Click here to switch to the map view.

The map label for this gene is ntpA

Identifier: 18310620

GI number: 18310620

Start: 1910442

End: 1912217

Strand: Reverse

Name: ntpA

Synonym: CPE1638

Alternate gene names: 18310620

Gene position: 1912217-1910442 (Counterclockwise)

Preceding gene: 18310621

Following gene: 18310619

Centisome position: 63.08

GC content: 37.73

Gene sequence:

>1776_bases
TTGAAAACGGGGAAAATTATCAAGGTTTCAGGTCCTTTAGTAGTTGCTGAAGGTATGGATGAAGCTAATGTATATGACGT
TGTAAAAGTTGGAGAAAAAGGTCTTATCGGAGAGATCATTGAAATGAGAGGAGATAAGGCTTCAATCCAGGTATATGAAG
AAACATCAGGTATTGGACCTGGGGACCCAGTTATAACTACTGGAGAACCACTTTCAGTAGAGTTAGGACCAGGACTTATA
GAGTCAATGTTCGATGGAATACAAAGACCTCTAGACGCTTTCATGAAAGCAGCTAATTCTGCTTTCTTAAGTAAAGGGGT
AGAAGTTAAATCTTTAAATAGAGAGAAAAAATGGCCTTTTGTGCCAACTGCTAAGGTTGGAGATAAGGTTTCAGCTGGAG
ACGTAATAGGAACAGTTCAAGAGACTGCCGTTGTTCTTCATAGAATAATGGTTCCTTTCGGCGTTGAAGGTACAATAAAA
GAAATCAAAGCTGGAGATTTCAATGTAGAAGAAGTTATCGCTGTAGTAGAAACTGAAAAAGGTGATAAGAATTTAACATT
AATGCAAAAATGGCCTGTAAGAAAAGGTAGACCATATGCAAGAAAATTAAATCCAGTTGAGCCAATGACTACAGGACAAA
GAGTTATAGATACTTTCTTCCCAGTAGCTAAAGGTGGAGCTGCTGCCGTTCCAGGACCTTTCGGAGCTGGTAAAACAGTA
GTTCAGCACCAAGTTGCTAAATGGGGAGATACTGAGATAGTTGTTTACGTTGGATGTGGAGAACGTGGTAACGAGATGAC
AGACGTTCTTAACGAATTCCCAGAACTTAAAGACCCTAAAACTGGGGAAAGCTTAATGAAGAGAACAGTTCTTATCGCTA
ATACATCTAACATGCCAGTTGCTGCCAGAGAAGCATCAATATATACTGGTATAACAATAGCAGAGTATTTTAGAGATATG
GGATACTCAGTATCAATCATGGCTGACTCAACTTCACGTTGGGCAGAAGCTCTAAGAGAAATGTCAGGAAGACTTGAAGA
AATGCCAGGAGACGAAGGTTACCCAGCATACTTAGGATCAAGACTTGCTGATTACTATGAAAGAGCTGGTAAAGTTGTAG
CTTTAGGTAAAGATGGAAGAGAAGGAGCCGTTACAGCTATCGGAGCAGTATCCCCTCCAGGAGGAGATATATCTGAGCCA
GTTACACAATCAACTTTAAGAATAGTTAAAGTTTTCTGGGGACTAGATGCTCAATTAGCATATAAGAGACACTTCCCATC
AATTAACTGGTTAACATCATACTCATTATACTTAGAAAAAATGGGTGAATGGATGGATGCTCACGTAGCAGACGATTGGT
CAGCATTAAGAACAGAAGCTATGGCACTTCTTCAAGAAGAAGCAAACTTAGAAGAAATAGTAAGACTTGTTGGTATGGAT
GCACTTTCAGAAGGTGATAGATTAAAACTTGAAGTTGCTAAGTCAATAAGAGAAGACTATTTACAACAAAACGCATTCCA
TGAGAATGACACATATACTTCATTAAATAAACAGTACAAAATGTTAAACTTAATCTTAAGTTTCAAACATGAGGCTGAAA
AAGCTTTAGAAGCTGGAGTTTATTTAGATAAAGTATTAAAACTTCCTGTTAGAGATAGAATTGCAAGAAGTAAATATATT
TCAGAAGAAGAAATAAGTAAGATGGATGACATCTTAGTTGAATTAAAATCAGAGATGAACAAGTTAATCAGCGAGGGAGG
TGTTCTAAATGCTTAA

Upstream 100 bases:

>100_bases
CCAAGCAATCAAGGAACTCTAAATATAGGAAAACAAAGAATATCAGATAACGTTGAAAAAGCAGTTGGCGTTAACATTTT
ATAGAAAGTAGGTAGATAAC

Downstream 100 bases:

>100_bases
AGAGTACAGAACAGTTACAGAAGTTGTAGGACCCTTAATGGCTGTTGAAGGCGTGGAAGGTGTTAAATACGATGAACTAG
TTGAAATAGAAATGCAAACT

Product: V-type ATP synthase subunit A

Products: NA

Alternate protein names: V-ATPase subunit A

Number of amino acids: Translated: 591; Mature: 591

Protein sequence:

>591_residues
MKTGKIIKVSGPLVVAEGMDEANVYDVVKVGEKGLIGEIIEMRGDKASIQVYEETSGIGPGDPVITTGEPLSVELGPGLI
ESMFDGIQRPLDAFMKAANSAFLSKGVEVKSLNREKKWPFVPTAKVGDKVSAGDVIGTVQETAVVLHRIMVPFGVEGTIK
EIKAGDFNVEEVIAVVETEKGDKNLTLMQKWPVRKGRPYARKLNPVEPMTTGQRVIDTFFPVAKGGAAAVPGPFGAGKTV
VQHQVAKWGDTEIVVYVGCGERGNEMTDVLNEFPELKDPKTGESLMKRTVLIANTSNMPVAAREASIYTGITIAEYFRDM
GYSVSIMADSTSRWAEALREMSGRLEEMPGDEGYPAYLGSRLADYYERAGKVVALGKDGREGAVTAIGAVSPPGGDISEP
VTQSTLRIVKVFWGLDAQLAYKRHFPSINWLTSYSLYLEKMGEWMDAHVADDWSALRTEAMALLQEEANLEEIVRLVGMD
ALSEGDRLKLEVAKSIREDYLQQNAFHENDTYTSLNKQYKMLNLILSFKHEAEKALEAGVYLDKVLKLPVRDRIARSKYI
SEEEISKMDDILVELKSEMNKLISEGGVLNA

Sequences:

>Translated_591_residues
MKTGKIIKVSGPLVVAEGMDEANVYDVVKVGEKGLIGEIIEMRGDKASIQVYEETSGIGPGDPVITTGEPLSVELGPGLI
ESMFDGIQRPLDAFMKAANSAFLSKGVEVKSLNREKKWPFVPTAKVGDKVSAGDVIGTVQETAVVLHRIMVPFGVEGTIK
EIKAGDFNVEEVIAVVETEKGDKNLTLMQKWPVRKGRPYARKLNPVEPMTTGQRVIDTFFPVAKGGAAAVPGPFGAGKTV
VQHQVAKWGDTEIVVYVGCGERGNEMTDVLNEFPELKDPKTGESLMKRTVLIANTSNMPVAAREASIYTGITIAEYFRDM
GYSVSIMADSTSRWAEALREMSGRLEEMPGDEGYPAYLGSRLADYYERAGKVVALGKDGREGAVTAIGAVSPPGGDISEP
VTQSTLRIVKVFWGLDAQLAYKRHFPSINWLTSYSLYLEKMGEWMDAHVADDWSALRTEAMALLQEEANLEEIVRLVGMD
ALSEGDRLKLEVAKSIREDYLQQNAFHENDTYTSLNKQYKMLNLILSFKHEAEKALEAGVYLDKVLKLPVRDRIARSKYI
SEEEISKMDDILVELKSEMNKLISEGGVLNA
>Mature_591_residues
MKTGKIIKVSGPLVVAEGMDEANVYDVVKVGEKGLIGEIIEMRGDKASIQVYEETSGIGPGDPVITTGEPLSVELGPGLI
ESMFDGIQRPLDAFMKAANSAFLSKGVEVKSLNREKKWPFVPTAKVGDKVSAGDVIGTVQETAVVLHRIMVPFGVEGTIK
EIKAGDFNVEEVIAVVETEKGDKNLTLMQKWPVRKGRPYARKLNPVEPMTTGQRVIDTFFPVAKGGAAAVPGPFGAGKTV
VQHQVAKWGDTEIVVYVGCGERGNEMTDVLNEFPELKDPKTGESLMKRTVLIANTSNMPVAAREASIYTGITIAEYFRDM
GYSVSIMADSTSRWAEALREMSGRLEEMPGDEGYPAYLGSRLADYYERAGKVVALGKDGREGAVTAIGAVSPPGGDISEP
VTQSTLRIVKVFWGLDAQLAYKRHFPSINWLTSYSLYLEKMGEWMDAHVADDWSALRTEAMALLQEEANLEEIVRLVGMD
ALSEGDRLKLEVAKSIREDYLQQNAFHENDTYTSLNKQYKMLNLILSFKHEAEKALEAGVYLDKVLKLPVRDRIARSKYI
SEEEISKMDDILVELKSEMNKLISEGGVLNA

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit

COG id: COG1155

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI19913424, Length=539, Percent_Identity=53.2467532467532, Blast_Score=598, Evalue=1e-171,
Organism=Homo sapiens, GI32189394, Length=387, Percent_Identity=27.906976744186, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI19913426, Length=345, Percent_Identity=26.9565217391304, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI19913428, Length=243, Percent_Identity=28.8065843621399, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI50345984, Length=243, Percent_Identity=29.2181069958848, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI4757810, Length=243, Percent_Identity=29.2181069958848, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1790170, Length=345, Percent_Identity=28.1159420289855, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1788251, Length=318, Percent_Identity=27.9874213836478, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1790172, Length=233, Percent_Identity=27.0386266094421, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17565854, Length=540, Percent_Identity=52.5925925925926, Blast_Score=584, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI17510931, Length=341, Percent_Identity=28.1524926686217, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25144756, Length=364, Percent_Identity=29.1208791208791, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17570191, Length=341, Percent_Identity=26.6862170087977, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71988074, Length=366, Percent_Identity=27.5956284153005, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71988080, Length=248, Percent_Identity=28.6290322580645, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71988063, Length=248, Percent_Identity=28.6290322580645, Blast_Score=89, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6320016, Length=335, Percent_Identity=50.4477611940299, Blast_Score=327, Evalue=4e-90,
Organism=Saccharomyces cerevisiae, GI6319603, Length=344, Percent_Identity=27.906976744186, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6322581, Length=353, Percent_Identity=29.4617563739377, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6319370, Length=236, Percent_Identity=28.3898305084746, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24583988, Length=541, Percent_Identity=53.0499075785582, Blast_Score=593, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24583986, Length=541, Percent_Identity=53.0499075785582, Blast_Score=593, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24583984, Length=541, Percent_Identity=53.0499075785582, Blast_Score=593, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24583992, Length=539, Percent_Identity=53.0612244897959, Blast_Score=592, Evalue=1e-169,
Organism=Drosophila melanogaster, GI20129479, Length=532, Percent_Identity=53.3834586466165, Blast_Score=579, Evalue=1e-165,
Organism=Drosophila melanogaster, GI28574560, Length=302, Percent_Identity=31.4569536423841, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24638766, Length=325, Percent_Identity=29.8461538461538, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI281361666, Length=371, Percent_Identity=26.4150943396226, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24646341, Length=371, Percent_Identity=26.4150943396226, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17136796, Length=371, Percent_Identity=26.4150943396226, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24658560, Length=243, Percent_Identity=28.8065843621399, Blast_Score=86, Evalue=7e-17,

Paralogues:

None

Copy number: 10836 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 8,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): VATA_CLOP1 (Q0TPW7)

Other databases:

- EMBL:   CP000246
- RefSeq:   YP_696323.1
- ProteinModelPortal:   Q0TPW7
- SMR:   Q0TPW7
- STRING:   Q0TPW7
- GeneID:   4201875
- GenomeReviews:   CP000246_GR
- KEGG:   cpf:CPF_1890
- TIGR:   CPF_1890
- eggNOG:   COG1155
- HOGENOM:   HBG288114
- OMA:   KITWNVI
- ProtClustDB:   PRK04192
- BioCyc:   CPER195103:CPF_1890-MONOMER
- HAMAP:   MF_00309
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- InterPro:   IPR022878

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 64873; Mature: 64873

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTGKIIKVSGPLVVAEGMDEANVYDVVKVGEKGLIGEIIEMRGDKASIQVYEETSGIGP
CCCCCEEEECCCEEEECCCCCCCHHHHHHCCCCCHHHHHHHHCCCCCEEEEEECCCCCCC
GDPVITTGEPLSVELGPGLIESMFDGIQRPLDAFMKAANSAFLSKGVEVKSLNREKKWPF
CCCEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCC
VPTAKVGDKVSAGDVIGTVQETAVVLHRIMVPFGVEGTIKEIKAGDFNVEEVIAVVETEK
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHHHHHCCCC
GDKNLTLMQKWPVRKGRPYARKLNPVEPMTTGQRVIDTFFPVAKGGAAAVPGPFGAGKTV
CCCCEEEEEECCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
VQHQVAKWGDTEIVVYVGCGERGNEMTDVLNEFPELKDPKTGESLMKRTVLIANTSNMPV
HHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCCCCHHHHHCEEEEEECCCCCE
AAREASIYTGITIAEYFRDMGYSVSIMADSTSRWAEALREMSGRLEEMPGDEGYPAYLGS
EECCCHHHCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
RLADYYERAGKVVALGKDGREGAVTAIGAVSPPGGDISEPVTQSTLRIVKVFWGLDAQLA
HHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHH
YKRHFPSINWLTSYSLYLEKMGEWMDAHVADDWSALRTEAMALLQEEANLEEIVRLVGMD
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCH
ALSEGDRLKLEVAKSIREDYLQQNAFHENDTYTSLNKQYKMLNLILSFKHEAEKALEAGV
HCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLDKVLKLPVRDRIARSKYISEEEISKMDDILVELKSEMNKLISEGGVLNA
HHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKTGKIIKVSGPLVVAEGMDEANVYDVVKVGEKGLIGEIIEMRGDKASIQVYEETSGIGP
CCCCCEEEECCCEEEECCCCCCCHHHHHHCCCCCHHHHHHHHCCCCCEEEEEECCCCCCC
GDPVITTGEPLSVELGPGLIESMFDGIQRPLDAFMKAANSAFLSKGVEVKSLNREKKWPF
CCCEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCC
VPTAKVGDKVSAGDVIGTVQETAVVLHRIMVPFGVEGTIKEIKAGDFNVEEVIAVVETEK
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHHHHHCCCC
GDKNLTLMQKWPVRKGRPYARKLNPVEPMTTGQRVIDTFFPVAKGGAAAVPGPFGAGKTV
CCCCEEEEEECCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
VQHQVAKWGDTEIVVYVGCGERGNEMTDVLNEFPELKDPKTGESLMKRTVLIANTSNMPV
HHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCCCCHHHHHCEEEEEECCCCCE
AAREASIYTGITIAEYFRDMGYSVSIMADSTSRWAEALREMSGRLEEMPGDEGYPAYLGS
EECCCHHHCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
RLADYYERAGKVVALGKDGREGAVTAIGAVSPPGGDISEPVTQSTLRIVKVFWGLDAQLA
HHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHH
YKRHFPSINWLTSYSLYLEKMGEWMDAHVADDWSALRTEAMALLQEEANLEEIVRLVGMD
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCH
ALSEGDRLKLEVAKSIREDYLQQNAFHENDTYTSLNKQYKMLNLILSFKHEAEKALEAGV
HCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLDKVLKLPVRDRIARSKYISEEEISKMDDILVELKSEMNKLISEGGVLNA
HHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA