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The map label for this gene is uraA [H]

Identifier: 18310487

GI number: 18310487

Start: 1757210

End: 1758508

Strand: Reverse

Name: uraA [H]

Synonym: CPE1505

Alternate gene names: 18310487

Gene position: 1758508-1757210 (Counterclockwise)

Preceding gene: 18310489

Following gene: 18310486

Centisome position: 58.01

GC content: 31.79

Gene sequence:

>1299_bases
ATGACAGAATCTGTACAAAATAAAGAGGTAGAACTACTAGAAGTCATAGGAGTAGAGGACAAGTTACCTCTAAAAAAAGC
AATTCCTTTAAGTGTCCAACATTTATTTGCAATGTTTGGATCATCAGTCTTAGTACCAATTCTTTTAAATATTGATCCAG
CAACGGTCTTATTCTTTAATGGAATAGGAACTTTATTATATGCTTTCATAACAAAAAGAAAAATTCCAGCATATTTAGGA
TCGAGTTTTGCATTTATATCACCAGTATTACTTTTAATGGGAGAGGGATATTCCTTCACTGAAGTACAAAGTGGCTTTGT
AGTATCAGGATTATTGTTTGCTACCATAGCAATCATTGTGGGTTTTGTAGGAACAGGATGGATTAGAAAATTATTTCCAC
CAGCTTCTATGGGGGCTATAGTAACAATAATAGGATTAGAGTTAGCACCAACAGCAGCAGATATGGCTGGTTTCCCAGTA
GGCTTATCAAATTCTAAGGTTTTAAATCCAACATGGGTATTAGTTTCAATGATTACAATAATAACTGTAATTTTAGCTTC
AGTATTATTAAGAGGATTTTTAAAGGTAATACCTATATTAATAGGTATAGTTACTGGATATTTAGTTAGTTGTTTTTTAG
GACTAGTAGATTTTACACAAGTAAAAGAGGCAAGCCTCTTTGTATTGCCACAAATACATATAGCTAAACCAAGTTTAAAT
GCAATTTTAACAATTTTACCTGCAACCTTTGTAGTAGTTGCAGAGCATGTTGGCCATTTAGTAGTAACAAGTAGCATAGT
TGGAAAAGATTTATCTAAAGATCCTGGACTTAATAGATCACTTTTAGGAGATGGTTTATCAACTATGATATCTGGATTTT
TTGGATCAGTTCCTACTACAACTTATGGTGAAAATATCGGAGTAATGGCATTAACAAAGGTTTATAGTTCCTACGTAATT
TGTGGAGCTGGGGTTTTATCTGTAATCTTAGGATTTTCAGGAAGCTTATCAGCTTTAATAAGAAGCATACCAACACCGGT
AATAGGGGGAGTTAGTTTGCTTTTATTTGGTACTATAGCTACCTCAGGATTAAGAACTTTCATAGAAGAGAAAGTTGATT
ATTCAAAATCAAAAAACTTAATATTAACATCAGTTACAATGATAGTTGGTTTAAGTAATATAGCAGTAAGATTTGGTGCA
ATAGAAATTAAAGGAATGGGACTTGCTACTATAGTTGCTATGATTTTAAGTATATCATTTATGATATTTGATAAATTAGG
TTTAATGAATGAAAAATAA

Upstream 100 bases:

>100_bases
AAATGCGACAAAAAAATATTGAATTATTATGAACGGTATGCTATATTTTATATAAACTTTTAATTTAGACCTGAGAGTCT
AGAAAAGGGAGGATAATAAT

Downstream 100 bases:

>100_bases
ATATTAATTAAAAAGCTAGATTCTATTAAGAGATTTAAATGAAAGATAAAGTATTAAATTTTTATGAAAGTTTCTTTGGA
TTTTAATAGAATTTAGCTTA

Product: uracil transporter

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MTESVQNKEVELLEVIGVEDKLPLKKAIPLSVQHLFAMFGSSVLVPILLNIDPATVLFFNGIGTLLYAFITKRKIPAYLG
SSFAFISPVLLLMGEGYSFTEVQSGFVVSGLLFATIAIIVGFVGTGWIRKLFPPASMGAIVTIIGLELAPTAADMAGFPV
GLSNSKVLNPTWVLVSMITIITVILASVLLRGFLKVIPILIGIVTGYLVSCFLGLVDFTQVKEASLFVLPQIHIAKPSLN
AILTILPATFVVVAEHVGHLVVTSSIVGKDLSKDPGLNRSLLGDGLSTMISGFFGSVPTTTYGENIGVMALTKVYSSYVI
CGAGVLSVILGFSGSLSALIRSIPTPVIGGVSLLLFGTIATSGLRTFIEEKVDYSKSKNLILTSVTMIVGLSNIAVRFGA
IEIKGMGLATIVAMILSISFMIFDKLGLMNEK

Sequences:

>Translated_432_residues
MTESVQNKEVELLEVIGVEDKLPLKKAIPLSVQHLFAMFGSSVLVPILLNIDPATVLFFNGIGTLLYAFITKRKIPAYLG
SSFAFISPVLLLMGEGYSFTEVQSGFVVSGLLFATIAIIVGFVGTGWIRKLFPPASMGAIVTIIGLELAPTAADMAGFPV
GLSNSKVLNPTWVLVSMITIITVILASVLLRGFLKVIPILIGIVTGYLVSCFLGLVDFTQVKEASLFVLPQIHIAKPSLN
AILTILPATFVVVAEHVGHLVVTSSIVGKDLSKDPGLNRSLLGDGLSTMISGFFGSVPTTTYGENIGVMALTKVYSSYVI
CGAGVLSVILGFSGSLSALIRSIPTPVIGGVSLLLFGTIATSGLRTFIEEKVDYSKSKNLILTSVTMIVGLSNIAVRFGA
IEIKGMGLATIVAMILSISFMIFDKLGLMNEK
>Mature_431_residues
TESVQNKEVELLEVIGVEDKLPLKKAIPLSVQHLFAMFGSSVLVPILLNIDPATVLFFNGIGTLLYAFITKRKIPAYLGS
SFAFISPVLLLMGEGYSFTEVQSGFVVSGLLFATIAIIVGFVGTGWIRKLFPPASMGAIVTIIGLELAPTAADMAGFPVG
LSNSKVLNPTWVLVSMITIITVILASVLLRGFLKVIPILIGIVTGYLVSCFLGLVDFTQVKEASLFVLPQIHIAKPSLNA
ILTILPATFVVVAEHVGHLVVTSSIVGKDLSKDPGLNRSLLGDGLSTMISGFFGSVPTTTYGENIGVMALTKVYSSYVIC
GAGVLSVILGFSGSLSALIRSIPTPVIGGVSLLLFGTIATSGLRTFIEEKVDYSKSKNLILTSVTMIVGLSNIAVRFGAI
EIKGMGLATIVAMILSISFMIFDKLGLMNEK

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=457, Percent_Identity=25.164113785558, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI40316845, Length=457, Percent_Identity=25.164113785558, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI44680145, Length=461, Percent_Identity=24.295010845987, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI44680143, Length=465, Percent_Identity=23.6559139784946, Blast_Score=83, Evalue=6e-16,
Organism=Escherichia coli, GI1788843, Length=414, Percent_Identity=57.2463768115942, Blast_Score=445, Evalue=1e-126,
Organism=Escherichia coli, GI87081818, Length=417, Percent_Identity=39.3285371702638, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI87082181, Length=437, Percent_Identity=27.9176201372998, Blast_Score=141, Evalue=9e-35,
Organism=Escherichia coli, GI1790087, Length=421, Percent_Identity=24.2280285035629, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI87082178, Length=368, Percent_Identity=26.6304347826087, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17558856, Length=216, Percent_Identity=29.6296296296296, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17541904, Length=229, Percent_Identity=27.5109170305677, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71993493, Length=217, Percent_Identity=28.110599078341, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17542262, Length=152, Percent_Identity=29.6052631578947, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17542260, Length=214, Percent_Identity=28.0373831775701, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21356175, Length=441, Percent_Identity=24.0362811791383, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 45696; Mature: 45565

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESVQNKEVELLEVIGVEDKLPLKKAIPLSVQHLFAMFGSSVLVPILLNIDPATVLFFN
CCCCCCCCCHHHHHHHCCCCCCCCHHCCCHHHHHHHHHHCCCEEEHHEECCCCHHHHHHH
GIGTLLYAFITKRKIPAYLGSSFAFISPVLLLMGEGYSFTEVQSGFVVSGLLFATIAIIV
HHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHH
GFVGTGWIRKLFPPASMGAIVTIIGLELAPTAADMAGFPVGLSNSKVLNPTWVLVSMITI
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
ITVILASVLLRGFLKVIPILIGIVTGYLVSCFLGLVDFTQVKEASLFVLPQIHIAKPSLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCEEECCCCHH
AILTILPATFVVVAEHVGHLVVTSSIVGKDLSKDPGLNRSLLGDGLSTMISGFFGSVPTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHHCCCCCC
TYGENIGVMALTKVYSSYVICGAGVLSVILGFSGSLSALIRSIPTPVIGGVSLLLFGTIA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHH
TSGLRTFIEEKVDYSKSKNLILTSVTMIVGLSNIAVRFGAIEIKGMGLATIVAMILSISF
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEECCEEEECCCHHHHHHHHHHHHH
MIFDKLGLMNEK
HHHHHHHCCCCC
>Mature Secondary Structure 
TESVQNKEVELLEVIGVEDKLPLKKAIPLSVQHLFAMFGSSVLVPILLNIDPATVLFFN
CCCCCCCCHHHHHHHCCCCCCCCHHCCCHHHHHHHHHHCCCEEEHHEECCCCHHHHHHH
GIGTLLYAFITKRKIPAYLGSSFAFISPVLLLMGEGYSFTEVQSGFVVSGLLFATIAIIV
HHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHH
GFVGTGWIRKLFPPASMGAIVTIIGLELAPTAADMAGFPVGLSNSKVLNPTWVLVSMITI
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
ITVILASVLLRGFLKVIPILIGIVTGYLVSCFLGLVDFTQVKEASLFVLPQIHIAKPSLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCEEECCCCHH
AILTILPATFVVVAEHVGHLVVTSSIVGKDLSKDPGLNRSLLGDGLSTMISGFFGSVPTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHHCCCCCC
TYGENIGVMALTKVYSSYVICGAGVLSVILGFSGSLSALIRSIPTPVIGGVSLLLFGTIA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHH
TSGLRTFIEEKVDYSKSKNLILTSVTMIVGLSNIAVRFGAIEIKGMGLATIVAMILSISF
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEECCEEEECCCHHHHHHHHHHHHH
MIFDKLGLMNEK
HHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]