHQNGVRVQTIGDLSRFPEEPKKAILWAMEKTKDNTGVVLSLALNYGGRNEIVRG
IKSVIEDVKAGKISIDDINEDMFNDYLYTKGMPDPDLIIRPSGEQRLSNFLLWQCAYSEFWYSQINWPDFNGEDLRKAIF
DYQNRDRRFGGIK

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=37.5, Blast_Score=165, Evalue=4e-41,
Organism=Homo sapiens, GI45580738, Length=224, Percent_Identity=37.5, Blast_Score=165, Evalue=4e-41,
Organism=Escherichia coli, GI1786371, Length=239, Percent_Identity=45.1882845188285, Blast_Score=231, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=35.8407079646018, Blast_Score=154, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6319474, Length=213, Percent_Identity=38.4976525821596, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323748, Length=222, Percent_Identity=36.9369369369369, Blast_Score=121, Evalue=1e-28,
Organism=Drosophila melanogaster, GI18857969, Length=228, Percent_Identity=33.3333333333333, Blast_Score=155, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_CLOPE (Q8XJQ9)

Other databases:

- EMBL:   BA000016
- RefSeq:   NP_562612.1
- ProteinModelPortal:   Q8XJQ9
- SMR:   Q8XJQ9
- GeneID:   990006
- GenomeReviews:   BA000016_GR
- KEGG:   cpe:CPE1696
- NMPDR:   fig|195102.1.peg.1759
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- PhylomeDB:   Q8XJQ9
- ProtClustDB:   PRK14830
- BioCyc:   CPER195102:CPE1696-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 29259; Mature: 29259

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 32-32

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDFFSKKGNEDSEEIVLIEDKMPKHIAIIMDGNGRWAKKRGLPRTMGHRAGVKTIKTIV
CCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCCHHHCCCCHHHHHHHHHHHHHHHH
KECDKLGVKYLTLYAFSTENWKRPEDEVNALMKLVVEFIKNEIDELHQNGVRVQTIGDLS
HHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHH
RFPEEPKKAILWAMEKTKDNTGVVLSLALNYGGRNEIVRGIKSVIEDVKAGKISIDDINE
HCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCEEEHHHCCH
DMFNDYLYTKGMPDPDLIIRPSGEQRLSNFLLWQCAYSEFWYSQINWPDFNGEDLRKAIF
HHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
DYQNRDRRFGGIK
HHCCCCCCCCCCC
>Mature Secondary Structure
MLDFFSKKGNEDSEEIVLIEDKMPKHIAIIMDGNGRWAKKRGLPRTMGHRAGVKTIKTIV
CCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCCHHHCCCCHHHHHHHHHHHHHHHH
KECDKLGVKYLTLYAFSTENWKRPEDEVNALMKLVVEFIKNEIDELHQNGVRVQTIGDLS
HHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHH
RFPEEPKKAILWAMEKTKDNTGVVLSLALNYGGRNEIVRGIKSVIEDVKAGKISIDDINE
HCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCEEEHHHCCH
DMFNDYLYTKGMPDPDLIIRPSGEQRLSNFLLWQCAYSEFWYSQINWPDFNGEDLRKAIF
HHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
DYQNRDRRFGGIK
HHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792842