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The map label for this gene is fdh [H]

Identifier: 18310530

GI number: 18310530

Start: 1813734

End: 1815722

Strand: Reverse

Name: fdh [H]

Synonym: CPE1548

Alternate gene names: 18310530

Gene position: 1815722-1813734 (Counterclockwise)

Preceding gene: 18310532

Following gene: 18310529

Centisome position: 59.9

GC content: 29.31

Gene sequence:

>1989_bases
ATGGAAGTATTAAGTCATGGGTGTACATTAGATTGCTTTGATTGTTGTAAATTTAATGTTTATAAAGAAGGAAGTGAAAT
TCTAAAAATAGAAGGTGACAAAGAGCATCCATTTACAAAGGGACTCATATGTAAAAAAGGAGTAGCTCACTTAAACAGAT
TGAATCATAAAGATAGAATATATACTCCTCTTTTAAAGAATAATGGAGTATGGGAAGAGATTTCCTTTGAAGATGCCTTA
GAAATAATGAAAGAGAAACTTGAATATACAAAAGAGAAATATTCTTCTAAGTCAATATTATATTATAGCCAATATGGAAG
TGGAGGAGTACTAAAGGGAATAGAGGATATATTCTTTAATTTTTATGGTGGTGTAAGTAAAGCTACAGGAGGTCCTTGTT
GGAGTGCTGGAATGAGAGCTCAAAAATATGATTTTGGAGATTCTGTATCAAATTCCTTAGAGGATATGATAAATAGTAAA
AACATATTTTTATGGGGTAAAAATCCTGCAAATACAACCATACATACTATGGCGATTTTAAATAAGGCAAAGAAAAACGG
GAGCAGAATAATAGTTATAGATCCAATAAATACTCAAAGTGCAAAGCTTGGAGATATTCATGTGAAAATTAAACCAGGGA
CAGATGGAGCTTTAGCTATGGCTATGGCAAAAATAATAATTTCTAAAGGTCTTCAAGATAAGGATTTTATAAATAAATAT
GTTTTAGGATTCCAAGAATATAAAGATCATTTAGAGAATTTTGATTTGGATTATTTAAGTGATGAATGTGGAATAGAAAT
AGAGGATATAGAAAAGCTAACTAAATACTATTGTGAAAAAAATTCTAGCATATATTTGGGATATGGAATGCAAAAATATA
AGAATGGTGGAAATACCATAAGAGCTATTGATGCCTTAGGTGCTTTAACTGGTCAAATTGGAGTTAAAGGCGGTGGAGTA
AATTACGCAAATAAGGTATTAAGTAGGATTTTAGATTCAGATCCCTTTAAAAGTGGAGAAGTTGGAGAAAATAGAGAATT
TTATGTCTCTAATATAAATGAGTTTATAGAAGAACCTAAAAAATATTCTTTAAGTGTAGAAGATTCTAATGCACCTATAA
AAATCATGGTAATAGCTAATAGCAATCTCATGAATCAACTTCCAAACTTAAATAGATTAAATAATAGTATAGATAAAGTT
GAGTTTAAAGTTTGTTTTGATATGTTTATGACAGATACTGCTTCGAAGTGTGACCTATTCATTCCTTGTACCAATACCTT
AGAAAGCGAGGATATGGTTTTTAGTTCAATGACTAATCCATATTTAATATATAATGAAAAGATAATAGAACCTAGAGAAA
AACTTATGGATGAATACTACTTTTTTAGAGAGTTAGCTAAAAGAATGAATTTAAAAGGATATCCAAGCCTATCTAAAAAA
GATTATTTAAGTAAGGTTATTGAACCTTTAATGAGCTATAATAAAGATATAACCTTAGATTATTTAAAAAATAATCCTTT
TACAGTTTATGATGATGTAGCTTGGGAAAATAAAAAGTTTAAAACACCTTCTGGCAAATTTGAACTTGCATCTAAAAGAG
CTTTAAAAGAGTGCGGAAGCTTAACACCAACATACTTAAGTCCTAGAATAAAAGAAAACTGTTTTAGATTGCTTACTAAT
CATTCTAAAGATTCATTATCAAGTCAGCATTATATAGATGTAGATGAAAAGGCAAAAGTATATTTAAATGAGAATATGAT
AAGAAAGTTTTCCTTAATTTGCGGAGAAAAGGTTAAATTAAAATCAAGGACTGGAGAGATTACAGCAATTTGTTCCTTGG
ATAATGGGGTTCAAGATTATGTGGCTTTAATGTATGTTGGTTGGTGGAAAAAACATGGGAATCCAAACTTTTTAACTGAA
TCAGGAATCTCTGATATGGGTGGACAAATAACATATAATGAAACCTTTATAGAGATTGAAAATATATAA

Upstream 100 bases:

>100_bases
TTTATAGTTGTTAAAGAAGGAACATTCATATAAAATTAGACTAAATTAGAAATAGAGGAATTTTATTATGTATGTCATTT
AAAGAGAAGGGGGAGTTATT

Downstream 100 bases:

>100_bases
AAATCAAAAGAGAAAGGCTGTATTTAAAGAGAATAAACATTAAAGAAAAAGGAGGATGCTTCAAAAAAATATTTTTGTGG
AGCGAAAAGATATGGTGAAT

Product: molybdopterin oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 662; Mature: 662

Protein sequence:

>662_residues
MEVLSHGCTLDCFDCCKFNVYKEGSEILKIEGDKEHPFTKGLICKKGVAHLNRLNHKDRIYTPLLKNNGVWEEISFEDAL
EIMKEKLEYTKEKYSSKSILYYSQYGSGGVLKGIEDIFFNFYGGVSKATGGPCWSAGMRAQKYDFGDSVSNSLEDMINSK
NIFLWGKNPANTTIHTMAILNKAKKNGSRIIVIDPINTQSAKLGDIHVKIKPGTDGALAMAMAKIIISKGLQDKDFINKY
VLGFQEYKDHLENFDLDYLSDECGIEIEDIEKLTKYYCEKNSSIYLGYGMQKYKNGGNTIRAIDALGALTGQIGVKGGGV
NYANKVLSRILDSDPFKSGEVGENREFYVSNINEFIEEPKKYSLSVEDSNAPIKIMVIANSNLMNQLPNLNRLNNSIDKV
EFKVCFDMFMTDTASKCDLFIPCTNTLESEDMVFSSMTNPYLIYNEKIIEPREKLMDEYYFFRELAKRMNLKGYPSLSKK
DYLSKVIEPLMSYNKDITLDYLKNNPFTVYDDVAWENKKFKTPSGKFELASKRALKECGSLTPTYLSPRIKENCFRLLTN
HSKDSLSSQHYIDVDEKAKVYLNENMIRKFSLICGEKVKLKSRTGEITAICSLDNGVQDYVALMYVGWWKKHGNPNFLTE
SGISDMGGQITYNETFIEIENI

Sequences:

>Translated_662_residues
MEVLSHGCTLDCFDCCKFNVYKEGSEILKIEGDKEHPFTKGLICKKGVAHLNRLNHKDRIYTPLLKNNGVWEEISFEDAL
EIMKEKLEYTKEKYSSKSILYYSQYGSGGVLKGIEDIFFNFYGGVSKATGGPCWSAGMRAQKYDFGDSVSNSLEDMINSK
NIFLWGKNPANTTIHTMAILNKAKKNGSRIIVIDPINTQSAKLGDIHVKIKPGTDGALAMAMAKIIISKGLQDKDFINKY
VLGFQEYKDHLENFDLDYLSDECGIEIEDIEKLTKYYCEKNSSIYLGYGMQKYKNGGNTIRAIDALGALTGQIGVKGGGV
NYANKVLSRILDSDPFKSGEVGENREFYVSNINEFIEEPKKYSLSVEDSNAPIKIMVIANSNLMNQLPNLNRLNNSIDKV
EFKVCFDMFMTDTASKCDLFIPCTNTLESEDMVFSSMTNPYLIYNEKIIEPREKLMDEYYFFRELAKRMNLKGYPSLSKK
DYLSKVIEPLMSYNKDITLDYLKNNPFTVYDDVAWENKKFKTPSGKFELASKRALKECGSLTPTYLSPRIKENCFRLLTN
HSKDSLSSQHYIDVDEKAKVYLNENMIRKFSLICGEKVKLKSRTGEITAICSLDNGVQDYVALMYVGWWKKHGNPNFLTE
SGISDMGGQITYNETFIEIENI
>Mature_662_residues
MEVLSHGCTLDCFDCCKFNVYKEGSEILKIEGDKEHPFTKGLICKKGVAHLNRLNHKDRIYTPLLKNNGVWEEISFEDAL
EIMKEKLEYTKEKYSSKSILYYSQYGSGGVLKGIEDIFFNFYGGVSKATGGPCWSAGMRAQKYDFGDSVSNSLEDMINSK
NIFLWGKNPANTTIHTMAILNKAKKNGSRIIVIDPINTQSAKLGDIHVKIKPGTDGALAMAMAKIIISKGLQDKDFINKY
VLGFQEYKDHLENFDLDYLSDECGIEIEDIEKLTKYYCEKNSSIYLGYGMQKYKNGGNTIRAIDALGALTGQIGVKGGGV
NYANKVLSRILDSDPFKSGEVGENREFYVSNINEFIEEPKKYSLSVEDSNAPIKIMVIANSNLMNQLPNLNRLNNSIDKV
EFKVCFDMFMTDTASKCDLFIPCTNTLESEDMVFSSMTNPYLIYNEKIIEPREKLMDEYYFFRELAKRMNLKGYPSLSKK
DYLSKVIEPLMSYNKDITLDYLKNNPFTVYDDVAWENKKFKTPSGKFELASKRALKECGSLTPTYLSPRIKENCFRLLTN
HSKDSLSSQHYIDVDEKAKVYLNENMIRKFSLICGEKVKLKSRTGEITAICSLDNGVQDYVALMYVGWWKKHGNPNFLTE
SGISDMGGQITYNETFIEIENI

Specific function: Terminal Reductase During Anaerobic Growth On Various Sulfoxide And N-Oxide Compounds (By Similarity). [C]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm Face Of The Membrane [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787870, Length=764, Percent_Identity=25.5235602094241, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI3868721, Length=491, Percent_Identity=26.6802443991853, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI171474008, Length=752, Percent_Identity=25.1329787234043, Blast_Score=161, Evalue=1e-40,
Organism=Escherichia coli, GI87081994, Length=659, Percent_Identity=23.5204855842185, Blast_Score=149, Evalue=7e-37,
Organism=Escherichia coli, GI87081797, Length=765, Percent_Identity=23.7908496732026, Blast_Score=135, Evalue=8e-33,
Organism=Escherichia coli, GI145693196, Length=658, Percent_Identity=22.7963525835866, Blast_Score=135, Evalue=9e-33,
Organism=Escherichia coli, GI1787231, Length=701, Percent_Identity=22.8245363766049, Blast_Score=122, Evalue=7e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 75196; Mature: 75196

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVLSHGCTLDCFDCCKFNVYKEGSEILKIEGDKEHPFTKGLICKKGVAHLNRLNHKDRI
CCCCCCCCCEEHHHHCCCCEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCE
YTPLLKNNGVWEEISFEDALEIMKEKLEYTKEKYSSKSILYYSQYGSGGVLKGIEDIFFN
ECCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHH
FYGGVSKATGGPCWSAGMRAQKYDFGDSVSNSLEDMINSKNIFLWGKNPANTTIHTMAIL
HHCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHH
NKAKKNGSRIIVIDPINTQSAKLGDIHVKIKPGTDGALAMAMAKIIISKGLQDKDFINKY
HHHHCCCCEEEEEECCCCCCCEECEEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHH
VLGFQEYKDHLENFDLDYLSDECGIEIEDIEKLTKYYCEKNSSIYLGYGMQKYKNGGNTI
HHHHHHHHHHHHCCCCHHCCCCCCEEHHHHHHHHHHHHCCCCEEEEECCHHHHCCCCCEE
RAIDALGALTGQIGVKGGGVNYANKVLSRILDSDPFKSGEVGENREFYVSNINEFIEEPK
EHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHCCCH
KYSLSVEDSNAPIKIMVIANSNLMNQLPNLNRLNNSIDKVEFKVCFDMFMTDTASKCDLF
HEEEEEECCCCCEEEEEEECCHHHHHCCCCHHHCCHHHHHHHHHHHHHHHCCCCCCCEEE
IPCTNTLESEDMVFSSMTNPYLIYNEKIIEPREKLMDEYYFFRELAKRMNLKGYPSLSKK
EECCCCCCCCHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
DYLSKVIEPLMSYNKDITLDYLKNNPFTVYDDVAWENKKFKTPSGKFELASKRALKECGS
HHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCC
LTPTYLSPRIKENCFRLLTNHSKDSLSSQHYIDVDEKAKVYLNENMIRKFSLICGEKVKL
CCCHHCCHHHHHHHHHHHHCCCHHHCCCCCEECCCCCCEEEECHHHHHHHHHHCCCCEEE
KSRTGEITAICSLDNGVQDYVALMYVGWWKKHGNPNFLTESGISDMGGQITYNETFIEIE
ECCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCEEEECCEEEEEE
NI
CC
>Mature Secondary Structure
MEVLSHGCTLDCFDCCKFNVYKEGSEILKIEGDKEHPFTKGLICKKGVAHLNRLNHKDRI
CCCCCCCCCEEHHHHCCCCEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCE
YTPLLKNNGVWEEISFEDALEIMKEKLEYTKEKYSSKSILYYSQYGSGGVLKGIEDIFFN
ECCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHH
FYGGVSKATGGPCWSAGMRAQKYDFGDSVSNSLEDMINSKNIFLWGKNPANTTIHTMAIL
HHCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHH
NKAKKNGSRIIVIDPINTQSAKLGDIHVKIKPGTDGALAMAMAKIIISKGLQDKDFINKY
HHHHCCCCEEEEEECCCCCCCEECEEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHH
VLGFQEYKDHLENFDLDYLSDECGIEIEDIEKLTKYYCEKNSSIYLGYGMQKYKNGGNTI
HHHHHHHHHHHHCCCCHHCCCCCCEEHHHHHHHHHHHHCCCCEEEEECCHHHHCCCCCEE
RAIDALGALTGQIGVKGGGVNYANKVLSRILDSDPFKSGEVGENREFYVSNINEFIEEPK
EHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHCCCH
KYSLSVEDSNAPIKIMVIANSNLMNQLPNLNRLNNSIDKVEFKVCFDMFMTDTASKCDLF
HEEEEEECCCCCEEEEEEECCHHHHHCCCCHHHCCHHHHHHHHHHHHHHHCCCCCCCEEE
IPCTNTLESEDMVFSSMTNPYLIYNEKIIEPREKLMDEYYFFRELAKRMNLKGYPSLSKK
EECCCCCCCCHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
DYLSKVIEPLMSYNKDITLDYLKNNPFTVYDDVAWENKKFKTPSGKFELASKRALKECGS
HHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCC
LTPTYLSPRIKENCFRLLTNHSKDSLSSQHYIDVDEKAKVYLNENMIRKFSLICGEKVKL
CCCHHCCHHHHHHHHHHHHCCCHHHCCCCCEECCCCCCEEEECHHHHHHHHHHCCCCEEE
KSRTGEITAICSLDNGVQDYVALMYVGWWKKHGNPNFLTESGISDMGGQITYNETFIEIE
ECCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCEEEECCEEEEEE
NI
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 1552862 [H]